2023
Maternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation?
Creasey N, Beijers R, O'Donnell K, de Weerth C, Tollenaar M. Maternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation? Development And Psychopathology 2023, 36: 967-978. PMID: 36896668, DOI: 10.1017/s0954579423000226.Peer-Reviewed Original ResearchAge 5 weeksChild mental healthMaternal sensitivityMental healthGlucocorticoid receptor gene methylationAge 6 yearsChildren's internalizingMethylation levelsMother-infant interactionDNA methylation levelsAnimal modelsEarly infancyStress regulatory systemsExternalizing behaviorsEarly caregiving environmentGene DNA methylationAge 6Longitudinal studyLower DNA methylation levelsResponsive caregivingSame childrenCommunity sampleCaregiving environmentGene methylationDNA methylation
2022
Natural history of TANGO2 deficiency disorder: Baseline assessment of 73 patients
Miyake C, Lay E, Soler-Alfonso C, Glinton K, Houck K, Tosur M, Moran N, Stephens S, Scaglia F, Howard T, Kim J, Pham T, Valdes S, Li N, Murali C, Zhang L, Kava M, Yim D, Beach C, Webster G, Liberman L, Janson C, Kannankeril P, Baxter S, Singer-Berk M, Wood J, Mackenzie S, Sacher M, Ghaloul-Gonzalez L, Pedroza C, Morris S, Ehsan S, Azamian M, Lalani S. Natural history of TANGO2 deficiency disorder: Baseline assessment of 73 patients. Genetics In Medicine 2022, 25: 100352. PMID: 36473599, PMCID: PMC10306319, DOI: 10.1016/j.gim.2022.11.020.Peer-Reviewed Original ResearchConceptsMetabolic crisisNatural historyCardiac crisisDeficiency disordersOngoing natural history studyMedical record reviewNatural history studiesAutosomal recessive diseaseMedian ageMultivitamin supplementationRecord reviewIntermittent ataxiaNeurodevelopmental delayEarly infancyPatientsBaseline assessmentSpeech difficultiesB complexDevelopmental milestonesRecessive diseaseParent interviewsUnrelated familiesAtaxiaHistory studiesProgressive delay
2021
Pacific Islands Families Study: adverse impact of food insecurity on child body composition.
Oyama S, Tautolo E, Tukuitonga C, Rush E. Pacific Islands Families Study: adverse impact of food insecurity on child body composition. The New Zealand Medical Journal 2021, 134: 30-38. PMID: 34695074.Peer-Reviewed Original ResearchConceptsFood insecurityHousehold food insecurityAppendicular skeletal muscle massVisceral adipose tissueAge 14 yearsPacific Islands Families StudyFood insecurity statusFood secure householdsHousehold food insecurity statusBody compositionInsecuritySecure householdsFood securityDual X-ray absorptiometry (DXA) measurementsChildren's body compositionPacific Island mothersSkeletal muscle massYouthVisceral fatWeeks postpartumGreater birthweightAdipose tissueEarly infancyMuscle massLater life
2020
A missense variant in CREBRF, rs373863828, is associated with fat-free mass, not fat mass in Samoan infants
Arslanian KJ, Fidow UT, Atanoa T, Unasa-Apelu F, Naseri T, Wetzel AI, Pomer A, Duckham RL, McGarvey ST, Strayer JA, Kershaw EE, Weeks DE, Hawley NL. A missense variant in CREBRF, rs373863828, is associated with fat-free mass, not fat mass in Samoan infants. International Journal Of Obesity 2020, 45: 45-55. PMID: 32884101, PMCID: PMC8329753, DOI: 10.1038/s41366-020-00659-4.Peer-Reviewed Original ResearchConceptsBody mass indexDual-energy X-ray absorptiometrySamoan infantsBone massFat massLean massEarly infantsBody compositionInfant body mass indexMinor alleleDeterminants of adiposityOdds of diabetesBone mass accretionMissense variantsX-ray absorptiometryFat-free massCross-sectional analysisMore bone massCREBRF variantProspective studyHigher oddsEarly infancyInfantsAdult populationNatural historyStiripentol fails to lower plasma oxalate in a dialysis-dependent PH1 patient
Kempf C, Pfau A, Holle J, Müller-Schlüter K, Bufler P, Knauf F, Müller D. Stiripentol fails to lower plasma oxalate in a dialysis-dependent PH1 patient. Pediatric Nephrology 2020, 35: 1787-1789. PMID: 32418144, PMCID: PMC7385015, DOI: 10.1007/s00467-020-04585-5.Peer-Reviewed Original ResearchConceptsEnd-stage renal diseaseChronic kidney diseaseLactate dehydrogenase 5Urinary oxalateAdvanced chronic kidney diseaseAnti-convulsive drugsMultisystemic metabolic disorderLiver-kidney transplantationMajority of patientsCurrent standard treatmentTreatment of childrenHyperoxaluria type 1Anuric infantsPH patientsUox excretionRenal diseaseDravet syndromeKidney diseasePrimary hyperoxaluriaCompassionate useStandard treatmentPlasma concentrationsMetabolic disordersPromising drugEarly infancy
2017
A multiregional proteomic survey of the postnatal human brain
Carlyle BC, Kitchen RR, Kanyo JE, Voss EZ, Pletikos M, Sousa AMM, Lam TT, Gerstein MB, Sestan N, Nairn AC. A multiregional proteomic survey of the postnatal human brain. Nature Neuroscience 2017, 20: 1787-1795. PMID: 29184206, PMCID: PMC5894337, DOI: 10.1038/s41593-017-0011-2.Peer-Reviewed Original ResearchConceptsProteomic surveyResident plasma membrane proteinsPostnatal human brainProtein dataPlasma membrane proteinsProtein abundance differencesQuantitative tandem mass spectrometryPost-translational eventsWhole transcriptome sequencingRNA expression dataMembrane proteinsFunctional variationExpression dataAbundance differencesBrain regionsTandem mass spectrometryHuman brainSimilar cortical regionsMass spectrometryEarly infancyRNACortical regionsSequencingProteinAbundance
2016
Linear Growth and Child Development in Burkina Faso, Ghana, and Malawi
Prado E, Abbeddou S, Adu-Afarwuah S, Arimond M, Ashorn P, Ashorn U, Brown K, Hess S, Lartey A, Maleta K, Ocansey E, Ouédraogo J, Phuka J, Somé J, Vosti S, Jimenez E, Dewey K. Linear Growth and Child Development in Burkina Faso, Ghana, and Malawi. 2016, 138: e20154698. PMID: 27474016, DOI: 10.1542/peds.2015-4698.Peer-Reviewed Original ResearchConceptsPersonal-social developmentDevelopmental stimulationAge z-scoreAge 18 monthsMaternal supplementationLinear growthNutritional supplementationGrowth falteringEarly infancyZ-scoreMotor developmentAdjusted estimatesBurkina FasoMonthsBirthChild developmentMotor skillsChildrenSDAssociationExecutive functionSupplementationStimulationExecutive function developmentPoor development
2015
Newborn Screening for Biliary Atresia
Wang K, Moss R, Caty M, Davidoff A, Fallat M, Heiss K, Holcomb G, Meyers R, Watterberg K, Aucott S, Benitz W, Cummings J, Eichenwald E, Goldsmith J, Poindexter B, Puopolo K, Stewart D, Wang K, Kerkar N, Karpen S, Sokol R, Schwarz K, Mogul D, Harpavat S. Newborn Screening for Biliary Atresia. 2015, 136: e1663-e1669. PMID: 26620065, PMCID: PMC4920543, DOI: 10.1542/peds.2015-3570.Peer-Reviewed Original ResearchConceptsBiliary atresiaNative liverPediatric end-stage liver diseaseEnd-stage liver diseasePediatric liver transplantationStool color cardSerum bilirubin concentrationSuccessful surgical drainagePotential screening strategiesRare infantsLiver transplantationCholestatic jaundiceSurgical drainageBiliary obstructionLiver diseaseLeading indicationCommon causeTimely diagnosisEarly diagnosisAtresiaEarly infancyBilirubin concentrationEarly identificationNewborn screeningScreening strategyEffect of Zinc & Multiple Micronutrient Supplements on Growth in Tanzanian Children
Locks L, Manji K, McDonald C, Kupka R, Kisenge R, Aboud S, Wang M, Spiegelman D, Fawzi W, Duggan C. Effect of Zinc & Multiple Micronutrient Supplements on Growth in Tanzanian Children. The FASEB Journal 2015, 29 DOI: 10.1096/fasebj.29.1_supplement.729.1.Peer-Reviewed Original ResearchDouble-blind clinical trialBlind clinical trialMultiple micronutrient supplementsAge 6 weeksRate of underweightRisk of mortalityGrowth of infantsAge z-scorePoor child growthMonths of ageRates of stuntingMedian complianceTanzanian infantsMultivitamin supplementsClinical trialsMicronutrient supplementsDaily zincMean changeGrowth falteringTanzanian childrenEarly infancyMultivitaminsZ-scoreUnderweightInfants
2014
Age‐Dependent Sex Effects on Outcomes After Pediatric Cardiac Surgery
Kochilas LK, Vinocur JM, Menk JS. Age‐Dependent Sex Effects on Outcomes After Pediatric Cardiac Surgery. Journal Of The American Heart Association 2014, 3: e000608. PMID: 24496232, PMCID: PMC3959673, DOI: 10.1161/jaha.113.000608.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsCardiac Surgical ProceduresChi-Square DistributionChildChild, PreschoolFemaleHealth Status DisparitiesHeart Defects, CongenitalHospital MortalityHumansInfantInfant, NewbornLogistic ModelsMaleMultivariate AnalysisNorth AmericaOdds RatioRegistriesRetrospective StudiesRisk FactorsSex FactorsTime FactorsTreatment OutcomeConceptsPediatric cardiac operationsPediatric cardiac surgeryCardiac surgeryCardiac operationsPostsurgical mortalityHigh-risk cardiac operationsPediatric Cardiac Care ConsortiumRisk of deathMonths of lifePotential sex differencesAge-dependent relationshipSurgical yearHospital mortalityUnadjusted mortalityPatient sexWhole cohortHigh-risk operationsCardiovascular diseaseSex effectsCardiovascular stressCare ConsortiumEarly infancyZ-scoreLogistic regressionMortality
2013
The longitudinal development of emotion regulation capacities in children at risk for externalizing disorders
Halligan S, Cooper P, Fearon P, Wheeler S, Crosby M, Murray L. The longitudinal development of emotion regulation capacities in children at risk for externalizing disorders. Development And Psychopathology 2013, 25: 391-406. PMID: 23627952, DOI: 10.1017/s0954579412001137.Peer-Reviewed Original ResearchConceptsEmotion regulation capacitiesMaternal sensitivityEmotion regulationRegulation capacityChildren's emotion regulationPoor emotion regulationEmotional regulation capacitySensitive maternal behaviorLower maternal sensitivityDirect observational assessmentsNegative emotionsInsensitive parentingPsychosocial adversityDevelopmental influencesBehavioral problemsLow-risk counterpartsHigh-risk childrenObservational assessmentLongitudinal studyLongitudinal developmentMaternal behaviorCausal roleStages of assessmentChildrenEarly infancy
2012
Ontogenetic differences in ethanol's motivational properties during infancy
Nizhnikov M, Pautassi R, Varlinskaya E, Rahmani P, Spear N. Ontogenetic differences in ethanol's motivational properties during infancy. Alcohol 2012, 46: 225-234. PMID: 22440692, PMCID: PMC3376757, DOI: 10.1016/j.alcohol.2011.09.026.Peer-Reviewed Original ResearchConceptsKappa-opioid agonistRat pupsOpioid agonistsHigh dosesAppetitive propertiesAversive propertiesAppetitive reinforcementDose of ethanolDoses of ethanolMotivational propertiesPercent body weight gainBody weight gainTaste conditioning procedureEthanol's motivational propertiesAdult rodentsEarly infancyYoung ratsBody weightInfant ratsOld pupsLow dosesWeight gainPupsDosesAppetitive responsesBrain Development: Neural Signature Predicts Autism's Emergence
Pelphrey KA, McPartland JC. Brain Development: Neural Signature Predicts Autism's Emergence. Current Biology 2012, 22: r127-r128. PMID: 22361148, DOI: 10.1016/j.cub.2012.01.025.Peer-Reviewed Original Research
2011
Paradoxical psychological functioning in early child development
Pascual-Leone A, Ramachandran V, Cole J, Della Sala S, Manly T, Mayes A, Sacks O, Lewkowicz D, Ghazanfar A. Paradoxical psychological functioning in early child development. 2011, 110-129. DOI: 10.1017/cbo9780511978098.008.Peer-Reviewed Original ResearchSensory inputOlder infantsEarly child developmentYoung infantsMultisensory coherencePerceptual narrowingSpeech contrastsMultisensory eventsPerceptual developmentPerceptual sensitivityRace facesPerceptual tuningPsychological functioningCognitive skillsSpeech gesturesMusical rhythmChild developmentNative inputEmergence of specializationDifferent culturesEarly infancyVocalizationsDevelopmental processesFunctioningGestures
2010
The Development of Mentalisation in Children From a Theory of Mind Perspective
Ensink K, Mayes L. The Development of Mentalisation in Children From a Theory of Mind Perspective. Psychoanalytic Inquiry 2010, 30: 301-337. DOI: 10.1080/07351690903206504.Peer-Reviewed Original ResearchActions of selfKey developmental questionsCognitive developmentalistsMind perspectiveCourse of developmentDevelopment of theoryDevelopmental questionsOwn behaviorTerm theoryYoung childrenBody of workSpecific domainsFeelingsEarly infancyBeliefsMindProductive linesBroader goalChildrenStartling evidenceMentalisationPsychologistsDevelopmentalistsIntentionalityDesire
2007
Maternal, Birth, and Early-Life Influences on Adult Body Size in Women
Terry MB, Wei Y, Esserman D. Maternal, Birth, and Early-Life Influences on Adult Body Size in Women. American Journal Of Epidemiology 2007, 166: 5-13. PMID: 17470452, DOI: 10.1093/aje/kwm094.Peer-Reviewed Original ResearchConceptsAge 20 yearsInfant factorsAdult BMIChildhood growthRapid childhood growthMaternal weight gainAge 40 yearsChildhood growth measuresEarly life influencesImportant predictorPersistence of effectsMaternal BMIBirth measuresBirth weightAge 40BMIEarly infancyMaternal factorsAge 20Weight gainWomenLife influencesLarger womenAge 1Standard statistical methods
1995
Primary care of children with HIV infection
Forsyth B. Primary care of children with HIV infection. Current Opinion In Pediatrics 1995, 7: 502-512. PMID: 8541949, DOI: 10.1097/00008480-199510000-00004.Peer-Reviewed Original ResearchConceptsPrimary care physiciansCare physiciansPneumocystis carinii pneumonia prophylaxisPediatric HIV diseasePrevention (CDC) classification systemSpecific treatment approachesComprehensive health carePneumonia prophylaxisIntravenous immunoglobulinAntiretroviral medicationsHIV diseaseHIV infectionPrimary careSpecialty clinicCoordinated careClinical aspectsEarly infancyNumber of childrenTreatment approachesEpidemic increaseDisease controlHealth careEarly introductionCareChildren
1991
Synaptogenesis in Monkey Somatosensory Cortex
Zecevic N, Rakic P. Synaptogenesis in Monkey Somatosensory Cortex. Cerebral Cortex 1991, 1: 510-523. PMID: 1822755, DOI: 10.1093/cercor/1.6.510.Peer-Reviewed Original ResearchConceptsYears of ageSomatosensory cortexSynaptic densityPostcentral gyrusLate fetal ageUpper limb representationDensity of synapsesMonkey somatosensory cortexNumber of synapsesSecond postnatal monthRate of synaptogenesisMicrons 3Timing of synaptogenesisPost-natal lifeSymmetrical synapsesDendritic shaftsSynaptic eliminationSomatosensory functionPostnatal monthDendritic spinesNeocortical areasCortical growthEarly infancyNeurotransmitter receptorsLimb representation
1990
Oculomotor responses to step-ramp targets by young human infants
Shea S, Aslin R. Oculomotor responses to step-ramp targets by young human infants. Vision Research 1990, 30: 1077-1092. PMID: 2392836, DOI: 10.1016/0042-6989(90)90116-3.Peer-Reviewed Original ResearchConceptsSecond postnatal monthPursuit gainSmooth pursuitDeg/secPostnatal monthFrequent saccadic intrusionsStep-ramp targetsSmooth pursuit systemSaccadic intrusionsPursuit velocityYoung human infantsDeg targetEarly infancyYoung infantsInfantsPursuit systemOculomotor responsesHuman infantsTarget velocitySlower target velocitiesMonthsScreen centerInfants' trackingTargetWeeks
1986
Dark vergence in human infants: implications for the development of binocular vision
Aslin R. Dark vergence in human infants: implications for the development of binocular vision. Acta Psychologica 1986, 63: 309-322. PMID: 3591441, DOI: 10.1016/0001-6918(86)90076-4.Peer-Reviewed Original Research
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