2025
A positron emission tomography tracer for the imaging of oxidative stress in the central nervous system
Wilde J, Sun Y, Simpson S, Hill E, Fu Z, Bian E, Kinkaid M, Villanueva P, Weybright A, Terrell W, Qureshi Z, Perera S, Sheppard H, Stone J, Kundu B, Kuan C, Neumann K. A positron emission tomography tracer for the imaging of oxidative stress in the central nervous system. Nature Biomedical Engineering 2025, 9: 716-729. PMID: 40044816, PMCID: PMC12092265, DOI: 10.1038/s41551-025-01362-3.Peer-Reviewed Original ResearchCentral nervous systemPositron emission tomographyInjection of sodium nitroprussideOxidative stressNervous systemClinical trials of antioxidantsMiddle cerebral arteryBlood-brain barrierTrials of antioxidantsPositron emission tomography tracersIntrastriatal injectionParametric mappingSodium nitroprussideCerebral arteryLongitudinally in vivoIn vivo quantificationQuantification of oxidative stressEmission tomographyPET imagingAntioxidant edaravoneDynamic PET imagesHuman plasma
2024
Practice patterns of cardiovascular magnetic resonance use in the diagnosis of pediatric myocarditis: A survey-based study
Jacobs H, Soslow J, Cornicelli M, Merves S, Garg R, Patel M, Agarwal A, Misra N, DiLorenzo M, Campbell M, Steele J, Co-Vu J, Robinson J, Lee S, Johnson J. Practice patterns of cardiovascular magnetic resonance use in the diagnosis of pediatric myocarditis: A survey-based study. Journal Of Cardiovascular Magnetic Resonance 2024, 26: 101091. PMID: 39270799, PMCID: PMC11647491, DOI: 10.1016/j.jocmr.2024.101091.Peer-Reviewed Original ResearchLake Louise criteriaDiagnosis of myocarditisCardiovascular magnetic resonancePractice patternsEvaluate clinical practice patternsCardiovascular magnetic resonance evaluationClinical cardiovascular magnetic resonanceNon-invasive cardiac imagingSuspicion of myocarditisParametric mappingPediatric normative dataMagnetic resonance evaluationSpecificity of diagnosisClinical practice patternsDiagnosing myocarditisPediatric myocarditisNormative dataResearch Electronic Data CapturePediatric centersPediatric populationMyocardial diseaseMyocarditisElectronic data captureCMR imagesDiagnostic uncertainty
2023
Group independent components underpin responses to items from a depression scale.
Stoyanov D, Khorev V, Paunova R, Kandilarova S, Kurkin S, Calhoun V. Group independent components underpin responses to items from a depression scale. Acta Neuropsychiatrica 2023, 36: 9-16. PMID: 37088536, DOI: 10.1017/neu.2023.22.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingGroup independent component analysisSelf-evaluation scaleFrontal gyrusCingulate cortexDepression ScaleRight superior frontal gyrusFunctional magnetic resonance imaging acquisitionHealthy controlsRight middle cingulate cortexAnterior cingulate cortexMiddle frontal gyrusSuperior frontal gyrusMiddle cingulate cortexIndependent component analysisGroup independent componentStatistical parametric mappingDepressive disorderDepressive episodeBrain circuitsBrain networksNeural network patternsDiagnostic conditionsParametric mappingGyrus
2021
Neuroanatomical and cognitive correlates of visual hallucinations in Parkinson’s disease and dementia with Lewy bodies: Voxel-based morphometry and neuropsychological meta-analysis
Pezzoli S, Sánchez-Valle R, Solanes A, Kempton M, Bandmann O, Shin J, Cagnin A, Goldman J, Merkitch D, Firbank M, Taylor J, Pagonabarraga J, Kulisevsky J, Blanc F, Verdolini N, Venneri A, Radua J. Neuroanatomical and cognitive correlates of visual hallucinations in Parkinson’s disease and dementia with Lewy bodies: Voxel-based morphometry and neuropsychological meta-analysis. Neuroscience & Biobehavioral Reviews 2021, 128: 367-382. PMID: 34171324, DOI: 10.1016/j.neubiorev.2021.06.030.Peer-Reviewed Original ResearchConceptsVoxel-based morphometryImmediate memory performanceVisual hallucinationsCognitive correlatesMemory performanceMeta-analyses of voxel-based morphometryAssociated with smaller grey matter volumesSmaller grey matter volumesSeed-based d mappingGray matter volumeParkinson's diseaseStatistical parametric mappingLewy body diseaseNeuropsychological studiesNeural substratesMatter volumeExecutive abilitiesBrain networksBrain regionsSDM-PSIParietal areasD mappingParametric mappingHallucinationsLewy bodies
2019
Understanding the Learning Disabilities Linked to Sagittal Craniosynostosis
Cabrejo R, Lacadie C, Brooks E, Beckett J, Sun A, Yang J, Chuang C, Eilbott J, Duncan C, Steinbacher D, Alperovich M, Ventola P, Pelphrey K, Constable T, Persing J. Understanding the Learning Disabilities Linked to Sagittal Craniosynostosis. Journal Of Craniofacial Surgery 2019, 30: 497-502. PMID: 30676447, DOI: 10.1097/scs.0000000000005194.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderFunctional magnetic resonance imagingSagittal nonsyndromic craniosynostosisSagittal craniosynostosisDifferent neural connectionsPrimary visual cortexVisual association cortexMagnetic resonance imagingStatistical parametric mappingDeficit hyperactivity disorderBrodmann area 11Association cortexVisual cortexResonance imagingNeurocognitive deficitsNeural connectionsPatientsFMRI scansHyperactivity disorderNonsyndromic craniosynostosisParametric mappingControl adolescentsAuditory processingArea 11Craniosynostosis
2018
Resting state functional connectivity of the amygdala and problem drinking in non-dependent alcohol drinkers
Hu S, Ide JS, Chao HH, Zhornitsky S, Fischer KA, Wang W, Zhang S, Li CR. Resting state functional connectivity of the amygdala and problem drinking in non-dependent alcohol drinkers. Drug And Alcohol Dependence 2018, 185: 173-180. PMID: 29454928, PMCID: PMC5889735, DOI: 10.1016/j.drugalcdep.2017.11.026.Peer-Reviewed Original ResearchConceptsState functional connectivityDorsal anterior cingulate cortexAlcohol misuseAlcohol drinkersFunctional connectivityInvolvement scoreProblem drinkingSubstance useWhole-brain rsFCComorbid substance useAmygdala-prefrontal cortical circuitAnterior cingulate cortexStatistical parametric mappingPotential sex differencesPrefrontal cortical structuresAmygdala connectivityCortical functionCortical circuitsCingulate cortexAmygdalaCortical structuresParametric mappingSex differencesDrinkingDrinkers
2017
Rapid computation of single PET scan rest‐stress myocardial blood flow parametric images by table look up
Guehl N, Normandin M, Wooten D, Rozen G, Ruskin J, Shoup T, Woo J, Ptaszek L, Fakhri G, Alpert N. Rapid computation of single PET scan rest‐stress myocardial blood flow parametric images by table look up. Medical Physics 2017, 44: 4643-4651. PMID: 28594441, PMCID: PMC5603217, DOI: 10.1002/mp.12398.Peer-Reviewed Original Research
2011
The Value of Three-Dimensional Echocardiography Derived Mitral Valve Parametric Maps and the Role of Experience in the Diagnosis of Pathology
Tsang W, Weinert L, Sugeng L, Chandra S, Ahmad H, Spencer K, Mor-Avi V, Lang R. The Value of Three-Dimensional Echocardiography Derived Mitral Valve Parametric Maps and the Role of Experience in the Diagnosis of Pathology. Journal Of The American Society Of Echocardiography 2011, 24: 860-867. PMID: 21719254, DOI: 10.1016/j.echo.2011.05.015.Peer-Reviewed Original ResearchConceptsMitral valveMV pathologyDegenerative MV diseaseParametric mappingThree-dimensional echocardiographyTransesophageal echocardiographic imagesSequential weekly sessionsMV anatomyTransesophageal echocardiographyMV diseaseSurgical findingsDiagnostic accuracySurgical planningReader accuracyReal-time three-dimensionalSegmental anatomyEchocardiographic imagesDiagnosis of pathologiesEchocardiographyTransesophagealPathologyExpert readersLevel of trainingImage typesAnatomyCerebral perfusion and automated individual analysis using SPECT among an obsessive-compulsive population
da Rocha E, Buchpiguel C, Miguel E, Peres S, Filho G. Cerebral perfusion and automated individual analysis using SPECT among an obsessive-compulsive population. Jornal Brasileiro De Psiquiatria 2011, 60: 1-6. DOI: 10.1590/s0047-20852011000100001.Peer-Reviewed Original ResearchStatistical parametric mappingBrain SPECT imagesCerebral perfusionPerfusion abnormalitiesPerfusional abnormalitiesSPECT examinationNormal groupNormal subjectsClinical practiceSample of subjectsParametric mappingAbnormalitiesPatientsSPECT imagesIndividual assessmentVoxel levelSubjectsOCDStatistical thresholdPerfusionIndividual analysis
2010
New open‐source ictal SPECT analysis method implemented in BioImage Suite
Scheinost D, Teisseyre TZ, Distasio M, DeSalvo MN, Papademetris X, Blumenfeld H. New open‐source ictal SPECT analysis method implemented in BioImage Suite. Epilepsia 2010, 51: 703-707. PMID: 20074234, PMCID: PMC2963625, DOI: 10.1111/j.1528-1167.2009.02425.x.Peer-Reviewed Original Research
2007
Validation of a Standardized Normalization Template for Statistical Parametric Mapping Analysis of 123I-FP-CIT Images
Kas A, Payoux P, Habert M, Malek Z, Cointepas Y, El Fakhri G, Chaumet-Riffaud P, Itti E, Remy P. Validation of a Standardized Normalization Template for Statistical Parametric Mapping Analysis of 123I-FP-CIT Images. Journal Of Nuclear Medicine 2007, 48: 1459-1467. PMID: 17704252, DOI: 10.2967/jnumed.106.038646.Peer-Reviewed Original ResearchConceptsStatistical parametric mappingDopamine transporterStatistical parametric mapping analysisIntraclass correlation coefficientStriatal (123)I-FP-CIT uptakeParkinson's diseaseStatistical parametric mapping approachEssential tremorBland-Altman graphical analysisStriatal volumeDopaminergic cell lossDAT imagingLow intraclass correlation coefficientsParametric mappingSpatial normalizationNo significant differencePD patientsCustomized templateIntergroup analysisCell lossSpatial normalization procedureResults of groupSPM normalizationSignificant differenceSPECT
2005
Localizing Value of Ictal–Interictal SPECT Analyzed by SPM (ISAS)
McNally KA, Paige AL, Varghese G, Zhang H, Novotny EJ, Spencer SS, Zubal IG, Blumenfeld H. Localizing Value of Ictal–Interictal SPECT Analyzed by SPM (ISAS). Epilepsia 2005, 46: 1450-1464. PMID: 16146441, DOI: 10.1111/j.1528-1167.2005.06705.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrain MappingElectroencephalographyEpilepsyEpilepsy, Temporal LobeFemaleFunctional LateralityHumansImage Processing, Computer-AssistedMaleMiddle AgedNeocortexPreoperative CareReproducibility of ResultsROC CurveTechnetium Tc 99m ExametazimeTomography, Emission-Computed, Single-PhotonVideotape RecordingConceptsStatistical parametric mappingIctal-interictal SPECTSeizure onsetMultiple brain regionsPostictal SPECTBrain regionsLateralized seizure onsetInterictal scansPostictal scansIctal SPECTDecreased perfusionSeizure endEpilepsy casesMesial temporalPerfusion increaseSPECT analysisSPECT scansSeizuresLocalized epilepsyParametric mappingTracer injectionSPECTInjectionPatientsEpilepsyQuantitative dynamic cardiac 82Rb PET using generalized factor and compartment analyses.
El Fakhri G, Sitek A, Guérin B, Kijewski M, Di Carli M, Moore S. Quantitative dynamic cardiac 82Rb PET using generalized factor and compartment analyses. Journal Of Nuclear Medicine 2005, 46: 1264-71. PMID: 16085581.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAlgorithmsComputer SimulationCoronary Artery DiseaseFeasibility StudiesFemaleHeartHumansImage Interpretation, Computer-AssistedMaleMiddle AgedModels, CardiovascularPositron-Emission TomographyRadiopharmaceuticalsReproducibility of ResultsRubidium RadioisotopesSensitivity and SpecificitySeverity of Illness IndexConceptsMyocardial perfusionAbsolute myocardial perfusionCatheterization resultsMyocardial tissue extractsDipyridamole stressCardiac PETClinical valueMyocardial factorsFactor analysis of dynamic sequencesPatient studiesLVNoninvasive estimationAccurate input functionPatientsCompartment analysisAverage errorPerfusionParametric mappingTissue extractsRV contributionRV
2004
Measurement of whole-brain atrophy in multiple sclerosis.
Pelletier D, Garrison K, Henry R. Measurement of whole-brain atrophy in multiple sclerosis. Journal Of Neuroimaging 2004, 14: 11s-19s. PMID: 15228755, DOI: 10.1177/1051228404266264.Peer-Reviewed Original ResearchConceptsWhole-brain atrophyMeasures of whole-brain atrophyMagnetic resonance imagingBrain atrophyMultiple sclerosisVoxel-based morphometryIndices of brain atrophyWhole-brain atrophy measuresClinical course of MSStatistical parametric mappingMeasure whole-brain atrophyStandard magnetic resonance imagingBrain parenchymal fractionBrain structuresCourse of MSBrain boundary shiftMS clinical trialsRegistration-based methodSensitive to subtle changesParametric mappingClinical courseParenchymal fractionAtrophy measuresBrainClinical trials
2000
Decreased Benzodiazepine Receptor Binding in Prefrontal Cortex in Combat-Related Posttraumatic Stress Disorder
Bremner J, Innis R, Southwick S, Staib L, Zoghbi S, Charney D. Decreased Benzodiazepine Receptor Binding in Prefrontal Cortex in Combat-Related Posttraumatic Stress Disorder. American Journal Of Psychiatry 2000, 157: 1120-1126. PMID: 10873921, DOI: 10.1176/appi.ajp.157.7.1120.Peer-Reviewed Original ResearchConceptsBenzodiazepine receptor bindingPosttraumatic stress disorderBenzodiazepine receptorsReceptor bindingPrefrontal cortexComparison subjectsCase-matched healthy comparison subjectsDistribution volumeStress disorderSymptoms of PTSDBenzodiazepine receptor functionLow distribution volumeHealthy comparison subjectsCombat-related posttraumatic stress disorderMedial prefrontal cortexCentral benzodiazepine receptorsSingle photon emissionStatistical parametric mappingFrontal cortexPTSD patientsPatientsReceptor functionCortexTomography imagingParametric mappingSPECT [I-123]iomazenil measurement of the benzodiazepine receptor in panic disorder
Bremner J, Innis R, White T, Fujita M, Silbersweig D, Goddard A, Staib L, Stern E, Cappiello A, Woods S, Baldwin R, Charney D. SPECT [I-123]iomazenil measurement of the benzodiazepine receptor in panic disorder. Biological Psychiatry 2000, 47: 96-106. PMID: 10664825, DOI: 10.1016/s0006-3223(99)00188-2.Peer-Reviewed Original ResearchConceptsBenzodiazepine receptor bindingBenzodiazepine receptor functionPanic disorder patientsBenzodiazepine receptorsPanic disorderReceptor bindingDisorder patientsPanic attacksReceptor functionPrefrontal cortexSingle photon emissionStatistical parametric mappingGABAergic transmissionHealthy controlsFrontal cortexLeft hippocampusAnimal modelsComparison subjectsPatientsChronic stressPanic anxietyTomography imagingParametric mappingCortexSpecific decrease
1998
Alterations of Benzodiazepine Receptors in Type II Alcoholic Subjects Measured With SPECT and 123IIomazenil
Abi-Dargham A, Krystal JH, Anjilvel S, Scanley BE, Zoghbi S, Baldwin RM, Rajeevan N, Ellis S, Petrakis IL, Seibyl JP, Charney DS, Laruelle M, Innis RB. Alterations of Benzodiazepine Receptors in Type II Alcoholic Subjects Measured With SPECT and 123IIomazenil. American Journal Of Psychiatry 1998, 155: 1550-1555. PMID: 9812116, DOI: 10.1176/ajp.155.11.1550.Peer-Reviewed Original ResearchConceptsHealthy comparison subjectsBenzodiazepine receptorsComparison subjectsAlcoholic subjectsDistribution volumeAlcoholic patientsAnterior cingulateBenzodiazepine receptor densityRight middle frontal gyrusLeft occipital cortexType II alcoholismSingle photon emissionMiddle frontal gyrusStatistical parametric mappingContinuous infusionReceptor radiotracerReceptor densityOccipital cortexCerebellar cortexCortical regionsPatientsFrontal gyrusInterest analysisVivo studiesParametric mapping
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