2023
Decay in Entorhinal White Matter/Gray Matter contrast in Alzheimer’s Disease Patients is reduced by 40Hz sensory stimulation
Da X, Hempel E, Malchano Z, Vaughan B, Megerian J, Hajos M, Cimenser A. Decay in Entorhinal White Matter/Gray Matter contrast in Alzheimer’s Disease Patients is reduced by 40Hz sensory stimulation. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.077337.Peer-Reviewed Original ResearchMagnetic resonance imagingEntorhinal regionAlzheimer's diseaseWhite matterPlacebo groupDisease patientsMRI measuresTreatment groupsPlacebo-controlled feasibility studyPhase I/IISensory stimulationMonth 6 visitMonths of treatmentStructural magnetic resonance imagingAlzheimer's disease patientsSignal intensityT1 magnetic resonance imagingLinear mixed-effects modelingMonth 3WM atrophyMyelin lossAD severityWM/GM contrastMixed-effects modelingAD patients
2022
Alcohol and cannabis co‐use and longitudinal gray matter volumetric changes in early and late adolescence
Luo X, Yang JJ, Buu A, Trucco EM, Li C. Alcohol and cannabis co‐use and longitudinal gray matter volumetric changes in early and late adolescence. Addiction Biology 2022, 27: e13208. PMID: 36001427, PMCID: PMC9413216, DOI: 10.1111/adb.13208.Peer-Reviewed Original ResearchConceptsGray matter volumeLate adolescenceCaudal middle frontal cortexEarly adolescent onsetGray matter volumetric changesMiddle frontal cortexSevere alcohol useBrain developmentCross-sectional findingsSocial cognitionExecutive controlNCANDA studyVolumetric declinesSupramarginal gyrusPotential sex differencesSuperior temporalImpact of alcoholAdolescent onsetSubstance useCortical regionsAlcohol useMatter volumeFrontal cortexResult of alcoholMixed-effects modeling
2020
Soluble ST2 Is Associated With New Epileptiform Abnormalities Following Nontraumatic Subarachnoid Hemorrhage
Lissak IA, Zafar SF, Westover MB, Schleicher RL, Kim JA, Leslie-Mazwi T, Stapleton CJ, Patel AB, Kimberly WT, Rosenthal ES. Soluble ST2 Is Associated With New Epileptiform Abnormalities Following Nontraumatic Subarachnoid Hemorrhage. Stroke 2020, 51: 1128-1134. PMID: 32156203, PMCID: PMC7123848, DOI: 10.1161/strokeaha.119.028515.Peer-Reviewed Original ResearchConceptsPlasma sST2 levelsSoluble ST2Epileptiform abnormalitiesNontraumatic subarachnoid hemorrhageSubarachnoid hemorrhageSST2 levelsNeurophysiologic changesCerebral ischemiaIL-6Continuous electroencephalographyMeasures mixed-effects modelsInnate immune response pathwaysAdmission risk factorsPlasma soluble ST2Secondary brain injurySubgroup of patientsSubarachnoid hemorrhage patientsSerial plasma samplesAssociation of biomarkersInnate immune responseWilcoxon rank sum testImmune response pathwaysMixed-effects modelingRank sum testInflammatory biomarkers
2017
Acculturation and Syndemic Risk: Longitudinal Evaluation of Risk Factors Among Pregnant Latina Adolescents in New York City
Martinez I, Kershaw TS, Keene D, Perez-Escamilla R, Lewis JB, Tobin JN, Ickovics JR. Acculturation and Syndemic Risk: Longitudinal Evaluation of Risk Factors Among Pregnant Latina Adolescents in New York City. Annals Of Behavioral Medicine 2017, 52: 42-52. PMID: 28707175, PMCID: PMC6367896, DOI: 10.1007/s12160-017-9924-y.Peer-Reviewed Original ResearchConceptsPregnant Latina adolescentsYear postpartumRisk factorsSyndemic riskSyndemic scoreLongitudinal mixed-effects modelingSubstance useIntimate partner violenceLatina adolescentsCo-occurring epidemicsHigh-risk adolescentsMixed-effects modelingPostpartum periodPartner violenceHealth outcomesPregnancyLongitudinal evaluationLongitudinal changesNew York CitySyndemicSeverityAdolescentsPostpartumRisk reductionYork CityEffects of Cognitive Behavioral Therapy for Insomnia on Sleep-Related Cognitions Among Patients With Stable Heart Failure
Redeker NS, Jeon S, Andrews L, Cline J, Mohsenin V, Jacoby D. Effects of Cognitive Behavioral Therapy for Insomnia on Sleep-Related Cognitions Among Patients With Stable Heart Failure. Behavioral Sleep Medicine 2017, 17: 342-354. PMID: 28745520, PMCID: PMC5904007, DOI: 10.1080/15402002.2017.1357120.Peer-Reviewed Original ResearchConceptsEffects of CBTHF patientsSleep disturbance questionnaireCognitive behavioral therapySleep-related cognitionsStable New York Heart Association class IINew York Heart Association class IIInsomnia severityChronic heart failure patientsBehavioral therapyPittsburgh Sleep Quality IndexHigh symptom burdenStable heart failureHeart failure patientsSleep Quality IndexImproved sleep qualityInsomnia Severity IndexSelf-reported fatigueDysfunctional sleep-related cognitionsSymptom burdenFailure patientsHeart failureMixed-effects modelingSleep latencyPoor sleep
2013
Dose Response and Pharmacokinetics of Tofacitinib (CP‐690,550), an Oral Janus Kinase Inhibitor, in the Treatment of Chronic Plaque Psoriasis
Tan H, Gupta P, Harness J, Wolk R, Chapel S, Menter A, Strober B, Langley R, Krishnaswami S, Papp K. Dose Response and Pharmacokinetics of Tofacitinib (CP‐690,550), an Oral Janus Kinase Inhibitor, in the Treatment of Chronic Plaque Psoriasis. CPT Pharmacometrics & Systems Pharmacology 2013, 2: 1-8. PMCID: PMC3674331, DOI: 10.1038/psp.2013.22.Peer-Reviewed Original ResearchBody weightPlacebo-controlled dose-ranging studyOral Janus kinase inhibitorPhase III clinical trialsPharmacokinetics of tofacitinibChronic plaque psoriasisDose-ranging studyPlaque psoriasis treatmentJanus kinase inhibitorNonlinear mixed-effects modelingTofacitinib 2Tofacitinib 5Confirmatory phase III clinical trialDose-response profilesPlaque psoriasisSystemic exposurePsoriasis treatmentSubgroup analysisMixed-effects modelingClinical trialsClinical dataTofacitinibPsoriasisKinase inhibitorsReduced efficacy
2012
Population Pharmacokinetics and Pharmacodynamics of Piperaquine in Children With Uncomplicated Falciparum Malaria
Tarning J, Zongo I, Somé FA, Rouamba N, Parikh S, Rosenthal PJ, Hanpithakpong W, Jongrak N, Day NP, White NJ, Nosten F, Ouedraogo J, Lindegardh N. Population Pharmacokinetics and Pharmacodynamics of Piperaquine in Children With Uncomplicated Falciparum Malaria. Clinical Pharmacology & Therapeutics 2012, 91: 497-505. PMID: 22258469, PMCID: PMC3736305, DOI: 10.1038/clpt.2011.254.Peer-Reviewed Original ResearchConceptsUncomplicated falciparum malariaFalciparum malariaPopulation pharmacokineticsThree-compartment distribution modelNonlinear mixed-effects modelingRecurrent malaria infectionsTotal piperaquine exposureArtemisinin combination treatmentWeight-normalized dosePlasma concentration-time profilesYoung childrenMixed-effects modelingConcentration-time profilesPiperaquine concentrationsPiperaquine exposureDose regimenMalaria infectionPlasma concentrationsPharmacodynamic propertiesCombination treatmentBody weightPiperaquineSignificant covariatesOlder childrenMalaria
2008
A randomized clinical trial for women with vulvodynia: Cognitive‐behavioral therapy vs. supportive psychotherapy
Masheb RM, Kerns RD, Lozano C, Minkin MJ, Richman S. A randomized clinical trial for women with vulvodynia: Cognitive‐behavioral therapy vs. supportive psychotherapy. Pain 2008, 141: 31-40. PMID: 19022580, PMCID: PMC2728361, DOI: 10.1016/j.pain.2008.09.031.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapySupportive psychotherapyPain severityRandomized clinical trialsOne-year followGreater patient satisfactionGreater improvementSelf-management skillsClinical improvementPatient satisfactionPhysician examinationSexual functionMixed-effects modelingClinical trialsPsychosocial treatmentsBetter outcomesTreatment approachesVulvodyniaCBT conditionTreatment improvementOne-yearRelative efficacySignificant decreaseTreatment effectsWomen
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