2025
Effectiveness of a group intervention to improve mental health in siblings of children with chronic disorders: a cluster randomized controlled trial
Kirchhofer S, Fredriksen T, Orm S, Botta M, Zahl E, Cogo-Moreira H, Prentice C, Vatne T, Haukeland Y, Silverman W, Fjermestad K. Effectiveness of a group intervention to improve mental health in siblings of children with chronic disorders: a cluster randomized controlled trial. Journal Of Pediatric Psychology 2025, 50: 443-453. PMID: 40146207, PMCID: PMC12206298, DOI: 10.1093/jpepsy/jsaf021.Peer-Reviewed Original ResearchConceptsSibling mental healthComplier average causal effectParents of childrenMental healthRandomized Controlled TrialsParent-child communicationIntention-to-treatSiblings of childrenCluster Randomized Controlled TrialChronic disordersImprove mental healthMental health problemsEligible siblingsPrimary careIntervention groupGroup interventionPreventive interventionsHospital settingWaitlist controlPrevention programsAverage causal effectHealth problemsManual-basedSecondary outcomesControlled Trials
2022
30-Day Postoperative Outcomes in Adults with Obstructive Sleep Apnea Undergoing Upper Airway Surgery
Knoedler S, Knoedler L, Baecher H, Kauke-Navarro M, Obed D, Hoch C, Diehm Y, Vosler P, Harréus U, Kneser U, Panayi A. 30-Day Postoperative Outcomes in Adults with Obstructive Sleep Apnea Undergoing Upper Airway Surgery. Journal Of Clinical Medicine 2022, 11: 7371. PMID: 36555986, PMCID: PMC9783895, DOI: 10.3390/jcm11247371.Peer-Reviewed Original ResearchObstructive sleep apneaOSA surgeryPostoperative outcomesMedical complicationsSleep apneaSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseMulti-institutional national databaseQuality Improvement Program databaseUpper airway surgeryTotal complication rateHistory of diabetesImprovement Program databasePositive safety profileAlkaline phosphatasePostoperative complicationsComplication ratePostoperative periodAirway surgeryFrequent comorbiditiesMale sexSafety profileUpper airwaySurgery outcomesChronic disordersPreliminary Effectiveness of a Remotely Monitored Blood Alcohol Concentration Device as Treatment Modality: Protocol for a Randomized Controlled Trial
Buono FD, Gleed C, Boldin M, Aviles A, Wheeler N. Preliminary Effectiveness of a Remotely Monitored Blood Alcohol Concentration Device as Treatment Modality: Protocol for a Randomized Controlled Trial. JMIR Research Protocols 2022, 11: e30186. PMID: 35029534, PMCID: PMC8800086, DOI: 10.2196/30186.Peer-Reviewed Original ResearchINTERNATIONAL REGISTERED REPORT IDENTIFIERAlcohol use disorderQuality of lifeBlood alcohol concentrationUse disordersAlcohol use disorder populationTreatment providersPsychological distressRandomized clinical trialsLong-term treatmentTreatment motivationCost-effective treatmentControlled TrialsDisease management approachTreatment modalitiesChronic disordersAlcohol concentrationClinical trialsDropout ratePreliminary effectivenessAlcohol dependenceTimely interventionDisorder populationMonthsHigher likelihood
2021
The Effect of Mental Health, Neurological Disease, and Liver Disease on Quality of Life in Patients With Wilson Disease
Camarata MA, Ala A, Coskun AK, Deng Y, Gonzalez-Peralta R, Maciejewski KR, Patel A, Rubman S, To U, Tomlin R, Schilsky ML, Zimbrean PC. The Effect of Mental Health, Neurological Disease, and Liver Disease on Quality of Life in Patients With Wilson Disease. Journal Of The Academy Of Consultation-Liaison Psychiatry 2021, 62: 528-537. PMID: 34044196, PMCID: PMC11165927, DOI: 10.1016/j.jaclp.2021.04.004.Peer-Reviewed Original ResearchConceptsRating Scale scoresP-QOL scoresP-QOLNeurological diseasesWilson's diseaseMental healthOverall QOLUnified Wilson's Disease Rating Scale scoreScale scoreEnd-stage liver disease (MELD) scoreDisease severityStage liver disease scoreDegree of liverNeurological disease severityLiver Disease scoreLiver disease severityMajor depressive disorderQuality of lifeMental health issuesChild-PughCirrhosis severityLiver diseaseNeurological assessmentPatients' qualityChronic disorders
2020
Gaucher disease and SARS-CoV-2 infection: Experience from 181 patients in New York
Fierro L, Nesheiwat N, Naik H, Narayanan P, Mistry PK, Balwani M. Gaucher disease and SARS-CoV-2 infection: Experience from 181 patients in New York. Molecular Genetics And Metabolism 2020, 132: 44-48. PMID: 33353808, PMCID: PMC7834197, DOI: 10.1016/j.ymgme.2020.12.288.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionSARS-CoV-2Gaucher diseaseAcid β-glucosidase activitySARS-CoV-2 nucleic acidCOVID-19-specific treatmentsMajority of patientsChronic inflammatory stateCross-sectional studyHigher antibody responseCOVID-19 symptomsCOVID-19 exposureRare disease populationSubset of adultsGBA genotypeQuantitative titersPrior splenectomyAntibody testingHigh morbidityImmune activationInflammatory statePrimary exposureAntibody responseChronic disordersMale genderGroup intervention for siblings and parents of children with chronic disorders (SIBS-RCT): study protocol for a randomized controlled trial
Fjermestad KW, Silverman WK, Vatne TM. Group intervention for siblings and parents of children with chronic disorders (SIBS-RCT): study protocol for a randomized controlled trial. Trials 2020, 21: 851. PMID: 33054825, PMCID: PMC7556945, DOI: 10.1186/s13063-020-04781-6.Peer-Reviewed Original ResearchConceptsParents of childrenGroup interventionNeurodevelopmental disordersQuality of lifeEvidence-based interventionsMental health problemsPoor family communicationSecondary outcomesPrimary outcomeOutcome predictorsChronic disordersHealth centersHealth problemsWaitlistParticipant subgroupsFamily communicationManual-based group interventionMental healthCurve analysisDisordersOptimal interventionInterventionParent group sessionsOutcomesGroup sessionsEvaluation of “SIBS”, An Intervention for Siblings and Parents of Children with Chronic Disorders
Haukeland Y, Czajkowski N, Fjermestad K, Silverman W, Mossige S, Vatne T. Evaluation of “SIBS”, An Intervention for Siblings and Parents of Children with Chronic Disorders. Journal Of Child And Family Studies 2020, 29: 2201-2217. DOI: 10.1007/s10826-020-01737-x.Peer-Reviewed Original ResearchParent-sibling communicationChronic disordersParents of childrenMental healthManual adherenceBehavioral problemsPoor mental healthOpen trialDisorder knowledgeSeparate group sessionsSiblings of childrenGroup interventionManual-based group interventionDisordersParticipant satisfactionInitial feasibilityGroup sessionsChildrenInterventionOutcomesSiblingsBeneficial outcomesBaselineGrowth curve modelingAdherence
2016
Hostility and telomere shortening among U.S. military veterans: Results from the National Health and Resilience in Veterans Study
Watkins LE, Harpaz-Rotem I, Sippel LM, Krystal JH, Southwick SM, Pietrzak RH. Hostility and telomere shortening among U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Psychoneuroendocrinology 2016, 74: 251-257. PMID: 27689898, DOI: 10.1016/j.psyneuen.2016.09.006.Peer-Reviewed Original ResearchConceptsU.S. military veteransClinical variablesNational HealthTelomere lengthMilitary veteransMultivariable binary logistic regression analysisVeterans StudyAccelerated cellular agingBinary logistic regression analysisLogistic regression analysisU.S. veteran populationNon-veteran populationsAge-related disordersPolymerase chain reaction methodChronic disordersRisk factorsChain reaction methodQuantitative polymerase chain reaction methodVeteran populationU.S. veteransSecondary analysisTreatment effortsVeteransRegression analysisBiological ageEffective Treatment of Paroxysmal Nonkinesigenic Dyskinesia With Oxcarbazepine
Kumar A, Szekely A, Jabbari B. Effective Treatment of Paroxysmal Nonkinesigenic Dyskinesia With Oxcarbazepine. Clinical Neuropharmacology 2016, 39: 201-205. PMID: 27046658, DOI: 10.1097/wnf.0000000000000149.Peer-Reviewed Original ResearchConceptsParoxysmal nonkinesigenic dyskinesiaRare chronic disorderOutcome of treatmentSeverity of episodesAvailable therapiesChronic disordersClinical trialsInvoluntary movementsEffective treatmentOxcarbazepinePharmaceutical agentsDyskinesiaPatientsTreatmentDisordersTherapyDebilitatingDiseaseTrialsSeverity
2015
A Practical Clinical Approach to Paediatric Phosphate Disorders
Imel EA, Carpenter TO. A Practical Clinical Approach to Paediatric Phosphate Disorders. Endocrine Development 2015, 28: 134-161. PMID: 26138840, DOI: 10.1159/000381036.Peer-Reviewed Original ResearchConceptsPhosphate disordersPractical clinical approachChronic clinical conditionsPhosphate metabolismChronic hypophosphataemiaPhosphate abnormalitiesAppropriate therapyChronic disordersPathophysiologic assessmentClinical conditionsClinical approachPhosphate physiologyCareful evaluationHyperphosphataemiaHypophosphataemiaDisordersMetabolismPatientsTherapyEtiologyAbnormalitiesDiseaseSchizotypal Personality Disorder
Garakani A, Siever L. Schizotypal Personality Disorder. 2015, 1-7. DOI: 10.1002/9781118625392.wbecp390.ChaptersSchizotypal personality disorderPersonality disorderLack of empathySchizophrenia spectrum disordersPatterns of functioningSpectrum disorderFocus of treatmentOccupational functioningCognitive deficitsMagical thinkingNeural abnormalitiesCognitive impairmentStereotyped behaviorDopamine agonistsAntipsychotic treatmentSchizophreniaChronic disordersFunctioningHealthy controlsHealthy relativesPsychiatric hospitalizationClinical linesDisordersPhenotypic associationsFamilial studies
2012
Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons
Dietrich MO, Horvath TL. Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons. Nature Reviews Drug Discovery 2012, 11: 675-691. PMID: 22858652, DOI: 10.1038/nrd3739.Peer-Reviewed Original ResearchConceptsNPY/AgRP neuronsNegative energy balanceSevere side effectsAgRP neuronsPOMC neuronsPositive energy balanceChronic disordersPeripheral tissuesReactive oxygen speciesSide effectsLong-term positive energy balanceCalorie restrictionAnti-obesity drug developmentBehavioral interventionsIntense behavioral interventionsPro-opiomelanocortin (POMC) neuronsChronic metabolic disorderLong-term treatmentWhite adipose tissueAlternative therapeutic approachAnti-obesity therapiesPromotion of satietyNew drug therapiesPopulations of neuronsHigher brain functions
2011
New-generation diabetes management: glucose sensor-augmented insulin pump therapy
Cengiz E, Sherr JL, Weinzimer SA, Tamborlane WV. New-generation diabetes management: glucose sensor-augmented insulin pump therapy. Expert Review Of Medical Devices 2011, 8: 449-458. PMID: 21728731, PMCID: PMC3177536, DOI: 10.1586/erd.11.22.Peer-Reviewed Original ResearchConceptsSensor-augmented insulinSensor-Augmented Insulin Pump TherapyCommon chronic disorderInsulin pump therapyContinuous subcutaneous insulin infusion systemsInsulin infusion systemField of diabetesPump therapyGlucose variabilityChronic disordersChallenging diseaseContinuous glucose monitorDelivery of insulinDiabetes managementInfusion systemTherapyInsulin deliveryTechnologic advancesInsulin
2009
Endoscopy of the esophagus in gastroesophageal reflux disease: are we losing sight of symptoms? Another perspective
Sharma P, Chey W, Hunt R, Laine L, Malfertheiner P, Wani S. Endoscopy of the esophagus in gastroesophageal reflux disease: are we losing sight of symptoms? Another perspective. Diseases Of The Esophagus 2009, 22: 461-466. PMID: 19191851, DOI: 10.1111/j.1442-2050.2008.00934.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGastroesophageal reflux diseaseGERD-like symptomsSuppressive therapyReflux diseaseAcid suppressive therapyErosive reflux diseaseProspective multicenter studyCommon chronic disorderPrimary care physiciansPrimary care settingSymptom-based classificationSymptom-based diagnosisHuge economic burdenInternational Consensus GroupErosive esophagitisGERD patientsTroublesome symptomsEmpiric trialPartial responseComplete responseCare physiciansImpaired qualityMulticenter studyBarrett's esophagusChronic disorders
2006
Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis
Wang XM, Zhang Y, Kim HP, Zhou Z, Feghali-Bostwick CA, Liu F, Ifedigbo E, Xu X, Oury TD, Kaminski N, Choi AM. Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis. Journal Of Experimental Medicine 2006, 203: 2895-2906. PMID: 17178917, PMCID: PMC1850940, DOI: 10.1084/jem.20061536.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsBleomycinCaveolin 1Collagen Type IEpithelial CellsExtracellular MatrixFibroblastsFibronectinsFibrosisGene ExpressionHumansHydroxyprolineJNK Mitogen-Activated Protein KinasesLungMiceMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein Kinase 8PhosphorylationPulmonary FibrosisRNA, Small InterferingSmad2 ProteinTransfectionTransforming Growth Factor beta1ConceptsIdiopathic pulmonary fibrosisPulmonary fibrosisCav-1 expressionCav-1Pulmonary fibroblastsPrimary pulmonary fibroblastsNovel therapeutic targetProgressive chronic disorderLung tissue samplesActivation of fibroblastsGrowth factor beta1Smad signaling cascadesHuman pulmonary fibroblastsC-Jun N-terminal kinase (JNK) pathwayIPF patientsLung fibrosisProfibrotic cytokinesChronic disordersN-terminal kinase pathwayLung tissueTherapeutic targetFibrosisHydroxyproline contentHistological analysisMarked reductionTreatment and Prevention of Depression in Women.
Sinha R, Rush A. Treatment and Prevention of Depression in Women. 2006, 45-70. DOI: 10.1037/11434-002.Peer-Reviewed Original ResearchEffective maintenance therapySerious public health problemTreatment of depressionMajor depressive disorderPrevention of depressionPublic health problemMental health servicesMaintenance therapyChronic disordersInitial episodeDepressive disorderMajor depressionRecurrent depressionEpisode treatmentHigh riskPrevention strategiesHealth problemsNumber of womenHealth servicesBehavioral treatmentSpecialized treatmentWomenDepressionPrevention approachesRecent evidence
2005
Clinical treatment of obsessive compulsive disorder.
Pittenger C, Kelmendi B, Bloch M, Krystal JH, Coric V. Clinical treatment of obsessive compulsive disorder. Innov Clin Neurosci 2005, 2: 34-43. PMID: 21120095, PMCID: PMC2993523.Peer-Reviewed Original ResearchObsessive-compulsive disorderSRI-resistant obsessive compulsive disorderMainstay of treatmentSerotonin reuptake inhibitorsEffective treatment modalityUse of clomipramineCurrent treatment strategiesRecent epidemiological studiesCommon psychiatric disordersCompulsive disorderCognitive behavioral therapyInvasive neurosurgical proceduresPartial responseAvailable medicationsPharmacologic treatmentReuptake inhibitorsTreatment armamentariumSignificant morbidityTreatment modalitiesChronic disordersMedication managementTreatment strategiesEpidemiological studiesPsychiatric disordersClinical treatment
2001
An Eight-Year Longitudinal Comparison of Clinical Course and Characteristics of Social Phobia Among Men and Women
Yonkers KA, Dyck IR, Keller MB. An Eight-Year Longitudinal Comparison of Clinical Course and Characteristics of Social Phobia Among Men and Women. Psychiatric Services 2001, 52: 637-643. PMID: 11331798, DOI: 10.1176/appi.ps.52.5.637.Peer-Reviewed Original ResearchConceptsHealth-related qualityHarvard/Brown Anxiety Research ProgramSuicide attemptsSocial phobiaComorbid substance use disorderPoorer baseline functioningLower Global AssessmentPercent of menPercent of womenSubstance use disordersPotential sex differencesComplete remissionRemission rateClinical courseChronic courseEight-year study periodChronic disordersHigh prevalenceObservational studyFunctioning scoresUse disordersBaseline functioningConcurrent agoraphobiaGreater chronicityGlobal assessment
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