2024
An Interventional Radiologist's Guide to Lung Cancer
Fish A, Madoff D. An Interventional Radiologist's Guide to Lung Cancer. Seminars In Interventional Radiology 2024, 41: 121-128. PMID: 38993601, PMCID: PMC11236454, DOI: 10.1055/s-0044-1786725.Peer-Reviewed Original ResearchLung cancer patientsLung cancerTissue diagnosisInterventional radiologistsCancer patientsField of interventional oncologyTreating lung cancer patientsTreatment of lung cancerEarly-stage diseaseAdvanced medical therapiesLung cancer complicationsBiopsy complicationsRadiation therapyPercutaneous ablationSurgical therapyMedical therapyInterventional oncologyEndovascular therapyInvasive treatmentCancer complicationsCancer deathTherapyGold standardCancerTreatment pathwaysUnsupervised clustering using multiple correspondence analysis reveals clinically-relevant demographic variables across multiple gastrointestinal cancers
Kramer R, Rhodin K, Therien A, Raman V, Eckhoff A, Thompson C, Tong B, Blazer D, Lidsky M, D’Amico T, Nussbaum D. Unsupervised clustering using multiple correspondence analysis reveals clinically-relevant demographic variables across multiple gastrointestinal cancers. Surgical Oncology Insight 2024, 1: 100009. DOI: 10.1016/j.soi.2024.100009.Peer-Reviewed Original ResearchNational Cancer DatabaseStage II/III esophageal cancerStage II/III gastric cancerStage III colon cancerIII colon cancerEsophageal cancerDemographic variablesMultiple correspondence analysisGastric cancerAt-risk populationsGastrointestinal malignanciesMultiple gastrointestinal cancersColon cancerUnsupervised clustering of patientsEducation quartileClusters of patientsIncome quartileKaplan-Meier survival methodInsurance typeCohort of patientsOutcomes researchHigher incomePrivate insuranceExamination outcomesTreatment pathwaysImpact of Sodium-Glucose Cotransporter-2 Inhibitors in the Management of Chronic Kidney Disease: A Middle East and Africa Perspective
Elkeraie A, Al-Ghamdi S, Abu-Alfa A, Alotaibi T, AlSaedi A, AlSuwaida A, Arici M, Ecder T, Ghnaimat M, Hafez M, Hassan M, Sqalli T. Impact of Sodium-Glucose Cotransporter-2 Inhibitors in the Management of Chronic Kidney Disease: A Middle East and Africa Perspective. International Journal Of Nephrology And Renovascular Disease 2024, 17: 1-16. PMID: 38196830, PMCID: PMC10771977, DOI: 10.2147/ijnrd.s430532.Peer-Reviewed Original ResearchChronic kidney diseaseSodium-glucose cotransporter 2 inhibitorsCotransporter 2 inhibitorsDiabetes mellitusKidney diseaseType 2 diabetes mellitusMajor public health concernAldosterone system inhibitorsBetter clinical outcomesCause of deathPublic health concernNephrology referralCKD managementClinical outcomesSystem inhibitorsCardioprotective propertiesEarly initiationTreatment pathwaysConsensus recommendationsHigh riskPatientsBetter careHealth concernEarly detectionHypertension
2023
Incorporating clinicopathological and molecular risk prediction tools to improve outcomes in early HR+/HER2– breast cancer
Curigliano G, Dent R, Llombart-Cussac A, Pegram M, Pusztai L, Turner N, Viale G. Incorporating clinicopathological and molecular risk prediction tools to improve outcomes in early HR+/HER2– breast cancer. Npj Breast Cancer 2023, 9: 56. PMID: 37380659, PMCID: PMC10307886, DOI: 10.1038/s41523-023-00560-z.Peer-Reviewed Original ResearchOptimal treatment pathwayBreast cancerCyclin D kinase 4/6 inhibitorDifferent adjuvant treatment modalitiesFuture risk stratification strategiesSimilar prognostic accuracyAdjuvant treatment modalitiesEarly breast cancerRisk of recurrenceRisk stratification strategiesRisk prediction toolsIndividual patient levelEpidermal growth factor receptorBreast cancer diagnosisGrowth factor receptorTreatment guidelinesRisk stratificationMultigene assaysTreatment modalitiesClinical trialsPatient levelPrognostic accuracyTreatment pathwaysEarly breast cancer diagnosisLevel I
2022
Quality Indicators for the Diagnosis and Management of Primary Hyperparathyroidism
Noltes M, Cottrell J, Madani A, Rotstein L, Gomez-Hernandez K, Devon K, Boggild M, Goldstein D, Wong E, Brouwers A, Kruijff S, Eskander A, Monteiro E, Pasternak J. Quality Indicators for the Diagnosis and Management of Primary Hyperparathyroidism. JAMA Otolaryngology - Head & Neck Surgery 2022, 148: 209-219. PMID: 34989783, PMCID: PMC8739767, DOI: 10.1001/jamaoto.2021.3858.Peer-Reviewed Original ResearchConceptsQuality of careQuality improvement studyCandidate indicatorsExpert panelQuality indicatorsMeasures of high-quality careImprovement studySurgical careCost-effectiveness of careEvidence-based guideline recommendationsEvidence-based treatment pathwaysHigh-quality careLos Angeles appropriateness methodologyRounds of evaluationFeasibility of measurementGuideline-based approachSystem registryGuideline recommendationsGeneral physiciansCareImprove qualityTreatment pathwaysClinical practiceAppropriate methodologiesPhysicians
2021
Cost-Effectiveness of Second-Line Therapies in Adult Patients with Chronic Immune Thrombocytopenia
Goshua G, Sinha P, Pischel L, Lee A, Cuker A. Cost-Effectiveness of Second-Line Therapies in Adult Patients with Chronic Immune Thrombocytopenia. Blood 2021, 138: 751. DOI: 10.1182/blood-2021-144819.Peer-Reviewed Original ResearchIncremental cost-effectiveness ratioChronic immune thrombocytopeniaOne-way deterministic sensitivity analysisPost-splenectomy sepsisTPO-RATPO-RA therapyImmune thrombocytopeniaOverall response rateTreatment pathwaysProbabilistic sensitivity analysesDeterministic sensitivity analysesResponse rateAdverse eventsASH guidelinesStandard second-line treatment optionSecond-line treatment optionSecond-line treatment strategiesEarly useComplete response rateSecond-line therapySevere septic shockThrombopoietin receptor agonistsSeptic shock mortalityHealth system perspectiveCost of surgery
2019
Loop diuretic resistance complicating acute heart failure
Cox ZL, Testani JM. Loop diuretic resistance complicating acute heart failure. Heart Failure Reviews 2019, 25: 133-145. PMID: 31520280, DOI: 10.1007/s10741-019-09851-9.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsLoop diuretic resistanceDiuretic resistanceHeart failureAcute heart failure hospitalizationMechanism-based classification systemAcute heart failureHeart failure hospitalizationOngoing clinical trialsUniversal clinical applicationDiuretic strategyFailure hospitalizationDiuretic efficacyClinical trialsWorse outcomesTreatment pathwaysAnatomical locationClinical applicationCurrent literatureResistance mechanismsCurrent best practiceOutcomesClassification systemLiterature reviewHospitalizationPatients
2018
Analysis of treatment pathways for three chronic diseases using OMOP CDM
Zhang X, Wang L, Miao S, Xu H, Yin Y, Zhu Y, Dai Z, Shan T, Jing S, Wang J, Zhang X, Huang Z, Wang Z, Guo J, Liu Y. Analysis of treatment pathways for three chronic diseases using OMOP CDM. Journal Of Medical Systems 2018, 42: 260. PMID: 30421323, PMCID: PMC6244882, DOI: 10.1007/s10916-018-1076-5.Peer-Reviewed Original ResearchConceptsTreatment pathwaysChronic diseasesStudy of drugsClinical data repositoryClinical treatmentDifferent medical institutionsProportion of monotherapyFirst-line medicationMedical institutionsFirst Affiliated HospitalType 2 diabetesNanjing Medical UniversityDifferent treatment pathwaysMost patientsCommon medicationsAffiliated HospitalMedicationsNational guidelinesMedication informationLocal hospitalMedical UniversitySame diseaseDiseasePatientsNew drugs
2016
Development of an evidence-based decision pathway for vestibular schwannoma treatment options
Linkov F, Valappil B, McAfee J, Goughnour SL, Hildrew DM, McCall AA, Linkov I, Hirsch B, Snyderman C. Development of an evidence-based decision pathway for vestibular schwannoma treatment options. American Journal Of Otolaryngology 2016, 38: 57-64. PMID: 27780583, DOI: 10.1016/j.amjoto.2016.09.019.Peer-Reviewed Original ResearchConceptsVestibular schwannomaGroup of patientsPost-operative symptomsEvidence-based dataPittsburgh Medical CenterEffectiveness of treatmentQuality of lifeComplex medical problemsHealth care systemTreatment Decision Support SystemVS patientsTreatment optionsTreatment pathwaysTreatment decisionsMedical CenterClinical informationTreatment selectionFocus groupsSide effectsPatient valuesPatientsPatient feedbackClinical investigatorsTreatment alternativesMedical problemsCharacterizing treatment pathways at scale using the OHDSI network
Hripcsak G, Ryan P, Duke J, Shah N, Park R, Huser V, Suchard M, Schuemie M, DeFalco F, Perotte A, Banda J, Reich C, Schilling L, Matheny M, Meeker D, Pratt N, Madigan D. Characterizing treatment pathways at scale using the OHDSI network. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 7329-7336. PMID: 27274072, PMCID: PMC4941483, DOI: 10.1073/pnas.1510502113.Peer-Reviewed Original ResearchConceptsAdministrative claims dataTreatment pathwaysClaims dataType 2 diabetes mellitusFirst-line medicationElectronic health record dataClinical trial resultsObservational researchHealth record dataElectronic health recordsDiabetes mellitusHypertension patientsDepression patientsConsistent therapyObservational studyOHDSI networkObservational Health Data SciencesPatientsTrial resultsClinical hypothesisHealth recordsRecord dataSignificant heterogeneityHealth Data SciencesHypertension
2015
Asthme de l’adulte : quelques actualités sur les évolutions à venir
Justet A, Pradère P, Taillé C. Asthme de l’adulte : quelques actualités sur les évolutions à venir. Revue Des Maladies Respiratoires 2015, 32: 629-638. PMID: 26163989, DOI: 10.1016/j.rmr.2015.01.002.Peer-Reviewed Original ResearchConceptsSevere asthmaMurine models of obesitySubgroup of asthmaticsModels of obesityObese asthmaticsBiologic therapyLong-term managementTh2 activityTh2 cytokinesBronchial thermoplastyMurine modelIL-17IL-1Asthma treatmentInflammatory pathwaysTreatment pathwaysWeight lossAsthmaTherapyClinical researchAsthmaticsPersonalized approachTreatmentLong standing effectsTh2Traumatic Brain Injury Imaging Research Roadmap
Wintermark M, Coombs L, Druzgal T, Field A, Filippi C, Hicks R, Horton R, Lui Y, Law M, Mukherjee P, Norbash A, Riedy G, Sanelli P, Stone J, Sze G, Tilkin M, Whitlow C, Wilde E, York G, Provenzale J. Traumatic Brain Injury Imaging Research Roadmap. American Journal Of Neuroradiology 2015, 36: e12-e23. PMID: 25655872, PMCID: PMC8013059, DOI: 10.3174/ajnr.a4254.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryBrain injuryNormative data baseClinical settingAdvanced neuroimaging studiesNormal control subjectsPatient-centered toolsPopulation-based researchClinical outcomesHistologic confirmationNeuroimaging testsControl subjectsNeurologic disordersAdvanced neuroimagingTreatment pathwaysPrognostic accuracyConsensus recommendationsLarge population sampleInjuryBrain tissuePatientsNeuroimaging protocolNeuroimaging studiesMicroscopic changesComprehensive imaging
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