2023
Towards precision medicine for anxiety disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs
Roseberry K, Le-Niculescu H, Levey D, Bhagar R, Soe K, Rogers J, Palkowitz S, Pina N, Anastasiadis W, Gill S, Kurian S, Shekhar A, Niculescu A. Towards precision medicine for anxiety disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs. Molecular Psychiatry 2023, 28: 2894-2912. PMID: 36878964, PMCID: PMC10615756, DOI: 10.1038/s41380-023-01998-0.Peer-Reviewed Original ResearchConceptsIndependent cohortCandidate biomarkersPsychiatric subjectsPersonalized approachConvergent functional genomics approachAnxiety disordersBest overall evidenceAdverse life eventsClinical worseningGene expression signaturesBlood biomarkersAnxiety medicationClinical utilityPsychiatric disordersHigh anxiety stateSevere anxietyUntreated anxietyDecrease qualityIndividual biomarkersAddiction potentialBiomarkersTop biomarkersAnxiety statesRisk predictionExpression signatures
1996
Risk Factors for Presenting Problems in Child Psychiatric Emergencies
PETERSON B, ZHANG H, SANTA LUCIA R, KING R, LEWIS M. Risk Factors for Presenting Problems in Child Psychiatric Emergencies. Journal Of The American Academy Of Child & Adolescent Psychiatry 1996, 35: 1162-1173. PMID: 8824060, DOI: 10.1097/00004583-199609000-00014.Peer-Reviewed Original ResearchConceptsRisk factorsEmergency roomPsychiatric emergenciesSuicide attemptsChild psychiatric emergenciesIndependent risk factorEmergency room visitsSimilar risk factorsHospitalization of childrenDemographic risk factorsYears of agePsychiatric emergency roomHospital emergency roomSubset of childrenStrength of associationAggressive presentationInitial visitMale sexRoom visitsSuicidal ideatorsSuicidal ideationYounger ageFuture suicidalityPsychiatric subjectsHospitalization
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