2017
Multiparameter Single Cell Profiling of Airway Inflammatory Cells
Yao Y, Welp T, Liu Q, Niu N, Wang X, Britto CJ, Krishnaswamy S, Chupp G, Montgomery RR. Multiparameter Single Cell Profiling of Airway Inflammatory Cells. Cytometry Part B Clinical Cytometry 2017, 92: 12-20. PMID: 27807928, PMCID: PMC5250532, DOI: 10.1002/cyto.b.21491.Peer-Reviewed Original ResearchConceptsSingle-cell methodsComplex trait diseasesSubgroup of asthmaticsSingle-cell analysisMultiparameter single cell analysisMillions of patientsTranscriptional analysisImmunologic underpinningsInduced sputumAirway diseaseAsthmatic patientsAirway samplesCell subsetsImmune statusFunctional statusClinical severityDistinct biologic mechanismsTreatment successPhysiologic manifestationsBiologic mechanismsCystic fibrosisCellular analysisPatientsCytometry studiesU.S. population
2015
Asthme de l’adulte : quelques actualités sur les évolutions à venir
Justet A, Pradère P, Taillé C. Asthme de l’adulte : quelques actualités sur les évolutions à venir. Revue Des Maladies Respiratoires 2015, 32: 629-638. PMID: 26163989, DOI: 10.1016/j.rmr.2015.01.002.Peer-Reviewed Original ResearchConceptsSevere asthmaMurine models of obesitySubgroup of asthmaticsModels of obesityObese asthmaticsBiologic therapyLong-term managementTh2 activityTh2 cytokinesBronchial thermoplastyMurine modelIL-17IL-1Asthma treatmentInflammatory pathwaysTreatment pathwaysWeight lossAsthmaTherapyClinical researchAsthmaticsPersonalized approachTreatmentLong standing effectsTh2
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