2025
Anticoagulants or antiplatelets for secondary prevention of cryptogenic stroke: an updated systematic review and meta-analysis
Chi K, Zarif T, Varrias D, Lee P, Chang Y, Song J, Osabutey A, Borkowski P, Chiang C, Chang Y, Lin Y, Nanna M, Nanna M. Anticoagulants or antiplatelets for secondary prevention of cryptogenic stroke: an updated systematic review and meta-analysis. Heart 2025, 111: 495-505. PMID: 39915077, PMCID: PMC12068992, DOI: 10.1136/heartjnl-2024-325288.Peer-Reviewed Original ResearchPresence of patent foramen ovaleOral anticoagulantsRandomised controlled trialsCryptogenic strokeAtrial cardiopathyIschaemic strokeIschaemic stroke riskSafety of oral anticoagulantsRisk factorsSecondary prevention of cryptogenic strokeStroke riskMeta-analysisOptimal antithrombotic strategyRisk of recurrent ischaemic strokePatent foramen ovaleInteraction p valuePersonalised treatment strategiesSystematic reviewRecurrent ischaemic strokePreventing ischaemic strokeBleeding riskNo significant differenceAntithrombotic strategiesClinical characteristicsForamen ovale
2024
Pulmonary embolism with thrombus in transit across a patent foramen ovale
Iyengar S, Stolear A, Dulgher M, Ahmed A, Shkolnik E, Zarich S. Pulmonary embolism with thrombus in transit across a patent foramen ovale. Oxford Medical Case Reports 2024, 2024: omae091. PMID: 39184868, PMCID: PMC11343825, DOI: 10.1093/omcr/omae091.Peer-Reviewed Original ResearchPatent foramen ovalePatent foramen ovale closureImpending paradoxical embolismPulmonary embolismForamen ovaleCritical left anterior descending coronary artery stenosisObstructive sleep apneaCoronary Artery Bypass GraftingOptimal treatment strategySaddle pulmonary embolusAbsence of standard guidelinesDeep vein thrombosisArtery Bypass GraftingLife-threatening conditionCoronary artery stenosisSleep apneaTransesophageal echocardiogramPulmonary emboliSurgical thrombectomyVein thrombosisDiagnostic challengeSurgical interventionRight atriumThrombolytic therapyBypass Grafting
2023
Chapter 28 Fossa ovalis, patent foramen ovale, and cardiac masses
Nasir A, Zafar M, Elefteriades J. Chapter 28 Fossa ovalis, patent foramen ovale, and cardiac masses. 2023, 403-437. DOI: 10.1016/b978-0-323-84906-7.00013-3.Peer-Reviewed Original ResearchFossa ovalisPatent foramenCardiac massCardiac myxomaSeptum primumPlatypnea-orthodeoxia syndromePatent foramen ovaleArterial emboliCryptogenic strokeCertain disease conditionsNonneoplastic entitiesOstium secundumFat emboliForamen ovaleCardiac proceduresPulmonary circuitRight atriumInteratrial septumLeft heartMalignant tumorsSurgical significanceSystemic circulationSurgical planeIncomplete unionEmbryonic septum
2020
Mechanical thrombectomy for pulmonary embolism in patients with patent foramen Ovale
Nezami N, Chockalingam A, Cornman-Homonoff J, Marino A, Pollak J, Mojibian H. Mechanical thrombectomy for pulmonary embolism in patients with patent foramen Ovale. CVIR Endovascular 2020, 3: 89. PMID: 33247349, PMCID: PMC7695793, DOI: 10.1186/s42155-020-00180-9.Peer-Reviewed Original ResearchMechanical thrombectomyPulmonary embolismHigh-risk pulmonary embolismMain pulmonary artery pressureInari FlowTriever SystemIntermediate-high riskRisk pulmonary embolismUnderwent mechanical thrombectomyPulmonary artery pressureRight heart strainDeep venous thrombosisClinical success ratePatent foramen ovaleCoronary artery angiogramFlowTriever SystemHospital mortalityArtery pressurePatent foramenVenous thrombosisForamen ovaleMental statusRetrospective analysisPatientsStroke 1ThrombectomyCatheter-directed therapies for pulmonary embolism: considerations for patients with patent foramen ovale
Chockalingam A, Nezami N, Murali N, Mojibian H, Pollak JS, Weiss CR. Catheter-directed therapies for pulmonary embolism: considerations for patients with patent foramen ovale. Journal Of Thrombosis And Thrombolysis 2020, 51: 516-521. PMID: 32557222, DOI: 10.1007/s11239-020-02189-2.Peer-Reviewed Original ResearchConceptsPatent foramen ovaleCatheter-directed therapyPulmonary embolismSurgical embolectomyPercutaneous PFO closureThrombolytic drug deliveryCatheter-directed thrombolysisAcute pulmonary embolismCatheter-based therapiesHigh-risk patientsSystemic thrombolysisParadoxical emboliParadoxical embolizationPFO closurePatent foramenEndovascular treatmentSurgical closureForamen ovaleThrombectomy devicesEmbolismPatientsDiagnostic echocardiographyTherapySuccessful outcomeEmbolectomy
2018
Novel Association of Juvenile Polyposis Syndrome With Atrial Septal Aneurysm and Patent Foramen Ovale
Bruceta M, De Souza L, Carr Z, Bonavia A, Karamchandani K. Novel Association of Juvenile Polyposis Syndrome With Atrial Septal Aneurysm and Patent Foramen Ovale. A&A Practice 2018, 10: 331-334. PMID: 29634562, DOI: 10.1213/xaa.0000000000000714.Peer-Reviewed Case Reports and Technical NotesAtrial septal aneurysmJuvenile polyposis syndromeSMAD-4 mutationsPolyposis syndromeSeptal aneurysmPatent foramenPropensity of patientsPatent foramen ovaleHereditary hemorrhagic telangiectasiaAutosomal dominant disorderEmbolic strokeCardiac workupForamen ovaleVascular malformationsHemorrhagic telangiectasiaRisk individualsGastrointestinal polypsSyndromeYoung womenAneurysmsNovel associationsForamen
2015
Ischemic Stroke Patients with Active Malignancy or Extracardiac Shunts Are More Likely to Have a Right-to-Left Shunt Found by TCD Than Echocardiogram
de Havenon A, Moore A, Sultan-Qurraie A, Majersik JJ, Stoddard G, Tirschwell D. Ischemic Stroke Patients with Active Malignancy or Extracardiac Shunts Are More Likely to Have a Right-to-Left Shunt Found by TCD Than Echocardiogram. Translational Stroke Research 2015, 6: 361-364. PMID: 26205844, DOI: 10.1007/s12975-015-0414-x.Peer-Reviewed Original ResearchConceptsIschemic stroke patientsTranscranial DopplerActive malignancyLeft shuntIschemic strokeExtracardiac shuntsStroke patientsPositive transcranial DopplersRecent ischemic strokePercent of patientsComorbid medical conditionsPatent foramen ovalePulmonary arteriovenous malformationsDetection of rightNegative TTEOccult malignancyTOAST classificationCryptogenic strokeStroke subtypesForamen ovaleStandard workupShunt statusArteriovenous malformationsMedical conditionsPatientsCombined percutaneous treatment of structural and congenital heart defects
Chamié F, Chamié D, do Nascimento Simões L, Mattos R. Combined percutaneous treatment of structural and congenital heart defects. Journal Of Transcatheter Interventions 2015, 23: 61-65. DOI: 10.1016/j.rbciev.2015.01.005.Peer-Reviewed Original ResearchPatent foramen ovaleSeptal defectOstium secundum atrial septal defectPulmonary valve stenosisCongenital heart defectsVentricular septal defectPatent ductus arteriosusAtrial septal defectLeft atrial appendageAortic coarctationResultsTen patientsAortopulmonary fistulaDuctus arteriosusHeart defectsValve stenosisTherapeutic optionsAtrial appendageCongenital defectsPercutaneous treatmentFollow-upForamen ovaleSpecialized centersConclusionsThe small numberCombined proceduresAged 1
2013
Stroke prevention by percutaneous closure of patent foramen ovale: a systematic review and meta-analysis
Wolfrum M, Froehlich GM, Knapp G, Casaubon LK, DiNicolantonio JJ, Lansky AJ, Meier P. Stroke prevention by percutaneous closure of patent foramen ovale: a systematic review and meta-analysis. Heart 2013, 100: 389. PMID: 23793373, DOI: 10.1136/heartjnl-2013-304394.Peer-Reviewed Original ResearchConceptsBest medical therapyPatent foramen ovalPercutaneous PFO closurePFO closureCryptogenic strokePercutaneous closureMedical therapyAtrial fibrillationRelative riskSystematic reviewNew-onset atrial fibrillationOnset atrial fibrillationPooled relative riskRisk of bleedingPatent foramen ovaleMain end pointSignificant risk reductionRandom-effects modelStroke preventionMultivariate adjustmentSecondary preventionForamen ovaleClosure groupClinical trialsSignificant treatment effect
2012
Early Experience with the New CARDIA Ultrasept™ Device for Patent Foramen Ovale Occlusion: Still a Good Option
Chamié F, do Nascimento Simões L, Mattos R, Chamié D, Tress J, Lacoste M. Early Experience with the New CARDIA Ultrasept™ Device for Patent Foramen Ovale Occlusion: Still a Good Option. Journal Of Transcatheter Interventions 2012, 20: 309-314. DOI: 10.1016/s2214-1235(15)30070-3.Peer-Reviewed Original ResearchPatent foramen ovaleAtrial septal aneurysmForamen ovaleResidual shuntSeptal aneurysmOcclusion of patent foramen ovaleRecurrence of neurological eventsFollow-up echocardiogramPoor clinical controlTransient ischemic attackNo history of strokeHistory of strokeTransesophageal echocardiogramClinical responseTransesophageal echocardiographyPercutaneous occlusionEmbolic eventsMicrobubble testOcclusion procedureNeurological eventsEfficacy criteriaNo historyBackgroundThe purposeIschemic attackClinical control
2008
Causes of Recurrent Focal Neurologic Events After Transcatheter Closure of Patent Foramen Ovale With the CardioSEAL Septal Occluder
Kutty S, Brown K, Asnes JD, Rhodes JF, Latson LA. Causes of Recurrent Focal Neurologic Events After Transcatheter Closure of Patent Foramen Ovale With the CardioSEAL Septal Occluder. The American Journal Of Cardiology 2008, 101: 1487-1492. PMID: 18471463, DOI: 10.1016/j.amjcard.2008.01.028.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCardiac CatheterizationCatheterizationConfidence IntervalsEmbolism, ParadoxicalEquipment DesignFemaleFollow-Up StudiesForamen Ovale, PatentHumansIncidenceIschemic Attack, TransientMagnetic Resonance ImagingMaleMiddle AgedPrognosisProportional Hazards ModelsRecurrenceRetrospective StudiesRisk FactorsStrokeTime FactorsTomography, X-Ray ComputedTreatment OutcomeUnited StatesConceptsStroke/transient ischemic attackTransient ischemic attackFocal neurologic eventsPFO closureRecurrent strokeNeurologic eventsMedical managementRecurrent stroke/transient ischemic attackEvent ratesOngoing randomized trialsPatent foramen ovaleTranscatheter PFO closureTranscatheter patent foramenCardioSEAL Septal OccluderEmbolic episodesIschemic attackPFO occlusionParadoxical emboliImmediate morbidityConsecutive patientsPatent foramenRandomized trialsTranscatheter closureForamen ovaleRecurrence rate
2003
Interatrial septal mobility predicts larger shunts across patent foramen ovales: An analysis with transmitral Doppler scanning
Fox E, Picard M, Chow C, Levine R, Schwamm L, Kerr A. Interatrial septal mobility predicts larger shunts across patent foramen ovales: An analysis with transmitral Doppler scanning. American Heart Journal 2003, 145: 730-736. PMID: 12679772, DOI: 10.1067/mhj.2003.5.Peer-Reviewed Original ResearchConceptsAtrial septal aneurysmCryptogenic strokeDegree of rightLarge shuntBubble scoreMitral inflow profileCerebral ischemic eventsEtiology of strokeRight atrial pressurePatent foramen ovaleSaline contrast studySize of shuntHigh-intensity signalIschemic eventsParadoxical embolismAtrial pressureConsecutive patientsSeptal aneurysmPatent foramenSeptal motionForamen ovaleRisk factorsContrast studiesDoppler scanningPatients
1992
Fetal Cardiovascular Physiology and Therapy
Kleinman C, Copel J. Fetal Cardiovascular Physiology and Therapy. Fetal Diagnosis And Therapy 1992, 7: 147-157. PMID: 1503650, DOI: 10.1159/000263663.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsFetal cardiovascular physiologyFetal lamb modelHuman fetal heartSurgical interventionFetal heartLamb modelCardiovascular physiologyFetal cardiovascular malformationsFetal ductus arteriosusFetal cardiovascular systemVentricular filling characteristicsFetal cardiac developmentSystolic reserveVentricular afterloadDuctus arteriosusThird trimesterForamen ovaleNeonatal periodVentricular hypoplasiaFetal lambsShunt flowPrenatal interventionTimely therapyCardiovascular malformationsHuman fetuses
1991
Foramen ovale size in the normal and abnormal human fetal heart: an indicator of transatrial flow physiology
Feit L, Copel J, Kleinman C. Foramen ovale size in the normal and abnormal human fetal heart: an indicator of transatrial flow physiology. Ultrasound In Obstetrics And Gynecology 1991, 1: 313-319. PMID: 12797035, DOI: 10.1046/j.1469-0705.1991.01050313.x.Peer-Reviewed Original ResearchHeart obstructive lesionsLeft heart obstructive lesionsObstructive lesionsColor Doppler studyDoppler studiesForamen ovaleColor flow Doppler studiesNormal cardiac anatomyCongenital heart diseaseRight ventricular developmentNormal flow patternsHuman fetal heartWeeks' gestationVentricular sizeDoppler interrogationFetal echocardiographyHeart diseaseAtrial septumHelpful adjunctNormal fetusesHuman fetusesFetal heartLesionsFetusesCardiac anatomy
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