2025
Association of Volume Overload With Kidney Function Outcomes Among Patients With Acute Decompensated Heart Failure
Moises A, Tighiouart H, Testani J, Tuttle M, Banlengchit R, Oka T, Lee K, Ferguson K, Sarnak H, Harding C, Kiernan M, Sarnak M, McCallum W. Association of Volume Overload With Kidney Function Outcomes Among Patients With Acute Decompensated Heart Failure. American Journal Of Kidney Diseases 2025 PMID: 40484339, DOI: 10.1053/j.ajkd.2025.03.026.Peer-Reviewed Original ResearchPulmonary capillary wedge pressureHigh central venous pressureCentral venous pressureAssociation of central venous pressureDecompensated heart failureRisk of dialysisVolume overloadInitiation of dialysisEGFR slopeHeart failureKidney functionDegree of volume overloadLow baseline kidney functionAcute decompensated heart failureRisk factorsAssociated with lower eGFRRight heart catheterizationCox proportional hazards regression modelsCapillary wedge pressureInitial central venous pressureAssociated with increased riskProportional hazards regression modelsBaseline kidney functionKidney function outcomesRestricted cubic splines
2024
Dapagliflozin enhances arterial and venous compliance during exercise in heart failure with preserved ejection fraction
Tada A, Burkhoff D, Naser J, Harada T, Pourmussa B, Reddy Y, Jensen M, Carter R, Testani J, Chirinos J, Borlaug B. Dapagliflozin enhances arterial and venous compliance during exercise in heart failure with preserved ejection fraction. European Heart Journal 2024, 45: ehae666.782. DOI: 10.1093/eurheartj/ehae666.782.Peer-Reviewed Original ResearchPulmonary capillary wedge pressureSodium-glucose cotransporter-2 inhibitorsSystemic arterial complianceEffects of dapagliflozinVenous capacitancePeak exerciseArterial complianceHemodynamic congestionHeart failureTotal arterial complianceImproved systemic arterial complianceInvasive hemodynamic exercise testingTime of baseline evaluationSystolic BPBlood volumeHemodynamic exercise testingCapillary wedge pressureCotransporter-2 inhibitorsSystemic vascular resistanceImproving clinical outcomesTotal blood volumeRadial artery pressureFluid-filled catheterWedge pressureStressed blood volumeEffects of dapagliflozin on body composition and its relation to hemodynamics in heart failure with preserved ejection fraction: the CAMEO-DAPA randomized clinical trial
Naser J, Tada A, Harada T, Reddy Y, Carter R, Testani J, Jensen M, Borlaug B. Effects of dapagliflozin on body composition and its relation to hemodynamics in heart failure with preserved ejection fraction: the CAMEO-DAPA randomized clinical trial. European Heart Journal 2024, 45: ehae666.1044. DOI: 10.1093/eurheartj/ehae666.1044.Peer-Reviewed Original ResearchPulmonary capillary wedge pressureFat-free massEffects of dapagliflozinDual-energy X-ray absorptiometryBone mineral contentTrunk fatBody compositionCardiac hemodynamicsHeart failureExercise pulmonary capillary wedge pressureTotal body fat-free massHemodynamic effectsBody fatEnergy X-ray absorptiometryReduced fat-free massWeeks of dapagliflozinDevelopment of heart failureBody fat-free massPlacebo-controlled studyFavorable hemodynamic effectsCapillary wedge pressureX-ray absorptiometryPlasma volumeDecreased risk of hospitalizationTotal body fatDapagliflozin Enhances Arterial and Venous Compliance During Exercise in Heart Failure With Preserved Ejection Fraction: Insights From the CAMEO-DAPA Trial
Tada A, Burkhoff D, Naser J, Harada T, Pourmussa B, Reddy Y, Jensen M, Carter R, Demmer R, Testani J, Chirinos J, Borlaug B. Dapagliflozin Enhances Arterial and Venous Compliance During Exercise in Heart Failure With Preserved Ejection Fraction: Insights From the CAMEO-DAPA Trial. Circulation 2024, 150: 997-1009. PMID: 39101201, PMCID: PMC11433515, DOI: 10.1161/circulationaha.124.068788.Peer-Reviewed Original ResearchConceptsSystemic arterial complianceEffects of dapagliflozinStressed blood volumeVenous capacitanceBlood volumePeak exerciseArterial complianceHemodynamic congestionHeart failureEstimating stressed blood volumeImproved systemic arterial complianceInvasive hemodynamic exercise testingSodium-glucose cotransporter-2 inhibitorsSystolic BPPulmonary capillary wedge pressureHemodynamic exercise testingCapillary wedge pressureCotransporter-2 inhibitorsSystemic vascular resistanceImproving clinical outcomesTotal blood volumeRadial artery pressureSimultaneous echocardiographyEjection fractionFluid-filled catheter
2022
Machine Learning Outperforms Existing Methods to Predict Post-Operative Mortality in Patients Bridged to Heart Transplantation with Temporary Mechanical Circulatory Support
Shou B, Russel J, Ong C, Lewis T, Zhou A, Verma A, Benharash P, Choi C. Machine Learning Outperforms Existing Methods to Predict Post-Operative Mortality in Patients Bridged to Heart Transplantation with Temporary Mechanical Circulatory Support. The Journal Of Heart And Lung Transplantation 2022, 41: s28-s29. DOI: 10.1016/j.healun.2022.01.063.Peer-Reviewed Original ResearchTemporary mechanical circulatory supportPost-operative mortalityMechanical circulatory supportHeart transplantationCirculatory supportPulmonary capillary wedge pressureCapillary wedge pressureCardiac Transplantation (IMPACT) scorePost-transplant mortalityOrgan Sharing databasePre-transplant evaluationTime of transplantConfidence intervalsHigh-risk populationReceiver operator characteristic curveRecipient functional statusRisk scoring methodOperator characteristic curveLarge clinical databaseLogistic regression modelsWedge pressureAdult patientsSerum creatinineMedian ageSharing database
2020
Relationship between NT-pro Brain Natriuretic Peptide and Filling Pressures in Ambulatory Patients with Left Ventricular Assist Devices and Accuracy to Detect Need for Optimization
Abbas A, Akintoye E, Duque E, Briasoulis A, Alvarez P. Relationship between NT-pro Brain Natriuretic Peptide and Filling Pressures in Ambulatory Patients with Left Ventricular Assist Devices and Accuracy to Detect Need for Optimization. The Journal Of Heart And Lung Transplantation 2020, 39: s344. DOI: 10.1016/j.healun.2020.01.390.Peer-Reviewed Original ResearchPulmonary capillary wedge pressureRight atrial pressureVentricular assist devicePulmonary artery pressureNT-proBNPAmbulatory patientsAssist deviceNatriuretic peptideN-terminal pro-brain natriuretic peptideNT-pro-brain natriuretic peptidePro-brain natriuretic peptideCapillary wedge pressureNT-proBNP levelsRight heart catheterizationMedian NT-proBNPBrain natriuretic peptideBest cutoff valuePg/mLWedge pressureArtery pressureHeart catheterizationAtrial pressurePatient characteristicsHemodynamic optimizationNoninvasive marker
2018
Assessment of diastolic function and atrial remodeling by MRI – validation and correlation with echocardiography and filling pressure
Seemann F, Baldassarre LA, Llanos‐Chea F, Gonzales RA, Grunseich K, Hu C, Sugeng L, Meadows J, Heiberg E, Peters DC. Assessment of diastolic function and atrial remodeling by MRI – validation and correlation with echocardiography and filling pressure. Physiological Reports 2018, 6: e13828. PMID: 30187654, PMCID: PMC6125607, DOI: 10.14814/phy2.13828.Peer-Reviewed Original ResearchConceptsLate gadolinium enhancementMagnetic resonance imagingPulmonary capillary wedge pressureLA late gadolinium enhancementCapillary wedge pressureTransthoracic echocardiographyDiastolic functionDiastolic parametersWedge pressureAtrial remodelingFilling pressureCardiovascular magnetic resonance imagingLeft atrial remodelingVentricular filling pressureAtrial late gadolinium enhancementLGE-magnetic resonance imagingDiastolic dysfunctionMedical chartsLA volumeAtrial fibrosisGadolinium enhancementResonance imagingPressure catheterizationLow interobserverEchocardiographyRelative Impairments in Hemodynamic Exercise Reserve Parameters in Heart Failure With Preserved Ejection Fraction A Study-Level Pooled Analysis
Pandey A, Khera R, Park B, Haykowsky M, Borlaug BA, Lewis GD, Kitzman DW, Butler J, Berry JD. Relative Impairments in Hemodynamic Exercise Reserve Parameters in Heart Failure With Preserved Ejection Fraction A Study-Level Pooled Analysis. JACC Heart Failure 2018, 6: 117-126. PMID: 29413366, PMCID: PMC8135913, DOI: 10.1016/j.jchf.2017.10.014.Peer-Reviewed Original ResearchConceptsPulmonary capillary wedge pressureCapillary wedge pressurePeak oxygen uptakePooled analysisWedge pressureEchocardiographic parametersHeart failureExercise intoleranceExaggerated increaseReserve parametersControl groupLower peak oxygen uptakeRelative impairmentStroke volume reserveOxygen uptakeChronic HFpEFHemodynamic reserveExercise toleranceExercise capacityEjection fractionChronotropic reserveControl subjectsCardinal manifestationsHFpEFSignificant abnormalitiesHemodynamic factors associated with serum chloride in ambulatory patients with advanced heart failure
Grodin JL, Mullens W, Dupont M, Taylor DO, McKie PM, Starling RC, Testani JM, Tang WHW. Hemodynamic factors associated with serum chloride in ambulatory patients with advanced heart failure. International Journal Of Cardiology 2018, 252: 112-116. PMID: 29249420, DOI: 10.1016/j.ijcard.2017.11.024.Peer-Reviewed Original ResearchConceptsPulmonary capillary wedge pressureAdvanced chronic heart failureFick cardiac indexPulmonary artery systolic pressureRight atrial pressureVentricular assist device placementHeart transplantHeart rateHeart failureSerum chlorideHigher cardiac filling pressuresPoor long-term outcomesSerum Cl levelsCapillary wedge pressureCardiac filling pressuresChronic heart failureAdvanced heart failureInvasive hemodynamic assessmentHeart failure patientsRisk of deathLong-term outcomesLower serum chlorideConventional clinical parametersBackward regression modelAssociation of hemodynamics
2016
Catheter‐measured Hemodynamics of Adult Fontan Circulation: Associations with Adverse Event and End‐organ Dysfunctions
Mori M, Hebson C, Shioda K, Elder RW, Kogon BE, Rodriguez FH, Jokhadar M, Book WM. Catheter‐measured Hemodynamics of Adult Fontan Circulation: Associations with Adverse Event and End‐organ Dysfunctions. Congenital Heart Disease 2016, 11: 589-597. PMID: 26932151, DOI: 10.1111/chd.12345.Peer-Reviewed Original ResearchMeSH KeywordsAdultCardiac CatheterizationChi-Square DistributionFemaleFontan ProcedureGeorgiaHeart Defects, CongenitalHeart FailureHeart TransplantationHemodynamicsHumansKidney DiseasesLinear ModelsLiver DiseasesMaleMultivariate AnalysisPredictive Value of TestsProportional Hazards ModelsRetrospective StudiesRisk FactorsTime FactorsTreatment OutcomeYoung AdultConceptsPulmonary capillary wedge pressureHigh central venous pressureCentral venous pressureEnd-organ dysfunctionSystemic vascular resistance indexCox proportional hazards analysisAdult Fontan patientsProportional hazards analysisCardiac indexFontan patientsAdverse eventsFontan circulationHemodynamic measurementsHigh systemic vascular resistance indexMultivariate Cox proportional hazards analysisRight heart catheterization dataSignificant associationLow cardiac indexVascular resistance indexCapillary wedge pressureChild-Pugh scoreSerious adverse eventsVenous outflow obstructionHigher cardiac indexPost-Fontan patients
2014
Comprehensive Assessment of Right Ventricular Function in Patients with Pulmonary Hypertension with Global Longitudinal Peak Systolic Strain Derived from Multiple Right Ventricular Views
Rajagopal S, Forsha DE, Risum N, Hornik CP, Poms AD, Fortin TA, Tapson VF, Velazquez EJ, Kisslo J, Samad Z. Comprehensive Assessment of Right Ventricular Function in Patients with Pulmonary Hypertension with Global Longitudinal Peak Systolic Strain Derived from Multiple Right Ventricular Views. Journal Of The American Society Of Echocardiography 2014, 27: 657-665.e3. PMID: 24656881, DOI: 10.1016/j.echo.2014.02.001.Peer-Reviewed Original ResearchConceptsRV longitudinal peak systolic strainLongitudinal peak systolic strainPulmonary hypertensionRight ventricular functionRV functionPeak systolic strainFour-chamber viewRight ventricleRV dysfunctionClinical characteristicsWalk distanceVentricular functionSystolic strainGlobal longitudinal peak systolic strainTricuspid annular plane systolic excursionAssessment of PHMean pulmonary artery pressurePulmonary capillary wedge pressureRV myocardial performance indexAnnular plane systolic excursionRegional RV dysfunctionCapillary wedge pressurePulmonary artery pressureCohort of patientsMyocardial performance index
2010
Potential Effects of Aggressive Decongestion During the Treatment of Decompensated Heart Failure on Renal Function and Survival
Testani JM, Chen J, McCauley BD, Kimmel SE, Shannon RP. Potential Effects of Aggressive Decongestion During the Treatment of Decompensated Heart Failure on Renal Function and Survival. Circulation 2010, 122: 265-272. PMID: 20606118, PMCID: PMC3025294, DOI: 10.1161/circulationaha.109.933275.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlood ProteinsBlood VolumeExtracellular FluidFemaleGlomerular Filtration RateHeart FailureHematocritHumansKidneyMaleMiddle AgedPulmonary Wedge PressureSerum AlbuminSodium Chloride Symporter InhibitorsSodium Potassium Chloride Symporter InhibitorsTreatment OutcomeVentricular PressureConceptsDecompensated heart failureRenal functionAggressive decongestionHeart failurePulmonary Artery Catheterization Effectiveness trialPulmonary capillary wedge pressureAggressive fluid removalCapillary wedge pressureIntravascular volume depletionRight atrial pressureCongestive heart failureEvidence of hemoconcentrationAggressive diuresisIntravascular substancesWedge pressureAtrial pressureBaseline characteristicsLoop diureticsTop tertileVolume depletionEffectiveness trialExtravascular fluidFluid removalHemoconcentrationHigh doses
2007
Pulmonary Hypertension in the Elderly: More Common Than We Thought?
Mannam P, Trow T. Pulmonary Hypertension in the Elderly: More Common Than We Thought? Clinical Pulmonary Medicine 2007, 14: 240-242. DOI: 10.1097/cpm.0b013e3180cac701.Peer-Reviewed Original Research
1996
Alterations of Cardiovascular Performance During Laparoscopic Colectomy
Harris S, Ballantyne G, Luther M, Perrino A. Alterations of Cardiovascular Performance During Laparoscopic Colectomy. Anesthesia & Analgesia 1996, 83: 482-487.. PMID: 8780267, DOI: 10.1097/00000539-199609000-00007.Peer-Reviewed Original ResearchConceptsEjection fraction areaSystemic vascular resistanceCoexisting cardiopulmonary diseaseCardiac indexLaparoscopic colectomyCardiovascular performancePulmonary capillary wedge pressureCardiopulmonary diseaseEnd-diastolic areaCapillary wedge pressurePulmonary artery catheterTransesophageal echocardiographyIntraoperative maneuversWedge pressurePeritoneal insufflationEchocardiographic dataVentricular preloadHyperdynamic stateArtery catheterVascular resistanceHemodynamic monitoringGeneral anesthesiaColectomyInsufflationTrendelenburgAlterations of Cardiovascular Performance During Laparoscopic Colectomy: A Combined Hemodynamic and Echocardiographic Analysis
Harris S, Ballantyne G, Luther M, Perrino A. Alterations of Cardiovascular Performance During Laparoscopic Colectomy: A Combined Hemodynamic and Echocardiographic Analysis. Anesthesia & Analgesia 1996, 83: 482. DOI: 10.1213/00000539-199609000-00007.Peer-Reviewed Original ResearchConceptsSystemic vascular resistanceEjection fraction areaCardiac indexLaparoscopic colectomyCardiovascular performanceCardiopulmonary diseasePulmonary capillary wedge pressureCapillary wedge pressurePulmonary artery catheterEnd-diastolic areaSignificant increaseHyperdynamic stateVascular resistanceWedge pressureArtery catheterPeritoneal insufflationVentricular preloadTrendelenburg positioningGeneral anesthesiaTransesophageal echocardiographyEchocardiographic analysisEchocardiographic dataIntraoperative maneuversHemodynamic responseHeart rate
1990
Prostaglandin E1 and intrapulmonary shunt in cardiac surgical patients with pulmonary hypertension
Heerdt P, Weiss C. Prostaglandin E1 and intrapulmonary shunt in cardiac surgical patients with pulmonary hypertension. The Annals Of Thoracic Surgery 1990, 49: 463-465. PMID: 2106846, DOI: 10.1016/0003-4975(90)90257-7.Peer-Reviewed Original ResearchConceptsPulmonary vascular resistancePulmonary capillary wedge pressureCapillary wedge pressurePulmonary arterial pressureSystemic vascular resistanceVascular resistanceIntrapulmonary shuntPulmonary hypertensionProstaglandin E1Wedge pressureArterial pressureSurgical patientsCardiac outputElevated pulmonary vascular resistanceMean pulmonary arterial pressureAdult respiratory distress syndromeMixed venous oxygen tensionPulmonary vascular responseCardiac surgical patientsRight atrial pressureRespiratory distress syndromeProstaglandin E1 infusionPulmonary arterial catheterRadial arterial cannulaVenous oxygen tension
1984
Noncardiogenic pulmonary edema after cardiopulmonary bypass An anaphylactic reaction to fresh frozen plasma
Hashim S, Kay H, Hammond G, Kopf G, Geha A. Noncardiogenic pulmonary edema after cardiopulmonary bypass An anaphylactic reaction to fresh frozen plasma. The American Journal Of Surgery 1984, 147: 560-564. PMID: 6711758, DOI: 10.1016/0002-9610(84)90022-9.Peer-Reviewed Original ResearchConceptsNoncardiogenic pulmonary edemaFresh frozen plasmaCardiac outputCardiopulmonary bypassPulmonary edemaFrozen plasmaWedge pressureAnaphylactic reactionsLeft-sided filling pressuresPulmonary artery diastolic pressurePulmonary capillary wedge pressureAdult respiratory distress syndromePositive end-expiratory pressureCapillary wedge pressureLow cardiac outputIntraaortic balloon pumpRespiratory distress syndromeAdministration of catecholaminesEnd-expiratory pressureSatisfactory cardiac outputNormal saline solutionAtrial pressureBalloon pumpDistress syndromeDiastolic pressure
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