2021
Obesity Induces Elevated Oxidative Stress in Uteri of Reproductive Age Mice
Huang J, Xiao E, Tal A, Kelly K, Kim J, Whirledge S, Flannery C. Obesity Induces Elevated Oxidative Stress in Uteri of Reproductive Age Mice. Journal Of The Endocrine Society 2021, 5: a752-a752. DOI: 10.1210/jendso/bvab048.1529.Peer-Reviewed Original ResearchWeeks of dietNC miceHF miceHigher body fatProtein carbonylsOxidative stressAge miceBody fatChronic diet-induced obesityDiet-induced obese miceObesity-related disruptionIndependent risk factorInsulin tolerance testingHigh-fat chowLong-term obesitySeverity of obesityC57BL/6 female miceDiet-induced obesityHigh fat consumptionUterine oxidative stressCYP enzymatic activitiesAge-dependent increaseElevated oxidative stressDNA damageCytochrome P450 expression
2016
Neuroblast Distribution after Cortical Impact Is Influenced by White Matter Injury in the Immature Gyrencephalic Brain
Taylor SR, Smith CM, Keeley KL, McGuone D, Dodge CP, Duhaime AC, Costine BA. Neuroblast Distribution after Cortical Impact Is Influenced by White Matter Injury in the Immature Gyrencephalic Brain. Frontiers In Neuroscience 2016, 10: 387. PMID: 27601978, PMCID: PMC4994423, DOI: 10.3389/fnins.2016.00387.Peer-Reviewed Original ResearchTraumatic brain injuryWhite matter injuryCortical impactSubventricular zoneWhite matterGyrencephalic brainBrain regionsInjury sitePostnatal populationGray matterPostnatal day 7Age-dependent increaseNumber of neuroblastsCortical contusionNeurogenic responseCortical injuryMajor white matterSham surgeryPND 14PND 5Potential complicationsBrain injuryPopulation of neuroblastsDay 7Chronic effectsAberrant expression of microRNAs as biomarker for schizophrenia: from acute state to partial remission, and from peripheral blood to cortical tissue
Lai C, Lee S, Scarr E, Yu Y, Lin Y, Liu C, Hwang T, Hsieh M, Liu C, Chien Y, Udawela M, Gibbons A, Everall I, Hwu H, Dean B, Chen W. Aberrant expression of microRNAs as biomarker for schizophrenia: from acute state to partial remission, and from peripheral blood to cortical tissue. Translational Psychiatry 2016, 6: e717-e717. PMID: 26784971, PMCID: PMC5068884, DOI: 10.1038/tp.2015.213.Peer-Reviewed Original ResearchConceptsPeripheral miRNAsState-dependent markersDiagnostic of schizophreniaHsa-miR-34aPostmortem brain tissueAberrant expression of microRNAsCaudate putamenSchizophreniaSubcortical regionsAcute stateExpression of microRNAsSeven-miRNARemission stateBrain samplesAberrant expressionClinically useful biomarkersExpression levelsBrainMonths of hospitalizationPartial remission stateAge-dependent increaseMiRNA dysregulationMiRNAsPartial remissionClinical symptoms
2000
Brain regional development of the activity of α-ketoglutarate dehydrogenase complex in the rat
Buerstatte C, Behar K, Novotny E, Lai J. Brain regional development of the activity of α-ketoglutarate dehydrogenase complex in the rat. Brain Research 2000, 125: 139-145. PMID: 11154769, DOI: 10.1016/s0165-3806(00)00134-6.Peer-Reviewed Original ResearchConceptsAdult levelsKGDHC activityCerebral cortexOlfactory bulbPostnatal day 2Age-dependent increaseGlucose oxidative metabolismAlpha-ketoglutarate dehydrogenase complex activityRat brainDay 2Pathophysiological implicationsPostnatal developmentDistinct region-specific patternsNeurotransmitter synthesisRegion-specific patternsOxidative metabolismDehydrogenase complex activityHippocampusStriatumEnergy metabolismCerebellumP30TCA cycle fluxP17P10
1987
Correlation of pulmonary ACE activity and capillary surface area during postnatal development
Pitt B, Lister G, Davies P, Reid L. Correlation of pulmonary ACE activity and capillary surface area during postnatal development. Journal Of Applied Physiology 1987, 62: 2031-2041. PMID: 3036759, DOI: 10.1152/jappl.1987.62.5.2031.Peer-Reviewed Original ResearchConceptsPulmonary ACE activityEndothelial cell surface areaACE activityPostnatal developmentDifferential postnatal developmentPulmonary arterial circulationAge-dependent increaseCO diffusing capacityCell surface areaDays of ageSeptal dimensionAtrial pressureVentilated lambsCapillary surface areaLung volumeArterial circulationAlveolar septaPulmonary microcirculationBenzoyl-phenylalanylFunctional assessmentPulmonary angiotensinDiffusing capacityDLCOAge groupsFunctional manifestations
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