The Perceived Value of Pharmacogenetic Testing in Depression Treatment: Mixed-Methods Results From the PRIME Care Study
Vest B, Wray L, Hull L, Lynch K, Chapman S, Thase M, Ramsey C, Simonetti J, Oslin D. The Perceived Value of Pharmacogenetic Testing in Depression Treatment: Mixed-Methods Results From the PRIME Care Study. Psychiatric Services 2025, 76: 589-597. PMID: 40235224, DOI: 10.1176/appi.ps.20240080.Peer-Reviewed Original ResearchConceptsMental health providersMixed-methods studyDepression treatmentHealth providersPGx testingPrimary care providersPatient buy-inPre-post changesPragmatic clinical trialsFollow-up surveyMixed-methods resultsRobust standard errorsDepression carePrimary careProviders' perceptionsCare providersCare studiesOrdinal regression modelClinical trialsTrial participantsQualitative interviewsEvidence baseBuy-inProvidersInterview dataEffects of sex on imaging-based intravenous thrombolysis for ischaemic stroke with unknown onset time: a pooled analysis of clinical trials.
Fukuda-Doi M, Koga M, Thomalla G, Jensen M, Inoue M, Yoshimura S, Miwa K, Gerloff C, Davis S, Donnan G, Ma H, Hacke W, Ringleb P, Wu O, Schwamm L, Warach S, Toyoda K. Effects of sex on imaging-based intravenous thrombolysis for ischaemic stroke with unknown onset time: a pooled analysis of clinical trials. European Stroke Journal 2025, 23969873241309512. PMID: 39749428, PMCID: PMC11696941, DOI: 10.1177/23969873241309512.Peer-Reviewed Original ResearchFavorable outcomeIntravenous thrombolysisPooled analysis of individual patient-level dataPooled analysisClinical trialsBaseline National Institutes of Health Stroke Scale scoreSex-based differencesPooled analysis of clinical trialsIschaemic strokeNational Institutes of Health Stroke Scale scoreSevere clinical statusIndividual patient-level dataStroke Scale scorePatient-level dataAnalysis of clinical trialsOrdinal regression modelAtrial fibrillationPatient sexClinical statusMultivariable adjustmentFemale sexThrombolysis trialsOnset timePrimary outcomeFunctional outcomes
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply