2025
APOE ε4 and Risk of Intracranial Hemorrhage in Patients With Atrial Fibrillation Taking Apixaban
Clocchiatti-Tuozzo S, Rivier C, Renedo D, Huo S, de Havenon A, Hawkes M, Gilmore E, Schwamm L, Sheth K, Gill T, Falcone G. APOE ε4 and Risk of Intracranial Hemorrhage in Patients With Atrial Fibrillation Taking Apixaban. JAMA Neurology 2025, 82 PMID: 40549373, PMCID: PMC12186128, DOI: 10.1001/jamaneurol.2025.0182.Peer-Reviewed Original ResearchRisk of intracranial hemorrhagePopulation-based studyYears of follow-up dataApo E4Cox proportional hazards modelsAPOE e4 alleleIntracranial hemorrhageRisk prediction scoreCerebral amyloid angiopathyClinical decision-makingProportional hazards modelAtrial fibrillationIncreased risk of ICHMultivariate Cox proportional hazards modelMain OutcomesIncident intracranial hemorrhageEuropean ancestryCohort studyInclusion criteriaHistory of ischemic strokeAmyloid angiopathyE4 variantHazards modelIncreased riskE4 allele
2024
A Multi‐Omic Analysis of Molecular Risk and Resilience Factors in Late‐Onset Alzheimer’s Disease in APOEe4 Carriers
Markov Y, Priyanka A, Higgins‐Chen A. A Multi‐Omic Analysis of Molecular Risk and Resilience Factors in Late‐Onset Alzheimer’s Disease in APOEe4 Carriers. Alzheimer's & Dementia 2024, 20: e092941. PMCID: PMC11709863, DOI: 10.1002/alz.092941.Peer-Reviewed Original ResearchLate-onset Alzheimer's diseaseMulti-omics analysisApolipoprotein ESusceptible to AD pathologyDisease resilienceDeep whole-exome sequencingMulti-omics datasetsDNA methylation profilesAlzheimer's diseaseWhole-exome sequencingMolecular signaturesLabel-free mass spectrometryIllumina EPIC arrayDNA methylationExome sequencingMethylation profilesEPIC arrayOmics levelsReligious Orders StudyAD pathologyMulti-tissueMutated genesGenesE4 alleleExtracellular matrixAPOE ε4 is associated with decreased synaptic density in cognitively impaired participants
He K, Li B, Wang J, Wang Y, You Z, Chen X, Chen H, Li J, Huang Q, Guo Q, Huang Y, Guan Y, Chen K, Zhao J, Deng Y, Xie F. APOE ε4 is associated with decreased synaptic density in cognitively impaired participants. Alzheimer's & Dementia 2024, 20: 3157-3166. PMID: 38477490, PMCID: PMC11095422, DOI: 10.1002/alz.13775.Peer-Reviewed Original ResearchApolipoprotein E4Tau pathologyAlzheimer's diseaseApo E4AD biomarkersAPOE e4 allele carriersAmyloid-betaEffects of apolipoprotein E4Synaptic lossAPOE e4 alleleSynaptic densitySynaptic density lossNon-carriersE4 alleleE4 allele carriersE4 genotypeTauGenotypesPositron emission tomographyAllele carriersMedial temporal lobeAllelesAmyloidEffect of APOE E4Cognitively impaired participants
2022
Maternal ApoE genotype and risk of recurrent pregnancy loss: An updated systematic review and meta‐analysis
Cargnin S, Agnusdei F, Shin J, Terrazzino S. Maternal ApoE genotype and risk of recurrent pregnancy loss: An updated systematic review and meta‐analysis. The Journal Of Gene Medicine 2022, 25: e3467. PMID: 36479790, DOI: 10.1002/jgm.3467.Peer-Reviewed Original ResearchConceptsBayesian false discovery probabilityRisk of recurrent pregnancy lossRisk of RPLIncreased risk of RPLFalse positive report probabilityOdds ratioWomen of Asian ancestryMeta-analysisSystematic reviewRecurrent pregnancy lossAPOE genotypeMethodological study qualityE4 alleleSignificant pooled odds ratioPooled odds ratioNewcastle-Ottawa ScaleCase-control studyAPOE e4 alleleWeb of KnowledgePregnancy lossRPL riskDiscovery probabilityComprehensive literature searchReport probabilityStudy quality
2020
Superior short-term memory in APOE ε2 carriers across the age range
Zokaei N, Board A, Slavkova E, Mackay C, Nobre A, Husain M. Superior short-term memory in APOE ε2 carriers across the age range. Behavioural Brain Research 2020, 397: 112918. PMID: 32961217, PMCID: PMC7732594, DOI: 10.1016/j.bbr.2020.112918.Peer-Reviewed Original ResearchConceptsShort-term memoryMemory advantageAssociated with individual differencesShort-term memory taskSignificant memory advantageAlzheimer's diseaseMemory performanceIndividual differencesTask difficultyAD-related pathologyAge rangeCognitive healthE3/E3 carriersSensitive to subtle changesAt-risk cohortElderly adultsApolipoprotein E4 alleleMemoryCognitionCohort of individualsMiddle-agedDevelopment of ADE4 alleleIndividualsPhenotypic effectsShort-term memory advantage for brief durations in human APOE ε4 carriers
Zokaei N, Grogan J, Fallon S, Slavkova E, Hadida J, Manohar S, Nobre A, Husain M. Short-term memory advantage for brief durations in human APOE ε4 carriers. Scientific Reports 2020, 10: 9503. PMID: 32528115, PMCID: PMC7289888, DOI: 10.1038/s41598-020-66114-6.Peer-Reviewed Original ResearchConceptsApolipoprotein E4 geneE4 geneAntagonistic pleiotropy effectsAlzheimer's diseaseE4 alleleGenetic risk factorsGene poolDeleterious genesAntagonistic pleiotropyShort-term memoryGenetic variantsApolipoprotein E4 alleleEvolutionary biologyGene allelesGenesMemory advantagePleiotropic effectsAllelesPleiotropy effectsNon-carriersShort-term memory performanceAPOE e4 carriersSignificant memory advantageHuman populationHuman cognitive functions
2019
Association between APOE polymorphisms and lipid profile in Mexican Amerindian population
Martínez‐Magaña J, Genis‐Mendoza A, Tovilla‐Zarate C, González‐Castro T, Juárez-Rojop IE, Hernández‐Díaz Y, Martinez‐Hernandez A, Garcia‐Ortíz H, Orozco L, López‐Narvaez M, Nicolini H. Association between APOE polymorphisms and lipid profile in Mexican Amerindian population. Molecular Genetics & Genomic Medicine 2019, 7: e958. PMID: 31557780, PMCID: PMC6825948, DOI: 10.1002/mgg3.958.Peer-Reviewed Original ResearchConceptsLDL-C levelsHDL-C levelsLipid profileLipoprotein cholesterolTotal cholesterolBiochemical variablesHigh-density lipoprotein cholesterolLow-density lipoprotein cholesterolHigher HDL-C levelsMexican Amerindian populationsAPOE e4 carriersDifferent APOE allelesObese individualsGene allelesApoE E3E2 alleleApoE isoformsAPOE polymorphismE4 alleleApolipoprotein EAnthropometric measurementsKruskal-Wallis testAPOE allelesLipid metabolismE3 allele
2018
Dissociable effects of the apolipoprotein-E (APOE) gene on short- and long-term memories
Zokaei N, Čepukaitytė G, Board A, Mackay C, Husain M, Nobre A. Dissociable effects of the apolipoprotein-E (APOE) gene on short- and long-term memories. Neurobiology Of Aging 2018, 73: 115-122. PMID: 30342272, PMCID: PMC6261846, DOI: 10.1016/j.neurobiolaging.2018.09.017.Peer-Reviewed Original ResearchConceptsLong-term memoryFunction of apolipoproteinsLong-term memory impairmentLong-term memory performanceMeasures of reportingPreclinical Alzheimer's diseasePhenotypic effectsMemory advantageNeural underpinningsItem identityMemory impairmentMemory performanceMeasure memoryShort-term memoryAlzheimer's diseaseDissociative effectsE4 alleleEffect of genotypeE4 carriersAllelesMemoryObject locationGenotypesApolipoproteinShort-
2001
Neuroimaging in alzheimer’s disease: Relevance for treatment
van Dyck C. Neuroimaging in alzheimer’s disease: Relevance for treatment. Current Psychiatry Reports 2001, 3: 13-19. PMID: 11177754, DOI: 10.1007/s11920-001-0066-2.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseAD patientsRegional cerebral glucose metabolismRegional cerebral blood flowApolipoprotein E e4 alleleAnti-amyloid therapiesCerebral glucose metabolismDisease-modifying agentsCentral cholinergic neurotransmissionWhole brain atrophyCerebral blood flowPutative disease-modifying agentsWidespread clinical testingStructural magnetic resonanceBrain atrophyPrevention therapyInvestigational trialsAsymptomatic subjectsEfficacy measuresCholinergic neurotransmissionE4 alleleSenile plaquesDrug dosingOutcome measuresBlood flow
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