2025
Peer Influence on Physicians in Adopting Opportunistic Salpingectomy at the Time of Hysterectomy
Xu X, Long J, Pollack C, Desai V, Gross C, Spatz E, Wright J. Peer Influence on Physicians in Adopting Opportunistic Salpingectomy at the Time of Hysterectomy. American Journal Of Obstetrics And Gynecology 2025 PMID: 40254276, DOI: 10.1016/j.ajog.2025.04.022.Peer-Reviewed Original ResearchRate of opportunistic salpingectomyOpportunistic salpingectomyInpatient hysterectomyOvarian cancer risk reductionHighest quartilesTime of hysterectomyCancer risk reductionIndex physicianCancer prevention strategiesMultivariate regression analysisFallopian tubePeer physiciansSurgical routeSurgical indicationsFemale patientsSalpingectomyHysterectomyCounseling patientsPatientsPrevention strategiesIncreased likelihoodPhysiciansRegression analysisRisk reductionComplete removal5. A rare case of 45X/46XY mosaic Turner syndrome in a neonate
Garg A, Hittelman A, Lepore C, Gujral J, Derar N, Vash-Margita A. 5. A rare case of 45X/46XY mosaic Turner syndrome in a neonate. Journal Of Pediatric And Adolescent Gynecology 2025, 38: 232. DOI: 10.1016/j.jpag.2025.01.038.Peer-Reviewed Original ResearchMosaic Turner syndromeTurner syndromeUrogenital sinusHemi-uterusStreak gonadsMullerian structuresFallopian tubeAmbiguous genitaliaInguinal canalSurgical findingsRare caseLeft inguinal hernia repairLeft inguinal canalRight streak gonadRisk of gonadoblastomaPrenatal cell-free DNAInguinal hernia repairSerum hormone evaluationCell-free DNAWeeks of lifeDysgenetic gonadsInguinal orchiopexySingle cervixDiagnostic laparoscopyUncomplicated pregnancies
2024
An Infant With DHX37 Variant: A Novel Etiology of 46,XY DSD and Literature Review
Yilmaz R, Hittelman A, Vash-Margita A, Dinauer C, Weinzimer S, Gujral J. An Infant With DHX37 Variant: A Novel Etiology of 46,XY DSD and Literature Review. JCEM Case Reports 2024, 3: luae239. PMID: 39726663, PMCID: PMC11669865, DOI: 10.1210/jcemcr/luae239.Peer-Reviewed Case Reports and Technical NotesAnti-Mullerian hormoneIntra-abdominal gonadsInhibin B levelsPrenatal ultrasound findingsElevated gonadotropin levelsRisk of malignancyHeterozygous pathogenic variantsGenotype-phenotype correlationNonpalpable gonadsGenital phenotypeLabioscrotal foldsFallopian tubeGonadotropin levelsClinical courseUrine retentionAtypical genitaliaUrogenital sinusVaginal openingCase reportSeparate uteriPathogenic variantsDEAH-boxRibosome biogenesisTestosterone levelsNovel etiologyAssessing the impact of deep‐learning assistance on the histopathological diagnosis of serous tubal intraepithelial carcinoma (STIC) in fallopian tubes
Bogaerts J, Steenbeek M, Bokhorst J, van Bommel M, Abete L, Addante F, Brinkhuis M, Chrzan A, Cordier F, Devouassoux‐Shisheboran M, Fernández‐Pérez J, Fischer A, Gilks C, Guerriero A, Jaconi M, Kleijn T, Kooreman L, Martin S, Milla J, Narducci N, Ntala C, Parkash V, de Pauw C, Rabban J, Rijstenberg L, Rottscholl R, Staebler A, Van de Vijver K, Zannoni G, van Zanten M, Bart J, Bentz J, Bosse T, Bulten J, Desouki M, Lastra R, Numan T, Schoolmeester J, Schwartz L, Shih I, Soong T, Turashvili G, Vang R, Volchek M, Aliredjo R, Kusters‐Vandevelde H, de Hullu J, Simons M, van der Laak J. Assessing the impact of deep‐learning assistance on the histopathological diagnosis of serous tubal intraepithelial carcinoma (STIC) in fallopian tubes. The Journal Of Pathology Clinical Research 2024, 10: e70006. PMID: 39439213, PMCID: PMC11496567, DOI: 10.1002/2056-4538.70006.Peer-Reviewed Original ResearchConceptsDeep learning modelsSerous tubal intraepithelial carcinomaArtificial intelligenceAI assistanceDiagnosis of serous tubal intraepithelial carcinomaTubal intraepithelial carcinomaReview timeFallopian tubeIntraepithelial carcinomaAI supportHigh-grade serous ovarian carcinomaSerous ovarian carcinomaStandalone performanceAverage sensitivityGroup of pathologistsAccuracyOvarian carcinomaHistopathological diagnosisPathologist performanceMixed-model analysisDiagnostic certaintyCarcinomaDiagnostic setting
2021
Physician attitudes and knowledge on prophylactic salpingectomy in perimenopausal patients
Fialkow M, Castleberry N, Wright JD, Schulkin J, Desai VB. Physician attitudes and knowledge on prophylactic salpingectomy in perimenopausal patients. Gynecologic Oncology Reports 2021, 37: 100824. PMID: 34295957, PMCID: PMC8281582, DOI: 10.1016/j.gore.2021.100824.Peer-Reviewed Original ResearchCancer risk reductionOvarian cancer risk reductionCollaborative Ambulatory Research NetworkProphylactic salpingectomyFallopian tubeRisk reductionTime of hysterectomySeverity of symptomsOvarian preservationBilateral salpingectomyOvarian conservationPerimenopausal patientsSurgical menopausePatient ageVaginal drynessVasomotor disturbancesBenign hysterectomyBenign indicationsCardiovascular healthOvarian removalObstetrician-GynecologistsOvarian cancerCardiovascular diseaseFamily historyPhysicians' attitudesDiseases of the Fallopian Tube
Xing D, Snir O, Hui P. Diseases of the Fallopian Tube. Practical Anatomic Pathology 2021, 193-223. DOI: 10.1007/978-3-030-68608-6_8.Peer-Reviewed Original ResearchSerous tubal intraepithelial carcinomaSerous tubal intraepithelial lesionsSecretory cell outgrowthsFallopian tubeSerous carcinomaPrimary fallopian tube carcinomaHigh-grade serous carcinomaFallopian tube neoplasmsLikelihood of overdiagnosisFallopian tube carcinomaTubal intraepithelial carcinomaTubal intraepithelial lesionsNon-neoplastic lesionsSpectrum of entitiesProbable Wolffian originFemale adnexal tumorNongynecologic originEctopic pregnancyMiscellaneous tumorsIntraepithelial lesionsP53 signatureRelated complicationsChronic inflammationIntraepithelial carcinomaMetastatic carcinoma86. Unilateral Ovarian Agenesis: A Systematic Review of the Literature and Report of Two Cases
Chen H, Vijayakumar P, Taylor-Giorlando M, Grimshaw A, Li D, Vash-Margita A. 86. Unilateral Ovarian Agenesis: A Systematic Review of the Literature and Report of Two Cases. Journal Of Pediatric And Adolescent Gynecology 2021, 34: 273-274. DOI: 10.1016/j.jpag.2021.02.090.Peer-Reviewed Original ResearchOvarian agenesisDistal fallopian tubeFallopian tubeUnilateral OAEctopic pregnancyPelvic painParatubal cystRound ligamentSystematic reviewRight tubal ectopic pregnancyMultiple peritoneal biopsiesNormal bilateral ovariesNormal-appearing ovariesRight paratubal cystUnilateral ovarian agenesisCommon presenting symptomHistory of nephrolithiasisRight fallopian tubeSevere abdominal painTubal ectopic pregnancyPositive pregnancy testCorpus luteum cystInfertility/subfertilityMajority of casesGenital chlamydia
2020
Imaging Evaluation of Fallopian Tubes and Related Disease: A Primer for Radiologists
Revzin MV, Moshiri M, Katz DS, Pellerito JS, Mankowski Gettle L, Menias CO. Imaging Evaluation of Fallopian Tubes and Related Disease: A Primer for Radiologists. RadioGraphics 2020, 40: 1473-1501. PMID: 32822282, DOI: 10.1148/rg.2020200051.Peer-Reviewed Original ResearchConceptsFallopian tube diseaseFallopian tubeFallopian tube ligationPelvic inflammatory diseaseCharacteristic imaging featuresFallopian tube involvementProper clinical managementLife-threatening infectionsLife-saving treatmentTubal torsionUterine ablationEctopic pregnancyOvarian torsionClinical managementImaging featuresInflammatory diseasesPathologic entityPelvic neoplasmsPatient managementTimely diagnosisMalignant processCorrect diagnosisOnline supplemental materialContrast materialAccurate diagnosisIn vivo modeling of metastatic human high-grade serous ovarian cancer in mice
Kim O, Park EY, Klinkebiel DL, Pack SD, Shin YH, Abdullaev Z, Emerson RE, Coffey DM, Kwon SY, Creighton CJ, Kwon S, Chang EC, Chiang T, Yatsenko AN, Chien J, Cheon DJ, Yang-Hartwich Y, Nakshatri H, Nephew KP, Behringer RR, Fernández FM, Cho CH, Vanderhyden B, Drapkin R, Bast RC, Miller KD, Karpf AR, Kim J. In vivo modeling of metastatic human high-grade serous ovarian cancer in mice. PLOS Genetics 2020, 16: e1008808. PMID: 32497036, PMCID: PMC7297383, DOI: 10.1371/journal.pgen.1008808.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsCell Line, TumorChromosomal InstabilityCystadenocarcinoma, SerousDEAD-box RNA HelicasesDisease Models, AnimalDNA RepairDrug Resistance, NeoplasmDrug Screening Assays, AntitumorFeasibility StudiesFemaleHumansMiceMice, KnockoutMutationNeoplasm GradingNeoplasm MetastasisOvarian NeoplasmsPeritoneal NeoplasmsPrimary Cell CulturePTEN PhosphohydrolaseRibonuclease IIITumor Suppressor Protein p53ConceptsHigh-grade serous carcinomaHuman HGSCHigh-grade serous ovarian cancerSerous ovarian cancerOvarian cancerPeritoneal metastasisHuman high-grade serous ovarian cancerMetastatic ovarian cancerOvarian cancer typesHuman cancer metastasisHuman cancer mortalityHemorrhagic ascitesClinical metastasisHistopathological similaritiesSerous carcinomaCancer mortalityFallopian tubeMurine modelPeritoneal cavityMouse modelPotential therapyMouse deathMetastasisCancer typesCancer metastasisOvarian BDNF promotes survival, migration, and attachment of tumor precursors originated from p53 mutant fallopian tube epithelial cells
Kang M, Chong KY, Hartwich TMP, Bi F, Witham AK, Patrick D, Morrisson MJ, Cady SL, Cerchia AP, Kelk D, Liu Y, Nucci J, Madarikan O, Ueno D, Shuch BM, Yang-Hartwich Y. Ovarian BDNF promotes survival, migration, and attachment of tumor precursors originated from p53 mutant fallopian tube epithelial cells. Oncogenesis 2020, 9: 55. PMID: 32471985, PMCID: PMC7260207, DOI: 10.1038/s41389-020-0243-y.Peer-Reviewed Original ResearchHigh-grade serous ovarian carcinomaBrain-derived neurotrophic factorFallopian tube epitheliumFTE cellsTumor precursorsPathophysiological processesTropomyosin receptor kinase BFallopian tube epithelial cellsBDNF/TrkBReceptor kinase BLethal gynecological malignancyGenetic alterationsSerous ovarian carcinomaFunction mutationsCommon TP53Gynecological malignanciesNeurotrophic factorFallopian tubeOvarian carcinomaRisk factorsFollicular fluidMutant p53 proteinVivo modelTP53 lossEpithelial cells
2019
B cell activation factor (BAFF) induces inflammation in the human fallopian tube leading to tubal pregnancy
Xu J, Luo X, Qu S, Yang G, Shen N. B cell activation factor (BAFF) induces inflammation in the human fallopian tube leading to tubal pregnancy. BMC Pregnancy And Childbirth 2019, 19: 169. PMID: 31088412, PMCID: PMC6518762, DOI: 10.1186/s12884-019-2324-5.Peer-Reviewed Original ResearchConceptsHuman fallopian tubeB cell activation factorTubal pregnancyFallopian tubeSerum levelsBAFF mRNAControl groupBAFF geneTissue samplesBenign uterine diseasesNormal fallopian tubesAdaptive immune responsesTumor necrosis factorTubal epithelial cellsFallopian tube occlusionWestern blotting methodBAFF proteinWhole blood samplesProinflammatory cytokinesIL-6Pregnancy typeActivation factorNecrosis factorPregnancy processUterine diseaseOvarian Torsion in an Adolescent with Beckwith-Wiedemann Syndrome and Unilateral Tubo-ovarian Hyperplasia
Mahat U, Dermawan JKT, Herman R, Mamoun I, Flagg A. Ovarian Torsion in an Adolescent with Beckwith-Wiedemann Syndrome and Unilateral Tubo-ovarian Hyperplasia. Journal Of Pediatric And Adolescent Gynecology 2019, 32: 446-449. PMID: 30981832, DOI: 10.1016/j.jpag.2019.04.008.Peer-Reviewed Case Reports and Technical NotesConceptsBeckwith-Wiedemann syndromeOvarian hyperplasiaBWS patientsAbdominal painOvarian torsionFallopian tubeOvid MEDLINEEmbryonal tumorsDatabases PubMedExtensive literature searchHyperplasiaOvergrowth syndromePatientsPostmortem specimensLiterature searchPhenotypic presentationOrgan hyperplasiaSyndromeBroad phenotypic presentationBrief literature reviewPrevious reportsLiterature reviewOnline searchPainEMBASEOlaparib and α-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial
Konstantinopoulos PA, Barry WT, Birrer M, Westin SN, Cadoo KA, Shapiro GI, Mayer EL, O'Cearbhaill RE, Coleman RL, Kochupurakkal B, Whalen C, Curtis J, Farooq S, Luo W, Eismann J, Buss MK, Aghajanian C, Mills GB, Palakurthi S, Kirschmeier P, Liu J, Cantley LC, Kaufmann SH, Swisher EM, D'Andrea AD, Winer E, Wulf GM, Matulonis UA. Olaparib and α-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial. The Lancet Oncology 2019, 20: 570-580. PMID: 30880072, PMCID: PMC7025391, DOI: 10.1016/s1470-2045(18)30905-7.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntineoplastic Combined Chemotherapy ProtocolsCarcinoma, Ovarian EpithelialDose-Response Relationship, DrugDrug-Related Side Effects and Adverse ReactionsFemaleGenome, HumanHumansMaximum Tolerated DoseMiddle AgedMutationOvarian NeoplasmsPhosphoinositide-3 Kinase InhibitorsPhthalazinesPiperazinesPoly(ADP-ribose) Polymerase InhibitorsThiazolesTreatment OutcomeConceptsEpithelial ovarian cancerPhase 2 dosePI3K inhibitor alpelisibPrimary peritoneal cancerPhase 1b trialRecurrent breast cancerGermline BRCA mutationsOvarian cancerBreast cancerDose levelsPeritoneal cancerBRCA mutationsFallopian tubeCommon treatment-related grade 3High-grade serous histologyTreatment-related grade 3Breast Cancer Research FoundationDecreased neutrophil countDose-escalation cohortsDose-expansion cohortsTreatment-related deathsTriple negative histologyResponse Evaluation CriteriaSolid Tumors 1.1Key eligibility criteria
2018
Fallopian tube lesions in women at high risk for ovarian cancer: A multicenter study
Visvanathan K, Shaw P, May BJ, Bahadirli-Talbot A, Kaushiva A, Risch H, Narod S, Wang TL, Parkash V, Vang R, Levine DA, Soslow R, Kurman R, Shih IM. Fallopian tube lesions in women at high risk for ovarian cancer: A multicenter study. Cancer Prevention Research 2018, 11: canprevres.0009.2018. PMID: 30232083, PMCID: PMC6760670, DOI: 10.1158/1940-6207.capr-18-0009.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsBiomarkers, TumorBRCA1 ProteinBRCA2 ProteinCystadenocarcinoma, SerousDisease ProgressionFallopian Tube NeoplasmsFallopian TubesFemaleHumansMedical History TakingMiddle AgedOvarian NeoplasmsOvaryPrecancerous ConditionsPrevalencePrognosisProspective StudiesRetrospective StudiesSalpingo-oophorectomyConceptsSerous tubal intraepithelial lesionsHigh-grade serous ovarian carcinomaSerous tubal intraepithelial carcinomaP53 signatureRisk/protective factorsProtective factorsMultiple lesionsFallopian tubePrognosis of womenHigh-risk womenTubal intraepithelial carcinomaTubal intraepithelial lesionsSerous ovarian carcinomaPutative precursor lesionsYears of ageIntraepithelial lesionsIntraepithelial carcinomaMulticenter studyInvasive cancerOvarian carcinomaDisease progressionPrecursor lesionsEpidemiologic dataCombined prevalenceTubal lesionsAssembly and Positioning of the Oocyte Meiotic Spindle
Mogessie B, Scheffler K, Schuh M. Assembly and Positioning of the Oocyte Meiotic Spindle. Annual Review Of Cell And Developmental Biology 2018, 34: 381-403. PMID: 30028643, DOI: 10.1146/annurev-cellbio-100616-060553.Peer-Reviewed Original ResearchBone Marrow-Derived Cells Trafficking to the Oviduct: Effect of Ischemia-Reperfusion Injury
Sahin C, Mamillapalli R, Taylor HS. Bone Marrow-Derived Cells Trafficking to the Oviduct: Effect of Ischemia-Reperfusion Injury. Reproductive Sciences 2018, 25: 1037-1044. PMID: 29658434, PMCID: PMC6346346, DOI: 10.1177/1933719118770552.Peer-Reviewed Original ResearchConceptsBone marrow-derived cellsRecruitment of BMDCsMarrow-derived cellsReperfusion injuryFallopian tubeFemale miceWild-type female miceIschemia-reperfusion injuryEquivalent surgeryIR injuryBMDC recruitmentMale miceBone marrowMammalian reproductive tractInjuryIschemiaReproductive tractMiceHealing processEarly embryo developmentOviductCrucial organCellsCritical roleRecruitmentPhase Ib study of anti-mesothelin antibody drug conjugate anetumab ravtansine in combination with pegylated liposomal doxorubicin in platinum-resistant ovarian, fallopian tube, or primary peritoneal cancer.
Bulat I, Moore K, Haceatrean A, Chung J, Rajagopalan P, Xia C, Laurent D, Childs B, Santin A. Phase Ib study of anti-mesothelin antibody drug conjugate anetumab ravtansine in combination with pegylated liposomal doxorubicin in platinum-resistant ovarian, fallopian tube, or primary peritoneal cancer. Journal Of Clinical Oncology 2018, 36: 5571-5571. DOI: 10.1200/jco.2018.36.15_suppl.5571.Peer-Reviewed Original ResearchSmall Cell Variant of Intravascular Large B‐Cell Lymphoma: Highlighting a Potentially Fatal and Easily Missed Diagnosis
Rahmani M, Halene S, Xu ML. Small Cell Variant of Intravascular Large B‐Cell Lymphoma: Highlighting a Potentially Fatal and Easily Missed Diagnosis. BioMed Research International 2018, 2018: 9413015. PMID: 29850589, PMCID: PMC5903319, DOI: 10.1155/2018/9413015.Peer-Reviewed Case Reports and Technical NotesConceptsIntravascular large B-cell lymphomaB-cell lymphomaLarge B-cell lymphomaSmall cell morphologySmall cell variantCases of IVLBCLCell variantHodgkin's B-cell lymphomaRandom skin biopsySmall bowel biopsyHigh clinical suspicionLarge atypical cellsSmall cell lymphomaSmall blood vesselsBowel biopsyClinical suspicionLymph nodesRetrospective reviewClinicopathologic featuresSmall bowelPoor prognosisAtypical cellsFallopian tubeSkin biopsiesDifferential diagnosisAssociated characteristics and impact on recurrence and survival of free-floating tumor fragments in the lumen of fallopian tubes in Type I and Type II endometrial cancer
Albright BB, Black JD, Passarelli R, Gysler S, Whicker M, Altwerger G, Menderes G, Buza N, Hui P, Santin AD, Azodi M, Silasi DA, Ratner ES, Litkouhi B, Schwartz PE. Associated characteristics and impact on recurrence and survival of free-floating tumor fragments in the lumen of fallopian tubes in Type I and Type II endometrial cancer. Gynecologic Oncology Reports 2018, 23: 28-33. PMID: 29387776, PMCID: PMC5771964, DOI: 10.1016/j.gore.2018.01.003.Peer-Reviewed Original ResearchLaparoscopic/robotic approachType II endometrial adenocarcinomaRisk of recurrenceDisease recurrenceFinal pathologyEndometrial adenocarcinomaFallopian tubeTumor fragmentsType II endometrial cancerRobotic approachCox proportional hazards modelHigher stage diseaseSingle institution experienceIndependent prognostic impactType IProportional hazards modelResult of traumaElectronic medical recordsCharacteristics of casesBaseline characteristicsExtensive diseaseLymphovascular invasionOverall survivalPatient comorbiditiesStage disease
2017
The impact of tumor fragments in the lumen of fallopian tubes on recurrence and survival in type I and type II endometrial cancers
Black J, Passarelli R, Lu L, Albright B, Gysler S, Whicker M, Altwerger G, Menderes G, Schwartz P. The impact of tumor fragments in the lumen of fallopian tubes on recurrence and survival in type I and type II endometrial cancers. Gynecologic Oncology 2017, 145: 129. DOI: 10.1016/j.ygyno.2017.03.300.Peer-Reviewed Original Research
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