2025
Clinical Evidence of Mesenchymal Stromal Cells for Cerebral Palsy: Scoping Review with Meta-Analysis of Efficacy in Gross Motor Outcomes
Paton M, Griffin A, Blatch-Williams R, Webb A, Verter F, Couto P, Bersenev A, Dale R, Popat H, Novak I, Finch-Edmondson M. Clinical Evidence of Mesenchymal Stromal Cells for Cerebral Palsy: Scoping Review with Meta-Analysis of Efficacy in Gross Motor Outcomes. Cells 2025, 14: 700. PMID: 40422203, PMCID: PMC12110704, DOI: 10.3390/cells14100700.Peer-Reviewed Original ResearchConceptsGross Motor Function MeasureCerebral palsyIPD meta-analysisTreatment of cerebral palsyMeta-analysisMotor Function MeasureGross motor outcomesData Meta-AnalysisScoping ReviewWell-designed trialsStudy heterogeneityMeta-analysesEffect sizeMotor outcomeFunction measurementsParticipation variablesSubgroup analysisMeta-analysis of efficacyRegistered trialsPalsyOutcomesVariable reportingReports of efficacyTrialsPublished reports2855 Dementia in elderly individuals with depression: a systematic review and Meta-analysis of longitudinal studies (2013–2024)
da Costa Galvão P, de Sousa Romeiro A, de Souza G, Prudente T, Dias E, Nogueira T, Silveira E. 2855 Dementia in elderly individuals with depression: a systematic review and Meta-analysis of longitudinal studies (2013–2024). Age And Ageing 2025, 54: afae277.130. DOI: 10.1093/ageing/afae277.130.Peer-Reviewed Original ResearchMild cognitive impairmentOlder adultsMeta-analysis of longitudinal studiesMeta-analysisLikelihood of older adultsSystematic reviewMini-Mental State ExaminationGeriatric Depression ScaleAssociated with higher likelihoodSymptoms of mild cognitive impairmentDepressed older adultsIdentification of risk factorsConclusion DepressionNon-depressed populationDepression ScaleMini-MentalState ExaminationDepressive symptomsTargeted interventionsI2 statisticAssess symptomsPRISMA recommendationsCohort studyDementiaStudy heterogeneity
2024
Cyclooxygenase 2 Inhibitors for Headache After Elective Cranial Neurosurgery: Results from a Systematic Review of Efficacy of Cyclooxygenase 2 Inhibitors for Headache After Acute Brain Injury
Comparan H, Khaliq A, Frota L, Pomar-Forero D, Ahmad B, Marnet E, Teixeira F, Thomas A, Patel P, Brunkal H, Singireddy S, Lucke-Wold B, Maciel C, Busl K. Cyclooxygenase 2 Inhibitors for Headache After Elective Cranial Neurosurgery: Results from a Systematic Review of Efficacy of Cyclooxygenase 2 Inhibitors for Headache After Acute Brain Injury. Neurocritical Care 2024, 42: 680-689. PMID: 39266865, DOI: 10.1007/s12028-024-02114-y.Peer-Reviewed Original ResearchIntervention groupSystematic reviewHeadache managementCyclooxygenase 2 inhibitorsAcute brain injuryElective cranial neurosurgeryPain scoresRandomized Controlled TrialsHospital length of stayRetrospective cohort studyLength of stayModerate to mild severityBrain injuryIndependent reviewersDescriptive statisticsCohort studyStudy heterogeneityInclusion criteriaControlled TrialsArticle selectionObservational studyInterventionMeta-analysisElective cranial surgeryHospital lengthSuicide Risk Screening Tools for Pediatric Patients: A Systematic Review of Test Accuracy.
Lowry N, Goger P, Hands Ruz M, Ye F, Cha C. Suicide Risk Screening Tools for Pediatric Patients: A Systematic Review of Test Accuracy. 2024, 153 PMID: 38356410, DOI: 10.1542/peds.2023-064172.Peer-Reviewed Original ResearchConceptsSuicide risk screening toolRisk screening toolAsk Suicide-Screening QuestionsNonpsychiatric medical settingsScreening toolMedical settingsSystematic reviews of test accuracySystematic reviewAccuracy of screening toolsTool's psychometric propertiesHealth care settingsStudy risk of biasSuicidal youthRisk of biasRobust evidence baseAdaptive screeningPeer-reviewed articlesCare settingsPediatric careMethodological qualityStratified resultsEvidence basePsychometric propertiesStudy heterogeneityMeta-analytic approach
2023
A systematic review and individual participant data meta-analysis of gonadal steroid hormone receptors in meningioma.
Miyagishima D, Sundaresan V, Gutierrez A, Barak T, Yeung J, Moliterno J, McGuone D, Claus E, Günel M. A systematic review and individual participant data meta-analysis of gonadal steroid hormone receptors in meningioma. Journal Of Neurosurgery 2023, 139: 1638-1647. PMID: 37243565, PMCID: PMC10226381, DOI: 10.3171/2023.3.jns221838.Peer-Reviewed Original ResearchConceptsIndividual participant dataHR statusProgesterone receptorAndrogen receptorEstrogen receptorHormone receptorsFemale patientsParticipant dataSystematic reviewGonadal steroid hormone receptorsRisk of biasGonadal steroid hormonesPubMed literature reviewProper patient stratificationSkull base locationSteroid hormone receptorsHormonal therapyER expressionUnduplicated articlesFemale sexGrade IIndependent associationPatient stratificationConvexity locationStudy heterogeneity
2021
Child‐father attachment in early childhood and behavior problems: A meta‐analysis
Deneault A, Bakermans‐Kranenburg M, Groh A, Fearon P, Madigan S. Child‐father attachment in early childhood and behavior problems: A meta‐analysis. New Directions For Child And Adolescent Development 2021, 2021: 43-66. PMID: 34651413, DOI: 10.1002/cad.20434.Peer-Reviewed Original ResearchCognitive-Behavioral Interventions Targeting Alcohol or Other Drug Use and Co-Occurring Mental Health Disorders: A Meta-Analysis
Mehta K, Hoadley A, Ray LA, Kiluk BD, Carroll KM, Magill M. Cognitive-Behavioral Interventions Targeting Alcohol or Other Drug Use and Co-Occurring Mental Health Disorders: A Meta-Analysis. Alcohol And Alcoholism 2021, 56: 535-544. PMID: 33778869, PMCID: PMC8406071, DOI: 10.1093/alcalc/agab016.Peer-Reviewed Original ResearchConceptsCognitive-behavioral interventionsMental health disordersCo-occurring mental health disordersHealth disordersDrug useEffect sizeDrug use disordersSignificant residual heterogeneityHigh-quality studiesMental health symptomsPost-traumatic stress disorderUnderstanding of treatmentMeta-regression modelsClinical trialsStudy qualityPromising effect sizesUse disordersStudy heterogeneityMHD diagnosisHealth symptomsMeta-analysisStress disorderAlcohol useTime pointsSmall effect sizes
2019
Disparities in cancer screening in people with mental illness across the world versus the general population: prevalence and comparative meta-analysis including 4 717 839 people
Solmi M, Firth J, Miola A, Fornaro M, Frison E, Fusar-Poli P, Dragioti E, Shin J, Carvalho A, Stubbs B, Koyanagi A, Kisely S, Correll C. Disparities in cancer screening in people with mental illness across the world versus the general population: prevalence and comparative meta-analysis including 4 717 839 people. The Lancet Psychiatry 2019, 7: 52-63. PMID: 31787585, DOI: 10.1016/s2215-0366(19)30414-6.Peer-Reviewed Original ResearchConceptsCancer screeningMental illnessGeneral populationPrevalence of cancer screeningOdds ratioColorectal cancerMeta-analysisBreast cancerNewcastle-Ottawa ScaleCervical cancerStudy qualityDatabase inceptionHand searchNewcastle-OttawaStudy heterogeneitySystematic reviewMedian qualityPrimary outcomeLanguage restrictionsObservational studyIllnessAssist peopleComparative Meta-AnalysisIncreased MortalityProstate cancer
2018
Early coronary angiography and survival after out-of-hospital cardiac arrest: a systematic review and meta-analysis
Khera R, CarlLee S, Blevins A, Schweizer M, Girotra S. Early coronary angiography and survival after out-of-hospital cardiac arrest: a systematic review and meta-analysis. Open Heart 2018, 5: e000809. PMID: 30402255, PMCID: PMC6203043, DOI: 10.1136/openhrt-2018-000809.Peer-Reviewed Original ResearchEarly coronary angiographyFavorable neurological outcomeCoronary angiographyHospital cardiac arrestNeurological outcomeCardiac arrestQ testAcute myocardial infarctionConcurrent control groupMultiple electronic databasesRandom-effects modelCochran's Q testSurvival outcomesMyocardial infarctionObservational studyCommon causePooled estimatesHigher oddsExposure groupOHCAAngiographyStudy heterogeneityControl groupElectronic databasesSystematic reviewFactors affecting local regrowth after watch and wait for patients with a clinical complete response following chemoradiotherapy in rectal cancer (InterCoRe consortium): an individual participant data meta-analysis
Chadi SA, Malcomson L, Ensor J, Riley RD, Vaccaro CA, Rossi GL, Daniels IR, Smart NJ, Osborne ME, Beets GL, Maas M, Bitterman DS, Du K, Gollins S, Myint A, Smith FM, Saunders MP, Scott N, O'Dwyer ST, de Castro Araujo RO, Valadao M, Lopes A, Hsiao CW, Lai CL, Smith RK, Paulson EC, Appelt A, Jakobsen A, Wexner SD, Habr-Gama A, Julião G, Perez R, Renehan AG. Factors affecting local regrowth after watch and wait for patients with a clinical complete response following chemoradiotherapy in rectal cancer (InterCoRe consortium): an individual participant data meta-analysis. The Lancet Gastroenterology & Hepatology 2018, 3: 825-836. PMID: 30318451, DOI: 10.1016/s2468-1253(18)30301-7.Peer-Reviewed Original ResearchConceptsClinical complete responseIndividual participant dataComplete responseLocal regrowthRectal cancerCumulative incidenceParticipant dataNeoadjuvant chemoradiotherapyHazard ratioSustained clinical complete responseProportion of patientsCenter heterogeneityRecent systematic reviewCox frailty modelStage cT1CT2 tumorsMajor surgeryPrimary outcomeTreatment characteristicsChemoradiotherapyLower riskPatientsStudy heterogeneitySystematic reviewNovel management strategiesDietary interventions to prevent and manage diabetes in worksite settings: a meta-analysis
Shrestha A, Karmacharya BM, Khudyakov P, Weber MB, Spiegelman D. Dietary interventions to prevent and manage diabetes in worksite settings: a meta-analysis. Journal Of Occupational Health 2018, 60: 31-45. PMID: 29187673, PMCID: PMC5799099, DOI: 10.1539/joh.17-0121-ra.Peer-Reviewed Original ResearchConceptsRandom-effects modelDietary interventionWorksite settingWorkplace dietary interventionsBlood sugar levelsAllied Health LiteraturePooled effect sizeFemale participantsMultivariate meta-regression modelWeb of ScienceIndividual-level interventionsLifestyle interventionGlucose toleranceMeta-regression modelsBorderline significanceMore effective interventionsCumulative IndexReference listsStudy heterogeneityHealth LiteratureEffective interventionsSugar levelsSearch termsInterventionEffect size
2017
Breastfeeding and Endometrial Cancer Risk
Jordan SJ, Na R, Johnatty SE, Wise LA, Adami HO, Brinton LA, Chen C, Cook LS, Dal Maso L, De Vivo I, Freudenheim JL, Friedenreich CM, La Vecchia C, McCann SE, Moysich KB, Lu L, Olson SH, Palmer JR, Petruzella S, Pike MC, Rebbeck TR, Ricceri F, Risch HA, Sacerdote C, Setiawan VW, Sponholtz TR, Shu XO, Spurdle AB, Weiderpass E, Wentzensen N, Yang HP, Yu H, Webb PM. Breastfeeding and Endometrial Cancer Risk. Obstetrics And Gynecology 2017, 129: 1059-1067. PMID: 28486362, PMCID: PMC5473170, DOI: 10.1097/aog.0000000000002057.Peer-Reviewed Original ResearchConceptsEndometrial cancer riskEndometrial cancerCancer riskOdds ratioStudy-specific odds ratiosEndometrial Cancer ConsortiumBody mass indexMultivariable logistic regressionConfidence intervalsCase-control studyMaternal benefitsNulliparous womenHistologic subtypeMass indexCommon cancerLower riskStudy heterogeneityCancer ConsortiumControl groupCancerLogistic regressionAverage durationLonger average durationWomenBreastfeeding
2016
Endoscopic submucosal dissection of gastric tumors: A systematic review and meta-analysis
Akintoye E, Obaitan I, Muthusamy A, Akanbi O, Olusunmade M, Levine D. Endoscopic submucosal dissection of gastric tumors: A systematic review and meta-analysis. World Journal Of Gastrointestinal Endoscopy 2016, 8: 517-532. PMID: 27606044, PMCID: PMC4980641, DOI: 10.4253/wjge.v8.i15.517.Peer-Reviewed Original ResearchGastric endoscopic submucosal dissectionEndoscopic submucosal dissectionR0 resectionResection rateSubmucosal dissectionGastric tumorsCurative resection rateFirst-line therapyR0 resection rateComprehensive literature searchMajor bleedingLine therapyResection statusClinical efficacyRecurrence rateSafety profileTumor recurrencePerforation rateStudy heterogeneitySystematic reviewMedical literatureLiterature searchTumorsWarrants considerationResection
2015
Association between fine particulate matter exposure and subclinical atherosclerosis: A meta-analysis
Akintoye E, Shi L, Obaitan I, Olusunmade M, Wang Y, Newman J, Dodson J. Association between fine particulate matter exposure and subclinical atherosclerosis: A meta-analysis. European Journal Of Preventive Cardiology 2015, 23: 602-612. PMID: 26025448, PMCID: PMC5133694, DOI: 10.1177/2047487315588758.Peer-Reviewed Original ResearchConceptsCarotid intima-media thicknessAnkle-brachial indexIntima-media thicknessSubclinical atherosclerosisArterial calcificationMedia thicknessFine particulate matter exposureAvailable observational studiesParticulate matter exposureRandom-effects modelNumber of studiesObservational studyInclusion criteriaEpidemiological studiesMatter exposureStudy heterogeneityPM2.5 exposureNoninvasive measureAtherosclerosisSimilar associationComprehensive searchConfidence intervalsStatistical significanceCalcificationAssociation
2013
Association between pioglitazone (PZD) therapy and bladder cancer (BC): A meta-analysis of epidemiologic evidence.
Shimanovsky A, Appiah J, Njei B, Clement J. Association between pioglitazone (PZD) therapy and bladder cancer (BC): A meta-analysis of epidemiologic evidence. Journal Of Clinical Oncology 2013, 31: 4546-4546. DOI: 10.1200/jco.2013.31.15_suppl.4546.Peer-Reviewed Original ResearchRisk ratioMeta-analysisArticles published JanuaryBladder cancerSubgroup analysisMeSH search termsCase-control studyRandom-effects modelPooled risk ratioDiabetes mellitusEgger's testIndependent reviewersFunnel plotPublication biasStudy designTreatment durationDM diagnosisStudy heterogeneityMarkers of insulin resistanceInclusion criteriaCochran's QEpidemiological evidenceSystematic searchInsulin resistanceCochrane Library
2010
A meta-analysis of the association between day-care attendance and childhood acute lymphoblastic leukaemia
Urayama KY, Buffler PA, Gallagher ER, Ayoob JM, Ma X. A meta-analysis of the association between day-care attendance and childhood acute lymphoblastic leukaemia. International Journal Of Epidemiology 2010, 39: 718-732. PMID: 20110276, PMCID: PMC2878455, DOI: 10.1093/ije/dyp378.Peer-Reviewed Original ResearchConceptsDay care attendanceAcute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaLymphoblastic leukemiaOdds ratioRisk of childhoodCase-control studyEarly life exposureRandom-effects modelCommon infectionsSubgroup analysisProphylactic interventionsInfluence of timingObservational studyChildhood leukemiaStudy heterogeneityPubMed databaseInfected individualsRisk estimatesSimilar findingsLeukemiaInfectionEarly childhoodRare responsesEffects model
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