2025
Frequency, characteristics, and reasons for termination of cerebral palsy clinical trials
Gouzoulis M, Caruana D, Yang A, Seddio A, Grauer J, Frumberg D. Frequency, characteristics, and reasons for termination of cerebral palsy clinical trials. PM&R 2025 PMID: 40278003, DOI: 10.1002/pmrj.13398.Peer-Reviewed Original ResearchCerebral palsyIndustry sponsorshipImprove careClinical trialsRisk of premature terminationTrial characteristicsMultivariate analysisRecruitment/retentionPalsyTrial terminationTrialsPredictive factorsAssociated with terminationCareNeurodevelopmental diseasesFactorsPotential riskPremature terminationReasonsSponsorshipScientific dataDatabase
2021
STL-seq reveals pause-release and termination kinetics for promoter-proximal paused RNA polymerase II transcripts
Zimmer JT, Rosa-Mercado NA, Canzio D, Steitz JA, Simon MD. STL-seq reveals pause-release and termination kinetics for promoter-proximal paused RNA polymerase II transcripts. Molecular Cell 2021, 81: 4398-4412.e7. PMID: 34520723, PMCID: PMC9020433, DOI: 10.1016/j.molcel.2021.08.019.Peer-Reviewed Original ResearchConceptsPause releaseRNA polymerase II transcriptsRNA polymerase II moleculesCis-acting DNA elementsTATA box-containing promotersPolymerase II transcriptsPromoter-proximal pausingCritical regulatory functionsTranscriptional regulationRNA turnoverTranscriptional controlDNA elementsTranscriptional shutdownPause sitesHyperosmotic stressRegulatory mechanismsRegulatory functionsPrinciples of regulationHormonal stimuliPausingPremature terminationTranscriptsRegulation
2014
Premature termination of genitourinary cancer clinical trials.
Stensland K, McBride R, Wisnivesky J, Latif A, Hendricks R, Roper N, Boffetta P, Hall S, Oh W, Galsky M. Premature termination of genitourinary cancer clinical trials. Journal Of Clinical Oncology 2014, 32: 288-288. DOI: 10.1200/jco.2014.32.4_suppl.288.Peer-Reviewed Original ResearchClinical trialsPoor accrualCancer clinical trialsCancer trialsKaplan-Meier methodPremature trial terminationRisk of premature terminationPremature terminationBladder cancerIndustry-funded trialsCohort of clinical trialsCox regressionCancer typesBladderOncology literatureClinical trial enterpriseTrial terminationTrialsCancerTestisRiskCommitment of patientsKidneyNovel approachesMultiple sites
2013
Prevalence and characteristics of prematurely terminated cancer clinical trials.
Stensland K, Latif A, Hendricks R, Roper N, McBride R, Hall S, Oh W, Galsky M. Prevalence and characteristics of prematurely terminated cancer clinical trials. Journal Of Clinical Oncology 2013, 31: 6613-6613. DOI: 10.1200/jco.2013.31.15_suppl.6613.Peer-Reviewed Original Research
2009
Substance User Treatment Dropout from Client and Clinician Perspectives: A Pilot Study
Palmer RS, Murphy MK, Piselli A, Ball SA. Substance User Treatment Dropout from Client and Clinician Perspectives: A Pilot Study. Substance Use & Misuse 2009, 44: 1021-1038. PMID: 19938942, PMCID: PMC3678276, DOI: 10.1080/10826080802495237.Peer-Reviewed Original ResearchConceptsClinician's perspectiveTreatment dropoutPilot studyClient-level factorsSample of cliniciansEarly therapeutic allianceAfrican AmericansTreatment retentionTreatment attendanceSubstance user treatmentAlcohol useCliniciansTherapeutic allianceUser treatmentHeavy drugSocial supportCaucasiansTreatmentClient motivationPremature terminationProgram characteristicsPrimary reasonAbstinence
1997
Family Experience of Barriers to Treatment and Premature Termination From Child Therapy
Kazdin A, Holland L, Crowley M. Family Experience of Barriers to Treatment and Premature Termination From Child Therapy. Journal Of Consulting And Clinical Psychology 1997, 65: 453-463. PMID: 9170769, DOI: 10.1037/0022-006x.65.3.453.Peer-Reviewed Original Research
1982
Genes for tRNA 5Lys from Drosophila melanogaster
DeFranco D, Burke K, Hayashi S, Tener G, Miller R, Söll D. Genes for tRNA 5Lys from Drosophila melanogaster. Nucleic Acids Research 1982, 10: 5799-5808. PMID: 6292853, PMCID: PMC320931, DOI: 10.1093/nar/10.19.5799.Peer-Reviewed Original Research
1981
Identification of the uvrA gene product
Sancar A, Wharton R, Seltzer S, Kacinski B, Clarke N, Rupp W. Identification of the uvrA gene product. Journal Of Molecular Biology 1981, 148: 45-62. PMID: 6273577, DOI: 10.1016/0022-2836(81)90234-5.Peer-Reviewed Original ResearchConceptsUvrA proteinUvrA geneSsb geneMr proteinE. coli genetic mapDirection of transcriptionEscherichia coli UvrAMaxicell procedureGenetic mapNonsense codonUvrA gene productGene productsSmall proteinsRestriction mappingDouble-stranded DNAGenesRecombinant plasmidProteinUvrANormal cellsPremature terminationPolypeptideDNAPlasmidSubsequent gel filtration
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