2025
Glomerular mesangial cells derived complement factor H regulates complement activation, influences cell proliferation, and maintains actin cytoskeleton
Li Y, Ni X, Li X, Kang Y, Yuan X, Xu G, Wang T, Li D, Shi S, Lv J, Zhao M, Zhang H, Zhu L. Glomerular mesangial cells derived complement factor H regulates complement activation, influences cell proliferation, and maintains actin cytoskeleton. International Immunopharmacology 2025, 154: 114544. PMID: 40157080, DOI: 10.1016/j.intimp.2025.114544.Peer-Reviewed Original ResearchConceptsActin cytoskeletonGlomerular mesangial cellsInfluence cell proliferationCell proliferationSingle-cell sequencing dataComplement factor HNon-canonical functionsExpression of Cdc42Mesangial cellsSequence dataCell motilityAffecting cell proliferationCytoskeletonRegulate complement activationRegulatory roleCanonical functionActinComplement activationIndependent of complement activationFactor HIgA1-containing immune complexesComplement proteinsCellsComplement-induced damageExpression
2024
Influenza B Triggering Atypical Hemolytic Uremic Syndrome (aHUS) in a Patient with Cobalamin C (CblC) Disease Carrier State and a Complement Factor H (CFH) Mutation
Becerra L, Moeckel G, Gunasekaran D. Influenza B Triggering Atypical Hemolytic Uremic Syndrome (aHUS) in a Patient with Cobalamin C (CblC) Disease Carrier State and a Complement Factor H (CFH) Mutation. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024vajywpws. DOI: 10.1681/asn.2024vajywpws.Peer-Reviewed Original ResearchNeuropsychiatric symptoms in cognitive decline and Alzheimer’s disease: biomarker discovery using plasma proteomics
Rabl M, Clark C, Dayon L, Popp J, Weiner M, Aisen P, Jack C, Jagust W, Landau S, Rivera-Mindt M, Okonkwo O, Shaw L, Lee E, Toga A, Beckett L, Harvey D, Green R, Saykin A, Nho K, Perrin R, Tosun D, Sachdev P, Drake E, Montine T, Conti C, Nosheny R, Sacrey D, Fockler J, Miller M, Kwang W, Jin C, Diaz A, Ashford M, Flenniken D, Kormos A, Rafii M, Raman R, Jimenez G, Donohue M, Salazar J, Fidell A, Boatwright V, Robison J, Zimmerman C, Cabrera Y, Walter S, Clanton T, Shaffer E, Webb C, Hergesheimer L, Smith S, Ogwang S, Mahboubi P, Pizzola J, Jenkins C, Beckett L, Harvey D, Donohue M, Saito N, Diaz A, Hussen K, Amaza H, Thao M, Parkins S, Ayo O, Glittenberg M, Hoang I, Germano K, Strong J, Weisensel T, Magana F, Thomas L, Guzman V, Ajayi A, Benedetto J, Talavera S, Felmlee J, Fox N, Thompson P, DeCarli C, Forghanian-Arani A, Borowski B, Reyes C, Hedberg C, Ward C, Schwarz C, Reyes D, Gunter J, Moore-Weiss J, Kantarci K, Matoush L, Senjem M, Vemuri P, Reid R, Malone I, Thomopoulos S, Nir T, Jahanshad N, Knaack A, Fletcher E, Harvey D, Tosun-Turgut D, Chen S, Choe M, Crawford K, Yushkevich P, Das S, Koepp R, Rabinovici G, Villemagne V, LoPresti B, Morris J, Franklin E, Bernhardt H, Cairns N, Taylor-Reinwald L, Lee E, Lee V, Korecka M, Brylska M, Wan Y, Trojanowki J, Crawford K, Neu S, Foroud T, Jo T, Risacher S, Craft H, Apostolova L, Nudelman K, Faber K, Potter Z, Lacy K, Kaddurah-Daouk R, Shen L, Karlawish J, Erickson C, Grill J, Largent E, Harkins K, Thal L, Kachaturian Z, Frank R, Snyder P, Buckholtz N, Hsiao J, Ryan L, Molchan S, Carrillo M, Potter W, Barnes L, Bernard M, González H, Ho C, Hsiao J, Jackson J, Masliah E, Masterman D, Ryan L, Silverberg N, Silbert L, Kaye J, White S, Pierce A, Thomas A, Clay T, Schwartz D, Devereux G, Taylor J, Ryan J, Nguyen M, DeCapo M, Shang Y, Schneider L, Munoz C, Ferman D, Conant C, Martin K, Oleary K, Pawluczyk S, Trejo E, Dagerman K, Teodoro L, Becerra M, Fairooz M, Garrison S, Boudreau J, Avila Y, Brewer J, Jacobson A, Gama A, Kim C, Little E, Frascino J, Ferng N, Trujillo S, Heidebrink J, Koeppe R, MacDonald S, Malyarenko D, Ziolkowski J, O'Connor J, Robert N, Lowe S, Rogers V, Hackenmiller B, Boeve B, Albers C, Kreuger C, Jones D, Knopman D, Botha H, Magnuson J, Graff-Radford J, Crawley K, Schumacher M, McKinzie S, Smith S, Helland T, Lowe V, Ramanan V, Pavlik V, Faircloth J, Bishop J, Nath J, Chaudhary M, Kataki M, Yu M, Pacini N, Barker R, Brooks R, Aggarwal R, Honig L, Stern Y, Mintz A, Cordona J, Hernandez M, Long J, Arnold A, Groves A, Middleton A, Vogler B, McCurry C, Mayo C, Raji C, Amtashar F, Klemp H, Elmore H, Ruszkiewicz J, Kusuran J, Stewart J, Horenkamp J, Greeson J, Wever K, Vo K, Larkin K, Rao L, Schoolcraft L, Gallagher L, Paczynski M, McMillan M, Holt M, Gagliano N, Henson R, LaBarge R, Swarm R, Munie S, Cepeda S, Winterton S, Hegedus S, Wilson T, Harte T, Bonacorsi Z, Geldmacher D, Watkins A, Barger B, Smelser B, Bates C, Stover C, McKinley E, Ikner G, Hendrix H, Cooper H, Mahaffey J, Robbins L, Ashley L, Natelson-Love M, Carter, Solomon V, Grossman H, Groome A, Ardolino A, Kaplan A, Sheppard F, Burgos-Rivera G, Garcia-Camilo G, Lim J, Neugroschl J, Jackson K, Evans K, Soleimani L, Sano M, Ghesani N, Binder S, Apuango X, Sood A, Troutman A, Blanchard K, Richards A, Nelson G, Hendrickson K, Yurko E, Plenge J, Rufo V, Shah R, Duara R, Lynch B, Chirinos C, Dittrich C, Campbell D, Mejia D, Perez G, Colvee H, Gonzalez J, Gondrez J, Knaack J, Acevedo M, Cereijo M, Greig-Cust M, Villar M, Wishnia M, Detling S, Barker W, Albert M, Moghekar A, Rodzon B, Demsky C, Pontone G, Pekar J, Farrington L, Pomper M, Johnson N, Alo T, Sadowski M, Ulysse A, Masurkar A, Marti B, Mossa D, Geesey E, Petrocca E, Schulze E, Wong J, Boonsiri J, Kenowsky S, Martinez T, Briglall V, Doraiswamy P, Nwosu A, Adhikari A, Hellegers C, Petrella J, James O, Wong T, Hawk T, Vaishnavi S, McCoubrey H, Nasrallah I, Rovere R, Maneval J, Robinson E, Rivera F, Uffelman J, Combs M, O'Donnell P, Manning S, King R, Nieto A, Glueck A, Mandal A, Swain A, Gamble B, Meacham B, Forenback D, Ross D, Cheatham E, Hartman E, Cornell G, Harp J, Ashe L, Goins L, Watts L, Yazell M, Mandal P, Buckler R, Vincent S, Rudd T, Lopez O, Malia A, Chiado C, Zik C, Ruszkiewicz J, Savage K, Fenice L, Oakley M, Tacey P, Berman S, Bowser S, Hegedus S, Saganis X, Porsteinsson A, Mathewson A, Widman A, Holvey B, Clark E, Morales E, Young I, Ruszkiewicz J, Hopkins K, Martin K, Kowalski N, Hunt R, Calzavara R, Kurvach R, D'Ambrosio S, Thai G, Vides B, Lieb B, McAdams-Ortiz C, Toso C, Mares I, Moorlach K, Liu L, Corona M, Nguyen M, Tallakson M, McDonnell M, Rangel M, Basheer N, Place P, Romero R, Tam S, Nguyen T, Thomas A, Frolov A, Khera A, Browning A, Kelley B, Dawson C, Mathews D, Most E, Phillips E, Nguyen L, Nunez M, Miller M, Jones M, Martinez N, Logan R, McColl R, Pham S, Fox T, Moore T, Levey A, Brown A, Kippels A, Ellison A, Lyons C, Hales C, Parry C, Williams C, McCorkle E, Harris G, Rose H, Jooma I, Al-Amin J, Lah J, Webster J, Swiniarski J, Chapman L, Donnelly L, Mariotti L, Locke M, Vaughn P, Penn R, Carpentier S, Yeboah S, Basadre S, Malakauskas S, Lyron S, Villinger T, Burney T, Burns J, Abusalim A, Dahlgren A, Montero A, Arthur A, Dooly H, Kreszyn K, Berner K, Gillen L, Scanlan M, Madison M, Mathis N, Switzer P, Townley R, Fikru S, Sullivan S, Wright E, Beigi M, Daley A, Ko A, Luong B, Nyborg G, Morales J, Durbin K, Garcia L, Parand L, Macias L, Monserratt L, Farchi M, Wu P, Hernandez R, Rodriguez T, Graff-Radford N, Marolt A, Thomas A, Aloszka D, Moncayo E, Westerhold E, Day G, Chrestensen K, Imhansiemhonehi M, McKinzie S, Stephens S, Grant S, Brosch J, Perkins A, Saunders A, Kovac D, Polson H, Mwaura I, Mejia K, Britt K, King K, Nichols K, Lawrence K, Rankin L, Farlow M, Wiesenauer P, Bryant R, Herring S, Lynch S, Wilson S, Day T, Korst W, Dyck C, Mecca A, Miller A, Brennan A, Khan A, Ruan A, Gunnoud C, Mendonca C, Raynes-Goldfinger D, Salardini E, Hidalgo E, Cooper E, Singh E, Murphy E, May J, Stanhope J, Lam J, Waszak J, Nelsen K, Sacaza K, Hasbani M, Donahue M, Chen M, Barcelos N, Eigenberger P, Bonomi R, O'Dell R, Jefferson S, Khasnavis S, Smilowitz S, DeStefano S, Good S, Camarro T, Clayton V, Cavrel Y, Lu Y, Chertkow H, Bergman H, Hosein C, Black S, Kapadia A, Bhan A, Lam B, Scott C, Gabriel G, Bray J, Zotovic L, Gutierrez M, Masellis M, Farshadi M, Gui M, Mitchell M, Taylor R, Endre R, Taghi-Zada Z, Hsiung R, English C, Kim E, Yau E, Tong H, Barlow L, Jennings L, Assaly M, Nunes P, Marian T, Kertesz A, Rogers J, Trost D, Wint D, Bernick C, Munic D, Grant I, Korkoyah A, Raja A, Lapins A, Ryan C, Pejic J, Basham K, Lukose L, Haddad L, Quinlan L, Houghtaling N, Sadowsky C, Martinez W, Villena T, Reynolds B, Forero A, Ward C, Brennan E, Figueroa E, Esposito G, Mallory J, Johnson K, Turner K, Seidenberg K, McCann K, Bassett M, Chadwick M, Turner R, Bean R, Sharma S, Marshall G, Haviari A, Pietras A, Wallace B, Munro C, Rivera-Delpin G, Hustead H, Levesque I, Ramirez J, Nolan K, Glennon K, Palou M, Erkkinen M, DaSilva N, Friedman P, Silver R, Salazar R, Polleys R, McGinnis S, Gale S, Hall T, Luu T, Chao S, Lin E, Coleman J, Epperson K, Vasanawala M, Atri A, Rangel A, Evans B, Monarrez C, Cline C, Liebsack C, Bandy D, Goldfarb D, Intorcia D, Olgin J, Clark K, King K, York K, Reade M, Callan M, Glass M, Johnson M, Gutierrez M, Goddard M, Trncic N, Choudhury P, Reyes P, Lowery S, Hall S, Olgin S, Santiago S, Alosco M, Ton A, Jimenez A, Ellison A, Tran A, Anderson B, Carter D, Veronelli D, Lenio S, Steinberg E, Mez J, Weller J, Johns J, Harkins J, Hoti I, Mwicigi J, Schultz O, Lauture M, Denis R, Killiany R, Singh S, Lenio S, Qiu W, Devis Y, Obisesan T, Stone A, Ordor D, Udodong I, Okonkwo I, Khan J, Turner J, Hughes K, Kadiri O, Duffy C, Moss A, Stapleton K, Toth M, Sanders M, Ayres M, Hamski M, Fatica P, Ogrocki P, Ash S, Pot S, Chen D, Soto A, Tanase C, Bissig D, Vanya H, Russell H, Patel H, Zhang H, Wallace K, Ayers K, Gallegos M, Forloines M, Sinn M, Kahulugan Q, Isip R, Calderon S, Hamm T, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Perrin A, Tariot P, Fleisher A, Reeder S, Capote H, Emborsky A, Mattle A, Ajtai B, Wagner B, Myers B, Slazyk D, Fragale D, Fransen E, Macnamara H, Falletta J, Hirtreiter J, Mechtler L, King M, Asbach M, Rainka M, Zawislak R, Wisniewski S, O'Malley S, Jimenez-Knight T, Peehler T, Aladeen T, Bates V, Wenner V, Elmalik W, Scharre D, Ramamurthy A, Bouchachi S, Kataki M, Tarawneh R, Kelley B, Celmins D, Leader A, Figueroa C, Bauerle H, Patterson K, Reposa M, Presto S, Ahmed T, Stewart W, Pearlson G, Blank K, Anderson K, Santulli R, Schwartz E, Williamson J, Jessup A, Williams A, Duncan C, O'Connell A, Gagnon K, Zamora E, Bateman J, Crawford F, Thompson D, Walker E, Rowell J, White M, Ledford P, Bohlman S, Henkle S, Bottoms J, Moretz L, Hoover B, Shannon M, Rogers S, Baker W, Harrison W, Wu C, DeMarco A, Stipanovich A, Arcuri D, Clark J, Davis J, Doyon K, Amoyaw M, Acosta M, Bailey R, Warren S, Fogerty T, Sanborn V, Riddle M, Salloway S, Malloy P, Correia S, Windon C, Blackburn M, Rosen H, Miller B, Smith A, Mba I, Echevarria J, Janavs J, Roglaski E, Yong M, Devine R, Okhravi H, Rivera E, Kalowsky T, Smith C, Rosario C, Masdeu J, Le R, Gurung M, Sabbagh M, Garcia A, Slaughter M, Elayan N, Acothley S, Pomara N, Hernando R, Pomara V, Reichert C, Brawman-Mintzer O, Acree A, Williams A, Long C, Long R, Newhouse P, Hill S, Boegel A, Seshadri S, Saklad A, Jones F, Hu W, Sotelo V, Rojas Y, Mintzer J, Longmire C, Spicer K. Neuropsychiatric symptoms in cognitive decline and Alzheimer’s disease: biomarker discovery using plasma proteomics. Journal Of Neurology Neurosurgery & Psychiatry 2024, 96: 370-382. PMID: 39288961, PMCID: PMC12015082, DOI: 10.1136/jnnp-2024-333819.Peer-Reviewed Original ResearchConceptsAssociated with neuropsychiatric symptomsNeuropsychiatric symptomsReceiver operating characteristic analysisPlasma proteinsClinical disease progressionComplement factor HSerum glutamic oxaloacetic transaminaseClinical evolutionCognitive declineCognitive impairmentAlzheimer's Disease Neuroimaging Initiative cohortDisease progressionLuminex xMAPProtein panelAlzheimer's diseaseAssociated with cognitive declineFactor HMild AD dementiaMild cognitive impairmentGlutamic oxaloacetic transaminasePlasma proteomeLogistic regressionCharacteristic analysisTime pointsBiomarker discoveryComplement factor H in molecular regulation of angiogenesis
Li J, Wang K, Starodubtseva M, Nadyrov E, Kapron C, Hoh J, Liu J. Complement factor H in molecular regulation of angiogenesis. Medical Review 2024, 4: 452-466. PMID: 39444793, PMCID: PMC11495524, DOI: 10.1515/mr-2023-0048.Peer-Reviewed Original ResearchComplement factor HComplement factor H geneAge-related macular degenerationComplement factor H proteinFactor HComplement activation fragmentsC-reactive proteinAnti-angiogenic effectsEndothelial heparan sulfateChoroidal neovascularizationMacular degenerationRegulation of angiogenesisMolecular regulation of angiogenesisDeficient miceComplement 3aMembrane attack complexComplement 5aPro-angiogenic eventsAngiogenesis-related diseasesCFH expressionPro-angiogenic capacityAlternative pathwayTherapeutic potentialComplement systemBlood vessels
2023
Mesangial C3 Deposition, Complement-Associated Variant, and Disease Progression in IgA Nephropathy
Kang Y, Xu B, Shi S, Zhou X, Chen P, Liu L, Li Y, Leng Y, Lv J, Zhu L, Zhang H. Mesangial C3 Deposition, Complement-Associated Variant, and Disease Progression in IgA Nephropathy. Clinical Journal Of The American Society Of Nephrology 2023, 18: 1583-1591. PMID: 37651123, PMCID: PMC10723908, DOI: 10.2215/cjn.0000000000000290.Peer-Reviewed Original ResearchConceptsMesangial C3 depositionGenome-wide association studiesIgA nephropathyComplement factor HC3 depositionGenotype-phenotype correlationIntensity of C3 depositionAssociation studiesLong-term kidney outcomesSusceptibility variantsProgression of IgA nephropathySevere clinical phenotypeKaplan-Meier analysisDeposition of IgAIgA nephropathy cohortIgA nephropathy progressionComplement component 3Chi-square testPrimary GNClinical phenotypeKidney outcomesFactor HGenotypesChinese patientsComplement regulators
2020
Systemic Alterations of Immune Response-Related Proteins during Glaucoma Development in the Murine Model DBA/2J
Cueto A, Álvarez L, García M, Artime E, Barrios A, Rodríguez-Uña I, Coca-Prados M, González-Iglesias H. Systemic Alterations of Immune Response-Related Proteins during Glaucoma Development in the Murine Model DBA/2J. Diagnostics 2020, 10: 425. PMID: 32585848, PMCID: PMC7345206, DOI: 10.3390/diagnostics10060425.Peer-Reviewed Original ResearchImmune responseSystemic levelsOptic nerve damageImportant molecular changesDiagnosis of glaucomaComplement factor HCandidate molecular biomarkersGlaucomatous miceAdvanced diseaseNerve damageControl miceGlaucoma developmentComplement system proteinsSystemic alterationsDBA/2J miceAnimal modelsComplement C4AFicolin-3Potential biomarkersDifferent experimental groupsEnzyme immunoassayApolipoprotein A4Neurodegenerative diseasesGlaucomaSerum samples
2019
Outcome of C3 glomerulopathy patients: largest single-centre experience from South Asia
Kumar A, Nada R, Ramachandran R, Rawat A, Tiewsoh K, Das R, Rayat C, Gupta K, Vasishta R. Outcome of C3 glomerulopathy patients: largest single-centre experience from South Asia. Journal Of Nephrology 2019, 33: 539-550. PMID: 31820418, DOI: 10.1007/s40620-019-00672-5.Peer-Reviewed Original ResearchConceptsAlternative complement pathwayC3G patientsPost-transplant recurrenceSingle-centre experienceMajority of patientsGenetic profileHistory of infectionComplement factor HLevels of C3C3 nephritic factorBackgroundC3 glomerulopathyPartial remissionC3GG patientsResistant diseaseGenetic workupMonoclonal paraproteinRenal transplantationAutoantibody testingC3 levelsClinical detailsMonoclonal immunoglobulinFollow-upPathogenic variantsHistopathological profilePoor allograft outcome in Indian patients with post-transplant C3 glomerulopathy
Kumar A, Ramachandran R, Rawat A, Das R, Rayat C, Kenwar D, Sharma A, Gupta K, Nada R. Poor allograft outcome in Indian patients with post-transplant C3 glomerulopathy. Clinical Kidney Journal 2019, 14: 291-300. PMID: 33564431, PMCID: PMC7857824, DOI: 10.1093/ckj/sfz135.Peer-Reviewed Original ResearchAutoantibodies to complement factor HComplement factor HComplement factor BAlternative complement pathwayCases of C3GC3G patientsComplement 3 glomerulopathyPost-transplant recurrenceRenal allograft biopsiesMonths of transplantationProgressive renal failureSerum complement levelsPoor allograft outcomesSerum CFH levelsC3 nephritic factorAllograft dysfunctionThrombotic microangiopathyAllograft outcomesGraft dysfunctionGraft lossG patientsRenal dysfunctionGenetic workupRecurrent casesRenal failureComplement factor H gene polymorphisms and vivax malaria associated thrombotic microangiopathy.
Agrawal P, Kumar A, Parwaiz A, Rawat A, Tiewsoh K, Nada R. Complement factor H gene polymorphisms and vivax malaria associated thrombotic microangiopathy. Saudi Journal Of Kidney Diseases And Transplantation 2019, 30: 540-544. PMID: 31031394, DOI: 10.4103/1319-2442.256865.Peer-Reviewed Original ResearchConceptsAcute kidney injuryComplement factor HThrombotic microangiopathyAlternative complement pathwayVivax malariaCFH gene polymorphismDysregulated alternate complement pathwayComplement factor H geneDevelopment of thrombotic microangiopathyCases of malariaMechanism of injuryKidney injuryExon 9Exon 7MalariaSingle-nucleotide polymorphismsMicroangiopathyVivaxComplement pathwayMortality rateFactor HPatientsInjuryPolymorphismComplement
2009
Atypical Hemolytic Uremic Syndrome Associated With Complement Factor H Autoantibodies and CFHR1/CFHR3 Deficiency
Lee B, Kwak S, Shin J, Lee S, Choi H, Kang H, Ha I, Lee J, Dragon-Durey M, Choi Y, Cheong H. Atypical Hemolytic Uremic Syndrome Associated With Complement Factor H Autoantibodies and CFHR1/CFHR3 Deficiency. Pediatric Research 2009, 66: 336-340. PMID: 19531976, DOI: 10.1203/pdr.0b013e3181b1bd4a.Peer-Reviewed Original ResearchConceptsAtypical hemolytic uremic syndromeComplement factor HImmunosuppressive therapyAutoantibodies to complement factor HComplement factor H autoantibodiesTreated with plasmapheresisFactor H autoantibodiesHemolytic uremic syndromeHomozygous genomic deletionCFHR3 genesMCP mutationsUremic syndromeAntigen levelsLow C3CFH-related proteinsFemale patientsComplement profileGenetic defectsPatientsDiagnostic testsFactor HPlasmapheresisCFHR1CFHR3Therapy
2007
Evidence for association between multiple complement pathway genes and AMD
Dinu V, Miller PL, Zhao H. Evidence for association between multiple complement pathway genes and AMD. Genetic Epidemiology 2007, 31: 224-237. PMID: 17266113, DOI: 10.1002/gepi.20204.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsPathway levelGenome-wide association studiesGenome-wide levelWide association studyGenome levelAdditional genesPathway genesAssociation studiesBiological knowledgeSNP signalsComplement factor HGenotype dataGenesNucleotide polymorphismsForms of AMDComplement pathway genesRisk allelesFactor HMBL2 single-nucleotide polymorphismsIntronsHaplotypesComplement pathwayAllelesPathway
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