2023
Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice
Kam C, Singh I, Gonzalez D, Matte-Martone C, Solá P, Solanas G, Bonjoch J, Marsh E, Hirschi K, Greco V. Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice. Cell 2023, 186: 2345-2360.e16. PMID: 37167971, PMCID: PMC10225355, DOI: 10.1016/j.cell.2023.04.017.Peer-Reviewed Original ResearchConceptsAdult endothelial cellsNeonatal endothelial cellsEndothelial cellsVascular maturationAdult homeostasisOrgan growthAdult maintenanceHomeostasisLive miceVessel regressionFundamental mechanismsGlobal ablationLocal ablationMaturationNetwork perfusionVascular plexusBlood vesselsLongitudinal imagingVessel repairMaintenanceVascular architecturePlexusFunctional networksMiceMechanism
2018
Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape
Baranowski C, Welsh M, Sham L, Eskandarian H, Lim H, Kieser K, Wagner J, McKinney J, Fantner G, Ioerger T, Walker S, Bernhardt T, Rubin E, Rego E. Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape. ELife 2018, 7: e37516. PMID: 30324906, PMCID: PMC6231781, DOI: 10.7554/elife.37516.Peer-Reviewed Original ResearchConceptsPenicillin-binding proteinsAsymmetric polar growthRod-shaped bacteriaPolar growthPolar elongationShape maintenanceCell wallGenetic relationshipsDrug targetsUnusual crosslinksD-transpeptidasesSingle cellsPeptidoglycanCellsCrosslinksProteinMycobacteriaBacteriaPathogensTypes of crosslinksElongationGrowthMaintenanceTargetLong‐term research in ecology and evolution: a survey of challenges and opportunities
Kuebbing S, Reimer A, Rosenthal S, Feinberg G, Leiserowitz A, Lau J, Bradford M. Long‐term research in ecology and evolution: a survey of challenges and opportunities. Ecological Monographs 2018, 88: 245-258. DOI: 10.1002/ecm.1289.Peer-Reviewed Original ResearchEvolutionary dynamicsEvolutionary scientistsEcological field experimentsLong-term researchEcological organizationEvolutionary knowledgeEvolutionary understandingEcological understandingGlobal changeEcologyLong-term experimentsExperimental approachField experimentCurrent research prioritiesEvolutionCommunitySubstantive advancesLimited numberUnderstandingWide rangeMaintenanceResearch priorities
2017
Type-B ARABIDOPSIS RESPONSE REGULATORs Directly Activate WUSCHEL
Zhang F, May A, Irish VF. Type-B ARABIDOPSIS RESPONSE REGULATORs Directly Activate WUSCHEL. Trends In Plant Science 2017, 22: 815-817. PMID: 28886911, DOI: 10.1016/j.tplants.2017.08.007.Peer-Reviewed Original ResearchCutaneous Fibrosis and Normal Wound Healing
Hamburg-Shields E, Myung P, Cowper S. Cutaneous Fibrosis and Normal Wound Healing. 2017, 577-600. DOI: 10.1007/978-3-319-29785-9_32.ChaptersNumerous cell typesWound healingOrchestrated processEnvironmental perturbationsTranslational mechanismsCell typesExtracellular matrixNormal roleCutaneous wound healingCoordinated productionNormal wound healingCellular playersEnvironmental influencesNormal cutaneous wound healingInjury repairIndividualized functionsMechanismProteinSpecific timeProductionCutaneous fibrosisUnnecessary scarsDisruptionMaintenanceGlucocorticoids and Reproduction: Traffic Control on the Road to Reproduction
Whirledge S, Cidlowski JA. Glucocorticoids and Reproduction: Traffic Control on the Road to Reproduction. Trends In Endocrinology And Metabolism 2017, 28: 399-415. PMID: 28274682, PMCID: PMC5438761, DOI: 10.1016/j.tem.2017.02.005.Peer-Reviewed Original ResearchConceptsDiverse cellular functionsStress-induced levelsCell-specific mannerCellular functionsGlucocorticoid receptorCellular processingGR geneReproductive functionNormal physiologyActivity of glucocorticoidsCompelling new evidenceReproductionReproductive dysfunctionGlucocorticoid responsivenessGlucocorticoidsSteroid hormonesGenesProteinDiversityPhysiologyRegulationFunctionReceptorsNew evidenceMaintenance
2016
Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis
Rivera-Gonzalez GC, Shook BA, Andrae J, Holtrup B, Bollag K, Betsholtz C, Rodeheffer MS, Horsley V. Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis. Cell Stem Cell 2016, 19: 738-751. PMID: 27746098, PMCID: PMC5135565, DOI: 10.1016/j.stem.2016.09.002.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAdipogenesisAnimalsCD24 AntigenCell ProliferationCell Self RenewalDermisGene Expression ProfilingHyperplasiaMice, Inbred C57BLModels, BiologicalPhosphatidylinositol 3-KinasesPlatelet-Derived Growth FactorProto-Oncogene Proteins c-aktReceptor, Platelet-Derived Growth Factor alphaSignal TransductionSkinStem CellsConceptsAdipocyte stem cellsAdipogenic programLipid-filled mature adipocytesStem Cell Self-RenewalCell Self-RenewalDistinct regulatory mechanismsASC proliferationPI3K/Akt2Stem cell populationWhite adipose tissueUnrecognized regulatorSelf-RenewalRegulatory mechanismsGenetic studiesMature adipocytesPDGFA expressionStem cellsCell populationsTissue growthProliferationActive mechanismDifferent WAT depotsHair growthMaintenanceAkt2Piwi maintains germline stem cells and oogenesis in Drosophila through negative regulation of Polycomb group proteins
Peng JC, Valouev A, Liu N, Lin H. Piwi maintains germline stem cells and oogenesis in Drosophila through negative regulation of Polycomb group proteins. Nature Genetics 2016, 48: 283-291. PMID: 26780607, PMCID: PMC4767590, DOI: 10.1038/ng.3486.Peer-Reviewed Original Research
2015
An Aminopeptidase in the Drosophila Testicular Niche Acts in Germline Stem Cell Maintenance and Spermatogonial Dedifferentiation
Lim C, Gandhi S, Biniossek M, Feng L, Schilling O, Urban S, Chen X. An Aminopeptidase in the Drosophila Testicular Niche Acts in Germline Stem Cell Maintenance and Spermatogonial Dedifferentiation. Cell Reports 2015, 13: 315-325. PMID: 26440886, PMCID: PMC4607668, DOI: 10.1016/j.celrep.2015.09.001.Peer-Reviewed Original ResearchConceptsGermline stem cellsDE-cadherinCell maintenanceTesticular nicheGermline stem cell maintenanceStem cell maintenanceCell dedifferentiationStem cellsAdult stem cellsSpecific aminopeptidase activityMutant phenotypeSpermatogonial DedifferentiationStem cell lossNiche factorsVivo functionExtrinsic cuesNicheAminopeptidase activityDedifferentiationImportant targetCellsMaintenanceOverexpressionMutationsPhenotype
2013
Investigation of Rett syndrome using pluripotent stem cells
Dajani R, Koo S, Sullivan GJ, Park I. Investigation of Rett syndrome using pluripotent stem cells. Journal Of Cellular Biochemistry 2013, 114: 2446-2453. PMID: 23744605, PMCID: PMC3773984, DOI: 10.1002/jcb.24597.Peer-Reviewed Original ResearchConceptsPluripotent stem cellsStem cellsRett syndromeFunction of MeCP2Pathophysiology of RTTEmbryonic stem cellsEpigenetic instabilityTranscription factorsDe novo mutationsRTT phenotypeCurrent iPSCHuman diseasesMeCP2Novo mutationsIPSCsCellsNeurodevelopmental disordersOverexpressionMutationsPhenotypeMurine modelRecapitulationMaintenanceIdentificationOrienting Attention Within Visual Short‐Term Memory: Development and Mechanisms
Shimi A, Nobre A, Astle D, Scerif G. Orienting Attention Within Visual Short‐Term Memory: Development and Mechanisms. Child Development 2013, 85: 578-592. PMID: 23937596, DOI: 10.1111/cdev.12150.Peer-Reviewed Original ResearchDeconstructing Dimensionality
Schwartz MA, Chen CS. Deconstructing Dimensionality. Science 2013, 339: 402-404. PMID: 23349278, DOI: 10.1126/science.1233814.Peer-Reviewed Original ResearchConceptsStem cell nicheVivo cellular behaviorTwo-dimensional cultureCell nicheVivo functionGene expressionExtracellular matrix gelCellular behaviorTissue culture plasticCell behaviorDifferentiated functionsCell processesCulture plasticThree-dimensional environmentMatrix gelCellsTissue engineersMorphogenesisNicheBiologistsMajor advancesExpressionFunctionOnly minimal changesMaintenance
2012
Cell polarity and cystic kidney disease
Fedeles S, Gallagher AR. Cell polarity and cystic kidney disease. Pediatric Nephrology 2012, 28: 1161-1172. PMID: 23161205, DOI: 10.1007/s00467-012-2337-z.Peer-Reviewed Original ResearchConceptsPlanar cell polarityCell polarityApical-basolateral polarityEpithelial cell polarityConserved Protein ComplexesCystic kidney diseasePolarity mechanismsProtein complexesOrgan developmentIntriguing crosstalkMolecular processesRecent findingsPolycystic kidney diseasePolarityInteresting questionsCrosstalkComplexesMaintenance
2010
The telomere protein tankyrase 1 regulates DNA damage responses at telomeres
Chang S. The telomere protein tankyrase 1 regulates DNA damage responses at telomeres. Aging 2010, 2: 639-642. PMID: 21076181, PMCID: PMC2993793, DOI: 10.18632/aging.100221.Peer-Reviewed Original ResearchFunctionally defective germline variants of sialic acid acetylesterase in autoimmunity
Surolia I, Pirnie SP, Chellappa V, Taylor KN, Cariappa A, Moya J, Liu H, Bell DW, Driscoll DR, Diederichs S, Haider K, Netravali I, Le S, Elia R, Dow E, Lee A, Freudenberg J, De Jager PL, Chretien Y, Varki A, MacDonald ME, Gillis T, Behrens TW, Bloch D, Collier D, Korzenik J, Podolsky DK, Hafler D, Murali M, Sands B, Stone JH, Gregersen PK, Pillai S. Functionally defective germline variants of sialic acid acetylesterase in autoimmunity. Nature 2010, 466: 243-247. PMID: 20555325, PMCID: PMC2900412, DOI: 10.1038/nature09115.Peer-Reviewed Original ResearchMeSH KeywordsAcetylationAcetylesteraseAllelesAnimalsAntibodies, AntinuclearArthritis, RheumatoidAutoimmune DiseasesAutoimmunityB-LymphocytesBiocatalysisCarboxylic Ester HydrolasesCase-Control StudiesCell LineDiabetes Mellitus, Type 1EuropeExonsGenetic Predisposition to DiseaseGerm-Line MutationHumansMiceN-Acetylneuraminic AcidOdds RatioPolymorphism, Single NucleotideSample SizeSequence Analysis, DNAMechanisms of Synapse and Dendrite Maintenance and Their Disruption in Psychiatric and Neurodegenerative Disorders
Lin YC, Koleske AJ. Mechanisms of Synapse and Dendrite Maintenance and Their Disruption in Psychiatric and Neurodegenerative Disorders. Annual Review Of Neuroscience 2010, 33: 349-378. PMID: 20367247, PMCID: PMC3063389, DOI: 10.1146/annurev-neuro-060909-153204.Peer-Reviewed Original ResearchCellular Maintenance and Repair of the Kidney
Guo JK, Cantley LG. Cellular Maintenance and Repair of the Kidney. Annual Review Of Physiology 2010, 72: 357-376. PMID: 20148680, DOI: 10.1146/annurev.physiol.010908.163245.Peer-Reviewed Original ResearchConceptsMultiple cell typesBone marrow-derived stemPrecise structural arrangementCellular maintenanceEx vivo programmingRenal lineagesAdult organsMammalian kidneyCell typesStem cellsProgenitor cellsComplex organRepair processCurrent understandingCell viabilityCellsFunctional stabilityCompartmentsLineagesCell injuryMaintenanceVivo programmingStructural arrangementOrgansActive reabsorptionTelomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients
Agarwal S, Loh YH, McLoughlin EM, Huang J, Park IH, Miller JD, Huo H, Okuka M, dos Reis RM, Loewer S, Ng HH, Keefe DL, Goldman FD, Klingelhutz AJ, Liu L, Daley GQ. Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. Nature 2010, 464: 292-296. PMID: 20164838, PMCID: PMC3058620, DOI: 10.1038/nature08792.Peer-Reviewed Original ResearchConceptsDyskeratosis congenita cellsDyskeratosis congenita patientsPluripotency-associated transcription factorsInduced pluripotent stem cellsPluripotent stem cellsTelomerase componentsTranscription factorsIPS cell technologyGenetic lesionsMultiple tissuesStem cellsDyskeratosis congenitaTERC expressionCellsElongationTelomeraseMaintenanceExpressionCell technologyPolarized traffic towards the cell surface: how to find the route
Carmosino M, Valenti G, Caplan M, Svelto M. Polarized traffic towards the cell surface: how to find the route. Biology Of The Cell 2010, 102: 75-91. PMID: 19909237, DOI: 10.1042/bc20090134.Peer-Reviewed Original Research
2009
PERSPECTIVE: Infection and inflammation in somatic maintenance, growth and longevity
Kopp EB, Medzhitov R. PERSPECTIVE: Infection and inflammation in somatic maintenance, growth and longevity. Evolutionary Applications 2009, 2: 132-141. PMID: 25567853, PMCID: PMC3352410, DOI: 10.1111/j.1752-4571.2008.00062.x.Peer-Reviewed Original ResearchSomatic maintenanceGenetic model systemExpense of reproductionAdaptive metabolic responseFavorable environmental conditionsInnate immune pathwaysOffspring survivalReproductive fitnessEnvironmental stressReproductive maturityCellular integrityAdditional environmental factorsPhysiologic strategiesEnvironmental conditionsImmune pathwaysReproductionCellular damageModel systemEnvironmental factorsEnvironmental adaptabilityCurrent viewMetabolic responseGrowthInfectious pathogensMaintenance
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