2024
TANGO1 inhibitors reduce collagen secretion and limit tissue scarring
Raote I, Rosendahl A, Häkkinen H, Vibe C, Küçükaylak I, Sawant M, Keufgens L, Frommelt P, Halwas K, Broadbent K, Cunquero M, Castro G, Villemeur M, Nüchel J, Bornikoel A, Dam B, Zirmire R, Kiran R, Carolis C, Andilla J, Loza-Alvarez P, Ruprecht V, Jamora C, Campelo F, Krüger M, Hammerschmidt M, Eckes B, Neundorf I, Krieg T, Malhotra V. TANGO1 inhibitors reduce collagen secretion and limit tissue scarring. Nature Communications 2024, 15: 3302. PMID: 38658535, PMCID: PMC11043333, DOI: 10.1038/s41467-024-47004-1.Peer-Reviewed Original ResearchConceptsEndoplasmic reticulum exit sitesECM proteinsSecretion of ECM proteinsPeptide inhibitorFibrotic diseasesCollagen exportTANGO1Binding interfaceWound healingZebrafish resultsECM componentsReduced granulation tissue formationGranulation tissue formationEffective therapyCutaneous wound healingInhibitor treatmentFibrotic processUncontrolled secretionWidespread occurrenceProtein levelsExit siteExcessive scarringAmount of collagenTherapeutic modulationTissue scarring
2023
Regulatory T cells in skin regeneration and wound healing
Knoedler S, Knoedler L, Kauke-Navarro M, Rinkevich Y, Hundeshagen G, Harhaus L, Kneser U, Pomahac B, Orgill D, Panayi A. Regulatory T cells in skin regeneration and wound healing. Military Medical Research 2023, 10: 49. PMID: 37867188, PMCID: PMC10591349, DOI: 10.1186/s40779-023-00484-6.Peer-Reviewed Original ResearchConceptsRegulatory T cellsT cellsRole of TregsIntegumentary systemNew treatment modalitiesTissue-resident cellsSubsequent wound healing processCutaneous wound healingExcessive inflammationImmune homeostasisTreatment modalitiesImmune cellsSkin adnexaWound healing processImmune responseTregsHealing processWound repairWound healingHealingEpidermal integrityCellsCollateral damageAdnexaInflammation
2017
Cutaneous Fibrosis and Normal Wound Healing
Hamburg-Shields E, Myung P, Cowper S. Cutaneous Fibrosis and Normal Wound Healing. 2017, 577-600. DOI: 10.1007/978-3-319-29785-9_32.ChaptersNumerous cell typesWound healingOrchestrated processEnvironmental perturbationsTranslational mechanismsCell typesExtracellular matrixNormal roleCutaneous wound healingCoordinated productionNormal wound healingCellular playersEnvironmental influencesNormal cutaneous wound healingInjury repairIndividualized functionsMechanismProteinSpecific timeProductionCutaneous fibrosisUnnecessary scarsDisruptionMaintenance
2016
The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization
Zhang F, Prahst C, Mathivet T, Pibouin-Fragner L, Zhang J, Genet G, Tong R, Dubrac A, Eichmann A. The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization. Nature Communications 2016, 7: 13517. PMID: 27882935, PMCID: PMC5123080, DOI: 10.1038/ncomms13517.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCapillary PermeabilityDiabetic RetinopathyIntercellular Signaling Peptides and ProteinsMiceMice, KnockoutNeovascularization, PathologicNerve Tissue ProteinsNetrin ReceptorsOxygen Inhalation TherapyPhosphorylationReceptors, Cell SurfaceReceptors, ImmunologicRetinal DiseasesRetinopathy of PrematuritySignal TransductionVascular Endothelial Growth Factor Receptor-2Wound HealingConceptsCytoplasmic domainOxygen-induced retinopathyVascular permeabilityRetinopathy of prematurityTransmembrane receptorsWound healingDiabetic wound healingCutaneous wound healingDiabetic patientsUNC5B receptorRobo4Transgenic miceTissue revascularizationRevascularizationVessel permeabilityRetinopathyMiceHealingNeovascularizationReceptorsDomainPhosphorylationDeletionPrematurityPathway
2011
The Multifunctional LigB Adhesin Binds Homeostatic Proteins with Potential Roles in Cutaneous Infection by Pathogenic Leptospira interrogans
Choy HA, Kelley MM, Croda J, Matsunaga J, Babbitt JT, Ko AI, Picardeau M, Haake DA. The Multifunctional LigB Adhesin Binds Homeostatic Proteins with Potential Roles in Cutaneous Infection by Pathogenic Leptospira interrogans. PLOS ONE 2011, 6: e16879. PMID: 21347378, PMCID: PMC3036719, DOI: 10.1371/journal.pone.0016879.Peer-Reviewed Original Research
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