2025
Zooid arrangement and colony growth in Porpita porpita
Oguchi K, Maeno A, Yoshida K, Yamamoto G, Kohtsuka H, Dunn C. Zooid arrangement and colony growth in Porpita porpita. Frontiers In Zoology 2025, 22: 11. PMID: 40551163, PMCID: PMC12183843, DOI: 10.1186/s12983-025-00565-3.Peer-Reviewed Original ResearchColony developmentColony growthStructure of coloniesReproductive polypsFeeding polypsGonozooidsGastrozooidsZooidsDactylozooidsLife historyPorpitaColoniesAboral chamberStructural variationsCoenosarcMorphological observationsConclusionsOur studyGrowth zoneMature onesGrowthMicro-CT techniqueSpeciesTentaclesEcologyMorphological investigations
2024
Exploring the metabolic daylength measurement system: implications for photoperiodic growth
Li M, Gendron J. Exploring the metabolic daylength measurement system: implications for photoperiodic growth. New Phytologist 2024, 245: 503-509. PMID: 39544075, PMCID: PMC12108125, DOI: 10.1111/nph.20275.Peer-Reviewed Original ResearchGrowth‐induced collective bending and kinetic trapping of cytoskeletal filaments
Banerjee D, Freedman S, Murrell M, Banerjee S. Growth‐induced collective bending and kinetic trapping of cytoskeletal filaments. Cytoskeleton 2024, 81: 409-419. PMID: 38775207, PMCID: PMC12039077, DOI: 10.1002/cm.21877.Peer-Reviewed Original ResearchActin networkFilamentous growthActin filamentsTurnover of actin filamentsActin filament growthKinetic trapsActin poolFilament polymerizationActin cortexCytoskeletal filamentsSubunit poolActinFilamentsSubunitConsequence of growthFilament mechanismNematic defectsCrowded environmentLong-livedGrowthPoolAbundanceBending patternCellsTurnoverPlants distinguish different photoperiods to independently control seasonal flowering and growth
Wang Q, Liu W, Leung C, Tarté D, Gendron J. Plants distinguish different photoperiods to independently control seasonal flowering and growth. Science 2024, 383: eadg9196. PMID: 38330117, PMCID: PMC11134419, DOI: 10.1126/science.adg9196.Peer-Reviewed Original ResearchConceptsPhotoperiodic growthSeasonal floweringControl expression of genesDuration of photosynthetic activityGrowth-regulating pathwaysExpression of genesPhotosynthetic periodMeasure photoperiodPhotoperiodic floweringPhotosynthetic activityControl expressionFlowering mechanismRegulation pathwaysSeasonal growthFlowersLong daysDifferent photoperiodsPhotoperiodLight intensityPlantsGrowthMutantsGenesPathway
2023
Identification of a New Integration Site and Study on Site-Specific Integration in CHO-K1 Cells
Liu H, Zhang W, Xie L, Hu Y. Identification of a New Integration Site and Study on Site-Specific Integration in CHO-K1 Cells. Pharmaceuticals 2023, 17: 8. PMID: 38275994, PMCID: PMC10819697, DOI: 10.3390/ph17010008.Peer-Reviewed Original ResearchTradeoffs in bacterial physiology determine the efficiency of antibiotic killing
Bren A, Glass D, Kohanim Y, Mayo A, Alon U. Tradeoffs in bacterial physiology determine the efficiency of antibiotic killing. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2312651120. PMID: 38096408, PMCID: PMC10742385, DOI: 10.1073/pnas.2312651120.Peer-Reviewed Original ResearchConceptsMinimal inhibitory concentrationBacterial physiologyCyclic adenosine monophosphateImprove antibiotic efficacyGrowth rateHigh-throughput assayEnvironmental conditionsRNA-seqAntibiotic killingAntibiotic actionBacterial deathAntibiotic efficacyInhibitory concentrationAntibiotic effectBactericidal activityGrowth conditionsCyclic adenosine monophosphate levelsAdenosine monophosphatePhysiological propertiesPhysiologyGrowthNonstress environmentsAssayDeathAntibioticsManipulating mitochondrial electron flow enhances tumor immunogenicity
Mangalhara K, Varanasi S, Johnson M, Burns M, Rojas G, Esparza Moltó P, Sainz A, Tadepalle N, Abbott K, Mendiratta G, Chen D, Farsakoglu Y, Kunchok T, Hoffmann F, Parisi B, Rincon M, Vander Heiden M, Bosenberg M, Hargreaves D, Kaech S, Shadel G. Manipulating mitochondrial electron flow enhances tumor immunogenicity. Science 2023, 381: 1316-1323. PMID: 37733872, PMCID: PMC11034774, DOI: 10.1126/science.abq1053.Peer-Reviewed Original ResearchConceptsElectron transport chainMethylation-controlled J proteinMitochondrial electron transport chainElectron flowMitochondrial electron flowJ-proteinsEpigenetic activationTransport chainMitochondrial respirationTumor growthPresentation genesElectron entryNoncancer cellsMelanoma tumor growthCommon mechanismTherapeutic potentialGenesRelative contributionProteinGrowthKnockoutAntigen presentationRespirationT cell-mediated killingExpressionDesign of a mucin-selective protease for targeted degradation of cancer-associated mucins
Pedram K, Shon D, Tender G, Mantuano N, Northey J, Metcalf K, Wisnovsky S, Riley N, Forcina G, Malaker S, Kuo A, George B, Miller C, Casey K, Vilches-Moure J, Ferracane M, Weaver V, Läubli H, Bertozzi C. Design of a mucin-selective protease for targeted degradation of cancer-associated mucins. Nature Biotechnology 2023, 42: 597-607. PMID: 37537499, PMCID: PMC11018308, DOI: 10.1038/s41587-023-01840-6.Peer-Reviewed Original ResearchCancer progressionSpecific protein glycoformsUndruggable proteinsTargeted degradationProtein degradationBreast cancer progressionCell surface bindingSubstrate selectivityCell-type selectivityCell deathGlycan motifsProtein glycoformsDiscrete peptidesCancer cellsProteinCulture modelProteaseTarget cellsTumor growthCancer-associated mucinsCellsMouse modelDegradersGrowthMotifNew Horizons in Plant Photoperiodism
Gendron J, Staiger D. New Horizons in Plant Photoperiodism. Annual Review Of Plant Biology 2023, 74: 481-509. PMID: 36854481, PMCID: PMC11114106, DOI: 10.1146/annurev-arplant-070522-055628.Peer-Reviewed Original ResearchConceptsPlant photoperiodismRecent molecular genetic studiesGene regulatory networksMolecular genetic studiesPhotoperiodic floweringPlant speciesRegulatory networksDevelopmental processesMetabolic networksGenetic studiesPhotoperiodismSeasonal changesOrganismsPlantsPotential rolePhotoperiodClimate changeLatitudinal migrationTranscriptomicsFloweringSpeciesGrowthMigrationReproductionRiceTetraspanin 4 stabilizes membrane swellings and facilitates their maturation into migrasomes
Dharan R, Huang Y, Cheppali S, Goren S, Shendrik P, Wang W, Qiao J, Kozlov M, Yu L, Sorkin R. Tetraspanin 4 stabilizes membrane swellings and facilitates their maturation into migrasomes. Nature Communications 2023, 14: 1037. PMID: 36823145, PMCID: PMC9950420, DOI: 10.1038/s41467-023-36596-9.Peer-Reviewed Original Research
2022
FIB-SEM analysis on three-dimensional structures of growing organelles in wild Chlorella pyrenoidosa cells
Feng L, Guo W, Guo J, Zhang X, Zou X, Rao M, Ye J, Kuang C, Chen G, Chen C, Qin S, Yang W, Cheng J. FIB-SEM analysis on three-dimensional structures of growing organelles in wild Chlorella pyrenoidosa cells. Protoplasma 2022, 260: 885-897. PMID: 36416933, DOI: 10.1007/s00709-022-01821-7.Peer-Reviewed Original ResearchConceptsSingle pyrenoidThree-dimensional structurePhotosynthetic growthCO2 fixationChlorella pyrenoidosa cellsStarch grainsBeam scanning electron microscopyIon beam scanning electron microscopyMitochondriaGrowth periodCellsMature statePyrenoidChloroplastsMeristemDynamic changesOrganellesNucleoliReplicationLarge partElongationGrowthNdc1 drives nuclear pore complex assembly independent of membrane biogenesis to promote nuclear formation and growth
Mauro MS, Celma G, Zimyanin V, Magaj MM, Gibson KH, Redemann S, Bahmanyar S. Ndc1 drives nuclear pore complex assembly independent of membrane biogenesis to promote nuclear formation and growth. ELife 2022, 11: e75513. PMID: 35852146, PMCID: PMC9296133, DOI: 10.7554/elife.75513.Peer-Reviewed Original ResearchConceptsNuclear pore complexNPC assemblyMembrane biogenesisNE formationNPC densityNuclear pore complex assemblyEndoplasmic reticulumPore complex assemblyNuclear growthPore complexNDC1Redundant rolesComplex assemblyNPC numberBiogenesisMembrane incorporationFast turnoverNuclear formationBilayer lipidsNup53Membrane synthesisFirst divisionAssemblyGrowthNup160Collective behavior and nongenetic inheritance allow bacterial populations to adapt to changing environments
Mattingly H, Emonet T. Collective behavior and nongenetic inheritance allow bacterial populations to adapt to changing environments. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2117377119. PMID: 35727978, PMCID: PMC9245662, DOI: 10.1073/pnas.2117377119.Peer-Reviewed Original ResearchConceptsNongenetic inheritanceCollective migrationPhenotype compositionIsogenic populationsDifferential lossSwimming phenotypeCell divisionBacterial populationsCell growthMultiple environmentsPhenotypePhenotypic compositionDifferent phenotypesInheritanceChemotactic bacteriaModel systemHigh inheritanceMigration speedDifferent environmentsNew environmentCollective behaviorMigrationPopulationGrowthDiversityKARRIKIN UP-REGULATED F-BOX 1 (KUF1) imposes negative feedback regulation of karrikin and KAI2 ligand metabolism in Arabidopsis thaliana
Sepulveda C, Guzmán MA, Li Q, Villaécija-Aguilar JA, Martinez SE, Kamran M, Khosla A, Liu W, Gendron JM, Gutjahr C, Waters MT, Nelson DC. KARRIKIN UP-REGULATED F-BOX 1 (KUF1) imposes negative feedback regulation of karrikin and KAI2 ligand metabolism in Arabidopsis thaliana. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2112820119. PMID: 35254909, PMCID: PMC8931227, DOI: 10.1073/pnas.2112820119.Peer-Reviewed Original ResearchConceptsKAI2-ligandsF-BOX 1Fire-prone environmentsArabidopsis thalianaNegative feedback loopKarrikinsNegative feedback regulationFeedback regulationExpression increasesPlantsGerminationLigand metabolismFeedback loopFurther activationMetabolismThalianaBiosynthesisGenesSpeciesRegulationPathwayActivationDiscoveryResponseGrowth
2021
Deficiency of the paternally inherited gene Magel2 alters the development of separation‐induced vocalization and maternal behavior in mice
Ortiz G, Santana GM, Dietrich MO. Deficiency of the paternally inherited gene Magel2 alters the development of separation‐induced vocalization and maternal behavior in mice. Genes Brain & Behavior 2021, 21: e12776. PMID: 34812568, PMCID: PMC9744533, DOI: 10.1111/gbb.12776.Peer-Reviewed Original ResearchConceptsOrigin-specific mannerGenomic imprintingMouse developmentPaternal genesMammalian offspringDeficient offspringLoss of Magel2Specific mannerGene Magel2GenesOffspring resultsMAGEL2Combined expressionOffspringAltered behaviorSeparation-induced vocalizationsVocal behaviorExpressionMammalsPostnatal developmentGrowthImprintingPup growthMechanical forces drive a reorientation cascade leading to biofilm self-patterning
Nijjer J, Li C, Zhang Q, Lu H, Zhang S, Yan J. Mechanical forces drive a reorientation cascade leading to biofilm self-patterning. Nature Communications 2021, 12: 6632. PMID: 34789754, PMCID: PMC8599862, DOI: 10.1038/s41467-021-26869-6.Peer-Reviewed Original ResearchConceptsVibrio cholerae biofilmsSurface-attached aggregatesBacterial communitiesCell-surface interactionsDevelopmental processesBiofilm developmentBacterial cellsCell reorientationExtracellular matrixNonadherent mutantsDifferential growthBacterial biofilmsMechanical forcesBiofilmsBacterial growthDifferential orderingCellsGrowthMutantsLarge collectionEnergy as a seasonal signal for growth and reproduction
Gendron JM, Leung CC, Liu W. Energy as a seasonal signal for growth and reproduction. Current Opinion In Plant Biology 2021, 63: 102092. PMID: 34461431, DOI: 10.1016/j.pbi.2021.102092.Peer-Reviewed Original ResearchSearching for the Secret of Stickiness: How Biofilms Adhere to Surfaces
Jiang Z, Nero T, Mukherjee S, Olson R, Yan J. Searching for the Secret of Stickiness: How Biofilms Adhere to Surfaces. Frontiers In Microbiology 2021, 12: 686793. PMID: 34305846, PMCID: PMC8295476, DOI: 10.3389/fmicb.2021.686793.Peer-Reviewed Original ResearchFluctuating asymmetry, a marker of poor growth quality, is associated with adult male metabolic rate
Longman D, Oyama S, Cracknell J, Thompson N, Gordon D, Stock J, Wells J. Fluctuating asymmetry, a marker of poor growth quality, is associated with adult male metabolic rate. American Journal Of Biological Anthropology 2021, 175: 646-655. PMID: 33768527, DOI: 10.1002/ajpa.24276.Peer-Reviewed Original ResearchConceptsEnergetic allocationLife-history traitsStrong selective pressureLarge body sizeLife history theoryEnergetic investmentAdult RMRSelective pressureMetabolic rateHistory theoryBody sizePhysiological functionsEvolutionary theoryMetabolic efficiencyMetabolic inefficiencyMetabolic costObserved interindividual variationHuman daily energy expenditureDaily energy expenditureGrowthFATraitsInterindividual variationLimitation of phosphate assimilation maintains cytoplasmic magnesium homeostasis
Bruna RE, Kendra CG, Groisman EA, Pontes MH. Limitation of phosphate assimilation maintains cytoplasmic magnesium homeostasis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2021370118. PMID: 33707210, PMCID: PMC7980370, DOI: 10.1073/pnas.2021370118.Peer-Reviewed Original ResearchConceptsCytoplasmic MgPhosphate assimilationRibosomal RNARegulatory logicP assimilationMolecular basisLoss of viabilityProtein inhibitsPi toxicityAdenosine triphosphateATP synthesisProtein synthesisATP accumulationHomeostasisBacterial growthCytosolic PiDependent processesMagnesium homeostasisBacteriaBiological moleculesInorganic orthophosphateEssential componentAssimilationGrowthRNA
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