2024
Prenatal and infant exposure to antibiotics and subsequent risk of neuropsychiatric disorders in children: A nationwide birth cohort study in South Korea
Oh J, Woo H, Kim H, Park J, Lee M, Rahmati M, Rhee S, Min C, Koyanagi A, Smith L, Fond G, Boyer L, Kim M, Shin J, Lee S, Yon D. Prenatal and infant exposure to antibiotics and subsequent risk of neuropsychiatric disorders in children: A nationwide birth cohort study in South Korea. Psychiatry Research 2024, 340: 116117. PMID: 39128166, DOI: 10.1016/j.psychres.2024.116117.Peer-Reviewed Original ResearchConceptsRisk of neuropsychiatric disordersNeuropsychiatric disordersAntibiotic exposureHazard ratioNationwide birth cohort studyHealth Screening CohortPostnatal lifeConfidence intervalsBirth cohort studyFollow-up durationDuration of prescriptionExposure to antibioticsEstimates of hazard ratiosLong-term riskScreening cohortChildhood neuropsychiatric disordersMaternal obesityPropensity score matchingAntibiotic prescriptionsPotential long-term risksCohort studyExposure statusIncreased riskBaseline variablesFamily factors
2023
Maternal medically diagnosed infection and antibiotic prescription during pregnancy and risk of childhood cancer: A population‐based cohort study in Taiwan, 2004 to 2015
Sirirungreung A, Lee P, Hu Y, Liew Z, Ritz B, Heck J. Maternal medically diagnosed infection and antibiotic prescription during pregnancy and risk of childhood cancer: A population‐based cohort study in Taiwan, 2004 to 2015. International Journal Of Cancer 2023, 154: 626-635. PMID: 37792464, PMCID: PMC10942658, DOI: 10.1002/ijc.34744.Peer-Reviewed Original ResearchConceptsPopulation-based cohort studyMaternal infectionAcute lymphoblastic leukemiaAntibiotic prescriptionsChildhood cancerCohort studyChildhood acute lymphoblastic leukemiaChild Health DatabaseRisk of hepatoblastomaProportional hazards modelMother-child pairsMedian followTaiwan MaternalCancer RegistryLymphoblastic leukemiaAntibiotic useNational HealthAntibiotic exposureElevated riskHigh riskHazards modelPregnancyChildhood leukemiaHealth databasesChildhood hepatoblastoma
2022
2314. Hospitalizations and Antibiotic Use in the Year Prior to an Incident C. difficile Infection for Medicare Beneficiaries in Four States, 2016–2018
Hatfield K, Baggs J, Reddy S, Aranmolate R, Meek J, Fridkin S, Szydlowski J, Hatwar T, Dumyati G, Watkins J, Wilson C, McDonald L, Jernigan J, Guh A. 2314. Hospitalizations and Antibiotic Use in the Year Prior to an Incident C. difficile Infection for Medicare Beneficiaries in Four States, 2016–2018. Open Forum Infectious Diseases 2022, 9: ofac492.146. PMCID: PMC9752406, DOI: 10.1093/ofid/ofac492.146.Peer-Reviewed Original ResearchOutpatient antibiotic useEmerging Infections ProgramClostridioides difficile infectionAntibiotic useCDI casesDifficile infectionRisk factorsMedicare beneficiariesPrevention's Emerging Infections ProgramAntibiotic classesPrior yearAntibiotic stewardship effortsC. difficile infectionMultiple risk factorsInpatient hospitalization dataMedicare Provider AnalysisTiming of hospitalizationGrant/research supportDifferent antibiotic classesAntibiotic prescriptionsCase patientsMedian lengthOutpatient antibioticsCDI surveillanceCDI diagnosisNational Cohort Study of Homebound Persons Living With Dementia: Antibiotic Prescribing Trends and Opportunities for Antibiotic Stewardship
Datta R, Fried T, O’Leary J, Zullo AR, Allore H, Han L, Juthani-Mehta M, Cohen A. National Cohort Study of Homebound Persons Living With Dementia: Antibiotic Prescribing Trends and Opportunities for Antibiotic Stewardship. Open Forum Infectious Diseases 2022, 9: ofac453. PMID: 36147594, PMCID: PMC9487603, DOI: 10.1093/ofid/ofac453.Peer-Reviewed Original ResearchHome-based primary careDays of therapyAntibiotic use ratesAntibiotic useHomebound personsOverall median lengthPhysician home visitsNational cohort studyAntibiotic prescribing trendsVeterans Health AdministrationUse ratesProvider visitsAntibiotic prescriptionsCohort studyPrescribing trendsTelephone visitsMedian agePrescription fillsMedian lengthAntibiotic stewardshipNational cohortPrimary careHome visitsHealth AdministrationPrescribed classThe protocol of improving safe antibiotic prescribing in telehealth: A randomized trial
McCabe B, Linder J, Doctor J, Friedberg M, Fox C, Goldstein N, Knight T, Kaiser K, Tibbels J, Haenchen S, Persell S, Warberg R, Meeker D. The protocol of improving safe antibiotic prescribing in telehealth: A randomized trial. Contemporary Clinical Trials 2022, 119: 106834. PMID: 35724841, DOI: 10.1016/j.cct.2022.106834.Peer-Reviewed Original ResearchConceptsAcute respiratory infectionsInappropriate antibiotic prescribingAntibiotic prescribing ratesAntibiotic prescribingPrescribing ratesRandomized quality improvement trialAntibiotic stewardship interventionsInappropriate antibiotic prescriptionsUrgent care visitsPrevious randomized trialsPrimary care clinicsQuality improvement trialEffective antibiotic useElectronic health recordsARI visitsInappropriate prescribingAntibiotic prescriptionsCare visitsSecondary outcomesPrimary outcomeRespiratory infectionsCare clinicsRandomized trialsStewardship interventionsAntibiotic useImpact of a pilot multimodal intervention to decrease antibiotic use for respiratory infections in a geriatric clinic
Chauhan L, Huang M, Abdo M, Church S, Fixen D, MaWhinney S, Miller M, Erlandson K. Impact of a pilot multimodal intervention to decrease antibiotic use for respiratory infections in a geriatric clinic. Antimicrobial Stewardship & Healthcare Epidemiology 2022, 2: e1. PMID: 36310812, PMCID: PMC9614947, DOI: 10.1017/ash.2021.238.Peer-Reviewed Original ResearchAntibiotic useAntibiotic prescriptionsOutpatient settingAcute respiratory conditionsAntibiotic order setsOverall antibiotic prescribingTotal antibiotic prescriptionsLong-term followOutpatient antibiotic useBroad-spectrum antibioticsQuality improvement initiativesMixed-effects regression modelsLow-cost interventionAntibiotic use dataAntibiotic durationStop datesAntibiotic guidelinesOlder patientsAntibiotic prescribingInappropriate antibioticsRespiratory infectionsAdverse reactionsSeniors ClinicClinical impactGeriatric clinic
2020
Antimicrobial Stewardship Optimization in the Emergency Department: The Effect of Multiplex Respiratory Pathogen Testing and Targeted Educational Intervention
Durant TJS, Kubilay NZ, Reynolds J, Tarabar AF, Dembry LM, Peaper DR. Antimicrobial Stewardship Optimization in the Emergency Department: The Effect of Multiplex Respiratory Pathogen Testing and Targeted Educational Intervention. The Journal Of Applied Laboratory Medicine 2020, 5: 1172-1183. PMID: 32918445, DOI: 10.1093/jalm/jfaa130.Peer-Reviewed Original ResearchConceptsAntibiotic prescription ratesEmergency departmentPrescription ratesAntibiotic prescriptionsED visitsRespiratory pathogen testingRespiratory tract infectionsAdult emergency departmentAntimicrobial treatment decisionsProvider-patient interactionsDetection of influenzaTargeted educational interventionsAntimicrobial stewardship educationOseltamivir prescriptionsASP interventionsTract infectionsInfluenza seasonIntervention cohortTreatment decisionsPatient engagementPatientsResult availabilityCohortEducational interventionStewardship education
2019
The effect of respiratory viral assay panel on antibiotic prescription patterns at discharge in adults admitted with mild to moderate acute exacerbation of COPD: a retrospective before- after study
Tickoo M, Ruthazer R, Bardia A, Doron S, Andujar-Vazquez GM, Gardiner BJ, Snydman DR, Kurz SG. The effect of respiratory viral assay panel on antibiotic prescription patterns at discharge in adults admitted with mild to moderate acute exacerbation of COPD: a retrospective before- after study. BMC Pulmonary Medicine 2019, 19: 118. PMID: 31262278, PMCID: PMC6604457, DOI: 10.1186/s12890-019-0872-0.Peer-Reviewed Original ResearchConceptsRespiratory viral panelChronic obstructive pulmonary diseaseObstructive pulmonary diseaseAntibiotic prescriptionsAcute exacerbationPulmonary diseaseViral panelAntibiotic prescription patternsPositive smoking statusAntibiotic prescription ratesProportion of patientsObstructive sleep apneaTertiary medical centerStudy of patientsUse of antibioticsAECOPD patientsConclusionsIn patientsPrescription patternsPrescription ratesPrimary outcomeSingle centerSleep apneaSmoking statusMean ageResultsA totalA Multifaceted Intervention Improves Prescribing for Acute Respiratory Infection for Adults and Children in Emergency Department and Urgent Care Settings
Yadav K, Meeker D, Mistry R, Doctor J, Fleming‐Dutra K, Fleischman R, Gaona S, Stahmer A, May L. A Multifaceted Intervention Improves Prescribing for Acute Respiratory Infection for Adults and Children in Emergency Department and Urgent Care Settings. Academic Emergency Medicine 2019, 26: 719-731. PMID: 31215721, PMCID: PMC8146207, DOI: 10.1111/acem.13690.Peer-Reviewed Original ResearchConceptsAcute respiratory infectionsEmergency departmentARI visitsRespiratory infectionsStewardship interventionsUrgent care center visitsViral acute respiratory infectionsHierarchical mixed-effects logistic regression modelsCluster-randomized clinical trialHealth systemAntibiotic stewardship interventionsUrgent care settingsOutpatient antibiotic prescriptionsPediatric emergency departmentMixed effects logistic regression modelsAcademic health systemLogistic regression modelsInappropriate prescribingAntibiotic prescribingAntibiotic prescriptionsInappropriate prescriptionsInfluenza seasonAntibiotic stewardshipClinical trialsOdds ratioAntibiotic prescribing trends among US dermatologists in Medicare from 2013 to 2016
Kakpovbia E, Feng H, Feng PW, Cohen JM. Antibiotic prescribing trends among US dermatologists in Medicare from 2013 to 2016. Journal Of Dermatological Treatment 2019, 32: 70-72. PMID: 31122085, DOI: 10.1080/09546634.2019.1623372.Peer-Reviewed Original ResearchConceptsOral antibiotic prescriptionsOral antibioticsAntibiotic prescriptionsImportant public health issueAntibiotic prescription practicesAntibiotic prescribing trendsMedicare Part D Prescriber Public Use FilePart D Prescriber Public Use FileProportion of prescriptionsPublic health issuePrescribing trendsRetrospective reviewPrescription practicesOptimal careInflammatory diseasesMedicare patientsMedicare claimsElderly populationNumber of dermatologistsPublic Use FileUS dermatologistsDermatologistsHealth issuesMost antibioticsAdverse effects
2018
256. A Cross-Disciplinary Educational Approach: Antibiotic Prescribing Practices and the Use of Prophylactic Antibiotics Prior to Dental Procedures
McCarthy M, Banach D, Andrews R. 256. A Cross-Disciplinary Educational Approach: Antibiotic Prescribing Practices and the Use of Prophylactic Antibiotics Prior to Dental Procedures. Open Forum Infectious Diseases 2018, 5: s108-s108. PMCID: PMC6255480, DOI: 10.1093/ofid/ofy210.267.Peer-Reviewed Original ResearchProphylactic antibiotic prescriptionsDental proceduresProphylactic antibioticsMedical providersAntibiotic prescribingAntibiotic prescriptionsMedical practitionersMost medical providersProphylactic antibiotic prescribingChronic kidney diseaseAntibiotic prescribing practicesProphylactic antibiotic usePrimary care physiciansCross-sectional electronic surveyPrevious endocarditisCardiac transplantPrescribing antibioticsDiabetes mellitusCare physiciansKidney diseasePrescribing practicesAntibiotic useDental practitionersSurgical specialistsMost dentistsBehavioral Economics Interventions to Improve Outpatient Antibiotic Prescribing for Acute Respiratory Infections: a Cost-Effectiveness Analysis
Gong C, Zangwill K, Hay J, Meeker D, Doctor J. Behavioral Economics Interventions to Improve Outpatient Antibiotic Prescribing for Acute Respiratory Infections: a Cost-Effectiveness Analysis. Journal Of General Internal Medicine 2018, 34: 846-854. PMID: 29740788, PMCID: PMC6544688, DOI: 10.1007/s11606-018-4467-x.Peer-Reviewed Original ResearchConceptsAcute respiratory infectionsQuality-adjusted life yearsInappropriate antibiotic prescriptionsAntibiotic prescriptionsBehavioral economic interventionsElectronic health recordsAntibiotic prescribingRespiratory infectionsProvider educationAccountable justificationSymptoms of ARIComputerized clinical decision supportIncremental cost-effectiveness ratioOutpatient antibiotic prescribingInappropriate antibiotic prescribingAssociated adverse eventsHealthcare resource utilizationTotal quality-adjusted life yearsHigher quality-adjusted life yearsCost-effectiveness ratioCDC surveillance dataPatients' electronic health recordsCost-effectiveness analysisUS societal perspectiveAdverse eventsPCORnet Antibiotics and Childhood Growth Study: Process for Cohort Creation and Cohort Description
Block J, Bailey L, Gillman M, Lunsford D, Boone-Heinonen J, Cleveland L, Finkelstein J, Horgan C, Jay M, Reynolds J, Sturtevant J, Forrest C, Group P, Adams W, Appelhans B, Brickman A, Bian J, Daley M, Davidson A, Dempsey A, Dugas L, Eneli I, Fitzpatrick S, Heerman W, Horberg M, Hsia D, Ingber J, Isasi C, Janicke D, Kane D, Kharbanda E, Meltzer D, Messito M, Nadkarni P, O'Bryan K, Peay H, Puro J, Ranade D, Rao G, Tirado-Ramos A, Rayas M, Razzaghi H, Ricket I, Rosenman M, Siegel R, Solomonides T, Taveras E, Taylor B, Tolia V, Willis Z, VanWormer J, Wysocki T, Zhou X. PCORnet Antibiotics and Childhood Growth Study: Process for Cohort Creation and Cohort Description. Academic Pediatrics 2018, 18: 569-576. PMID: 29477481, PMCID: PMC9746871, DOI: 10.1016/j.acap.2018.02.008.Peer-Reviewed Original ResearchConceptsAntibiotic prescriptionsAntibiotic useObservational studySex-specific body mass indexCohort inclusion criteriaEarly antibiotic useSame-day heightSingle antibiotic prescriptionsBody mass indexLongitudinal observational studyClinical Research NetworkBroad-spectrum antibioticsMonths of agePCORnet common data modelCohort creationSevere obesityNational PatientMass indexCohort descriptionObesity prevalenceInclusion criteriaCohort characteristicsHealth care dataCare dataClinical research
2016
Clinical Utility of On-Demand Multiplex Respiratory Pathogen Testing among Adult Outpatients
Green DA, Hitoaliaj L, Kotansky B, Campbell SM, Peaper DR. Clinical Utility of On-Demand Multiplex Respiratory Pathogen Testing among Adult Outpatients. Journal Of Clinical Microbiology 2016, 54: 2950-2955. PMID: 27654334, PMCID: PMC5121384, DOI: 10.1128/jcm.01579-16.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAmbulatory Care FacilitiesAnti-Bacterial AgentsAsthmaEmergency Service, HospitalFemaleHumansInfluenza, HumanMaleMiddle AgedOrthomyxoviridaeOseltamivirPractice Patterns, Physicians'Pulmonary Disease, Chronic ObstructiveRespiratory Tract InfectionsRetrospective StudiesConceptsNon-influenza virusesRespiratory pathogen testingInfluenza virusAntibiotic prescriptionsPrescription ratesAdult outpatientsLarge Veterans Administration Medical CenterVeterans Administration Medical CenterAntibiotic prescription ratesPathogen testingRespiratory tract infectionsUnnecessary antibiotic useFilmArray Respiratory PanelPatients' medical recordsSpecific therapeutic interventionsTract infectionsRespiratory panelOutpatient centerAntibiotic useAntimicrobial prescriptionsMedical recordsRespiratory pathogensMedical CenterClinical utilityCommon pathogens
2015
Tobacco Smoking as a Risk Factor for Increased Antibiotic Prescription
Steinberg MB, Akincigil A, Kim EJ, Shallis R, Delnevo CD. Tobacco Smoking as a Risk Factor for Increased Antibiotic Prescription. American Journal Of Preventive Medicine 2015, 50: 692-698. PMID: 26702478, PMCID: PMC5189690, DOI: 10.1016/j.amepre.2015.11.009.Peer-Reviewed Original ResearchConceptsAntibiotic prescriptionsTobacco useTobacco usersNational Ambulatory Medical Care SurveyAmbulatory Medical Care SurveyHigher antibiotic prescriptionAntibiotic prescribing patternsAntibiotic prescription ratesPrimary care physiciansNon-tobacco usersCurrent tobacco usersProvider-patient encountersTobacco use statusEvidence-based rationaleCross-sectional surveyHalf of encountersFirst U.S. studyAmbulatory medical servicesComorbid asthmaInfectious diagnosisPrescribing patternsPublic health crisisAntibiotic prescribedPrescription ratesRespiratory infectionsAssociation Between Outpatient Antibiotic Prescribing Practices and Community-Associated Clostridium difficile Infection
Dantes R, Mu Y, Hicks L, Cohen J, Bamberg W, Beldavs Z, Dumyati G, Farley M, Holzbauer S, Meek J, Phipps E, Wilson L, Winston L, McDonald L, Lessa F. Association Between Outpatient Antibiotic Prescribing Practices and Community-Associated Clostridium difficile Infection. Open Forum Infectious Diseases 2015, 2: ofv113. PMID: 26509182, PMCID: PMC4551478, DOI: 10.1093/ofid/ofv113.Peer-Reviewed Original ResearchClostridium difficile infectionCA-CDI ratesOutpatient antibiotic prescribingAntibiotic useAntibiotic prescribingDifficile infectionCommunity-Associated Clostridium difficile InfectionIMS Health Xponent databaseOutpatient antibiotic prescribing practicesAmoxicillin/clavulanic acidCA-CDI casesSurveillance area residentAntibiotic prescribing ratesAntibiotic prescription ratesAntibiotic prescribing practicesCourse of antibioticsOral antibiotic prescriptionsLaboratory-based surveillance dataOutpatient antibiotic useCDI preventionAntibiotic prescriptionsPrescribing ratesHospital admissionPrescription ratesPrescribing practices
2014
Confounding by indication affects antimicrobial risk factors for methicillin-resistant Staphylococcus aureus but not vancomycin-resistant enterococci acquisition
Datta R, Kleinman K, Rifas-Shiman S, Placzek H, Lankiewicz J, Platt R, Huang SS, for the CDC Prevention Epicenters. Confounding by indication affects antimicrobial risk factors for methicillin-resistant Staphylococcus aureus but not vancomycin-resistant enterococci acquisition. Antimicrobial Resistance & Infection Control 2014, 3: 19. PMID: 24932407, PMCID: PMC4057914, DOI: 10.1186/2047-2994-3-19.Peer-Reviewed Original ResearchMethicillin-resistant Staphylococcus aureusVancomycin-resistant enterococci acquisitionEmpiric antibioticsRisk factorsVRE acquisitionAntibiotic prescriptionsMRSA acquisitionScreening culturesIntensive care unit patientsAntibiotic utilization dataMRSA-positive patientsVRE-positive patientsCare unit patientsMedical record reviewDiagnosis of infectionEvidence of treatmentSymptoms of infectionStaphylococcus aureusBackgroundObservational studiesEmpiric therapyUnit patientsRecord reviewTreatment indicationsPrior historyLow prevalenceNudging Guideline-Concordant Antibiotic Prescribing: A Randomized Clinical Trial
Meeker D, Knight T, Friedberg M, Linder J, Goldstein N, Fox C, Rothfeld A, Diaz G, Doctor J. Nudging Guideline-Concordant Antibiotic Prescribing: A Randomized Clinical Trial. JAMA Internal Medicine 2014, 174: 425-431. PMID: 24474434, PMCID: PMC4648560, DOI: 10.1001/jamainternmed.2013.14191.Peer-Reviewed Original ResearchConceptsAcute respiratory infectionsInappropriate antibiotic prescribingAntibiotic prescribing ratesPrescribing ratesAntibiotic prescribingClinical trialsIntervention periodOutpatient primary care clinicsInappropriate prescribing ratePrimary care clinicsAppropriate antibiotic prescriptionRandomized clinical trialsExamination roomLow-cost interventionStandard practice controlsQuality improvement effortsARI diagnosesARI visitsAntibiotic prescriptionsPatient ageRespiratory infectionsCare clinicsInsurance statusMAIN OUTCOMEClinical practice
2013
Use of behavioral economics and social psychology to improve treatment of acute respiratory infections (BEARI): rationale and design of a cluster randomized controlled trial [1RC4AG039115-01] - study protocol and baseline practice and provider characteristics
Persell S, Friedberg M, Meeker D, Linder J, Fox C, Goldstein N, Shah P, Knight T, Doctor J. Use of behavioral economics and social psychology to improve treatment of acute respiratory infections (BEARI): rationale and design of a cluster randomized controlled trial [1RC4AG039115-01] - study protocol and baseline practice and provider characteristics. BMC Infectious Diseases 2013, 13: 290. PMID: 23806017, PMCID: PMC3701464, DOI: 10.1186/1471-2334-13-290.Peer-Reviewed Original ResearchConceptsAcute respiratory infectionsInappropriate antibiotic prescribingAntibiotic prescribingInappropriate prescribingRespiratory infectionsComputerized clinical decision supportAntibiotic prescribing ratesTrial study protocolInappropriate antibiotic useAdverse drug eventsCost of careUnit of randomizationPatients' electronic health recordsElectronic health recordsPersistence of effectsARI diagnosesNonbacterial infectionsAntibiotic prescriptionsSecondary outcomesClinical decision supportPrescribing ratesPrimary outcomeBehavioral economic strategiesGuideline recommendationsYear follow
2009
The Effect of Alternative Graphical Displays Used to Present the Benefits of Antibiotics for Sore Throat on Decisions about Whether to Seek Treatment: A Randomized Trial
Carling CL, Kristoffersen DT, Flottorp S, Fretheim A, Oxman AD, Schünemann HJ, Akl EA, Herrin J, MacKenzie TD, Montori VM. The Effect of Alternative Graphical Displays Used to Present the Benefits of Antibiotics for Sore Throat on Decisions about Whether to Seek Treatment: A Randomized Trial. PLOS Medicine 2009, 6: e1000140. PMID: 19707579, PMCID: PMC2726763, DOI: 10.1371/journal.pmed.1000140.Peer-Reviewed Original ResearchConceptsSore throatVisual analog scaleBenefits of antibioticsVAS scoresRelative importance scoresDay threeDuration of symptomsTreatment effectsConsequence of treatmentProportion of peopleDetailed patient informationAntibiotic prescriptionsSymptom reliefRandomized trialsAnalog scaleAdult volunteersHealth programsSymptomsLogistic regressionAverage durationPatient informationMost participantsTrialsAntibioticsSignificant differences
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