DNA Damage Response Alterations Predict for Neoadjuvant Chemotherapy Sensitivity in Muscle-Invasive Bladder Cancer: A Correlative Analysis of the SWOG S1314 Trial
Iyer G, Tangen C, Sarfaty M, Regazzi A, Lee I, Fong M, Choi W, Dinney C, Flaig T, Thompson I, Lerner S, McConkey D, Rosenberg J. DNA Damage Response Alterations Predict for Neoadjuvant Chemotherapy Sensitivity in Muscle-Invasive Bladder Cancer: A Correlative Analysis of the SWOG S1314 Trial. JCO Precision Oncology 2024, 8: e2400287. PMID: 39499893, PMCID: PMC12088707, DOI: 10.1200/po.24.00287.Peer-Reviewed Original ResearchConceptsNeoadjuvant cisplatin-based chemotherapyMuscle-invasive bladder cancerProgression-free survivalDDR alterationsDNA damage response alterationPathological responseBladder cancerDNA damage responseAssociated with pathological responseNeoadjuvant chemotherapy sensitivityPretreatment tumor specimensPathological response rateCisplatin-based chemotherapyDNA damage response genesEstimates of hazard ratiosOverall survivalRadical cystectomyTumor specimensPerformance statusClinical stageChemotherapy sensitivityCox regressionHazard ratioNext-generation sequencingPatientsPrenatal and infant exposure to antibiotics and subsequent risk of neuropsychiatric disorders in children: A nationwide birth cohort study in South Korea
Oh J, Woo H, Kim H, Park J, Lee M, Rahmati M, Rhee S, Min C, Koyanagi A, Smith L, Fond G, Boyer L, Kim M, Shin J, Lee S, Yon D. Prenatal and infant exposure to antibiotics and subsequent risk of neuropsychiatric disorders in children: A nationwide birth cohort study in South Korea. Psychiatry Research 2024, 340: 116117. PMID: 39128166, DOI: 10.1016/j.psychres.2024.116117.Peer-Reviewed Original ResearchConceptsRisk of neuropsychiatric disordersNeuropsychiatric disordersAntibiotic exposureHazard ratioNationwide birth cohort studyHealth Screening CohortPostnatal lifeConfidence intervalsBirth cohort studyFollow-up durationDuration of prescriptionExposure to antibioticsEstimates of hazard ratiosLong-term riskScreening cohortChildhood neuropsychiatric disordersMaternal obesityPropensity score matchingAntibiotic prescriptionsPotential long-term risksCohort studyExposure statusIncreased riskBaseline variablesFamily factors
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply