2023
Lessons learned in translating pain knowledge into practice
Becker J, Effraim P, Dib-Hajj S, Rittner H. Lessons learned in translating pain knowledge into practice. PAIN Reports 2023, 8: e1100. PMID: 37928204, PMCID: PMC10624476, DOI: 10.1097/pr9.0000000000001100.Peer-Reviewed Original ResearchPain knowledgeCalcitonin gene-related peptide antagonistsGrowth factorNovel pain treatmentsClinical phase IISevere side effectsMechanisms of nociceptionBetter preclinical modelsNeuronal growth factorsHands of cliniciansLack of effectMore patientsMusculoskeletal painPain treatmentChronic painClinical updateNew analgesicsClinical trialsNeurokinin receptorsPreclinical modelsPreclinical studiesSide effectsPatientsJoint replacementAvailable evidenceMifepristone as a pharmacological intervention for stress‐induced alcohol craving: A human laboratory study
Haass‐Koffler C, Magill M, Cannella N, Brown J, Aoun E, Cioe P, Sinha R, Swift R, Ciccocioppo R, Leggio L. Mifepristone as a pharmacological intervention for stress‐induced alcohol craving: A human laboratory study. Addiction Biology 2023, 28: e13288. PMID: 37369125, PMCID: PMC10313137, DOI: 10.1111/adb.13288.Peer-Reviewed Original ResearchConceptsAlcohol use disorderHuman laboratory studiesAdverse eventsAlcohol pharmacokineticsAlcohol cravingSubjective effectsSafety of mifepristonePlacebo-controlled trialStress-induced alcoholLack of effectCue-reactivity procedureBlood pressurePhase 1/2Alcohol drinkingGeneralized Estimating EquationsYohimbine administrationHemodynamic parametersPharmacological interventionsSaliva outputDay administrationUse disordersMifepristoneNon-treatment seekersAlcohol consumptionPlacebo conditionDyslipidemia and Risk of Preeclampsia: A Multiancestry Mendelian Randomization Study
Hosier H, Lipkind H, Rasheed H, DeWan A, Rogne T. Dyslipidemia and Risk of Preeclampsia: A Multiancestry Mendelian Randomization Study. Hypertension 2023, 80: 1067-1076. PMID: 36883459, DOI: 10.1161/hypertensionaha.122.20426.Peer-Reviewed Original ResearchConceptsRisk of preeclampsiaProtective effectCholesteryl Ester Transfer Protein InhibitionLack of effectMendelian randomization studyMendelian randomization analysisMaternal morbidityElevated HDLLeading causeLipid levelsObservational studyPreeclampsiaLipid measurementsReduced riskAncestry groupsPharmacological targetsRandomization studyHDLLDLRandomization analysisSingle nucleotide polymorphismsNew targetsDyslipidemiaRiskProtein inhibition
2019
Effect of Universal Testing and Treatment on HIV Incidence — HPTN 071 (PopART)
Hayes RJ, Donnell D, Floyd S, Mandla N, Bwalya J, Sabapathy K, Yang B, Phiri M, Schaap A, Eshleman SH, Piwowar-Manning E, Kosloff B, James A, Skalland T, Wilson E, Emel L, Macleod D, Dunbar R, Simwinga M, Makola N, Bond V, Hoddinott G, Moore A, Griffith S, Deshmane Sista N, Vermund SH, El-Sadr W, Burns DN, Hargreaves JR, Hauck K, Fraser C, Shanaube K, Bock P, Beyers N, Ayles H, Fidler S. Effect of Universal Testing and Treatment on HIV Incidence — HPTN 071 (PopART). New England Journal Of Medicine 2019, 381: 207-218. PMID: 31314965, PMCID: PMC6587177, DOI: 10.1056/nejmoa1814556.Peer-Reviewed Original ResearchConceptsHIV-positive participantsViral suppressionHIV infectionGroup BGroup AGroup CMonth 12Universal testingPrevention interventionsPopulation cohortHuman immunodeficiency virus (HIV) infectionHome-based HIV testingBaseline HIV prevalenceCombination prevention interventionsImmunodeficiency virus infectionHIV-positive adultsPopulation-level incidenceNew HIV infectionsAdjusted rate ratiosCommunity-randomized trialLack of effectHIV carePrevious trial resultsStandard careART adherence
2018
Characterization of renal NaCl and oxalate transport in Slc26a6−/− mice
Knauf F, Velazquez H, Pfann V, Jiang Z, Aronson PS. Characterization of renal NaCl and oxalate transport in Slc26a6−/− mice. American Journal Of Physiology. Renal Physiology 2018, 316: f128-f133. PMID: 30427220, PMCID: PMC6383200, DOI: 10.1152/ajprenal.00309.2018.Peer-Reviewed Original ResearchConceptsWild-type miceNaCl homeostasisBlood pressureProximal tubulesFree-flow micropuncture studiesSurface proximal tubulesLow-salt dietMean blood pressureLower blood pressureUrine flow rateLack of effectFurosemide infusionNet renal secretionSodium excretionUrine oxalateFractional excretionMicropuncture studiesNaCl deliveryRenal secretionApical membrane ClExchanger SLC26A6MiceRenal NaClNaCl transportHomeostasis
2017
Lack of Effect of Murine Astrovirus Infection on Dextran Sulfate-induced Colitis in NLRP3-deficient Mice.
Compton SR, Booth CJ, Macy JD. Lack of Effect of Murine Astrovirus Infection on Dextran Sulfate-induced Colitis in NLRP3-deficient Mice. Journal Of The American Association For Laboratory Animal Science 2017, 67: 400-406. PMID: 28935001, PMCID: PMC5621567.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstroviridaeAstroviridae InfectionsColitisColonDextran SulfateDisease Models, AnimalFemaleGastrointestinal MicrobiomeInflammasomesMaleMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinRandom AllocationReal-Time Polymerase Chain ReactionReproducibility of ResultsRodent DiseasesRodentiaConceptsColitis modelInflammatory bowel disease researchNOD-like receptor 3Induced colitis modelSeverity of colitisDextran sodium sulfateDSS colitis modelNLRP3-deficient miceDefective inflammasome activationLack of effectMucosal ulcerationIntestinal inflammationHistopathologic changesIntestinal permeabilityAstrovirus infectionFemale miceClinical signsDeficient miceNLRP3 mutationsClinical diseaseInflammasome activationGastrointestinal tractMurine astrovirusIntestinal bacteriaIntestinal epitheliumLength of Stay From the Hospital Perspective
Rosen JE, Salazar MC, Dharmarajan K, Kim AW, Detterbeck FC, Boffa DJ. Length of Stay From the Hospital Perspective. Annals Of Surgery 2017, 266: 383-388. PMID: 27564681, DOI: 10.1097/sla.0000000000001971.Peer-Reviewed Original ResearchConceptsMedian LOSLength of stayEarly discharge practicesDischarge practicesReadmission ratesEarly dischargeCancer-accredited hospitalsNational Cancer DatabaseLung cancer surgeryRisk of readmissionHospital discharge practicesHierarchical logistic regression modelsLack of effectLogistic regression modelsMore readmissionsUnplanned readmissionThoracotomy approachCancer surgeryReadmission riskLung cancerCancer DatabaseInclusion criteriaReadmissionHospital perspectivePatients
2016
Matrix metalloproteinase inhibitor, doxycycline and progression of calcific aortic valve disease in hyperlipidemic mice
Jung JJ, Razavian M, Kim HY, Ye Y, Golestani R, Toczek J, Zhang J, Sadeghi MM. Matrix metalloproteinase inhibitor, doxycycline and progression of calcific aortic valve disease in hyperlipidemic mice. Scientific Reports 2016, 6: 32659. PMID: 27619752, PMCID: PMC5020643, DOI: 10.1038/srep32659.Peer-Reviewed Original ResearchConceptsCalcific aortic valve diseaseAortic valve diseaseEffect of doxycyclineWestern dietCAVD progressionMatrix metalloproteinasesValve diseaseMicro-single photon emissionNonselective MMP inhibitorTherapeutic blood levelsLack of effectSingle photon emissionMatrix metalloproteinase inhibitorsGroups of animalsAortic stenosisMedical therapyHyperlipidemic miceEarly diseaseBlood levelsCommon causeTissue analysisMMP activationMMP inhibitionGelatinase activityDoxycycline
2004
Effect of Prenatal Vitamin Supplementation on Lower-Genital Levels of HIV Type 1 and Interleukin Type 1β at 36 Weeks of Gestation
Fawzi W, Msamanga G, Antelman G, Xu C, Hertzmark E, Spiegelman D, Hunter D, Anderson D. Effect of Prenatal Vitamin Supplementation on Lower-Genital Levels of HIV Type 1 and Interleukin Type 1β at 36 Weeks of Gestation. Clinical Infectious Diseases 2004, 38: 716-722. PMID: 14986257, DOI: 10.1086/381673.Peer-Reviewed Original ResearchConceptsHIV-1HIV-1-infected pregnant womenVitamin AHIV-1-infected womenType 1Human immunodeficiency virus type 1Immunodeficiency virus type 1Genital HIV-1Prenatal multivitamin supplementsHIV-1 transmissionCervicovaginal lavage specimensHIV Type 1HIV-1 infectionLower genital tractWeeks of gestationPrenatal vitamin supplementationUse of vitaminsVirus type 1Lack of effectPregnancy outcomesVaginal inflammationViral sheddingVitamin supplementationMultivitamin supplementsPregnant women
2003
Lack of effect of a single dose of hydrocortisone on serotonin1A receptors in recovered depressed patients measured by positron emission tomography with [11C]WAY-100635
Bhagwagar Z, Montgomery A, Grasby P, Cowen P. Lack of effect of a single dose of hydrocortisone on serotonin1A receptors in recovered depressed patients measured by positron emission tomography with [11C]WAY-100635. Biological Psychiatry 2003, 54: 890-895. PMID: 14573316, DOI: 10.1016/s0006-3223(03)00466-9.Peer-Reviewed Original ResearchConceptsReceptor BPMajor depressionPositron emission tomographySerotonin-1A receptor bindingEmission tomographyPositron emission tomography scanAcute major depressionEmission tomography scanCertain brain areasElevated cortisol levelsLack of effectCortisol hypersecretionAcute administrationSingle doseHydrocortisone treatmentDepressed patientsTomography scanHealthy volunteersBrain areasCrossover designCortisol levelsSerotonin1A receptorsMale subjectsFemale subjectsPatientsBenefits and Risks of Abciximab Use in Primary Angioplasty for Acute Myocardial Infarction
Tcheng JE, Kandzari DE, Grines CL, Cox DA, Effron MB, Garcia E, Griffin JJ, Guagliumi G, Stuckey T, Turco M, Fahy M, Lansky AJ, Mehran R, Stone GW. Benefits and Risks of Abciximab Use in Primary Angioplasty for Acute Myocardial Infarction. Circulation 2003, 108: 1316-1323. PMID: 12939213, DOI: 10.1161/01.cir.0000087601.45803.86.Peer-Reviewed Original ResearchMeSH KeywordsAbciximabAdultAgedAngioplasty, Balloon, CoronaryAntibodies, MonoclonalCombined Modality TherapyCoronary AngiographyEndpoint DeterminationFemaleHumansImmunoglobulin Fab FragmentsMaleMiddle AgedMyocardial InfarctionPlatelet Aggregation InhibitorsPlatelet Glycoprotein GPIIb-IIIa ComplexStentsTreatment OutcomeConceptsComposite end pointTarget vessel revascularizationIschemia-driven target vessel revascularizationPrimary percutaneous coronary interventionAbciximab treatmentPercutaneous coronary interventionAcute myocardial infarctionMyocardial infarctionCoronary interventionEnd pointPlatelet glycoprotein IIb/IIIa inhibitorsGlycoprotein IIb/IIIa inhibitorsIIb/IIIa inhibitorsInfarct artery reocclusionPrespecified secondary analysisEvent-free survivalFactorial design trialLack of effectAbciximab useAngiographic substudyCADILLAC trialTVR ratesPrimary angioplastyPrimary stentingAngiographic outcomes
2002
Lack of Effect of Chlorhexidine Varnish on Streptococcus mutans Transmission and Caries in Mothers and Children
Dasanayake AP, Wiener HW, Li Y, Vermund S, Caufield PW. Lack of Effect of Chlorhexidine Varnish on Streptococcus mutans Transmission and Caries in Mothers and Children. Caries Research 2002, 36: 288-293. PMID: 12218279, DOI: 10.1159/000063922.Peer-Reviewed Original ResearchConceptsChlorhexidine varnishSalivary S. mutans levelsChild's fourth birthdayRandomized clinical trialsS. mutans levelsMother-child pairsFourth birthdayMother-child transmissionS. mutans colonizationLack of effectCaries experienceMutans levelsPlacebo varnishClinical trialsFirst babyTreatment groupsControl groupWeekly intervalsCariesMothersChildrenMonthsStreptococcus mutansGroupBabies
2000
Glutamate excitotoxicity — a mechanism for axonal damage and oligodendrocyte death in Multiple Sclerosis?
Werner P, Pitt D, Raine CS. Glutamate excitotoxicity — a mechanism for axonal damage and oligodendrocyte death in Multiple Sclerosis? Journal Of Neural Transmission. Supplementa 2000, 375-385. PMID: 11205156, DOI: 10.1007/978-3-7091-6301-6_27.Peer-Reviewed Original ResearchConceptsCentral nervous systemAMPA/kainate antagonistMultiple sclerosisGlutamate excitotoxicityImmune cellsKainate antagonistAxonal damageAntigen-primed T cellsMyelin-producing cellsLack of effectSite of entryCNS inflammationInflammatory attacksExperimental autoimmunePerivascular cuffsAutoimmune demyelinationInflammatory lesionsClinical differencesOligodendrocyte survivalEffective therapyGlutamate receptorsOligodendrocyte deathT cellsExcitotoxicityLesion sizeGlutamate excitotoxicity in a model of multiple sclerosis
Pitt D, Werner P, Raine C. Glutamate excitotoxicity in a model of multiple sclerosis. Nature Medicine 2000, 6: 67-70. PMID: 10613826, DOI: 10.1038/71555.Peer-Reviewed Original ResearchConceptsGlutamate excitotoxicityMultiple sclerosisAMPA/kainate antagonist NBQXAMPA/kainate typeCentral nervous system inflammationAMPA/kainate antagonistAntigen-primed T cellsCentral nervous system2Nervous system inflammationExperimental autoimmune encephalomyelitisCentral nervous systemMyelin-producing cellsLack of effectDemyelinating modelKainate typeSystem inflammationAutoimmune encephalomyelitisInflammatory attacksKainate antagonistAntagonist NBQXAutoimmune demyelinationPathologic featuresClinical differencesReceptor damageOligodendrocyte survival
1998
Does Masking Author Identity Improve Peer Review Quality?: A Randomized Controlled Trial
Justice A, Cho M, Winker M, Berlin J, Rennie D, Investigators A. Does Masking Author Identity Improve Peer Review Quality?: A Randomized Controlled Trial. JAMA 1998, 280: 240-242. PMID: 9676668, DOI: 10.1001/jama.280.3.240.Peer-Reviewed Original Research
1994
Increased Systemic, but Not Regional, Neopterin Production Following Intraperitoneral Administration of Interleukin-2 and Lack of Effect of Pterins upon the Lymphokine-Activated Killer Cell Phenomenon
Roberts J, Bigelow J, Moore A, Belinson J, Stewart J, Hacker M. Increased Systemic, but Not Regional, Neopterin Production Following Intraperitoneral Administration of Interleukin-2 and Lack of Effect of Pterins upon the Lymphokine-Activated Killer Cell Phenomenon. Journal Of Immunotherapy 1994, 15: 53-58. PMID: 8110731, DOI: 10.1097/00002371-199401000-00007.Peer-Reviewed Original ResearchConceptsLymphokine-activated killer cellsNeopterin productionInterleukin-2Killer cellsIntraperitoneal interleukin-2Killer cell phenomenonUrinary neopterin excretionRoute of administrationActivated T cellsPresence of neopterinNumber of cytokinesLack of effectN-acetyl serotoninIncreased SystemicNeopterin excretionOvarian carcinomaT cellsImmune responseClinical administrationNeopterinCytotoxic effectsAdministrationSynthesis inhibitorCell phenomenonCells
1988
N-cadherin and integrins: Two receptor systems that mediate neuronal process outgrowth on astrocyte surfaces
Tomaselli K, Neugebauer K, Bixby J, Lilien J, Reichard L. N-cadherin and integrins: Two receptor systems that mediate neuronal process outgrowth on astrocyte surfaces. Neuron 1988, 1: 33-43. PMID: 2856086, DOI: 10.1016/0896-6273(88)90207-3.Peer-Reviewed Original ResearchConceptsBeta 1 antibodyCultured astrocytesNeurite outgrowthN-cadherinReceptor systemProcess outgrowthCiliary ganglion neuronsNeuronal cell surface proteinsLack of effectReceptor-mediated interactionsNeuronal process outgrowthGanglion neuronsCell adhesion moleculeAstrocyte surfaceCNS axonsNeuronal receptorsAstrocytesOutgrowth of neuritesAxon growthAdhesion moleculesNeuronsN-CAMAntibodiesReceptor heterodimersCell surface proteins
1984
Autoradiographic visualization of angiotensin-converting enzyme in rat brain with [3H]captopril: localization to a striatonigral pathway.
Strittmatter SM, Lo MM, Javitch JA, Snyder SH. Autoradiographic visualization of angiotensin-converting enzyme in rat brain with [3H]captopril: localization to a striatonigral pathway. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 1599-1603. PMID: 6324207, PMCID: PMC344885, DOI: 10.1073/pnas.81.5.1599.Peer-Reviewed Original ResearchConceptsCaudate putamenSubstantia nigraStriatonigral pathwayRat brainAngiotensin II involvementIpsilateral caudate putamenTrans-synaptic changesIpsilateral substantia nigraMedian preoptic areaAngiotensin-converting enzymeLack of effectStriatal interneuronsAngiotensin IIEntopeduncular nucleusNeuronal perikaryaSubfornical organZona reticulataGlobus pallidusACE activityLocus coeruleusParaventricular nucleusPreoptic areaIbotenic acidMedial habenulaNeuronal pathways
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