2025
Association between guideline-directed medical therapy and reintervention risk following peripheral vascular interventions in patients with peripheral artery disease
Callegari S, Romain G, Capuano I, Cleman J, Scierka L, Smolderen K, Mena-Hurtado C. Association between guideline-directed medical therapy and reintervention risk following peripheral vascular interventions in patients with peripheral artery disease. Vascular Medicine 2025, 30: 293-301. PMID: 39992181, DOI: 10.1177/1358863x251320347.Peer-Reviewed Original ResearchGuideline-directed medical therapyGuideline-directed medical therapy ratesPeripheral vascular interventionsPeripheral arterial diseaseReintervention outcomesReintervention riskMedical therapyArtery diseaseVascular interventionsAngiotensin receptor blockersCompeting Risk AnalysisScore-matched cohortReceipt of statinsPost-PVIAngiotensin-converting enzymeReceptor blockersReinterventionMedicare outcomesMedication adherencePatientsRegistry dataTherapyOutcomesReceiptRisk
2023
Testosterone-associated blood pressure dysregulation in women with androgen excess polycystic ovary syndrome
Stone T, Yanes Cardozo L, Oluwatade T, Leone C, Burgos M, Okifo F, Pal L, Reckelhoff J, Stachenfeld N. Testosterone-associated blood pressure dysregulation in women with androgen excess polycystic ovary syndrome. AJP Heart And Circulatory Physiology 2023, 325: h232-h243. PMID: 37327000, PMCID: PMC10393337, DOI: 10.1152/ajpheart.00164.2023.Peer-Reviewed Original ResearchConceptsSympathetic nervous system activityBlood pressure dysregulationPolycystic ovary syndromeBody mass indexBaroreflex gainOvary syndromeBlood pressureObese insulin-resistant womenPolycystic ovary syndrome phenotypesRenin-angiotensin system activationSerum angiotensin-converting enzymeGonadotropin-releasing hormone antagonistLower sympathetic nervous system activityLower body negative pressureHeightened cardiovascular riskInsulin-resistant womenSystolic blood pressureBody negative pressureNervous system activityAngiotensin-converting enzymeIR womenCardiovascular riskSerum aldosteroneBaroreflex controlDiastolic BPUrsodeoxycholic acid is associated with a reduction in SARS‐CoV‐2 infection and reduced severity of COVID‐19 in patients with cirrhosis
John B, Bastaich D, Webb G, Brevini T, Moon A, Ferreira R, Chin A, Kaplan D, Taddei T, Serper M, Mahmud N, Deng Y, Chao H, Sampaziotis F, Dahman B. Ursodeoxycholic acid is associated with a reduction in SARS‐CoV‐2 infection and reduced severity of COVID‐19 in patients with cirrhosis. Journal Of Internal Medicine 2023, 293: 636-647. PMID: 37018129, PMCID: PMC12036735, DOI: 10.1111/joim.13630.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionCritical COVID-19Ursodeoxycholic acidPropensity scoreCOVID-19Severe acute respiratory syndrome coronavirus 2Farnesoid X receptor activityAcute respiratory syndrome coronavirus 2Human lungRespiratory syndrome coronavirus 2COVID-19-related deathsRetrospective cohort studyModerate COVID-19Symptomatic COVID-19Multivariable logistic regressionLarge national cohortSyndrome coronavirus 2Coronavirus disease 2019Angiotensin-converting enzymePotential novel targetUDCA useClinical characteristicsCohort studyVaccination statusCoronavirus 2
2020
Risk factors of COVID-19 mortality: a systematic review of current literature and lessons from recent retracted articles.
Lee K, Kim J, Hong S, Seong D, Choi Y, Ahn Y, Kim K, Kim S, Lee S, Sim W, Kim D, Jun B, Yang J, Yon D, Lee S, Kim M, Dragioti E, Li H, Jacob L, Koyanagi A, Abou Ghayda R, Shin J, Smith L. Risk factors of COVID-19 mortality: a systematic review of current literature and lessons from recent retracted articles. European Review For Medical And Pharmacological Sciences 2020, 24: 13089-13097. PMID: 33378062, DOI: 10.26355/eurrev_202012_24216.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAngiotensin Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsAsian PeopleBlack PeopleCoronary Artery DiseaseCOVID-19COVID-19 Drug TreatmentDatabases, FactualDiabetes MellitusDrug Therapy, CombinationEnzyme InhibitorsHeart FailureHumansHydroxychloroquineHypertensionImmunocompromised HostInformation DisseminationMacrolidesObesityOrgan Dysfunction ScoresProtective FactorsPulmonary Disease, Chronic ObstructiveRandomized Controlled Trials as TopicRetraction of Publication as TopicRisk FactorsSARS-CoV-2Severity of Illness IndexSex FactorsSmokingConceptsAssociated with higher risk of mortalityAssociated with higher riskHigher risk of mortalityAngiotensin receptor blockersRisk of mortalityAngiotensin-converting enzyme inhibitorsAssociated with reduced riskAngiotensin-converting enzymeSystematic reviewRisk factorsCombination therapyCOVID-19 mortalityAssociated with reduced risk of mortalityCombination therapy of hydroxychloroquineSystematic review of randomized controlled trialsReview of randomized controlled trialsRelevant cohort studiesClinical risk factorsClinical issuesRandomized Controlled TrialsCOVID-19 patientsReceptor blockersCohort studyControlled TrialsCOVID-19
2014
Prevalence of Guideline-Directed Medical Therapy Among Patients Receiving Cardiac Resynchronization Therapy Defibrillator Implantation in the National Cardiovascular Data Registry During the Years 2006 to 2008
Schneider PM, Pellegrini CN, Wang Y, Fein AS, Reynolds MR, Curtis JP, Masoudi FA, Varosy PD. Prevalence of Guideline-Directed Medical Therapy Among Patients Receiving Cardiac Resynchronization Therapy Defibrillator Implantation in the National Cardiovascular Data Registry During the Years 2006 to 2008. The American Journal Of Cardiology 2014, 113: 2052-2056. PMID: 24793671, PMCID: PMC4346333, DOI: 10.1016/j.amjcard.2014.03.049.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAged, 80 and overAngiotensin-Converting Enzyme InhibitorsCardiac Resynchronization TherapyCombined Modality TherapyDeath, Sudden, CardiacDefibrillators, ImplantableFemaleFollow-Up StudiesHeart FailureHumansMaleMiddle AgedPractice Guidelines as TopicPrevalenceRegistriesRetrospective StudiesRisk AssessmentSurvival AnalysisTreatment OutcomeUnited StatesVentricular Dysfunction, LeftConceptsGuideline-directed medical therapyCardiac resynchronization therapyImplantable Cardioverter-Defibrillator RegistryAngiotensin II receptor inhibitorΒ-blockersMedical therapyClass IReceptor inhibitorsNational Cardiovascular Data Registry Implantable Cardioverter Defibrillator RegistryCardiac resynchronization therapy defibrillator implantationLeft ventricular systolic dysfunctionSevere heart failure symptomsAngiotensin-converting enzyme inhibitorNational Cardiovascular Data RegistryClass I indicationsCRT-D implantationHeart failure symptomsVentricular systolic dysfunctionProportion of patientsSelection of patientsReal-world patientsAngiotensin-converting enzymePrevalence of guidelinesContemporaneous guidelinesQuality improvement targets
2013
Use of Evidence-based Cardiac Prevention Therapy Among Outpatients with Atrial Fibrillation
Hess PL, Kim S, Piccini JP, Allen LA, Ansell JE, Chang P, Freeman JV, Gersh BJ, Kowey PR, Mahaffey KW, Thomas L, Peterson ED, Fonarow GC. Use of Evidence-based Cardiac Prevention Therapy Among Outpatients with Atrial Fibrillation. The American Journal Of Medicine 2013, 126: 625-632.e1. PMID: 23787195, PMCID: PMC4037289, DOI: 10.1016/j.amjmed.2013.01.037.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAntihypertensive AgentsAtrial FibrillationCardiovascular DiseasesComorbidityDefibrillators, ImplantableEvidence-Based PracticeFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsLogistic ModelsMalePlatelet Aggregation InhibitorsPractice Guidelines as TopicRegistriesRisk FactorsConceptsCardiovascular comorbid conditionsEvidence-based therapiesAtrial fibrillationRisk factorsComorbid conditionsEvidence-based therapy useMore evidence-based therapiesGuideline-recommended therapiesAngiotensin receptor blockersAntiarrhythmic drug therapyCardiovascular risk factorsPeripheral vascular diseaseMinority of patientsCoronary artery diseaseMultivariable logistic regressionUS national registryAngiotensin-converting enzymeAldosterone antagonistsComorbid illnessesReceptor blockersComorbid diseasesAntiplatelet agentsArtery diseaseDiabetes mellitusHeart failure
2012
Hydrogen peroxide induces overexpression of angiotensin-converting enzyme in human umbilical vein endothelial cells
Mu X, He K, Sun H, Zhou X, Chang L, Li X, Chu W, Qiao G, Lu Y. Hydrogen peroxide induces overexpression of angiotensin-converting enzyme in human umbilical vein endothelial cells. Free Radical Research 2012, 47: 116-122. PMID: 23153326, DOI: 10.3109/10715762.2012.749987.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisCell LineCell SurvivalColforsinCREB-Binding ProteinCyclic AMPCyclic AMP-Dependent Protein KinasesEndothelial CellsHuman Umbilical Vein Endothelial CellsHumansHydrogen PeroxideHypertensionIn Situ Nick-End LabelingOligodeoxyribonucleotidesOxidative StressPeptidyl-Dipeptidase ARNA, MessengerSignal TransductionTranscriptional ActivationConceptsCAMP response element-binding proteinAngiotensin-Converting Enzyme ExpressionCyclic adenosine monophosphateProtein kinase AHuman umbilical vein endothelial cellsAngiotensin-converting enzymeCyclic adenosine monophosphate measurementsTransferase-mediated dUTP nick end-labeling (TUNEL) assayEnzyme-linked immunosorbent assayACE expressionUmbilical vein endothelial cellsVein endothelial cellsCyclic adenosine monophosphate agonistsElement-binding proteinOverexpression of angiotensin-converting enzymeEndothelial cellsExpression of angiotensin-converting enzymeAngiotensin-converting enzyme mRNAsReal-time PCRPathophysiology of hypertensionCAMP/PKA/CREB signaling pathwaySignaling pathwayRenin-angiotensin systemOxidative stressCell apoptosis
1997
Absence of Tachykinin Involvement in Leukotriene D4and Antigen-Induced Contraction of Guinea Pig Isolated Bronchus 1
Cibulsky S, Thompson D. Absence of Tachykinin Involvement in Leukotriene D4and Antigen-Induced Contraction of Guinea Pig Isolated Bronchus 1. Journal Of Pharmacology And Experimental Therapeutics 1997, 283: 1102-1109. PMID: 9399982, DOI: 10.1016/s0022-3565(24)37168-x.Peer-Reviewed Original ResearchConceptsD4-induced contractionAntigen-induced contractionGuinea-pig bronchiLeukotriene D4Endogenous tachykininsPig bronchiNeutral endopeptidaseLeukotriene D4-induced contractionMast cell-derived mediatorsAirway smooth muscle cellsConcentration of tachykininOvalbumin-induced contractionGuinea pig airwaysCell-derived mediatorsPresence of tetrodotoxinNeurokinin receptor antagonistsAngiotensin-converting enzymeSmooth muscle cellsTachykinin involvementTachykininergic responsesContractile actionPig airwaysReceptor antagonistTetrodotoxin treatmentTachykinins
1993
Renin expression in renal proximal tubule.
Moe OW, Ujiie K, Star RA, Miller RT, Widell J, Alpern RJ, Henrich WL. Renin expression in renal proximal tubule. Journal Of Clinical Investigation 1993, 91: 774-779. PMID: 7680667, PMCID: PMC288027, DOI: 10.1172/jci116296.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBlotting, SouthernCells, CulturedCloning, MolecularColforsinEnalaprilIn Vitro TechniquesIsoproterenolKidney Tubules, ProximalKineticsMaleMolecular Sequence DataMuscle, Smooth, VascularOligodeoxyribonucleotidesPoly APolymerase Chain ReactionRabbitsRatsRats, Sprague-DawleyReninRNARNA, MessengerTranscription, GeneticConceptsProximal tubule cellsCultured proximal tubule cellsRenin-angiotensin systemProximal tubulesRenal proximal tubulesTubule cellsRenin activityLocal renin-angiotensin systemPrimary culturesPresence of reninRabbit proximal tubule cellsAngiotensin-converting enzymeMammalian renal proximal tubulePrevious immunohistochemical studiesSynthesized reninAngiotensin receptorsAngiotensin IIRenin contentPolymerase chain reactionRenin expressionImmunohistochemical studyM isoproterenolM forskolinNormal ratsRenin mRNA
1986
Angiotensin-Converting Enzyme Localized in the Rat Pituitary and Adrenal Glands by [3H]Captopril Autoradiography*
STRITTMATTER S, DE SOUZA E, LYNCH D, SNYDER S. Angiotensin-Converting Enzyme Localized in the Rat Pituitary and Adrenal Glands by [3H]Captopril Autoradiography*. Endocrinology 1986, 118: 1690-1699. PMID: 3004925, DOI: 10.1210/endo-118-4-1690.Peer-Reviewed Original ResearchConceptsFmol/Adrenal medullaReserpine treatmentAdrenal glandAnterior pituitaryAngiotensin-converting enzymeRat pituitary glandAngiotension-converting enzymeAdrenal cortexDexamethasone treatmentPituitary glandPosterior pituitaryBrattleboro ratsMedullaBovine adrenal medullaPituitaryRatsIntermediate pituitaryGlandHypophysectomyAutoradiographyTreatmentChromaffin granulesAdrenalectomyAngiotensin
1985
A rat brain isozyme of angiotensin-converting enzyme. Unique specificity for amidated peptide substrates.
Strittmatter SM, Thiele EA, Kapiloff MS, Snyder SH. A rat brain isozyme of angiotensin-converting enzyme. Unique specificity for amidated peptide substrates. Journal Of Biological Chemistry 1985, 260: 9825-9832. PMID: 2991265, DOI: 10.1016/s0021-9258(17)39310-9.Peer-Reviewed Original ResearchConceptsBrain ACESubstance PLung ACERat brain corpus striatumSubstance KMet-NH2Substance P 5Hormone-releasing hormoneLung enzymeThyrotropin-releasing hormoneAngiotensin-converting enzymeSubstance P 1Striatonigral pathwayCorpus striatumRat lungAmidated peptidesLungStriatal enzymeACE isozymeGly-LeuBrain enzymeBrain isozymeSimilar extentImmunological propertiesACE
1984
Autoradiographic visualization of angiotensin-converting enzyme in rat brain with [3H]captopril: localization to a striatonigral pathway.
Strittmatter SM, Lo MM, Javitch JA, Snyder SH. Autoradiographic visualization of angiotensin-converting enzyme in rat brain with [3H]captopril: localization to a striatonigral pathway. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 1599-1603. PMID: 6324207, PMCID: PMC344885, DOI: 10.1073/pnas.81.5.1599.Peer-Reviewed Original ResearchConceptsCaudate putamenSubstantia nigraStriatonigral pathwayRat brainAngiotensin II involvementIpsilateral caudate putamenTrans-synaptic changesIpsilateral substantia nigraMedian preoptic areaAngiotensin-converting enzymeLack of effectStriatal interneuronsAngiotensin IIEntopeduncular nucleusNeuronal perikaryaSubfornical organZona reticulataGlobus pallidusACE activityLocus coeruleusParaventricular nucleusPreoptic areaIbotenic acidMedial habenulaNeuronal pathways
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