2020
p75NTR Promotes Astrocyte Proliferation in Response to Cortical Stab Wound
Chen M, Guo L, Hao J, Ni J, Lv Q, Xin X, Liao H. p75NTR Promotes Astrocyte Proliferation in Response to Cortical Stab Wound. Cellular And Molecular Neurobiology 2020, 42: 1153-1166. PMID: 33201418, PMCID: PMC11441203, DOI: 10.1007/s10571-020-01006-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesCell ProliferationGliosisMiceNerve Tissue ProteinsReceptors, Growth FactorReceptors, Nerve Growth FactorWounds, StabConceptsCortical stab woundAstrocyte proliferationStab woundsMouse astrocytesCell cycle progressionG2/MInjury mouse modelCycle progressionCortical stabP75NTR overexpressionAstrocyte activationFunctional recoveryAstrocytic responseReceptor upregulationBrain traumaAstrocyte apoptosisBrain injuryCDK2 protein levelsMouse modelCDK2 expressionAstrocytesCell cycle entryS phaseProfound alterationsProtein levels
2017
Pan-Trk Immunohistochemistry Is an Efficient and Reliable Screen for the Detection of NTRK Fusions
Hechtman J, Benayed R, Hyman D, Drilon A, Zehir A, Frosina D, Arcila M, Dogan S, Klimstra D, Ladanyi M, Jungbluth A. Pan-Trk Immunohistochemistry Is an Efficient and Reliable Screen for the Detection of NTRK Fusions. The American Journal Of Surgical Pathology 2017, 41: 1547-1551. PMID: 28719467, PMCID: PMC5636652, DOI: 10.1097/pas.0000000000000911.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorBiopsyDNA Copy Number VariationsFemaleGene DosageGene FusionGene RearrangementGenetic Predisposition to DiseaseHumansImmunohistochemistryMaleMembrane GlycoproteinsMutationNeoplasmsPhenotypePredictive Value of TestsProspective StudiesReceptor, trkAReceptor, trkBReceptor, trkCReceptors, Nerve Growth FactorReproducibility of ResultsSequence Analysis, DNAConceptsNeurotrophic tyrosine receptor kinasePan-TRK immunohistochemistryNTRK fusionsETV6-NTRK3 fusionNTRK rearrangementsMembrane accentuationETV6-NTRK3Fusion transcriptsDNA-based next-generation sequencing assaysMismatch repair-deficient colorectal carcinomasCase of secretory carcinomaDetection of NTRK fusionsDetect NTRK fusionsNext-generation sequencing assayLMNA-NTRK1 fusionTyrosine receptor kinaseFunctional fusion transcriptsPositive IHC casesPan-TrkIHC casesSecretory carcinomaAdvanced malignanciesCongenital fibrosarcomaMSK-IMPACTLMNA-NTRK1
2012
Role of Neurotrophins in the Development and Function of Neural Circuits That Regulate Energy Homeostasis
Fargali S, Sadahiro M, Jiang C, Frick AL, Indall T, Cogliani V, Welagen J, Lin WJ, Salton SR. Role of Neurotrophins in the Development and Function of Neural Circuits That Regulate Energy Homeostasis. Journal Of Molecular Neuroscience 2012, 48: 654-659. PMID: 22581449, PMCID: PMC3480664, DOI: 10.1007/s12031-012-9790-9.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAnimalsAutonomic Fibers, PostganglionicBasal MetabolismBrain StemCorticotropin-Releasing HormoneEatingEnergy MetabolismGene Expression RegulationGlucocorticoidsHomeostasisHumansHypothalamusNerve Growth FactorsNeural PathwaysNeuropeptidesReceptors, Nerve Growth FactorSignal TransductionSpinal CordSympathetic Nervous SystemConceptsNeurotrophic growth factorsNeurotrophic factorGrowth factorBrain-derived neurotrophic factorEnergy homeostasisRole of neurotrophinsSympathetic nervous systemPeripheral metabolic tissuesWhite adipose tissueNerve growth factorCiliary neurotrophic factorCentral nervous system developmentNeurotrophin-4/5Neurotrophin-3Neurotrophin familyNeuronal survivalNervous system developmentSpinal cordAdipose tissueNervous systemCircuit formationNeural circuitsMetabolic tissuesEnergy expenditureCritical gene productsDesmoplastic trichoepithelioma with perineural involvement: a series of seven cases
Jedrych J, Leffell D, McNiff JM. Desmoplastic trichoepithelioma with perineural involvement: a series of seven cases. Journal Of Cutaneous Pathology 2012, 39: 317-323. PMID: 22335590, DOI: 10.1111/j.1600-0560.2012.01876.x.Peer-Reviewed Original ResearchConceptsDesmoplastic trichoepitheliomaPerineural involvementDesmoplastic stromaMicrocystic adnexal carcinomaBasal cell carcinomaBenign epithelial proliferationsP75 neurotrophin receptorMiddle-aged womenBenign follicular tumorsCK20-positive cellsSmall dermal nervesAdnexal carcinomaCell carcinomaTumor recurrenceTypical presentationBasaloid epitheliumDermal nervesPerineural spaceNeurotrophin receptorBasaloid cellsEpithelial proliferationDermal proliferationDiffuse expressionFollicular tumorsPatients
2010
Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271
Boiko A, Razorenova O, van de Rijn M, Swetter S, Johnson D, Ly D, Butler P, Yang G, Joshua B, Kaplan M, Longaker M, Weissman I. Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271. Nature 2010, 466: 133-137. PMID: 20596026, PMCID: PMC2898751, DOI: 10.1038/nature09161.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, NeoplasmBone and BonesBone TransplantationDNA-Binding ProteinsHumansLung NeoplasmsMelanomaMelanoma-Specific AntigensMiceMice, KnockoutNeoplasm MetastasisNeoplasm ProteinsNeoplasm TransplantationNeoplastic Stem CellsNerve Tissue ProteinsNeural CrestReceptors, Nerve Growth FactorSkinSkin TransplantationTransplantation, Heterologous
2009
Axon Growth and Guidance: Receptor Regulation and Signal Transduction
O'Donnell M, Chance R, Bashaw G. Axon Growth and Guidance: Receptor Regulation and Signal Transduction. Annual Review Of Neuroscience 2009, 32: 383-412. PMID: 19400716, PMCID: PMC4765433, DOI: 10.1146/annurev.neuro.051508.135614.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody PatterningCell CommunicationCell DifferentiationCuesGrowth ConesHumansNerve Growth FactorsNervous SystemNeural PathwaysReceptors, Nerve Growth FactorSignal TransductionConceptsNeural developmental disordersReceptor regulationGrowth cone cytoskeletonAxon growthGrowth cone guidanceSignal transductionGuidance receptorsPathway functionWiring specificityRegulated actionGuidance cuesNervous systemNeuronal receptorsRegulationReceptorsRecent advancesCytoskeletonTransductionConsiderable progressDevelopmental disordersGrowthTemporal distributionMechanismConnectivity patternsFamilyElevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression
Alavian KN, Sgadò P, Alberi L, Subramaniam S, Simon HH. Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression. Neural Development 2009, 4: 11. PMID: 19291307, PMCID: PMC2667502, DOI: 10.1186/1749-8104-4-11.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCell DeathCells, CulturedDisease Models, AnimalDopamineHeterozygoteHomeodomain ProteinsImmunohistochemistryMesencephalonMiceMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3MutationNerve Tissue ProteinsNeuronsParkinson DiseaseReceptors, Nerve Growth FactorReverse Transcriptase Polymerase Chain ReactionUp-RegulationConceptsMesDA neuronsBcl-2 familyAnti-apoptotic membersCell death signalsExpression levelsMutant embryosHaplotype variationDeath signalsMitochondrial stabilityEngrailedERK1/2 activityEngrailed-1Mitochondrial insultDopaminergic neuronsGenesPostnatal maintenanceReceptor geneElevated expressionMidbrain dopaminergic neuronsHeterozygote animalsDependent mannerMutant miceNigrostriatal dopaminergic systemERK1/2 suppressionMesencephalic dopaminergic neurons
2004
Paracrine and Autocrine Functions of Brain-derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) in Brain-derived Endothelial Cells*
Kim H, Li Q, Hempstead BL, Madri JA. Paracrine and Autocrine Functions of Brain-derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) in Brain-derived Endothelial Cells*. Journal Of Biological Chemistry 2004, 279: 33538-33546. PMID: 15169782, DOI: 10.1074/jbc.m404115200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBlotting, WesternBrainBrain-Derived Neurotrophic FactorCaspase 3CaspasesCell Line, TransformedCerebral CortexEndothelial CellsEnzyme ActivationEnzyme InhibitorsFlow CytometryGene Expression RegulationHypoxiaImmunohistochemistryImmunosorbent TechniquesMAP Kinase Kinase KinasesMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Mitogen-Activated Protein KinasesNerve Growth FactorPhosphoinositide-3 Kinase InhibitorsPhosphorylationRatsReceptor, Nerve Growth FactorReceptor, trkBReceptors, Nerve Growth FactorRecombinant Fusion ProteinsRecombinant ProteinsTransfectionVascular Endothelial Growth Factor Receptor-2ConceptsBrain-derived neurotrophic factorEndogenous brain-derived neurotrophic factorBrain-derived endothelial cellsNerve growth factorEndothelial cellsNeurotrophic factorAutocrine functionExpression of BDNFCentral nervous system (CNS) endotheliumPro-nerve growth factorGrowth factorExpression of TrkBNormoxic conditionsCentral nervous systemBDNF levelsBDNF expressionBDNF responseTrkB phosphorylationNervous systemTrkBSurvival/apoptosisCell survival/apoptosisRobust angiogenesisAkt pathwayInhibitor of phosphatidylinositol
2003
The Nogo-66 receptor: focusing myelin inhibition of axon regeneration
McGee AW, Strittmatter SM. The Nogo-66 receptor: focusing myelin inhibition of axon regeneration. Trends In Neurosciences 2003, 26: 193-198. PMID: 12689770, DOI: 10.1016/s0166-2236(03)00062-6.Peer-Reviewed Original ResearchMeSH KeywordsAcute-Phase ProteinsAnimalsAxonsCells, CulturedGPI-Linked ProteinsHumansIn Vitro TechniquesMiceMyelin ProteinsMyelin SheathMyelin-Associated GlycoproteinMyelin-Oligodendrocyte GlycoproteinNerve RegenerationNeural InhibitionNeuronal PlasticityNogo ProteinsNogo Receptor 1RatsReceptor, Nerve Growth FactorReceptors, Cell SurfaceReceptors, Nerve Growth FactorSignal TransductionConceptsNogo-66 receptorMembrane protein NogoSpinal cord injuryFunctional recoveryCord injuryAxonal regrowthSecond messenger pathwaysProtein NogoAdult CNSAxon regenerationMyelin inhibitionAxonal outgrowthAdditional studiesCNS myelinMyelinNeurite elongationPhysiological roleReceptorsMolecular determinantsInhibitorsInhibitionNGRCurrent understanding
2002
Inhibition of Human CD4+CD25+high Regulatory T Cell Function
Baecher-Allan C, Viglietta V, Hafler DA. Inhibition of Human CD4+CD25+high Regulatory T Cell Function. The Journal Of Immunology 2002, 169: 6210-6217. PMID: 12444126, DOI: 10.4049/jimmunol.169.11.6210.Peer-Reviewed Original ResearchMeSH KeywordsAntigensCD4-Positive T-LymphocytesCoculture TechniquesCytokinesGlucocorticoid-Induced TNFR-Related ProteinHumansImmune ToleranceInterleukin-10Lymphocyte ActivationModels, ImmunologicalReceptors, Interleukin-2Receptors, Nerve Growth FactorReceptors, Tumor Necrosis FactorSignal TransductionT-Lymphocyte SubsetsTransforming Growth Factor betaConceptsAutoreactive T cellsT cellsRegulatory cellsRegulatory T cell functionInflammatory immune responseT cell functionStrength of stimulationPathologic responseInhibition of humanMicrobial AgsResponder cellsImmune responseEffector functionsTCR stimuliTime pointsCell functionTCR signalsPotent regulatorDifferential activationExtent of suppressionStimulationActivationCellsSuppressionStimuli
1998
Differential Regulation of Neurotrophin and trkReceptor mRNAs in Catecholaminergic Nuclei during Chronic Opiate Treatment and Withdrawal
Numan S, Lane-Ladd S, Zhang L, Lundgren K, Russell D, Seroogy K, Nestler E. Differential Regulation of Neurotrophin and trkReceptor mRNAs in Catecholaminergic Nuclei during Chronic Opiate Treatment and Withdrawal. Journal Of Neuroscience 1998, 18: 10700-10708. PMID: 9852605, PMCID: PMC6793370, DOI: 10.1523/jneurosci.18-24-10700.1998.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain-Derived Neurotrophic FactorDrug Administration ScheduleDrug ImplantsGene Expression RegulationLocus CoeruleusMaleMesencephalonMorphineNerve Growth FactorsNeurotrophin 3RatsRats, Sprague-DawleyReceptor Protein-Tyrosine KinasesReceptor, Ciliary Neurotrophic FactorReceptor, trkCReceptors, Nerve Growth FactorRNA, MessengerTime FactorsVentral Tegmental AreaConceptsBrain-derived neurotrophic factorVentral tegmental areaChronic morphine treatmentChronic opiate treatmentLocus coeruleusHr of withdrawalMorphine treatmentNeurotrophin-3TrkC mRNAOpiate treatmentNeurotrophin brain-derived neurotrophic factorNT-3 mRNA expressionLevels of TrkBOpiate-induced plasticityTrkB mRNA levelsChronic morphine exposureNT-3 mRNATrkC mRNA levelsMRNA levelsEndogenous neurotrophinsExogenous neurotrophinsTrk mRNABDNF mRNAMorphine exposureTrkB mRNA
1997
Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex.
Anton E, Marchionni M, Lee K, Rakic P. Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex. Development 1997, 124: 3501-10. PMID: 9342043, DOI: 10.1242/dev.124.18.3501.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsCell CommunicationCell MovementCerebral CortexCulture TechniquesFatty Acid-Binding Protein 7Fatty Acid-Binding ProteinsGlycoproteinsNerve Growth FactorsNerve Tissue ProteinsNeuregulinsNeurogliaNeuronsRatsRats, Sprague-DawleyReceptor, ErbB-2Receptors, Nerve Growth FactorSignal TransductionConceptsRadial glial developmentRadial glial cellsBrain lipid-binding proteinCerebral cortexGlial cellsNeuronal migrationGlial developmentRadial glial cell functionGlial growth factorGlial cell functionRadial glial fibersRadial glial fiber systemNeuronal cell migrationCortical neuronsGlial interactionsRadial gliaGlial fibersGlial moleculesCortexNeuronsGrowth factorErbB2 receptorCell functionDependent mannerCell migrationSorting of Two Polytopic Proteins, the γ-Aminobutyric Acid and Betaine Transporters, in Polarized Epithelial Cells*
Perego C, Bulbarelli A, Longhi R, Caimi M, Villa A, Caplan M, Pietrini G. Sorting of Two Polytopic Proteins, the γ-Aminobutyric Acid and Betaine Transporters, in Polarized Epithelial Cells*. Journal Of Biological Chemistry 1997, 272: 6584-6592. PMID: 9045687, DOI: 10.1074/jbc.272.10.6584.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBiological TransportCarrier ProteinsCell CompartmentationCell LineCell MembraneCell PolarityCytosolDogsEndoplasmic ReticulumFluorescent Antibody Technique, IndirectGABA Plasma Membrane Transport ProteinsHumansMembrane ProteinsMembrane Transport ProteinsMolecular Sequence DataOrganic Anion TransportersReceptors, Nerve Growth FactorRecombinant Fusion ProteinsRecombinant ProteinsStructure-Activity RelationshipTransfectionConceptsCytosolic tailMadin-Darby canine kidney cellsCanine kidney cellsBetaine transporterEndoplasmic reticulumPolarized epithelial cellsTerminal cytosolic domainHuman nerve growth factor receptorKidney cellsPolytopic proteinsApical proteinsCytosolic domainChimeric transportersGrowth factor receptorApical localizationBasolateral distributionBasic residuesBasolateral localizationTransporter isoformsGAT-1Nerve growth factor receptorBgtBasolateral surfaceFactor receptorProtein
1993
Low-affinity p75 nerve growth factor receptor expression in the embryonic monkey telencephalon: Timing and localization in diverse cellular elements
Meinecke D, Rakic P. Low-affinity p75 nerve growth factor receptor expression in the embryonic monkey telencephalon: Timing and localization in diverse cellular elements. Neuroscience 1993, 54: 105-116. PMID: 8515837, DOI: 10.1016/0306-4522(93)90386-t.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEmbryo, MammalianImmunohistochemistryMacaca mulattaNerve FibersReceptors, Nerve Growth FactorTelencephalonTime FactorsTissue DistributionConceptsDiverse cellular elementsNerve growth factor receptorGrowth factor receptorCerebral cortexCellular elementsFactor receptorAxonal processesNerve growth factor receptor expressionLow-affinity nerve growth factor receptorGrowth factorEmbryonic day 45Transient subplate neuronsGrowth factor receptor expressionFactor receptor expressionOnset of neurogenesisNerve growth factorHuman nerve growth factor receptorGrowth factor familyMonkey telencephalonSubplate neuronsSubplate zoneReceptor expressionFetal brainActive neurogenesisNeuronal proliferation
1992
Estrogen receptors colocalize with low-affinity nerve growth factor receptors in cholinergic neurons of the basal forebrain.
Toran-Allerand CD, Miranda RC, Bentham WD, Sohrabji F, Brown TJ, Hochberg RB, MacLusky NJ. Estrogen receptors colocalize with low-affinity nerve growth factor receptors in cholinergic neurons of the basal forebrain. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 4668-4672. PMID: 1316615, PMCID: PMC49144, DOI: 10.1073/pnas.89.10.4668.Peer-Reviewed Original ResearchConceptsLow-affinity nerve growth factor receptorNerve growth factor receptorGrowth factor receptorBasal forebrainCholinergic neuronsSame neuronsFactor receptorCholinergic marker enzyme choline acetyltransferaseGonadal steroid hormone estrogenBrain-derived neurotrophic factorPrimate basal forebrainRodent basal forebrainSteroid hormone estrogenEnzyme choline acetyltransferaseNerve growth factorSitu hybridization histochemistryEstrogen deficiencyNeurotrophic factorNeurotrophin-3Cholinergic functionCholine acetyltransferaseNeuronal survivalHormone estrogenEstrogen receptorClinical conditionsTwo RFLPs near HOX2@INGFR at locus D17S444E
Kennedy J, Honer W, Kaufmann C, Martignetti J, Brosius J, Kidd K. Two RFLPs near HOX2@INGFR at locus D17S444E. Nucleic Acids Research 1992, 20: 1171-1171. PMID: 1372406, PMCID: PMC312148, DOI: 10.1093/nar/20.5.1171.Peer-Reviewed Original Research
1988
N-cadherin and integrins: Two receptor systems that mediate neuronal process outgrowth on astrocyte surfaces
Tomaselli K, Neugebauer K, Bixby J, Lilien J, Reichard L. N-cadherin and integrins: Two receptor systems that mediate neuronal process outgrowth on astrocyte surfaces. Neuron 1988, 1: 33-43. PMID: 2856086, DOI: 10.1016/0896-6273(88)90207-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesCadherinsCerebral CortexChickensDendritesGanglia, ParasympatheticImmune SeraIntegrinsNerve Growth FactorsRatsRats, Inbred StrainsReceptors, Cell SurfaceReceptors, Nerve Growth FactorConceptsBeta 1 antibodyCultured astrocytesNeurite outgrowthN-cadherinReceptor systemProcess outgrowthCiliary ganglion neuronsNeuronal cell surface proteinsLack of effectReceptor-mediated interactionsNeuronal process outgrowthGanglion neuronsCell adhesion moleculeAstrocyte surfaceCNS axonsNeuronal receptorsAstrocytesOutgrowth of neuritesAxon growthAdhesion moleculesNeuronsN-CAMAntibodiesReceptor heterodimersCell surface proteins
1986
DNA polymorphisms for the nerve growth factor receptor gene exclude its role in familial dysautonomia.
Breakefield X, Ozelius L, Bothwell M, Chao M, Axelrod F, Kramer P, Kidd K, Lanahan A, Johnson D, Ross A. DNA polymorphisms for the nerve growth factor receptor gene exclude its role in familial dysautonomia. Molecular Biology & Medicine 1986, 3: 483-94. PMID: 2886891.Peer-Reviewed Original ResearchConceptsNerve growth factor receptor geneGrowth factor receptor geneFactor receptor geneReceptor geneExcellent genetic markerAshkenazic Jewish populationPolymorphic restriction sitesDNA polymorphismsFamilial dysautonomiaGenetic markersBeta subunitLinkage analysisGenesRestriction sitesChromosome 17qAutosomal recessive modeAllelesPossible roleRecessive modeAffected individualsNeuronal factorsPolymorphismNGF actionCentimorgansMore members
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