2020
79 Leptospirosis
Vinetz J, Watt G. 79 Leptospirosis. 2020, 636-640. DOI: 10.1016/b978-0-323-55512-8.00079-x.Peer-Reviewed Original ResearchSevere leptospirosisAcute kidney injuryEndothelial cell dysfunctionKey pathologic featuresThird-generation cephalosporinsMarked functional impairmentHigh mortality ratePathogenesis of leptospirosisMost disease transmissionRefractory shockKidney injuryOral doxycyclineParenteral penicillinPulmonary hemorrhageSubstantial morbidityPathologic featuresHistopathologic changesFunctional impairmentAvailable vaccinesCell dysfunctionDiagnostic confirmationRisk populationsMilder casesMortality rateLeptospirosis
2017
Lack of Effect of Murine Astrovirus Infection on Dextran Sulfate-induced Colitis in NLRP3-deficient Mice.
Compton SR, Booth CJ, Macy JD. Lack of Effect of Murine Astrovirus Infection on Dextran Sulfate-induced Colitis in NLRP3-deficient Mice. Journal Of The American Association For Laboratory Animal Science 2017, 67: 400-406. PMID: 28935001, PMCID: PMC5621567.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstroviridaeAstroviridae InfectionsColitisColonDextran SulfateDisease Models, AnimalFemaleGastrointestinal MicrobiomeInflammasomesMaleMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinRandom AllocationReal-Time Polymerase Chain ReactionReproducibility of ResultsRodent DiseasesRodentiaConceptsColitis modelInflammatory bowel disease researchNOD-like receptor 3Induced colitis modelSeverity of colitisDextran sodium sulfateDSS colitis modelNLRP3-deficient miceDefective inflammasome activationLack of effectMucosal ulcerationIntestinal inflammationHistopathologic changesIntestinal permeabilityAstrovirus infectionFemale miceClinical signsDeficient miceNLRP3 mutationsClinical diseaseInflammasome activationGastrointestinal tractMurine astrovirusIntestinal bacteriaIntestinal epithelium
1997
In Situ Characterization of the Human Host Response to Leishmania panamensis
Palma G, Saravia N. In Situ Characterization of the Human Host Response to Leishmania panamensis. American Journal Of Dermatopathology 1997, 19: 585-590. PMID: 9415615, DOI: 10.1097/00000372-199712000-00006.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnimalsAntibodies, ProtozoanAntigen-Antibody ReactionsAntigens, ProtozoanBiomarkersBiopsyCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesEpidermisFluorescent Antibody Technique, IndirectGranulocytesGranulomaHumansImmunity, CellularImmunohistochemistryLeishmaniaLeishmaniasisLymphocyte ActivationMaleMiddle AgedNecrosisRegression AnalysisSkinConceptsHuman host responseHost responseLeishmania panamensisPresence of amastigotesT cell subpopulationsImmune response dataIndirect immunoperoxidase methodCD8 ratioDermal infiltrateMale patientsHistopathologic changesParticular cell populationPrognostic indicatorLeishmania infectionSkin biopsiesPlasma cellsT cellsDermal distributionCutaneous leishmaniasisProspective analysisB cellsB lymphocytesUpper dermisImmunoperoxidase methodDisease evolution
1982
Effects of Vaccination on Cytomegalovirus-Associated Interstitial Pneumonia in Strain 2 Guinea Pigs
Bia F, Lucia H, Fong C, Tarsio M, Hsiung G. Effects of Vaccination on Cytomegalovirus-Associated Interstitial Pneumonia in Strain 2 Guinea Pigs. The Journal Of Infectious Diseases 1982, 145: 742-747. PMID: 6281341, DOI: 10.1093/infdis/145.2.742.Peer-Reviewed Original ResearchConceptsStrain 2 guinea pigsInterstitial pneumoniaCMV infectionGuinea pigsMinimal histopathologic changesTissue culture infective dosesBilateral interstitial pneumoniaEffect of vaccinationStudy of pathogenesisGuinea pig cytomegalovirusHistologic evidenceHistopathologic changesPneumoniaVaccinated animalsInfective dosesCytomegalovirusInfectionLungInfected tissuesPathogenesisPigsTissuePreventionAnimalsViremia
1976
Kidney transplant biopsies in the diagnosis and management of acute rejection reactions
Finkelstein F, Siegel N, Bastl C, Forrest J, Kashgarian M. Kidney transplant biopsies in the diagnosis and management of acute rejection reactions. Kidney International 1976, 10: 171-178. PMID: 787617, DOI: 10.1038/ki.1976.92.Peer-Reviewed Original ResearchConceptsAcute clinical rejectionTime of biopsyClinical rejectionAcute rejectionTransplant biopsiesGraft recipientsClinical statusRejection reactionAcute rejection reactionGlomerular endothelial swellingStandard immunosuppressive treatmentInstitution of treatmentKidney transplant biopsiesRenal transplant biopsiesHistopathologic categorizationImmunosuppressive treatmentClinical responseRenal functionEndothelial swellingHistologic featuresEndothelial edemaHistopathologic changesInterstitial edemaClinical dataRetrospective analysis
1975
Demonstration of Immune Complexes in Spontaneous and Histamine-Induced Lesions and in Normal Skin of Patients with Leukocytoclastic Angiitis
Braverman I, Yen A. Demonstration of Immune Complexes in Spontaneous and Histamine-Induced Lesions and in Normal Skin of Patients with Leukocytoclastic Angiitis. Journal Of Investigative Dermatology 1975, 64: 105-112. PMID: 123546, DOI: 10.1111/1523-1747.ep12510321.Peer-Reviewed Original ResearchConceptsHistamine-induced whealElectron-dense depositsImmune complexesUninvolved skinSpontaneous lesionsDirect immunofluorescenceImmune reactantsImmune complex pathogenesisImmune complex diseaseVessel wallLeukocytoclastic angiitisHistopathologic changesComplex pathogenesisLocal injectionNormal skinPostcapillary venulesLesionsPatientsWhealDamage ensuesImmunofluorescenceAngitisSkinNeutrophilsHistamine
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