2025
Exogenous pyruvate is therapeutic against colitis by targeting cytosolic phospholipase A2
Hasan S, Ghani N, Zhao X, Good J, Liu C. Exogenous pyruvate is therapeutic against colitis by targeting cytosolic phospholipase A2. Genes & Diseases 2025, 12: 101571. DOI: 10.1016/j.gendis.2025.101571.Peer-Reviewed Original ResearchInflammatory bowel diseaseUlcerative colitisBowel diseaseDextran sodium sulfate-induced colitisChronic inflammatory bowel diseaseUlcerative colitis pathogenesisTight junction proteinsPhase of inflammationCytosolic phospholipase A2Immune dysregulationColitis pathogenesisReal-time PCRNFkB translocationCellular metabolitesColon histologyJunction proteinsInflammatory diseasesColitis modelQuantitative real-time PCRTherapeutic effectUlcerative colitis modelAction of pyruvateImmunofluorescence stainingColitisRNA sequencing analysis
2024
Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling
Cadinu P, Sivanathan K, Misra A, Xu R, Mangani D, Yang E, Rone J, Tooley K, Kye Y, Bod L, Geistlinger L, Lee T, Mertens R, Ono N, Wang G, Sanmarco L, Quintana F, Anderson A, Kuchroo V, Moffitt J, Nowarski R. Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling. Cell 2024, 187: 2010-2028.e30. PMID: 38569542, PMCID: PMC11017707, DOI: 10.1016/j.cell.2024.03.013.Peer-Reviewed Original ResearchConceptsMultiplexed error-robust fluorescence in situ hybridizationFluorescence in situ hybridizationSpatial organizationCell-cell interactionsDiverse cell populationsHealthy gutMouse colitis modelExpression profilesBiogeographyGutNon-immune cellsGut inflammationSpatial remodelingInflammation-associated fibroblastsTissue neighborhoodsInflammation-induced remodelingCell populationsFibroblastsImmune cellsCellsColitis modelUlcerative colitisFibroblastic originStage progressionExpression
2017
Lack of Effect of Murine Astrovirus Infection on Dextran Sulfate-induced Colitis in NLRP3-deficient Mice.
Compton SR, Booth CJ, Macy JD. Lack of Effect of Murine Astrovirus Infection on Dextran Sulfate-induced Colitis in NLRP3-deficient Mice. Journal Of The American Association For Laboratory Animal Science 2017, 67: 400-406. PMID: 28935001, PMCID: PMC5621567.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstroviridaeAstroviridae InfectionsColitisColonDextran SulfateDisease Models, AnimalFemaleGastrointestinal MicrobiomeInflammasomesMaleMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinRandom AllocationReal-Time Polymerase Chain ReactionReproducibility of ResultsRodent DiseasesRodentiaConceptsColitis modelInflammatory bowel disease researchNOD-like receptor 3Induced colitis modelSeverity of colitisDextran sodium sulfateDSS colitis modelNLRP3-deficient miceDefective inflammasome activationLack of effectMucosal ulcerationIntestinal inflammationHistopathologic changesIntestinal permeabilityAstrovirus infectionFemale miceClinical signsDeficient miceNLRP3 mutationsClinical diseaseInflammasome activationGastrointestinal tractMurine astrovirusIntestinal bacteriaIntestinal epitheliumMembrane‐bound Dickkopf‐1 in Foxp3+ regulatory T cells suppresses T‐cell‐mediated autoimmune colitis
Chae W, Park J, Henegariu O, Yilmaz S, Hao L, Bothwell ALM. Membrane‐bound Dickkopf‐1 in Foxp3+ regulatory T cells suppresses T‐cell‐mediated autoimmune colitis. Immunology 2017, 152: 265-275. PMID: 28556921, PMCID: PMC5588763, DOI: 10.1111/imm.12766.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsAutoimmune DiseasesAutoimmunityCell MembraneCell ProliferationCHO CellsColitisColonCricetulusDisease Models, AnimalDNA-Binding ProteinsForkhead Transcription FactorsGenetic Predisposition to DiseaseIntercellular Signaling Peptides and ProteinsLymphocyte ActivationMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein KinasesPhenotypeSelf ToleranceSignal TransductionT-Lymphocytes, RegulatoryTime FactorsTransfectionConceptsRegulatory T cellsTreg cellsDKK-1 expressionAutoimmune colitisDickkopf-1T cellsT cell-mediated toleranceEffector CD4 T cellsCD4 T cellsInduction of toleranceT cell proliferationT cell receptor stimulationNovel TregColitis modelImmunological homeostasisImmunological toleranceFoxp3Receptor stimulationCanonical Wnt pathwayColitisFunctional inhibitionMonoclonal antibodiesDe novo protein synthesisProtein kinase pathwaySuppressor functionMembrane-bound Dickkopf-1 in Foxp3+ regulatory T cells suppresses T cell-mediated autoimmune colitis
Chae W, Hao L, Henegariu O, Yilmaz S, Bothwell A. Membrane-bound Dickkopf-1 in Foxp3+ regulatory T cells suppresses T cell-mediated autoimmune colitis. The Journal Of Immunology 2017, 198: 156.8-156.8. DOI: 10.4049/jimmunol.198.supp.156.8.Peer-Reviewed Original ResearchDKK-1 expressionDickkopf-1T cellsImmunological toleranceT cell-mediated toleranceEffector CD4 T cellsT cell-mediated colitisRegulatory T cellsCD4 T cellsT cell receptor stimulationCell receptor stimulationActivated TregsAutoimmune colitisTreg markersColitis modelReceptor stimulationTregsCanonical Wnt pathwayDe novo protein synthesisCell proliferationColitisWnt pathwayNovo protein synthesisMAPK pathwayWnt ligands
2016
Sex Differences and Drug Dose Influence the Role of the α7 Nicotinic Acetylcholine Receptor in the Mouse Dextran Sodium Sulfate-Induced Colitis Model
AlSharari S, Bagdas D, Akbarali H, Lichtman P, Raborn E, Cabral G, Carroll F, McGee E, Damaj M. Sex Differences and Drug Dose Influence the Role of the α7 Nicotinic Acetylcholine Receptor in the Mouse Dextran Sodium Sulfate-Induced Colitis Model. Nicotine & Tobacco Research 2016, 19: 460-468. PMID: 27639096, PMCID: PMC6894014, DOI: 10.1093/ntr/ntw245.Peer-Reviewed Original ResearchConceptsΑ7 nicotinic acetylcholine receptorWild-type miceColitis severityNicotinic acetylcholine receptorsFemale miceHigher tumor necrosis factor-alpha levelsAcetylcholine receptorsTumor necrosis factor-alpha levelsNecrosis factor-alpha levelsLittermate wild-type miceAnti-colitis activityAnti-colitis effectΑ7 knockout miceDextran sodium sulfatePathogenesis of colitisAnti-inflammatory effectsFemale adult miceViable therapeutic approachSeverity of diseaseSex differencesColon lengthDisease activityColonic levelsColitis modelUlcerative colitis
2015
Sex Differences and Drug Dose Influence the Role of the α-7 Nicotinic Acetylcholine Receptor in the Mouse Dextran Sodium Sulfate-Induced Colitis Model
AlSharari S, Bagdas D, Akbarali H, Cabral G, Carroll I, Damaj I, Lichtman P. Sex Differences and Drug Dose Influence the Role of the α-7 Nicotinic Acetylcholine Receptor in the Mouse Dextran Sodium Sulfate-Induced Colitis Model. The American Journal Of Gastroenterology 2015, 110: s776. DOI: 10.14309/00000434-201510001-01826.Peer-Reviewed Original Research
2011
Interleukin-1β (IL-1β) promotes susceptibility of Toll-like receptor 5 (TLR5) deficient mice to colitis
Carvalho FA, Nalbantoglu I, Ortega-Fernandez S, Aitken JD, Su Y, Koren O, Walters WA, Knight R, Ley RE, Vijay-Kumar M, Gewirtz AT. Interleukin-1β (IL-1β) promotes susceptibility of Toll-like receptor 5 (TLR5) deficient mice to colitis. Gut 2011, 61: 373. PMID: 21646247, DOI: 10.1136/gut.2011.240556.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalCecumColitis, UlcerativeDisease Models, AnimalDisease SusceptibilityGene Expression ProfilingInterleukin-1betaMaleMetagenomeMiceMice, KnockoutMyeloid Differentiation Factor 88Receptors, Interleukin-10Reverse Transcriptase Polymerase Chain ReactionSignal TransductionToll-Like Receptor 5ConceptsToll-like receptor 4T5KO miceGut microbiotaColitis modelIL-1βAbsence of TLR4Toll-like receptor 5 deficient (T5KO) miceAnti-inflammatory cytokine interleukin-10Endogenous anti-inflammatory pathwayToll-like receptor 5Loss of TLR5Anti-inflammatory pathwayIL-10 receptorCytokine interleukin-10Double knockoutIL-10 signalingIL-1 receptorProinflammatory gene expressionWild-type littermatesColitogenic microbiotaSpontaneous colitisUniform colitisSevere colitisImmune dysregulationIntestinal inflammation
2009
NOD2 regulates hematopoietic cell function during graft-versus-host disease
Penack O, Smith O, Cunningham-Bussel A, Liu X, Rao U, Yim N, Na I, Holland A, Ghosh A, Lu S, Jenq R, Liu C, Murphy G, Brandl K, van den Brink M. NOD2 regulates hematopoietic cell function during graft-versus-host disease. Journal Of Experimental Medicine 2009, 206: 2101-2110. PMID: 19737867, PMCID: PMC2757869, DOI: 10.1084/jem.20090623.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsNOD2 deficiencyHost diseaseCrohn's diseaseExperimental allogeneic bone marrow transplantationAllogeneic bone marrow transplantationHost antigen-presenting cellsAllo-BMT recipientsDevelopment of GVHDExperimental colitis modelHematopoietic cellsHost hematopoietic cellsDonor T cellsIndependent risk factorBone marrow chimerasBone marrow transplantationChimeric recipientsIntestinal inflammationProinflammatory stateColitis modelMarrow transplantationNOD2 mutationsRisk factorsT cellsPaneth cells
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