2019
Parkinson’s disease protein DJ-1 regulates ATP synthase protein components to increase neuronal process outgrowth
Chen R, Park HA, Mnatsakanyan N, Niu Y, Licznerski P, Wu J, Miranda P, Graham M, Tang J, Boon AJW, Cossu G, Mandemakers W, Bonifati V, Smith PJS, Alavian KN, Jonas EA. Parkinson’s disease protein DJ-1 regulates ATP synthase protein components to increase neuronal process outgrowth. Cell Death & Disease 2019, 10: 469. PMID: 31197129, PMCID: PMC6565618, DOI: 10.1038/s41419-019-1679-x.Peer-Reviewed Original ResearchConceptsDJ-1C subunitATP synthaseParkinson's disease protein DJ-1Β-subunitProtein componentsATP synthase β subunitMitochondrial uncouplingDJ-1 bindsATP synthase efficiencyATP synthase F1Synthase β subunitATP production efficiencyProtein DJ-1Neuronal process extensionProtein levelsNeuronal process outgrowthDJ-1 knockoutWild-type counterpartsSubunit protein levelsDJ-1 mutationsSevere defectsCell metabolismKO neuronsKO cultures
2015
Bcl-xL Is Necessary for Neurite Outgrowth in Hippocampal Neurons
Park HA, Licznerski P, Alavian KN, Shanabrough M, Jonas EA. Bcl-xL Is Necessary for Neurite Outgrowth in Hippocampal Neurons. Antioxidants And Redox Signaling 2015, 22: 93-108. PMID: 24787232, PMCID: PMC4281845, DOI: 10.1089/ars.2013.5570.Peer-Reviewed Original ResearchConceptsDeath receptor 6Hippocampal neuronsNeurite outgrowthExacerbation of hypoxiaBcl-xLNeuronal outgrowthNeuronal process outgrowthNeuronal injuryNeurodegenerative stimuliVivo ischemiaHypoxic injuryNeuronal survivalBrain injuryImpairs neurite outgrowthHypoxic controlsSynapse numberAxonal pruningNeurite damageB cellsReceptor 6Synaptic plasticityDR6 expressionSynapse formationEarly increaseNeurons
2006
Gelation under dynamic conditions: A strategy for in vitro cell ordering
Doncel-Pérez E, Darder M, Martín-López E, Vázquez L, Nieto-Sampedro M, Ruiz-Hitzky E. Gelation under dynamic conditions: A strategy for in vitro cell ordering. Journal Of Materials Science: Materials In Medicine 2006, 17: 795-802. PMID: 16932860, DOI: 10.1007/s10856-006-9837-y.Peer-Reviewed Original ResearchConceptsSpin-coating conditionsAtomic force microscopyNeuronal process outgrowthLow-temperature scanning electron microscopyScanning electron microscopyBiodegradable substrateRat C6 glioma cellsFluorescence microscopyCentrifugal forceCell orderingDynamic conditionsC6 glioma cellsForce microscopyProcess outgrowthAxon growthFibrin hydrogelsUniform distributionCell modelGlioma cellsC6 cellsElectron microscopy
1988
N-cadherin and integrins: Two receptor systems that mediate neuronal process outgrowth on astrocyte surfaces
Tomaselli K, Neugebauer K, Bixby J, Lilien J, Reichard L. N-cadherin and integrins: Two receptor systems that mediate neuronal process outgrowth on astrocyte surfaces. Neuron 1988, 1: 33-43. PMID: 2856086, DOI: 10.1016/0896-6273(88)90207-3.Peer-Reviewed Original ResearchConceptsBeta 1 antibodyCultured astrocytesNeurite outgrowthN-cadherinReceptor systemProcess outgrowthCiliary ganglion neuronsNeuronal cell surface proteinsLack of effectReceptor-mediated interactionsNeuronal process outgrowthGanglion neuronsCell adhesion moleculeAstrocyte surfaceCNS axonsNeuronal receptorsAstrocytesOutgrowth of neuritesAxon growthAdhesion moleculesNeuronsN-CAMAntibodiesReceptor heterodimersCell surface proteins
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