2025
Real world treatment patterns for recurrent and metastatic head and neck cancer in the post-KEYNOTE 048 era
Lee D, Pan A, Yaskolko M, Chiorazzi M, Bhatia A, Burtness B, Ishizuka J. Real world treatment patterns for recurrent and metastatic head and neck cancer in the post-KEYNOTE 048 era. Frontiers In Oncology 2025, 15: 1577509. PMID: 40416868, PMCID: PMC12099209, DOI: 10.3389/fonc.2025.1577509.Peer-Reviewed Original ResearchHead and neck squamous cell carcinomaCombined positive scoreAnti-PD1 monotherapyMetastatic head and neck squamous cell carcinomaOral cavity primariesMetastatic head and neck cancerNon-HPV-associated tumorsPatients treated first-lineToxicity of combined treatmentNeck squamous cell carcinomaReal-world treatment patternsHead and neck cancerFlatiron Health databaseAnti-PD1 therapyChemotherapy improves survivalHPV-associated diseasesFirst-line treatmentSquamous cell carcinomaLog-rank testSubgroup of patientsKaplan-Meier curvesTreatment group differencesKEYNOTE-048Non-HPVAnti-PD1
2019
Predictors of early immunotherapy response in head and neck cancer: Per lesion analysis of a prospective randomized trial with nivolumab.
Yu Y, Chen L, Riaz N, Kang J, Tsai C, Sherman E, Lee N, McBride S. Predictors of early immunotherapy response in head and neck cancer: Per lesion analysis of a prospective randomized trial with nivolumab. Journal Of Clinical Oncology 2019, 37: 6041-6041. DOI: 10.1200/jco.2019.37.15_suppl.6041.Peer-Reviewed Original ResearchNon-irradiated lesionsOral cavity primariesRisk of progressionNeck cancerExact testLogistic regressionNeck primary sitePrimary tumor subsiteTrials of nivolumabPD-L1 statusLymph node metastasisMultivariate logistic regressionPredictors of responsePrimary tumor siteStereotactic body radiotherapyFisher's exact testElicit clinical responsesStable diseaseCheckpoint inhibitorsMetastatic headClinical responseFirst doseLiver metastasesMetastasis locationProgressive disease
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