2025
Carcinogenic Industrial Air Emissions and Lung Cancer Risk in a Cohort of 440,000 Americans.
Madrigal J, Fisher J, Pruitt C, Liao L, Graubard B, Ward M, Silverman D, Jones R. Carcinogenic Industrial Air Emissions and Lung Cancer Risk in a Cohort of 440,000 Americans. American Journal Of Respiratory And Critical Care Medicine 2025, 211: 1241-1252. PMID: 40315142, DOI: 10.1164/rccm.202409-1738oc.Peer-Reviewed Original ResearchConceptsLung cancer riskCancer riskAssociated with riskNIH-AARP DietEvaluate lung cancer riskLung carcinogensAssociated with lung cancerCox proportional hazards modelsNIH-AARPHealth StudyProportional hazards modelSquamous cell carcinomaStrong associationsAssociated with benzeneHazards modelIndustrial air emissionsEnrollment residenceCell carcinomaOverall riskLung cancer developmentSmokingAssociationRiskHistological subtypesLung cancerLong-Term Exposure to Uranium and Arsenic in Community Drinking Water and CKD Risk Among California Women
Medgyesi D, Mohan S, Bangia K, Spielfogel E, Spaur M, Basu A, Fisher J, Madrigal J, Domingo-Relloso A, Jones R, Ward M, Lacey J, Sanchez T, Investigators C. Long-Term Exposure to Uranium and Arsenic in Community Drinking Water and CKD Risk Among California Women. American Journal Of Kidney Diseases 2025 PMID: 40381930, DOI: 10.1053/j.ajkd.2025.04.008.Peer-Reviewed Original ResearchChronic kidney disease riskCommunity water suppliesCKD riskRegulatory limitsParticipant's residential addressNeighborhood socioeconomic statusCommunity waterCalifornia Teachers StudyAssociated with CKD riskChronic kidney diseaseCardiovascular diseaseAssociated with riskDrinking waterAbstractText Label="PLAIN-LANGUAGE SUMMARYBody mass indexIncreased CKD riskYoung individualsHigh uranium concentrationsCommunity drinking waterWater supplyResidential addressesArsenic concentrationsDamage kidney functionSocioeconomic statusAssociated with chronic kidney diseaseMetabolomic and Proteomic Signatures of Ultra-processed Foods Are Positively Associated with Adverse Liver Outcomes
Zhao L, Chen Y, Clay-Gilmour A, Zhang J, Zhang X, Steck S. Metabolomic and Proteomic Signatures of Ultra-processed Foods Are Positively Associated with Adverse Liver Outcomes. Journal Of Nutrition 2025, 155: 1851-1858. PMID: 40334783, DOI: 10.1016/j.tjnut.2025.04.034.Peer-Reviewed Original ResearchConceptsUltra-processed food intakeUltra-processed foodsAssociated with increased riskAdverse liver outcomesAssociated with riskHigher consumption of ultra-processed foodsConsumption of ultra-processed foodsMultiple 24-h dietary recallsAssociated with increased risk of obesityHazard ratioLiver outcomesConfidence intervalsFood intakeEstimate hazard ratiosRisk of obesityIn-hospital recordsData of participantsCox proportional hazards modelsProteomic signatureLiver diseaseDeath RegistryProportional hazards modelUK BiobankDietary recallsMedian Follow-UpThe associations between dairy intake and chronic liver disease mortality and liver cancer incidence: a prospective cohort study
Liu X, Zhang X, Zhao L, Petrick J, Liao L, Wang W, He N, Giovannucci E, Zhang Z, McGlynn K, Zhang X. The associations between dairy intake and chronic liver disease mortality and liver cancer incidence: a prospective cohort study. American Journal Of Clinical Nutrition 2025, 122: 263-273. PMID: 40306387, PMCID: PMC12308092, DOI: 10.1016/j.ajcnut.2025.04.028.Peer-Reviewed Original ResearchConceptsChronic liver disease mortalityHigh-fat dairyLiver cancer incidenceTotal dairy intakeLow-fat dairyAssociated with intakeAssociated with riskDairy intakeCancer incidenceIncident liver cancer casesIntakes of high-fat dairyHigh-fat dairy intakeHealth Study cohortLiver disease mortalitySelf-administered validated questionnairePre-existing cancer diagnosisIntake of dairy productsLiver cancer riskLow-fat dairy productsChronic liver diseaseHigh-fat milkAssociated with liver cancerLow-fat milkProspective cohort studyCox proportional hazards modelsPhenotypic complexities of rare heterozygous neurexin-1 deletions
Fernando M, Fan Y, Zhang Y, Tokolyi A, Murphy A, Kammourh S, Deans P, Ghorbani S, Onatzevitch R, Pero A, Padilla C, Williams S, Flaherty E, Prytkova I, Cao L, Knowles D, Fang G, Slesinger P, Brennand K. Phenotypic complexities of rare heterozygous neurexin-1 deletions. Nature 2025, 642: 710-720. PMID: 40205044, DOI: 10.1038/s41586-025-08864-9.Peer-Reviewed Original ResearchMeSH KeywordsAlternative SplicingAnimalsCalcium-Binding ProteinsCell Adhesion Molecules, NeuronalDNA Copy Number VariationsFemaleGABAergic NeuronsGene DeletionHeterozygoteHumansInduced Pluripotent Stem CellsLoss of Function MutationMaleMiceNeural Cell Adhesion MoleculesPhenotypeSequence DeletionSynapsesConceptsLoss-of-functionGain-of-functionGain-of-function mechanismCopy number variantsSynaptic activityCell type-specific effectsCell adhesion proteinsPrecision medicineIncreased wild-typeSplicing resultsAlternative splicingIsoform repertoireNRXN1 deletionsAberrant splicingHuman induced pluripotent stem cellsPatient-specific mutationsIncreased synaptic activityDecreased synaptic activityMutant isoformsNRXN1Associated with riskPluripotent stem cellsHeterozygous deletionWild-typeDeletionDefining Kidney Health Dimensions and Their Associations with Adverse Outcomes in Persons with Diabetes and CKD
Peschard V, Scherzer R, Estrella M, Sarnak M, Ascher S, Lash J, Bonventre J, Greenberg J, Gutierrez O, Schelling J, Katz R, Cheung K, Levitan E, Schrauben S, Cushman M, Ilori T, Parikh C, Kimmel P, Rao P, Taliercio J, Sondheimer J, Shulman R, Coca S, Chen J, Ramachandran V, Ix J, Shlipak M, Investigators O. Defining Kidney Health Dimensions and Their Associations with Adverse Outcomes in Persons with Diabetes and CKD. Clinical Journal Of The American Society Of Nephrology 2025, 20: 665-675. PMID: 40085155, PMCID: PMC12097179, DOI: 10.2215/cjn.0000000676.Peer-Reviewed Original ResearchAssociated with higher mortality riskRisk of CKD progressionHealth dimensionsHigher mortality riskCKD progressionTubular damageMortality riskSystemic inflammationESKD eventsAdverse outcomesPlasma biomarkersBaseline clinical risk factorsHigher risk of CKD progressionAssociated with adverse outcomesAssociated with CKD progressionCohort of personsKidney tubule biomarkersAssociated with riskChronic Renal Insufficiency CohortClinical risk factorsCox proportional hazards modelsHigher systemic inflammationFactor analysisProportional hazards modelExploratory factor analysisChronic chemotherapy-induced peripheral neuropathy: living with neuropathy during and after cancer treatments
Rahman N, Sukumar J, Lustberg M. Chronic chemotherapy-induced peripheral neuropathy: living with neuropathy during and after cancer treatments. Annals Of Palliative Medicine 2025, 14: 19616-19216. PMID: 40211744, DOI: 10.21037/apm-24-154.Peer-Reviewed Original ResearchConceptsQuality of lifeChemotherapy-induced peripheral neuropathyFunctional statusPrevalence of chemotherapy-induced peripheral neuropathyImpact of chemotherapy-induced peripheral neuropathyTreatment strategiesAssociated with riskPatients experience symptomsCancer survivorsCurrent treatment strategiesPatient experiencePeripheral nerve damageDebilitating side effectsPrevention strategiesSymptoms of sadnessDose adjustmentPsychological impactClinical presentationClinical factorsNerve damagePeripheral neuropathyChemotherapeutic agentsSymptomatic reliefRisk factorsDiagnostic evaluation
2024
Validation and expansion of Baveno VII criteria for cACLD and CSPH based on liver stiffness and platelet count: Correlation with risk of hepatic decompensation and death.
Vutien P, Barnard Giustini A, Kim N, Moon A, Hsu C, Mezzacappa C, Borgerding J, Johnson K, VoPham T, Berry K, Beste L, Kaplan D, Taddei T, Ioannou G. Validation and expansion of Baveno VII criteria for cACLD and CSPH based on liver stiffness and platelet count: Correlation with risk of hepatic decompensation and death. Hepatology 2024 PMID: 39689352, DOI: 10.1097/hep.0000000000001183.Peer-Reviewed Original ResearchClinically Significant Portal HypertensionRisk of deathHepatic decompensationLiver stiffnessChronic liver diseasePlatelet countStratify risk of deathLiver diseaseRisk of hepatic decompensationMedian Follow-UpRisk of adverse outcomesSignificant portal hypertensionAssociated with risk of adverse outcomesRisk of decompensationAssociated with riskPortal hypertensionStratify riskFollow-upDecompensationAdverse outcomesCACLDPlatelet measuresPatientsPlateletDeathAutoimmune Diseases and Risk of Non‐Hodgkin Lymphoma: A Mendelian Randomisation Study
Shi X, Wallach J, Ma X, Rogne T. Autoimmune Diseases and Risk of Non‐Hodgkin Lymphoma: A Mendelian Randomisation Study. Cancer Medicine 2024, 13: e70327. PMID: 39506244, PMCID: PMC11540836, DOI: 10.1002/cam4.70327.Peer-Reviewed Original ResearchConceptsRisk of non-Hodgkin lymphomaNon-Hodgkin's lymphomaAutoimmune diseasesMendelian randomisationType 1 diabetesAssociated with risk of non-Hodgkin lymphomaWeak instrument biasNon-Hodgkin lymphoma subtypesTwo-sample MRNon-Hodgkin lymphoma riskRisk factorsSusceptibility to type 1 diabetesMendelian randomisation studiesCohorts of European ancestryAssociated with riskNo significant associationPotential pleiotropyPotential risk factorsUK BiobankFinnGen studyNon-HodgkinHaematological malignanciesRandomised studyEuropean ancestrySignificant associationAssociation between childhood abuse and risk of post-COVID-19 conditions: Results from three large prospective cohort studies
Vyas C, Wang S, Menor A, Kubzansky L, Slopen N, Rich-Edwards J, Chavarro J, Kang J, Roberts A. Association between childhood abuse and risk of post-COVID-19 conditions: Results from three large prospective cohort studies. Brain Behavior And Immunity 2024, 123: 143-150. PMID: 39191351, PMCID: PMC11698154, DOI: 10.1016/j.bbi.2024.08.046.Peer-Reviewed Original ResearchPost-COVID-19 conditionPost-COVID conditionsHealth-relatedPhysical/emotional abusePsychological factorsRisk of poor health outcomesGrowing Up Today StudyNurses' Health StudyPoor health outcomesAssociated with riskAssociated with increased riskChildhood abusePost-COVID-19COVID-19 surveyCOVID-19 questionnaireHealth outcomesHealth StudyProspective studyEmotional abuse subscaleSexual abuseSelf-ReportCohort studyNo childhood abuseCOVID-19-related symptomsToday StudyHigh ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia: an observational study
Rogne T, Wang R, Wang P, Deziel N, Metayer C, Wiemels J, Chen K, Warren J, Ma X. High ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia: an observational study. The Lancet Planetary Health 2024, 8: e506-e514. PMID: 38969477, PMCID: PMC11260908, DOI: 10.1016/s2542-5196(24)00121-9.Peer-Reviewed Original ResearchConceptsRisk of childhood acute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaAcute lymphoblastic leukemiaLymphoblastic leukemiaLatino childrenNon-Latino white childrenAssociated with risk of adverse pregnancy outcomesCalifornia Cancer RegistryRisk of acute lymphoblastic leukemiaCalifornia birth recordsRisk of adverse pregnancy outcomesPre-pregnancy periodAssociated with riskBayesian meta-regressionNational Institutes of HealthCancer RegistryCases of childhood acute lymphoblastic leukemiaNational Center for Advancing Translational SciencesAdverse pregnancy outcomesAcute lymphoblastic leukemia casesInstitutes of HealthInvestigation of mechanistic pathwaysBirth recordsGestational weeks 8Pre-pregnancyPharmacoepidemiology evaluation of bumetanide as a potential candidate for drug repurposing for Alzheimer's disease
Morales J, Gabriel N, Natarajan L, LaCroix A, Shadyab A, Xu R, Silverman J, Feldman H, Hernandez I, Aslanyan V, Bang A, Bevins E, Bowman G, Boyarko B, Chen X, Clelland C, Dodge H, Durant J, Edland S, Evans A, Galasko D, Gerwick W, Greenberg B, Herman M, Herold T, Hook V, Jacobs D, Kaye J, Kim D, Koo E, Kosik K, Léger G, Lupo J, Messer K, Momper J, Nygaard H, Pa J, Quinti L, Revta C, Rexach J, Rizzo S, Rynearson K, Schneider L, Slusher B, Tanzi R, Territo P, Yokoyama J. Pharmacoepidemiology evaluation of bumetanide as a potential candidate for drug repurposing for Alzheimer's disease. Alzheimer's & Dementia 2024, 20: 5236-5246. PMID: 39030734, PMCID: PMC11350022, DOI: 10.1002/alz.13872.Peer-Reviewed Original ResearchRisk of ADCross-sectional analysis of electronic health recordsAnalysis of electronic health recordsAD riskAssociated with risk of ADAssociated with AD riskAssociated with decreased prevalenceElectronic health recordsRetrospective cohort study designMedicare claims dataCohort study designCox proportional hazards regressionAssociated with riskCross-sectional analysisProportional hazards regressionPrevalence of ADMultiple sensitivity analysesAlzheimer's diseaseHealth recordsMedicare beneficiariesMedicare dataClaims dataStudy designHazards regressionPatient characteristicsPre‐diagnostic plasma inflammatory proteins and risk of hepatocellular carcinoma in three population‐based cohort studies from the United States and the United Kingdom
Zhao L, Zhang X, Birmann B, Danford C, Lai M, Simon T, Chan A, Giovannucci E, Ngo L, Libermann T, Zhang X. Pre‐diagnostic plasma inflammatory proteins and risk of hepatocellular carcinoma in three population‐based cohort studies from the United States and the United Kingdom. International Journal Of Cancer 2024, 155: 1593-1603. PMID: 38861327, PMCID: PMC11537828, DOI: 10.1002/ijc.35054.Peer-Reviewed Original ResearchConceptsHealth Professionals Follow-up StudyNurses' Health StudyAssociated with riskOdds ratioStatistical significance thresholdRisk of hepatocellular carcinomaHepatocellular carcinoma riskUK BiobankPopulation-based cohort studyConfidence intervalsMultivariate odds ratiosNested Case-Control StudyConditional logistic regressionHepatocellular carcinomaIncident HCC casesPre-diagnostic plasmaCase-control studyInflammatory proteinsHealth StudyAssociated with risk of hepatocellular carcinomaCohort studyGeneral populationLogistic regressionHepatocellular carcinoma etiologiesFollow-up studyAssociations Between Ultra-Processed Food Consumption and Adverse Brain Health Outcomes.
Bhave V, Oladele C, Ament Z, Kijpaisalratana N, Jones A, Couch C, Patki A, Garcia Guarniz A, Bennett A, Crowe M, Irvin M, Kimberly W. Associations Between Ultra-Processed Food Consumption and Adverse Brain Health Outcomes. Neurology 2024, 102: e209432. PMID: 38776524, PMCID: PMC11175629, DOI: 10.1212/wnl.0000000000209432.Peer-Reviewed Original ResearchConceptsUltra-processed foodsIntake of ultra-processed foodsRisk of cognitive impairmentIncident cognitive impairmentRecommended dietary patternsMinimally processed foodsCognitive impairmentEffects of ultra-processed foodsDietary patternsUltra-processed food consumptionAssociated with higher risk of cognitive impairmentSelf-reported dietary dataBaseline food frequency questionnaireAssociated with risk of strokeHigher risk of cognitive impairmentMediterranean-DASH InterventionBrain health outcomesFood frequency questionnaireAssociated with riskAssociated with higher riskIndependent of adherenceHistory of strokeReview of medical recordsCox proportional hazards modelsUltra-processedResidential proximity to dioxin-emitting facilities and risk of non-Hodgkin lymphoma in the NIH-AARP Diet and Health Study
Fisher J, Medgyesi D, Deziel N, Nuckols J, Ward M, Jones R. Residential proximity to dioxin-emitting facilities and risk of non-Hodgkin lymphoma in the NIH-AARP Diet and Health Study. Environment International 2024, 188: 108767. PMID: 38795658, PMCID: PMC11218044, DOI: 10.1016/j.envint.2024.108767.Peer-Reviewed Original ResearchIndustrial sourcesPolychlorinated dibenzo-p-dioxinsRisk of non-Hodgkin lymphomaDibenzo-p-dioxinsPersistent organic pollutantsNIH-AARP DietCoal-fired power plantsPCDD/F sourcesAverage emission indexDioxin emissionsResidential proximityOrganic pollutantsNIH-AARPNon-Hodgkin's lymphomaPeriod prior to enrollmentHigher emissionsElevated risk of non-Hodgkin lymphomaIncident cases of non-Hodgkin's lymphomaEvaluate associationsWind directionAssociated with higher emissionsAssociated with riskNon-Hodgkin lymphoma riskEnrollment addressHealth StudyASSOCIATIONS OF ULTRA LONG-TERM VISIT-TO-VISIT BLOOD PRESSURE VARIABILITY SINCE CHILDHOOD WITH VASCULAR AGING IN MIDLIFE: A 30-YEAR PROSPECTIVE COHORT STUDY
Wang Y, -Ma A, Zhao P, Chu C, Du M, Wang D, Jia H, Hu G, Ma Q, Yan Y, Chang J, Delles C, Chen F, Mu J. ASSOCIATIONS OF ULTRA LONG-TERM VISIT-TO-VISIT BLOOD PRESSURE VARIABILITY SINCE CHILDHOOD WITH VASCULAR AGING IN MIDLIFE: A 30-YEAR PROSPECTIVE COHORT STUDY. Journal Of Hypertension 2024, 42: e11. DOI: 10.1097/01.hjh.0001019424.08488.b4.Peer-Reviewed Original ResearchLong-term BP variabilityPresence of carotid plaqueBlood pressureAverage real variabilityArterial stiffnessBP variabilityCarotid hypertrophyMean BPCarotid plaquesSubpopulation treatment effect pattern plot methodologyVascular agingFunctional arterial propertiesYears of follow-upAssociated with arterial stiffnessPredictor of cardiovascular diseaseHigher BP variabilityPredictor of cardiovascular outcomesLong-term blood pressureAssociated with riskExposure to BPParticipants aged 6Clinical characteristicsFollow-upCohort studyCardiovascular outcomesGender, assigned sex at birth, and gender diversity: Windows into diagnostic timing disparities in autism
McQuaid G, Ratto A, Jack A, Khuu A, Smith J, Duane S, Clawson A, Lee N, Verbalis A, Pelphrey K, Kenworthy L, Wallace G, Strang J. Gender, assigned sex at birth, and gender diversity: Windows into diagnostic timing disparities in autism. Autism 2024, 28: 2806-2820. PMID: 38587289, PMCID: PMC11458814, DOI: 10.1177/13623613241243117.Peer-Reviewed Original ResearchGender identityGender diversityGender diverse peopleGender diverse populationsAutism diagnosisReduce mental health risksFemale sexMental health problemsCisgender peopleClinic-based sampleMental health risksAutistic peopleAssociated with riskAutism diagnosis in adulthoodAssigned sexClinic-basedDiagnosis in adulthoodHealth problemsGenderAutistic sampleFemale genderIdentityAutismPeopleMale genderDeep learning-based epicardial adipose tissue measurement, maximizing prognostic information from attenuation correction imaging
Shanbhag A, Miller R, Killekar A, Lemley M, Bednarski B, Van Kriekinge S, Kavanagh P, Feher A, Miller E, Bateman T, Liang J, Builoff V, Berman D, Dey D, Slomka P. Deep learning-based epicardial adipose tissue measurement, maximizing prognostic information from attenuation correction imaging. Progress In Biomedical Optics And Imaging 2024, 12930: 129300b-129300b-6. DOI: 10.1117/12.3007914.Peer-Reviewed Original ResearchEpicardial adipose tissueUngated CTMyocardial infarctionEAT volumeRisk stratificationComputed tomographyEAT volume measurementEpicardial adipose tissue measurementsEpicardial adipose tissue volumeAssociated with risk of cardiovascular eventsRisk of cardiovascular eventsMedian Follow-UpIncreased risk of deathGated computed tomographyImprove risk stratificationAdipose tissue measurementsAssociated with riskRisk of deathAttenuation correction imagesGated CTChest CTNo significant differencePrognostic informationCardiovascular eventsFollow-upWhole-exome sequencing in UK Biobank reveals rare genetic architecture for depression
Tian R, Ge T, Kweon H, Rocha D, Lam M, Liu J, Singh K, Levey D, Gelernter J, Stein M, Tsai E, Huang H, Chabris C, Lencz T, Runz H, Chen C. Whole-exome sequencing in UK Biobank reveals rare genetic architecture for depression. Nature Communications 2024, 15: 1755. PMID: 38409228, PMCID: PMC10897433, DOI: 10.1038/s41467-024-45774-2.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesRare Coding VariantsWhole-exome sequencingGenetic architectureGenetic relationshipsLoss-of-function intolerant genesContribution of rare coding variantsRare damagingAssociated with risk of depressionElectronic health recordsUK Biobank participantsPolygenic risk scoresRisk of depressionAssociated with riskIntolerant genesRisk lociAssociation studiesCoding variantsBiobank participantsHealth recordsUK BiobankDepression definitionsDepression riskBurden analysisRare variantsAssociation between urinary C4d levels and disease progression in IgA nephropathy
Dong Y, Wang Z, Guo W, Zhu L, Zhou X, Shi S, Liu L, Lv J, Zhang H. Association between urinary C4d levels and disease progression in IgA nephropathy. Nephrology Dialysis Transplantation 2024, 39: 1279-1287. PMID: 38178632, DOI: 10.1093/ndt/gfae001.Peer-Reviewed Original ResearchEnd-stage kidney diseaseC4d- groupRenal outcomesC4d levelsRisk of poor renal outcomeIgA nephropathyIncreased risk of CKD progressionProgression eventsResponse to immunosuppressive therapyAssociated with decreased eGFRRisk of CKD progressionPoor renal outcomeMedian Follow-UpBiopsy-proven IgANTime of biopsyUrine samplesRisk of kidney failureSequential urine samplesProgression of IgANBaseline urine samplesAssociated with riskTraditional risk factorsEnzyme-linked immunosorbent assayNon-invasive biomarkersImmunosuppressive therapy
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