2025
Latent Health Status Trajectories in Individuals With New or Worsening Claudication Symptoms.
Grubman S, Romain G, Cleman J, Scierka L, Pajarillo C, Kluger J, Mena-Hurtado C, Smolderen K. Latent Health Status Trajectories in Individuals With New or Worsening Claudication Symptoms. Journal Of The American Heart Association 2025, 14: e039455. PMID: 40530482, DOI: 10.1161/jaha.124.039455.Peer-Reviewed Original ResearchConceptsHealth status trajectoriesPeripheral artery disease careStatus trajectoriesDisease careHealth statusClaudication symptomsTrajectory subgroupsPeripheral Artery QuestionnaireVascular specialty clinicsPeripheral artery questionnaire scoresHierarchical multivariable logistic regressionImprove health statusMultivariate logistic regressionClinically meaningful thresholdsRegistry of patientsPsychosocial factorsBiopsychosocial modelDepressive symptomsSpecialty clinicsAlcohol use disorderQuestionnaire scoresRecovery trajectoriesLogistic regressionHealthLatent trajectory modelsInsight and Its Trajectory: Predicting the Risk of Psychiatric Hospitalizations Among First-Episode Psychosis During the First Year of Coordinated Specialty Care
Hazan H, Ferrara M, Gibbs-Dean T, Tayfur S, Corbera S, Karmani S, Song Z, Li F, Vlachos I, Selakovic M, Tek C, Srihari V. Insight and Its Trajectory: Predicting the Risk of Psychiatric Hospitalizations Among First-Episode Psychosis During the First Year of Coordinated Specialty Care. Schizophrenia Bulletin 2025, sbaf019. PMID: 40227145, DOI: 10.1093/schbul/sbaf019.Peer-Reviewed Original ResearchCoordinated Specialty CareFirst-episode psychosisBaseline insightRisk of psychiatric hospitalizationFirst-episodeEarly psychosisInsight groupLength of stayPsychiatric hospitalSpecialty carePsychosisLongitudinal trajectoriesGreater reductionsHospital outcomesHigh-low-highPredicting clinical improvementHospital dataModifiable factorsMonths pre-ParticipantsHospitalization riskClinical improvementRecovery trajectoriesReduce hospitalizationsBaselineTundra recovery post-fire in the Yukon–Kuskokwim Delta, Alaska
Clayton L, Schaefer K, Hoy E, Elder C, French N, Frost G, Wig E, Lee X. Tundra recovery post-fire in the Yukon–Kuskokwim Delta, Alaska. Environmental Research Letters 2025, 20: 044018. DOI: 10.1088/1748-9326/adbfaa.Peer-Reviewed Original ResearchWater table depthBurned areaPost-fireYukon-Kuskokwim DeltaSoil moistureUnburned areasYukon-KuskokwimRecovery of vegetationSurface organic layerActive layer thicknessSubsurface soil moistureOrganic layerEcological successionVegetation greennessSynthetic aperture radar productsTundra ecosystemsRecovery trajectoriesClimate changeSoilLandsat 8 imagerySouthwestern AlaskaField dataVegetationMoistureSubstitution methodologyNew onset refractory status epilepticus: Long‐term outcomes beyond seizures
Espino P, Eschbach K, Blank L, Cervenka M, Muscal E, Farias‐Moeller R, Gilmore E, Gopaul M, Haider H, Hanin A, Hirsch L, Kellogg M, Kluger G, Lee S, Melendez‐Zaidi A, Navarro V, Oliger A, Pasini E, Reuner G, Sharpe C, Sheikh Z, Steigleder L, Steriade C, Stredny C, Strzelczyk A, Taraschenko O, van Baalen A, Vinette S, Wickström R, Wong N, Yoo J, Gofton T. New onset refractory status epilepticus: Long‐term outcomes beyond seizures. Epilepsia 2025, 66: 988-1005. PMID: 39825688, PMCID: PMC11997932, DOI: 10.1111/epi.18267.Peer-Reviewed Original ResearchQuality of lifeLong-term outcomesCaregiver burdenConsensus-building processDevelopment of targeted management strategiesWorking GroupOutcome domainsLong-term mortalityOutcome measuresConsensus processExpert panelRecovery trajectoriesSurvivorsOutcomesPubMed searchResearch studiesKnowledge gapsCaregiversStandard dataPsychiatric
2024
Delayed Withdrawal of Life-Sustaining Treatment in Disorders of Consciousness: Practical and Theoretical Considerations
Williams A, Bass G, Hampton S, Klinedinst R, Giacino J, Fischer D. Delayed Withdrawal of Life-Sustaining Treatment in Disorders of Consciousness: Practical and Theoretical Considerations. Neurocritical Care 2024, 42: 1064-1073. PMID: 39407075, PMCID: PMC12137379, DOI: 10.1007/s12028-024-02143-7.Peer-Reviewed Original ResearchWithdrawal of life-sustaining treatmentPatient's recovery trajectorySurrogate decision makersSurrogates of patientsPost-acute-care facilityAcute care cliniciansLife-sustaining treatmentDisorders of consciousnessQuality of lifeNeurological recoveryCare cliniciansPsychosocial factorsSevere acute brain injuryAcute time periodAcceptable quality of lifeHospital dischargeRecovery trajectoriesCliniciansPost-injuryBrain injuryNeurological prognosisDecision-makingPatientsPreestablished goalsInjurySoft phenotyping for sepsis via EHR time-aware soft clustering
Jiang S, Gai X, Treggiari M, Stead W, Zhao Y, Page C, Zhang A. Soft phenotyping for sepsis via EHR time-aware soft clustering. Journal Of Biomedical Informatics 2024, 152: 104615. PMID: 38423266, PMCID: PMC11073833, DOI: 10.1016/j.jbi.2024.104615.Peer-Reviewed Original ResearchElectronic health recordsRecovery trajectoriesSub-phenotypesHealth recordsClustering algorithmTiming of interventionLogistic regressionCondition associated with high mortalitySoft clustering algorithmDisease sub-phenotypesSepsis prediction modelSoft clusteringClinical variablesOptimal timing of interventionTemporal informationMedical plausibilityHigher mortalityClustering procedureAccurate informationOrgan dysfunctionAlgorithmDysregulated immune response to infectionInterventionHospitalSepsis-related organ dysfunction
2022
Characterization of multi-domain postoperative recovery trajectories after cardiac surgery using a digital platform
Mori M, Dhruva S, Geirsson A, Krumholz H. Characterization of multi-domain postoperative recovery trajectories after cardiac surgery using a digital platform. Npj Digital Medicine 2022, 5: 192. PMID: 36564550, PMCID: PMC9789027, DOI: 10.1038/s41746-022-00736-0.Peer-Reviewed Original ResearchPatient-reported outcome measuresCardiac surgeryProspective cohort studyPROM data collectionPostoperative complicationsCohort studyPostoperative recoveryTertiary centerPatients' perceptionsOutcome measuresClinical practicePatientsSurgeryRecovery progressionRecovery trajectoriesTrajectory membershipComplicationsOverall recoveryDaysAnxiety trajectoriesRecoveryProgressionCare
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