2024
Asparaginase Treatment Patterns, Toxicity, and Outcomes Among Patients with Extranodal NK/T-Cell Lymphoma: A North American Multicenter Retrospective Cohort Study
Allen P, Bagley E, Graf K, Sethi T, Foss F, Dong N, Saeed H, Wang J, Dittus C, Paulino D, Wilcox R, Barta S, Carvajal V, Mehta-Shah N, Mou E, Ravindra A, Haverkos B, Mehta A, Shea L, Zain J, Reef D, Ayzman A, Greenwell I. Asparaginase Treatment Patterns, Toxicity, and Outcomes Among Patients with Extranodal NK/T-Cell Lymphoma: A North American Multicenter Retrospective Cohort Study. Blood 2024, 144: 1690. DOI: 10.1182/blood-2024-211424.Peer-Reviewed Original ResearchExtranodal NK/T-cell lymphomaNK/T-cell lymphomaAsparaginase useENKTL patientsResponse rateTreatment patternsDiscontinued due to toxicityMulticenter retrospective cohort studyNon-ASP groupAssociated with significant ratesTherapy related deathsEBV-associated lymphomasKaplan-Meier methodCox proportional hazards regressionRetrospective cohort studyQuarter of patientsProportional hazards regressionStatistically significant advantageHigh response rateLimitations of therapyAnalysis of outcomesAssociated lymphomaChemotherapy backboneNeutropenic feverAsparaginase doses
2023
NK/T-cell Lymphoma With Orbital Involvement: A Case Report and Systematic Review of the Literature
Dhodapkar R, Spadaro J, Heng J, Sinard J, Lee Y, Habib L, Pointdujour-Lim R. NK/T-cell Lymphoma With Orbital Involvement: A Case Report and Systematic Review of the Literature. Ophthalmic Plastic And Reconstructive Surgery 2023, 39: 316-327. PMID: 36692957, DOI: 10.1097/iop.0000000000002317.Peer-Reviewed Original ResearchConceptsNK/T-cell lymphomaT-cell lymphomaImproved survivalOrbital involvementCases of NKTLAdvanced Ann Arbor stageAnn Arbor stageRecurrence of diseaseUse of radiotherapyLacrimal drainage systemMedian survivalPeriorbital swellingSurgical debulkingClinical courseMean agePoor prognosisOcular adnexaCase reportTumor locationVision lossPoor survivalEarly diagnosisLacrimal glandOcular structuresPubMed database
2022
Incorporation of Machine Learning Tools to Predict Global Outcomes for Patients with Relapsed and Refractory Peripheral T and NK/T-Cell Lymphomas in the Contemporary Era
Boussi L, Koh M, Han X, Peng L, Koh M, Eche I, Ford J, Singh S, Miranda E, Chiattone C, Van Der Weyden C, Prince H, Foss F, Yoon S, Kim W, Panchoo G, Verburgh E, Alturas J, Al-mansour M, Manni M, Federico M, Cabrera M, Casadei B, Zinzani P, Yoshida N, Okatani T, Merrill M, Jacobsen E, O'Connor O, Marchi E, Jain S. Incorporation of Machine Learning Tools to Predict Global Outcomes for Patients with Relapsed and Refractory Peripheral T and NK/T-Cell Lymphomas in the Contemporary Era. Blood 2022, 140: 10976-10978. DOI: 10.1182/blood-2022-162944.Peer-Reviewed Original ResearchNK/T-cell lymphomaT-cell lymphomaComparative Outcomes for Mature T and NK/T-cell Lymphomas in People with and without HIV and to AIDS-Defining Lymphomas
Koh MJ, Merrill MH, Koh MJ, Stuver R, Alonso CD, Foss FM, Mayor AM, Gill J, Epeldegui M, Cachay E, Thorne JE, Silverberg MJ, Horberg MA, Althoff K, Nijhawan AE, McGinnis KA, Lee JS, Rabkin CS, Napravnik S, Li J, Castilho JL, Shen C, Jain S. Comparative Outcomes for Mature T and NK/T-cell Lymphomas in People with and without HIV and to AIDS-Defining Lymphomas. Blood Advances 2022, 6: 1420-1431. PMID: 35026839, PMCID: PMC8905704, DOI: 10.1182/bloodadvances.2021006208.Peer-Reviewed Original ResearchConceptsT-cell lymphomaAnaplastic large cell lymphomaB-cell lymphomaHodgkin's lymphomaNorth American AIDS Cohort CollaborationNK/T-cell lymphomaPrimary central nervous system lymphomaModern antiretroviral therapy (ART) eraCentral nervous system lymphomaLarge B-cell lymphomaAntiretroviral therapy eraComprehensive Oncology MeasuresMature T-cell lymphomasNervous system lymphomaLarge cell lymphomaT-cell malignanciesMature T cellsCohort CollaborationTherapy eraOverall survivalSystem lymphomaHistologic confirmationLymphoma treatmentT cellsComparative outcomes
2021
Comparative Analysis of Mature T-Cell and NK/T-Cell Lymphomas in Patients with and without HIV: Results from the NA-Accord and Complete Cohorts
Koh M, Merrill M, Koh M, Stuver R, Alonso C, Foss F, Mayor A, Gill M, Epeldegui M, Cachay E, Thorne J, Silverberg M, Horberg M, Atlhoff K, Nijhawan A, McGinnis K, Rabkin C, Napravnik S, Shen C, Jain S. Comparative Analysis of Mature T-Cell and NK/T-Cell Lymphomas in Patients with and without HIV: Results from the NA-Accord and Complete Cohorts. Blood 2021, 138: 1380. DOI: 10.1182/blood-2021-147837.Peer-Reviewed Original ResearchNK/T-cell lymphomaT-cell lymphomaB-cell lymphomaNA-ACCORDViral loadBurkitt's lymphomaLymphoma diagnosisCurrent antiretroviral therapy eraWorse median overall survivalPeripheral T-cell lymphomaAnaplastic large cell lymphomaLarge B-cell lymphomaAntiretroviral therapy eraBaseline clinical characteristicsMedian overall survivalMulticenter cohort studyOutcomes of patientsSpeakers bureauChronic kidney diseasePrimary CNS lymphomaYear of diagnosisCommon histological subtypeMature T-cell lymphomasSurvival of patientsLarge observational cohortPrimary sinonasal large B cell lymphoma is as histopathologically heterogeneous as systemic large B cell lymphoma but may show subtype-specific tropism for specific sinonasal anatomic sites
Desai M, Sethi T, Yenamandra A, Morgan D, Thompson M, Reddy N, Kovach A. Primary sinonasal large B cell lymphoma is as histopathologically heterogeneous as systemic large B cell lymphoma but may show subtype-specific tropism for specific sinonasal anatomic sites. Journal Of Hematopathology 2021, 14: 269-275. DOI: 10.1007/s12308-021-00473-5.Peer-Reviewed Original ResearchLarge B-cell lymphomaB-cell lymphomaHigh-grade B-cell lymphomaCell lymphomaSinonasal tractDLBCL-NOSAnatomic sitesAnatomic locationExtranodal NK/T-cell lymphomaNK/T-cell lymphomaGerminal center B-cell phenotypeMaxillary sinus tumorsT-cell lymphomaB-cell phenotypeClassification of lymphomasNon-GCB tumorsStage IIEFemale patientsSinus tumorLymphoma characteristicsSitu hybridization studiesWHO criteriaNasopharyngeal diseaseWHO classificationVariable presentation
2018
NCCN Guidelines Insights: T-Cell Lymphomas, Version 2.2018.
Horwitz S, Ansell S, Ai W, Barnes J, Barta S, Choi M, Clemens M, Dogan A, Greer J, Halwani A, Haverkos B, Hoppe R, Jacobsen E, Jagadeesh D, Kim Y, Lunning M, Mehta A, Mehta-Shah N, Oki Y, Olsen E, Pro B, Rajguru S, Shanbhag S, Shustov A, Sokol L, Torka P, Wilcox R, William B, Zain J, Dwyer M, Sundar H. NCCN Guidelines Insights: T-Cell Lymphomas, Version 2.2018. Journal Of The National Comprehensive Cancer Network 2018, 16: 123-135. PMID: 29439173, DOI: 10.6004/jnccn.2018.0007.Peer-Reviewed Original ResearchConceptsExtranodal NK/T-cell lymphomaNK/T-cell lymphomaNatural killer (NK)/T-cell lymphomaSubtype of non-Hodgkin lymphomaNon-Hodgkin's lymphomaT-cell lymphomaNCCN Guidelines InsightsUpper aerodigestive tractManagement of patientsNasal typeNK/T-cellRare malignancyStandard therapyNCCN guidelinesAerodigestive tractT cellsLymphomaRandomized trialsPatientsNCCNMalignancyRegimensTherapySubtypesDiagnosis
2017
Clinical Practice Recommendations on Indication and Timing of Hematopoietic Cell Transplantation in Mature T Cell and NK/T Cell Lymphomas: An International Collaborative Effort on Behalf of the Guidelines Committee of the American Society for Blood and Marrow Transplantation
Kharfan-Dabaja MA, Kumar A, Ayala E, Hamadani M, Reimer P, Gisselbrecht C, d'Amore F, Jantunen E, Ishida T, Bazarbachi A, Foss F, Advani R, Fenske TS, Lazarus HM, Friedberg JW, Aljurf M, Sokol L, Tobinai K, Tse E, Burns LJ, Chavez JC, Reddy NM, Suzuki R, Ahmed S, Nademanee A, Mohty M, Gopal AK, Fanale MA, Pro B, Moskowitz AJ, Sureda A, Perales MA, Carpenter PA, Savani BN. Clinical Practice Recommendations on Indication and Timing of Hematopoietic Cell Transplantation in Mature T Cell and NK/T Cell Lymphomas: An International Collaborative Effort on Behalf of the Guidelines Committee of the American Society for Blood and Marrow Transplantation. Transplantation And Cellular Therapy 2017, 23: 1826-1838. PMID: 28797780, DOI: 10.1016/j.bbmt.2017.07.027.Peer-Reviewed Original ResearchConceptsAngioimmunoblastic T-cell lymphomaNK/T cellsT-cell lymphomaFront-line consolidationClinical practice recommendationsHematopoietic cell transplantationALCL-ALKAuto-HCTT cellsAllo-HCTHepatosplenic lymphomaCell lymphomaHistological subtypesMature T cellsRefractory diseaseMarrow transplantationNatural killerPTCL-NOSCell transplantationAnaplastic large cell lymphoma-anaplastic lymphoma kinaseMycosis fungoides/Sezary syndromeNK/T-cell lymphomaAutologous hematopoietic cell transplantationPeripheral T-cell lymphomaAdult T-cell leukemia/lymphoma
2013
PD-L1 Expression Is Characteristic of a Subset of Aggressive B-cell Lymphomas and Virus-Associated Malignancies
Chen BJ, Chapuy B, Ouyang J, Sun HH, Roemer MG, Xu ML, Yu H, Fletcher CD, Freeman GJ, Shipp MA, Rodig SJ. PD-L1 Expression Is Characteristic of a Subset of Aggressive B-cell Lymphomas and Virus-Associated Malignancies. Clinical Cancer Research 2013, 19: 3462-3473. PMID: 23674495, PMCID: PMC4102335, DOI: 10.1158/1078-0432.ccr-13-0855.Peer-Reviewed Original ResearchConceptsDiffuse large B-cell lymphomaAggressive B-cell lymphomasB-cell lymphomaPosttransplant lymphoproliferative disorderClassical Hodgkin lymphomaLarge B-cell lymphomaPD-L1Hodgkin's lymphomaT-cell/histiocyte-rich B-cell lymphomaExtranodal NK/T-cell lymphomaTissue biopsiesEBV-positive posttransplant lymphoproliferative disordersHistiocyte-rich B-cell lymphomaPD-1/PD-L1 pathwayNK/T-cell lymphomaPD-1/PD-L1Primary mediastinal large B-cell lymphomaNodular lymphocyte predominant Hodgkin lymphomaMixed cellularity classical Hodgkin lymphomaMediastinal large B-cell lymphomaCell death ligand 1Lymphocyte predominant Hodgkin lymphomaPD-L1 protein expressionPD-L1 expressionPD-L1 pathway
2009
Development of a Reflex FISH Assay Panel for Lymphoid Neoplasms Resulted Negative by Cytogenetics and Current FISH Panel and Positive by Hematopathology.
Mitter N, Lanno S, Blackson J, Donskoy M, Ehrenpreis R. Development of a Reflex FISH Assay Panel for Lymphoid Neoplasms Resulted Negative by Cytogenetics and Current FISH Panel and Positive by Hematopathology. Blood 2009, 114: 4722. DOI: 10.1182/blood.v114.22.4722.4722.Peer-Reviewed Original ResearchFluorescence in situ hybridization panelAnaplastic large cell lymphomaFluorescence in situ hybridizationLarge cell lymphomaFISH panelLymphoid neoplasmsLoss of heterozygosityLocus-specific probesT cellsCell lymphomaKi-1+ anaplastic large cell lymphomaGene rearrangementsKi-1-positive anaplastic large cell lymphomaSubtype of non-Hodgkin lymphomaFluorescence in situ hybridization studiesNK/T-cell lymphomaT-cell disordersNon-Hodgkin's lymphomaT-cell lymphomaKi-1 antigenPeripheral T cellsProportion of patientsSpecific probesLow percentage of cellsRate of abnormalities
2005
Distribution and phenotype of Epstein–Barr virus-infected cells in human pharyngeal tonsils
Hudnall SD, Ge Y, Wei L, Yang NP, Wang HQ, Chen T. Distribution and phenotype of Epstein–Barr virus-infected cells in human pharyngeal tonsils. Modern Pathology 2005, 18: 519-527. PMID: 15696119, DOI: 10.1038/modpathol.3800369.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntigens, CDB-LymphocytesChildChild, PreschoolEpstein-Barr Virus InfectionsEpstein-Barr Virus Nuclear AntigensFemaleGene Expression Regulation, ViralHerpesvirus 4, HumanHumansImmunohistochemistryImmunophenotypingMaleMiddle AgedPalatine TonsilT-LymphocytesViral Matrix ProteinsViral ProteinsConceptsEpstein-Barr virusEBER-positive cellsT cellsHuman tonsilsNK cellsPlasma cellsEpithelial cellsB cellsBiology of EBVNK/T-cell lymphomaEpstein-Barr virus-infected cellsEBV latent protein EBNA1CD20-positive B cellsCD3-positive T cellsEarly Protein BZLF1Non-B cell typeNatural killer cellsRare T cellsT-cell lymphomaLMP1-positive cellsVirus-infected cellsMost tonsilsPlasmacytoid morphologyKiller cellsInterfollicular zones
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