2025
Comparison of clinical symptoms and symptom structure across different onset ages in schizophrenia inpatients
Liu Z, Wang X, Chen W, Huang J, Tong J, Wang J, Liu R, Deng H, Yang K, Li W, Chen S, Xie T, Tian L, Yang F, Tian B, Li Y, Li C, Tan Y. Comparison of clinical symptoms and symptom structure across different onset ages in schizophrenia inpatients. Schizophrenia Research 2025, 277: 177-184. PMID: 40073617, DOI: 10.1016/j.schres.2025.03.015.Peer-Reviewed Original ResearchConceptsEarly-onset schizophreniaLate-onset schizophreniaPositive and Negative Syndrome ScaleAge of onset groupsSymptom network structureNegative symptomsSchizophrenia inpatientsSymptom networksSymptom severityNegative Syndrome ScaleSevere negative symptomsClinical symptom profilesOnset groupTreatment outcomesDevelopment of personalized treatment strategiesPoor treatment outcomesGeneral psychopathologyPositive symptomsSyndrome ScaleSymptom structureDisorganized thoughtsBridge symptomsSchizophrenia patientsSchizophreniaSymptom profiles
2024
Short-term antipsychotic treatment reduces functional connectivity of the striatum in first-episode drug-naïve early-onset schizophrenia
Hu W, Ran X, Wu Z, Zhu H, Kou Y, Zhang S, Yang G, Li W, Yang Y, Lv L, Zhang Y. Short-term antipsychotic treatment reduces functional connectivity of the striatum in first-episode drug-naïve early-onset schizophrenia. Schizophrenia Research 2024, 270: 281-288. PMID: 38944974, DOI: 10.1016/j.schres.2024.06.016.Peer-Reviewed Original ResearchPositive and Negative Syndrome ScaleEarly-onset schizophreniaEarly-onset schizophrenia patientsDorsal caudal putamenStriatal FCFunctional connectivityAntipsychotic treatmentStriatal subregionsFrontal gyrusPositive and Negative Syndrome Scale negative scoresResting-state functional magnetic resonance imaging scansShort-term antipsychotic treatmentFunctional magnetic resonance imaging scansWeeks of treatmentEarly stages of schizophreniaHealthy controlsLeft supplementary motor areaNegative Syndrome ScaleInferior frontal gyrusStages of schizophreniaMiddle frontal gyrusInferior parietal lobuleMeasure psychiatric symptomsAbnormal functional connectivityRight postcentral gyrus
2018
Course, outcome and diagnosis stability of early-onset schizophrenia in Yunnan Province, China-a three years follow-up study
Kang C, Zhou H, Yang J, Yang R, Sun N, Wang S, Yang C, Han D, Srihari VH. Course, outcome and diagnosis stability of early-onset schizophrenia in Yunnan Province, China-a three years follow-up study. Psychiatry Research 2018, 271: 144-149. PMID: 30472510, DOI: 10.1016/j.psychres.2018.11.013.Peer-Reviewed Original ResearchConceptsEarly-onset schizophreniaICD-10 diagnosisDiagnostic stabilityMini International Neuropsychiatric InterviewFirst Affiliated HospitalInternational Neuropsychiatric InterviewKunming Medical UniversityHigh diagnostic stabilityDepartment of PsychiatryPoor outcomeAffiliated HospitalNeuropsychiatric InterviewInternational ClassificationBetter outcomesModerate outcomeMedical UniversityGlobal functioningICD-10Psychosocial outcomesPatientsSchizophreniaDiagnosis stabilityDiagnosisOutcomesHospital
2000
White matter hyperintensity volume in late‐onset and early‐onset schizophrenia
Rivkin P, Kraut M, Barta P, Anthony J, Arria A, Pearlson G. White matter hyperintensity volume in late‐onset and early‐onset schizophrenia. International Journal Of Geriatric Psychiatry 2000, 15: 1085-1089. PMID: 11180463, DOI: 10.1002/1099-1166(200012)15:12<1085::aid-gps250>3.0.co;2-x.Peer-Reviewed Original ResearchConceptsWhite matter hyperintensitiesMagnetic resonance imagingWhite matter hyperintensity volumeLate-onset psychosisEarly-onset schizophreniaEarly-onset schizophrenicsNeuro-imaging studiesNeuro-degenerative processesControl subjectsCase ascertainmentOnset psychosisHyperintensity volumeMatter hyperintensitiesOnset schizophreniaWMH volumeAnatomic correlatesResonance imagingStudy designSchizophreniaSignificant differencesWMH measurementsPresent studySchizophrenicsContinuous measureLatent vulnerability
1999
Progressive Cortical Change During Adolescence in Childhood-Onset Schizophrenia: A Longitudinal Magnetic Resonance Imaging Study
Rapoport JL, Giedd JN, Blumenthal J, Hamburger S, Jeffries N, Fernandez T, Nicolson R, Bedwell J, Lenane M, Zijdenbos A, Paus T, Evans A. Progressive Cortical Change During Adolescence in Childhood-Onset Schizophrenia: A Longitudinal Magnetic Resonance Imaging Study. JAMA Psychiatry 1999, 56: 649-654. PMID: 10401513, DOI: 10.1001/archpsyc.56.7.649.Peer-Reviewed Original ResearchConceptsChildhood-onset schizophreniaCortical gray matter volumeWhite matter volumeDisease-specific patternsGray matter volumeMatter volumeHealthy controlsCortical changesBrain tissueGray matterSchizophrenia groupLongitudinal magnetic resonance imaging studyBrain developmentBrain ventricular enlargementProgressive cortical changesMagnetic resonance imaging studyBrain magnetic resonanceEarly-onset schizophreniaTemporal gray matterAbnormal brain developmentResonance imaging studyVentricular enlargementMean ageOnset schizophreniaPatient's illness
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