2021
Sex- or Gender-specific Differences in the Clinical Presentation, Outcome, and Treatment of SARS-CoV-2
Wolfe J, Safdar B, Madsen TE, Sethuraman KN, Becker B, Greenberg MR, McGregor AJ. Sex- or Gender-specific Differences in the Clinical Presentation, Outcome, and Treatment of SARS-CoV-2. Clinical Therapeutics 2021, 43: 557-571.e1. PMID: 33583576, PMCID: PMC7833665, DOI: 10.1016/j.clinthera.2021.01.015.Peer-Reviewed Original ResearchConceptsImmunologic responseBody's immunologic responseCOVID-19 presentationComplications of infectionSARS-CoV-2Influence of hormonesGender-specific differencesClinical presentationLaboratory presentationOutcomesSex differencesSexBody responseInfectionTreatmentPresentationGender differencesResponseComplicationsDifferencesHormonePrevention
2019
Gender-Related Reporting Within Foot and Ankle Subspecialty Orthopaedic Literature is Lacking
Gianakos A, George N, Merklein M, Chambers L, Daniel J, DiGiovanni C, Kennedy J. Gender-Related Reporting Within Foot and Ankle Subspecialty Orthopaedic Literature is Lacking. Foot & Ankle Orthopaedics 2019, 4: 2473011419s00183. PMCID: PMC8696778, DOI: 10.1177/2473011419s00183.Peer-Reviewed Original ResearchGender-specific differencesGender-specific analysisOrthopaedic FootOrthopaedic literatureRandomized control studySignificant differencesPrevalence of footAnkle fracturesCase seriesFemale patientsAnkle literatureProspective studyRetrospective studyAnkle injuriesAnkle surgeryKnee surgerySports TraumatologyGender-specific outcomesTreatment outcomesIndependent reviewersAnimal studiesCadaveric studyControl studySports medicineFemale populationGender Differences in Outcomes After Implantation of Left Ventricular Assist Devices
Ahmed A, Adegbala O, Akintoye E, Inampudi C, Ajam M, Yassin A, Olawusi E, Shokr M, Alvarez P, Briasoulis A. Gender Differences in Outcomes After Implantation of Left Ventricular Assist Devices. The Annals Of Thoracic Surgery 2019, 109: 780-786. PMID: 31479642, DOI: 10.1016/j.athoracsur.2019.07.032.Peer-Reviewed Original ResearchConceptsLVAD implantationContinuous-flow LVADVentricular assist device implantationLeft ventricular assist deviceAcute kidney injuryAssist device implantationMost common complicationsExtracorporeal membrane oxygenationMedian hospitalization costNational Inpatient SamplePostoperative cardiac tamponadeLength of stayYears of ageVentricular assist deviceGender-specific differencesHospital mortalityPostoperative thromboembolismCardiac tamponadeHospital outcomesKidney injuryPeriprocedural complicationsPostoperative sepsisCommon complicationInpatient mortalityLVAD placement
2018
Gender Differences in Patient‐Reported Outcomes Among Adults With Atherosclerotic Cardiovascular Disease
Okunrintemi V, Valero‐Elizondo J, Patrick B, Salami J, Tibuakuu M, Ahmad S, Ogunmoroti O, Mahajan S, Khan SU, Gulati M, Nasir K, Michos ED. Gender Differences in Patient‐Reported Outcomes Among Adults With Atherosclerotic Cardiovascular Disease. Journal Of The American Heart Association 2018, 7: e010498. PMID: 30561253, PMCID: PMC6405598, DOI: 10.1161/jaha.118.010498.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAtherosclerosisCross-Sectional StudiesFemaleHealth CommunicationHealth Knowledge, Attitudes, PracticeHealth Status DisparitiesHealthcare DisparitiesHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedPatient Reported Outcome MeasuresPatient SatisfactionPhysician-Patient RelationsPlatelet Aggregation InhibitorsQuality of LifeRetrospective StudiesRisk FactorsSex FactorsUnited StatesYoung AdultConceptsHealth-related qualityBackground Atherosclerotic cardiovascular diseaseLower health-related qualityAtherosclerotic cardiovascular diseasePatient experienceCardiovascular diseaseHealth outcomesPoor patient-provider communicationImportant public health implicationsSelf-reported patient experienceNinth Revision codesPatient-centered outcomesPatient-reported outcomesPatient-provider communicationThird of deathsPoor perceptionPoor patient experiencePositive patient experiencePublic health implicationsMedical Expenditure PanelPerception of healthGender-specific differencesRepresentative US sampleGender differencesASCVD patientsGender differences in psychiatric and medical comorbidity with post-traumatic stress disorder
Husky MM, Mazure CM, Kovess-Masfety V. Gender differences in psychiatric and medical comorbidity with post-traumatic stress disorder. Comprehensive Psychiatry 2018, 84: 75-81. PMID: 29723769, DOI: 10.1016/j.comppsych.2018.04.007.Peer-Reviewed Original ResearchConceptsSevere post-traumatic stress disorderPost-traumatic stress disorderMedical conditionsPsychiatric disordersComposite International Diagnostic Interview Short FormStress disorderComorbid psychiatric disordersCross-sectional general population surveySubstance use disordersGender-specific differencesGeneral population surveyMedical comorbiditiesMedical morbiditySevere headacheComorbid depressionSocietal burdenGeneral populationSevere casesUse disordersGreater oddsGender differencesNeck problemsPTSD diagnosisPTSD sufferersAnxiety disorders
2017
The role of endothelial HIF-1 αin the response to sublethal hypoxia in C57BL/6 mouse pups
Li Q, Michaud M, Park C, Huang Y, Couture R, Girodano F, Schwartz ML, Madri JA. The role of endothelial HIF-1 αin the response to sublethal hypoxia in C57BL/6 mouse pups. Laboratory Investigation 2017, 97: 356-369. PMID: 28092362, DOI: 10.1038/labinvest.2016.154.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornApoptosisBlotting, WesternCell HypoxiaCell ProliferationCells, CulturedDentate GyrusEndothelial CellsFemaleHypoxiaHypoxia-Inducible Factor 1, alpha SubunitLateral VentriclesMaleMice, Inbred C57BLMice, KnockoutMice, TransgenicMicroscopy, FluorescenceMotor ActivityNeural Stem CellsConceptsHIF-1 αBrain microvascular endothelial cellsNeuronal precursor cellsSubventricular zoneMicrovascular endothelial cellsOpen-field activityEndothelial cellsSublethal hypoxiaHIF-1 α expressionOpen-field activity testChronic sublethal hypoxiaEndothelial HIF-1Hypoxic conditionsC57BL/6 mouse pupsGender-specific differencesPremature birthC57BL/6 WTDentate gyrusHippocampal tissueDeficient miceΑ expressionMouse pupsMotor handicapParacrine effectsDentate gyrus tissue
2016
Gender-specific differences in PPARγ regulation of follicular helper T cell responses with estrogen
Park HJ, Park HS, Lee JU, Bothwell AL, Choi JM. Gender-specific differences in PPARγ regulation of follicular helper T cell responses with estrogen. Scientific Reports 2016, 6: 28495. PMID: 27335315, PMCID: PMC4917844, DOI: 10.1038/srep28495.Peer-Reviewed Original ResearchConceptsFollicular helper T cell responsesHelper T cell responsesT cell responsesCell responsesTfh cellsT cellsGC responseMale T cellsPeroxisome proliferator-activated receptor gammaTfh cell responsesEffector T cellsPPARγ agonist pioglitazoneProliferator-activated receptor gammaT cell regulationWild-type miceRole of PPARγGerminal center B cellsT cell activationGender-specific differencesTfh responsesAgonist pioglitazoneAutoimmune diseasesMenstrual cycleFemale miceMale mice
2012
Age- and gender-related changes in plaque composition in patients with acute coronary syndrome: the PROSPECT study.
Ruiz-García J, Lerman A, Weisz G, Maehara A, Mintz GS, Fahy M, Xu K, Lansky AJ, Cristea E, Farah TG, Teles R, Botker HE, Templin B, Zhang Z, de Bruyne B, Serruys PW, Stone GW. Age- and gender-related changes in plaque composition in patients with acute coronary syndrome: the PROSPECT study. EuroIntervention 2012, 8: 929-38. PMID: 23253546, DOI: 10.4244/eijv8i8a142.Peer-Reviewed Original ResearchConceptsMajor adverse cardiac eventsAcute coronary syndromeNon-culprit lesionsUntreated non-culprit lesionsCoronary syndromePlaque burdenIncidence of MACEAge groupsObstructive coronary artery diseaseNecrotic coreGreater plaque burdenLarger plaque volumeAdverse cardiac eventsCoronary artery diseaseRadiofrequency intravascular ultrasoundYears of ageSame age groupGender-specific differencesSex-related effectsCardiac eventsArtery diseaseAdverse outcomesAtherosclerosis developmentCoronary plaquesGender-related changes
2010
Gender Differences of Externalizing and Internalizing Behavior Problems According to the Extracurricular Education
Song J, Jon D, Soek J, Hong N, Kim Y, Hong H. Gender Differences of Externalizing and Internalizing Behavior Problems According to the Extracurricular Education. Journal Of Korean Academy Of Child And Adolescent Psychiatry 2010, 21: 37-44. DOI: 10.5765/jkacap.2010.21.1.037.Peer-Reviewed Original ResearchChapter 3 Gender Differences in Pediatric Pulmonary Disease
Sheares B. Chapter 3 Gender Differences in Pediatric Pulmonary Disease. 2010, 35-50. DOI: 10.1016/b978-0-12-374271-1.00003-4.Peer-Reviewed Original ResearchPulmonary diseaseRespiratory diseasePediatric lung disordersCommon respiratory diseasesPediatric pulmonary diseaseNormal lung developmentGender-specific differencesPathophysiologic mechanismsLung disordersGender differencesHormonal differencesLung developmentRespiratory systemDiseasePrenatal developmentInfluence of genderAdolescent yearsMalesFemalesSocio-cultural factorsDifferencesMedical interestIncidenceDiagnosis
2007
Gender-Specific Outcomes After Sirolimus-Eluting Stent Implantation
Solinas E, Nikolsky E, Lansky AJ, Kirtane AJ, Morice MC, Popma JJ, Schofer J, Schampaert E, Pucelikova T, Aoki J, Fahy M, Dangas GD, Moses JW, Cutlip DE, Leon MB, Mehran R. Gender-Specific Outcomes After Sirolimus-Eluting Stent Implantation. Journal Of The American College Of Cardiology 2007, 50: 2111-2116. PMID: 18036446, DOI: 10.1016/j.jacc.2007.06.056.Peer-Reviewed Original ResearchConceptsSirolimus-eluting stentsBare metal stentsSegment binary restenosisBinary restenosisClinical outcomesMajor adverse cardiac eventsSirolimus-eluting stent implantationAdverse cardiac eventsOutcomes of patientsTarget vessel revascularizationCongestive heart failureOutcomes of womenPercutaneous coronary interventionOverall clinical outcomeGender-specific differencesVessel revascularizationCardiac eventsCoronary interventionAngiographic featuresDiabetes mellitusHeart failureIndependent predictorsMultivariable analysisClinical benefitStent implantation
2004
3 Gender-Specific Pulmonary Disease
Sheares B. 3 Gender-Specific Pulmonary Disease. 2004, 25-35. DOI: 10.1016/b978-012440905-7/50267-x.Peer-Reviewed Original ResearchRespiratory distress syndromeRespiratory diseasePulmonary diseasePediatric respiratory diseasesCommon respiratory diseasesGender-specific differencesAirway functionDistress syndromePremature infantsPathophysiologic mechanismsClinical manifestationsLung diseaseLung disordersLung growthSex-specific differencesHormonal differencesClinical arenaRespiratory systemDiseaseSex differencesAdolescent yearsGender differencesSociocultural factorsDifferencesInfants
2002
Alcohol Use Disorders in Primary Care
Brienza RS, Stein MD. Alcohol Use Disorders in Primary Care. Journal Of General Internal Medicine 2002, 17: 387-397. PMID: 12047738, PMCID: PMC1495039, DOI: 10.1046/j.1525-1497.2002.10617.x.Peer-Reviewed Original ResearchConceptsAlcohol use disorderPrimary care physiciansUse disordersCoronary artery disease mortalityPrevalence of AUDGender-specific differencesCare physiciansPsychiatric comorbidityAccelerated progressionDisease mortalityPrimary careRisk drinkingBreast cancerModerate drinkersAlcohol consumptionAlcohol toxicityHeavy drinkersBrief interventionTreatment programWomenPast historyCommon barriersMenMortalityPhysiciansAlcohol use disorders in primary care
Brienza R, Stein M. Alcohol use disorders in primary care. Journal Of General Internal Medicine 2002, 17: 387-397. DOI: 10.1007/s11606-002-0046-1.Peer-Reviewed Original ResearchAlcohol use disorderPrimary care physiciansUse disordersCoronary artery disease mortalityPrevalence of AUDGender-specific differencesCare physiciansPsychiatric comorbidityAccelerated progressionDisease mortalityPrimary careRisk drinkingBreast cancerModerate drinkersAlcohol consumptionAlcohol toxicityHeavy drinkersBrief interventionTreatment programWomenPast historyCommon barriersMenMortalityPhysicians
2001
Virologic and Immunologic Determinants of Heterosexual Transmission of Human Immunodeficiency Virus Type 1 in Africa
Fideli L, Allen S, Musonda R, Trask S, Hahn B, Weiss H, Mulenga J, Kasolo F, Vermund S, Aldrovandi G. Virologic and Immunologic Determinants of Heterosexual Transmission of Human Immunodeficiency Virus Type 1 in Africa. AIDS Research And Human Retroviruses 2001, 17: 901-910. PMID: 11461676, PMCID: PMC2748905, DOI: 10.1089/088922201750290023.Peer-Reviewed Original ResearchConceptsCopies/Heterosexual transmissionRisk ratioMultivariate Cox regression analysisHuman immunodeficiency virus type 1Immunodeficiency virus type 1Plasma viral loadCox regression analysisCorresponding risk ratioHIV-1 RNAVirus type 1Female transmissionCase-control designGender-specific differencesPlasma VLImmunologic correlatesViral loadProspective studySerology resultsWorld's HIVVirus isolationType 1Immunologic determinantsReference groupNontransmitters
1997
Syphilis in injecting drug users: clues for high-risk sexual behaviour in female IDUs
Muga R, Roca J, Tor J, Pigem C, Rodriguez R, Egea J, Vlahov D, Muñoz A. Syphilis in injecting drug users: clues for high-risk sexual behaviour in female IDUs. International Journal Of STD & AIDS 1997, 8: 225-228. PMID: 9147154, DOI: 10.1258/0956462971919967.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusRapid plasma reagentEnzyme-linked immunosorbent assaySerologic syphilisDrug usersSex partnersHigh-risk sexual behaviorCross-sectional analysisGender-specific differencesMale IDUsHIV infectionImmunodeficiency virusFemale IDUsSexual transmissionTreponemal testsReactive samplesSyphilisSexual partnersWestern blotImmunosorbent assayIDUsPlasma reagentWomenSexual behaviorMen
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