2025
Greater Accumulation of Brain White Matter Hyperintensities in People Diagnosed and Treated During Acute HIV Compared With People Without HIV
Holroyd K, Chan P, Sacdalan C, Dumrongpisutikul N, Sriplienchan S, Promensa P, Sailasuta P, Pothisri M, Puttamaswin S, Vasan S, Valcour V, Trautmann L, Spudich S, Paul R, Bolenzius J, Team A. Greater Accumulation of Brain White Matter Hyperintensities in People Diagnosed and Treated During Acute HIV Compared With People Without HIV. Neurology 2025, 104: e213591. PMID: 40327828, PMCID: PMC12060792, DOI: 10.1212/wnl.0000000000213591.Peer-Reviewed Original ResearchConceptsAcute HIV infectionAntiretroviral therapyWhite matter hyperintensitiesWMH changeViral suppressionHIV infectionBaseline CD4<sup>+</sup> T-cell countVascular comorbiditiesCD4<sup>+</sup> T-cell countIncreased rate of ischemic strokeUndetectable plasma viral loadT2-fluid-attenuated inversion recovery sequencesPlasma viral loadT-cell countsAntiretroviral therapy initiationEarly ART initiationFluid-attenuated inversion recovery sequencesBrain white matter hyperintensityHistory of psychiatric disordersFollow-up periodRate of ischemic strokeRepeated-measures ANOVAIncreased risk of strokeTwo-year follow-upExposure to HIVSafety, pharmacokinetics, and biological activity of CD4-mimetic BNM-III-170 in SHIV-infected rhesus macaques
Viox E, Richard J, Grandea A, Nguyen K, Harper J, Auger J, Ding S, Gasser R, Prévost J, Marchitto L, Medjahed H, Bourassa C, Gaudette F, Pagliuzza A, Trifone C, Gavegnano C, Hurwitz S, Park J, Clark N, Hammad I, Capuano S, Martin M, Schinazi R, Silvestri G, Kulpa D, Kumar P, Chomont N, Pazgier M, Smith A, Sodroski J, Evans D, Finzi A, Paiardini M. Safety, pharmacokinetics, and biological activity of CD4-mimetic BNM-III-170 in SHIV-infected rhesus macaques. Journal Of Virology 2025, 99: e00062-25. PMID: 40192306, PMCID: PMC12090809, DOI: 10.1128/jvi.00062-25.Peer-Reviewed Original ResearchConceptsSHIV-infected rhesus macaquesShock-and-kill approachADCC-mediating antibodiesCD4-inducedHIV-1Rhesus macaquesDosing regimenSmall-molecule CD4-mimetic compoundsGp120 subunit of EnvLatent HIV-1 reservoirHIV-1 envelope glycoproteinAnti-HIV-1 antibodiesInfected cellsPlasma of treated animalsCD4-mimetic compoundsCure HIV-1HIV-1 reservoirUninfected rhesus macaquesPlasma viral loadBind to infected cellsHIV-1 EnvNon-neutralizing antibodiesCD4-bound conformationSerum half-livesViral rebound
2023
1494. Impact of Polypharmacy on Gait Speed and Falls in Older People Living with HIV.
Kosana P, Wu K, Tassiopoulos K, Letendre S, Ma Q, Erlandson K, Farhadian S. 1494. Impact of Polypharmacy on Gait Speed and Falls in Older People Living with HIV. Open Forum Infectious Diseases 2023, 10: ofad500.1329. PMCID: PMC10677239, DOI: 10.1093/ofid/ofad500.1329.Peer-Reviewed Original ResearchSlow gait speedGait speedPrescription medicationsLogistic regression modelsStudy participantsMedical comorbiditiesRecurrent fallsOlder PWHIncreased oddsClinical informationOlder peopleAntiretroviral drug useImpact of polypharmacyManagement of polypharmacyHigher CD4 countsNumber of comorbiditiesPlasma viral loadPercent of participantsCross-sectional analysisSelf-reported raceGeriatric outcomesLow CD4Medication burdenCD4 countCD8 ratio
2020
Central Nervous System Safety During Brief Analytic Treatment Interruption of Antiretroviral Therapy Within 4 Human Immunodeficiency Virus Remission Trials: An Observational Study in Acutely Treated People Living With Human Immunodeficiency Virus
Hellmuth J, Muccini C, Colby DJ, Kroon E, de Souza M, Crowell TA, Chan P, Sacdalan C, Intasan J, Benjapornpong K, Tipsuk S, Puttamaswin S, Chomchey N, Valcour V, Sarnecki M, Tomaka F, Krebs SJ, Slike BM, Jagodzinski LL, Dumrongpisutikul N, Sailasuta N, Samboju V, Michael NL, Robb ML, Vasan S, Ananworanich J, Phanuphak P, Phanuphak N, Paul R, Spudich S. Central Nervous System Safety During Brief Analytic Treatment Interruption of Antiretroviral Therapy Within 4 Human Immunodeficiency Virus Remission Trials: An Observational Study in Acutely Treated People Living With Human Immunodeficiency Virus. Clinical Infectious Diseases 2020, 73: e1885-e1892. PMID: 32916708, PMCID: PMC8492357, DOI: 10.1093/cid/ciaa1344.Peer-Reviewed Original ResearchConceptsAnalytic treatment interruptionHuman immunodeficiency virusAntiretroviral therapyCentral nervous systemRemission trialsDiffusion tensor imagingTreatment interruptionMedian timeImmunodeficiency virusCentral nervous system safetyCSF HIV-1 RNAAdverse CNS effectsAcute HIV infectionImmune activation markersPlasma viral loadHIV-1 RNAMedian participant ageCerebrospinal fluid samplingCognitive performanceHIV remission trialsBrain diffusion tensor imagingMagnetic resonance spectroscopyART resumptionCNS safetyMild worseningA randomized trial of vorinostat with treatment interruption after initiating antiretroviral therapy during acute HIV-1 infection
Kroon EDMB, Ananworanich J, Pagliuzza A, Rhodes A, Phanuphak N, Trautmann L, Mitchell JL, Chintanaphol M, Intasan J, Pinyakorn S, Benjapornpong K, Chang JJ, Colby DJ, Chomchey N, Fletcher JLK, Eubanks K, Yang H, Kapson J, Dantanarayana A, Tennakoon S, Gorelick RJ, Maldarelli F, Robb ML, Kim JH, Spudich S, Chomont N, Phanuphak P, Lewin SR, de Souza MS, Teams F. A randomized trial of vorinostat with treatment interruption after initiating antiretroviral therapy during acute HIV-1 infection. Journal Of Virus Eradication 2020, 6: 100004. PMID: 33251022, PMCID: PMC7646672, DOI: 10.1016/j.jve.2020.100004.Peer-Reviewed Original ResearchAcute HIV infectionAntiretroviral therapyTreatment interruptionViral loadAcute HIV-1 infectionHIV RNA copies/Open-label pilot studyPeripheral blood mononuclear cellsControl HIV replicationSubsequent treatment interruptionTotal HIV DNASerious adverse eventsHIV viral loadPlasma viral loadRNA copies/HIV-1 infectionBlood mononuclear cellsCopies/mLProportion of participantsCell-associated RNAAlternative treatment strategiesHistone deacetylase inhibitorsVL reboundHIV RNAViral reboundPsychosocial Factors, Condomless Sex, and Detectable Viral Load in HIV-Positive Women in Serodiscordant Couples in Nairobi, Kenya
Blain M, Richardson B, Kinuthia J, Poole D, Jaoko W, Wilson K, Kaggiah A, Simoni J, Farquhar C, McClelland R. Psychosocial Factors, Condomless Sex, and Detectable Viral Load in HIV-Positive Women in Serodiscordant Couples in Nairobi, Kenya. AIDS And Behavior 2020, 24: 3346-3358. PMID: 32394232, PMCID: PMC7655612, DOI: 10.1007/s10461-020-02907-0.Peer-Reviewed Original ResearchConceptsProstate specific antigenCondomless sexIntimate partner violenceViral loadSerodiscordant couplesDetectable plasma viral loadPlasma viral loadDetectable viral loadAssociated with increased riskHIV transmission potentialHIV-positive womenAlcohol useComprehensive HIV carePsychosocial factorsAlcohol use disorderHazardous/harmful alcohol useViral suppressionSpecific antigenProspective studyVaginal secretionsFollow-upHIV carePrevalence of intimate partner violenceUse disorderKenyan women
2019
Self-reported antiretroviral therapy adherence and viral load in criminal justice-involved populations
Cunningham WE, Nance RM, Golin CE, Flynn P, Knight K, Beckwith CG, Kuo I, Spaulding A, Taxman FS, Altice F, Delaney JA, Crane HM, Springer SA. Self-reported antiretroviral therapy adherence and viral load in criminal justice-involved populations. BMC Infectious Diseases 2019, 19: 913. PMID: 31664910, PMCID: PMC6819597, DOI: 10.1186/s12879-019-4443-z.Peer-Reviewed Original ResearchConceptsViral loadART adherenceAdherence measuresSelf-reported antiretroviral therapy (ART) adherenceCriminal justice-involved populationsSelf-reported ART adherenceLogistic regressionSelf-reported health statusContinuum of HIVDetectable viral loadPlasma viral loadAIDS Research NetworkAntiretroviral therapy adherenceAssociation of adherenceHealth status levelsVisual analog scaleViral load dataMixed-effects logistic regressionMixed effects linear regressionEffects linear regressionJustice-involved populationsEffects logistic regressionVL outcomesCD4 countART doses
2018
New England BK consortium: Regional survey of BK screening and management protocols in comparison to published consensus guidelines
Gabardi S, Pavlakis M, Tan C, Francis J, Cardarelli F, Asch W, Bodziak K, Chobanian M, Gilligan H, Gohh R, Kung S, Inker L, Martin S, Rodig N, Rossi A, Chandraker A. New England BK consortium: Regional survey of BK screening and management protocols in comparison to published consensus guidelines. Transplant Infectious Disease 2018, 20: e12985. PMID: 30175491, DOI: 10.1111/tid.12985.Peer-Reviewed Original ResearchConceptsRenal transplant recipientsConsensus guidelinesBKPyV-associated nephropathyCNI dose reductionPlasma viral loadUse of leflunomideCopies/mLHalf of centersMajority of centersManagement protocolCause biopsiesImmunosuppression reductionIntravenous immunoglobulinTransplant recipientsRenal biopsyViral loadBK polyomavirusPrimary treatmentDose reductionBiopsyUniform screeningNephropathyBKPyVShort durationScreening
2016
HIV-Associated Neurologic Disorders and Central Nervous System Opportunistic Infections in HIV
Le LT, Spudich SS. HIV-Associated Neurologic Disorders and Central Nervous System Opportunistic Infections in HIV. Seminars In Neurology 2016, 36: 373-381. PMID: 27643907, DOI: 10.1055/s-0036-1585454.Peer-Reviewed Original ResearchConceptsCombination antiretroviral therapyAsymptomatic neurocognitive impairmentPlasma viral loadViral loadMild neurocognitive disorderCerebral toxoplasmosisCryptococcal meningitisOpportunistic infectionsNeurocognitive disordersCentral nervous system opportunistic infectionsCNS immune reconstitution inflammatory syndromeDetectable plasma viral loadImmune reconstitution inflammatory syndromeCentral nervous system symptomsClassic opportunistic infectionsCSF viral loadProgressive neurologic symptomsReconstitution inflammatory syndromeT-cell countsProgressive multifocal leukoencephalopathyNervous system symptomsPresentation of infectionHigher mortality riskHigher CD4Immune recoveryImmune Activation and HIV-Specific CD8+ T Cells in Cerebrospinal Fluid of HIV Controllers and Noncontrollers
Ganesh A, Lemongello D, Lee E, Peterson J, McLaughlin BE, Ferre AL, Gillespie GM, Fuchs D, Deeks SG, Hunt PW, Price RW, Spudich SS, Shacklett BL. Immune Activation and HIV-Specific CD8+ T Cells in Cerebrospinal Fluid of HIV Controllers and Noncontrollers. AIDS Research And Human Retroviruses 2016, 32: 791-800. PMID: 27019338, PMCID: PMC4971411, DOI: 10.1089/aid.2015.0313.Peer-Reviewed Original ResearchMeSH KeywordsADP-ribosyl Cyclase 1Anti-HIV AgentsAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountCD8-Positive T-LymphocytesDisease ResistanceGene ExpressionHIV InfectionsHIV-1HLA-DR AntigensHost-Pathogen InteractionsHumansLeukocyte Common AntigensLymphocyte ActivationReceptors, CCR5Receptors, CCR7RNA, ViralViral LoadViremiaConceptsCentral nervous systemHIV controllersAntiretroviral therapyT cellsCerebrospinal fluidViral loadCopies/HIV-specific T cellsMajor histocompatibility complex class IActivation markers CD38CSF viral loadHIV-specific CD8Undetectable plasma viremiaExpression of CCR5Majority of HIVPlasma viral loadEffector memory cellsHIV-negative controlsHistocompatibility complex class IAbsence of therapyComplex class ILong-term controlPlasma viremiaElite controllersHIV infectionHealth-Related Everyday Functioning in the Internet Age: HIV-Associated Neurocognitive Disorders Disrupt Online Pharmacy and Health Chart Navigation Skills
Woods S, Iudicello J, Morgan E, Cameron M, Doyle K, Smith T, Cushman C, Group T, Grant I, Atkinson J, Ellis R, McCutchan J, Marcotte T, Marquie-Beck J, Sherman M, Ellis R, McCutchan J, Letendre S, Capparelli E, Schrier R, Rosario D, Heaton R, Cherner M, Iudicello J, Moore D, Morgan E, Dawson M, Jernigan T, Fennema-Notestine C, Archibald S, Hesselink J, Annese J, Taylor M, Masliah E, Achim C, Everall I, Richman D, Smith D, McCutchan J, Achim C, Lipton S, Atkinson J, Gamst A, Cushman C, Abramson I, Vaida F, Deutsch R, Umlauf A, DeLuca J, Goverover Y, Franklin D, Corkran S. Health-Related Everyday Functioning in the Internet Age: HIV-Associated Neurocognitive Disorders Disrupt Online Pharmacy and Health Chart Navigation Skills. Archives Of Clinical Neuropsychology 2016, 31: 176-185. PMID: 26743327, PMCID: PMC4758381, DOI: 10.1093/arclin/acv090.Peer-Reviewed Original ResearchConceptsHealth-related behaviorsNeurocognitive disordersHigh plasma viral loadHIV-Associated Neurocognitive DisordersPlasma viral loadEffects of HIVLow health literacyImportant health-related behaviorsHIV infectionViral loadHealth literacyYears of educationOnline pharmaciesStudy participantsPharmacyDisordersFrequent Internet useParticipantsHealthcare managementSeronegativesHIVNavigation skillsInfectionIndividuals
2015
Adenovirus-Vectored Broadly Neutralizing Antibodies Directed Against gp120 Prevent Human Immunodeficiency Virus Type 1 Acquisition in Humanized Mice
Liu S, Jackson A, Beloor J, Kumar P, Sutton RE. Adenovirus-Vectored Broadly Neutralizing Antibodies Directed Against gp120 Prevent Human Immunodeficiency Virus Type 1 Acquisition in Humanized Mice. Human Gene Therapy 2015, 26: 622-634. PMID: 25953321, PMCID: PMC4575530, DOI: 10.1089/hum.2014.146.Peer-Reviewed Original ResearchConceptsHumanized miceHuman immunodeficiency virus type 1 (HIV-1) acquisitionHuman immunodeficiency virus type 1Immunodeficiency virus type 1Plasma viral loadHigher serum levelsSingle intramuscular injectionBroadly Neutralizing AntibodiesVirus type 1First-generation adenoviral vectorsSerum levelsViral loadNeutralizing antibodiesIntramuscular injectionEffective vaccineT cellsHIV-1Therapeutic approachesHigh doseTherapeutic useType 1Adenoviral vectorAdV vectorsMiceAntibodies8th IAS Conference on HIV Pathogenesis, Treatment & Prevention 19–22 July 2015, Vancouver, Canada
Pate K, Pohlmeyer C, Walker‐Sperling V, Foote J, Najarro K, Cryer C, Salgado M, Gama L, Engle E, Shirk E, Queen S, Chioma S, Vermillion M, Bullock B, Li M, Lyons C, Adams R, Zink C, Clements J, Mankowski J, Blankson J, Micci L, Ryan E, Fromentin R, Benne C, Chomont N, Lifson J, Paiardini M, Lee S, Chomont N, Fromentin R, Silicano R, Silicano J, Richman D, O'Doherty U, Palmer S, Burbelo P, Deeks S, Ghneim K, Ahlers J, Fourati S, Shive C, Cameron M, Mukerjee P, Ghannoum M, Rodriguez B, Deeks S, Lederman M, Sekaly R, Frange P, Faye A, Avettand‐Fenoel V, Bellaton E, Deschamps D, Angin M, Caillat‐Zucman S, Peytavin G, Le Chenadec J, Warszawski J, Rouzioux C, Saez‐Cirion A, Cohort A, Chang C, Cameron P, Elliott J, Perelson A, Roche M, Dantanarayana A, Solomon A, Naranbhai V, Tenakoon S, Hoh R, McMahon J, Sikaris K, Hartogensis W, Bacchetti P, Hecht F, Lifson J, Deeks S, Lewin S, Byrareddy S, Arthos J, Cicala C, Reimann K, Parslow T, Santangelo P, Villinger F, Fauci A, Ansari A, George M, Weiser B, Burger H, Lewy T, Anastos K, Asmuth D, Somsouk M, Hunt P, Min Z, Miller C, Li X, Hinkle J, Shaw A, Weaver E, Klein G, Viljoen K, Wendoh J, Karaoz U, Brodie E, Mulder N, Botha G, Kidzeru E, Butcher J, Gray C, Rosenthal K, Abimiku A, Cameron B, Stintzi A, Jaspan H, Schafer J, Evans T, Li H, Reeves R, Kroon M, Dunning L, Hsiao M, Myer L, Crowell C, Maiga A, Sylla M, Taiwo B, Koné N, Murphy R, Marcelin A, Traore B, Fofana D, Chadwick E, Ásbjörnsdóttir K, Slyker J, Wamalwa D, De Rosa S, Hughes J, Rowhani‐Rahbar A, Chohan B, Benki‐Nugent S, Tapia K, John‐Stewart G, Kizito H, Gaur A, Prasitsuebsai W, Rakhmanina N, Chokephaibulkit K, Fourie J, Bekker L, Shao Y, Bennett S, Quirk E, Prasitsuebsai W, Teeraananchai S, Truong K, Ananworanich J, Chau V, Van Nguyen L, Kosalaraksa, Kurniati N, Sudjaritruk T, Chokephaibulkit K, Singtoroj T, Kerr S, Sohn A, Study T, Lombaard J, Bunupuradah T, Flynn P, Ramapuram J, Ssali F, Crauwels H, Hoogstoel A, Van Eygen V, Stevens M, Boven K, Jao J, Myer L, Phillips T, Petro G, Zerbe A, Abrams E, Hanrahan C, Martinson N, Link‐Barnes G, Msandiwa R, Chaisson R, Golub J, Evans D, Schnippel K, Budgell E, Shearer K, Berhanu R, Long L, Rosen S, Schultze A, Efsen A, Post F, Panteleev A, Furrer H, Miller R, Losso M, Toibaro J, Skrahin A, Miro J, Caylà J, Girardi E, Bruyand M, Obel N, Podlekareva D, Lundgren J, Mocroft A, Kirk O, EuroCoord T, Baddeley A, Doherty M, Kanchar A, Matteelli A, Timimi H, Getahun H, Hosseinipour M, Bisson G, Miyahara S, Sun X, Moses A, Riviere C, Kirui F, Badal‐Faesen S, Lagat D, Nyirenda M, Naidoo K, Hakim J, Mugyenyi P, Henostroza G, Leger P, Lama J, Mohapi L, Alave J, Mave V, Veloso V, Pillay S, Kumarasamy N, Bao J, Hogg E, Jones L, Zolopa A, Kumwenda J, Gupta A, Team A, Cohen M, Chen Y, McCauley M, Gamble T, Hosseinipour M, Kumarasamy N, Hakim J, Kumwenda N, Brum T, Grinsztejn B, Godbole S, Chariyalertsak S, Santos R, Mayer K, Hoffman I, Eshleman S, Piwowar‐Manning E, Ou S, Cottle L, Makhema J, Mills L, Panchia R, Badal‐Faesen S, Eron J, Gallant J, Havlir D, Swindells S, Elharrar V, Burns D, Taha T, Nielsen K, Celentano D, Essex M, Fleming T, Group H, Jean K, Puren A, Cutler E, Singh B, Bouscaillou J, Rain‐Taljaard R, Taljjard D, Lissouba P, Peytavin G, Auvert B, Jenkins L, Nordio J, Vasarhelyi K, Nunez A, Barrios R, Rutherford A, Iwuji C, Dray‐Spira R, Calmy A, Larmarange J, Orne‐Gliemann J, Dabis F, Pillay D, Porter K, Barnabas R, van Rooyen H, Tumwesigye E, Brantley J, Baeten J, van Heerden A, Turyamureeba B, Joseph P, Krows M, Hughes J, Celum C, Linkages, Eshleman S, Hudelson S, Ou S, Redd A, Swanstrom R, Porcella S, Chen Y, Piwowar‐Manning E, McCauley M, Gamble T, Sievers M, Martens C, Bruno D, Ping L, Dukhovlinova E, Quinn T, Kumwenda J, Maliwichi M, Nhando N, Akelo V, Moyo S, Panchia R, Kumarasamy N, Chotirosniramit N, Rocha M, Bustorff F, Grinsztejn B, Mayer K, Hughes J, Cohen M, Team F, Haas A, Tenthani L, Msukwa M, Jahn A, Midiani D, Mhango E, Gadabu O, Tal K, Spörri A, Egger M, Chimbwandira F, van Oosterhout J, Keiser O, Rosenberg N, Mtande T, Saidi F, Stanley C, Jere E, Mwangomba L, Kumwenda K, Mofolo I, Mwale M, Chauma A, Miller W, Hoffman I, Hosseinipour M, Buzdugan R, McCoy S, Watadzaushe C, Dufour M, Petersen M, Dirawo J, Mushavi A, Mujuru H, Mahomva A, Engelsmann B, Hakobyan A, Mugurungi O, Cowan F, Padian N, Lallemant M, Amzal B, Urien S, Sripan P, Cressey T, Ngo‐Giang‐Huong N, Rawangban B, Sabsanong P, Siriwachirachai T, Jarupanich T, Kanjanavikai P, Wanasiri P, Koetsawang S, Jourdain G, Le Cœur S, team P, Ochoa‐Moreno I, Mangenah C, Buzdugan R, Padian N, McCoy S, Cowan F, Bautista‐Arredondo S, Wambura M, Hayes R, Grund J, Kapiga S, Mahler H, Mshana G, Kuringe E, Plotkin M, Bock N, Larke N, Changalucha J, Weiss H, Group V, Thirumurthy H, Akello I, Murray K, Masters S, Maman S, Omanga E, Agot K, Duwve J, Hoover K, Conrad C, Galang R, Hillman D, Hoots B, Patel M, Peters P, Pontones P, Roseberry J, Shields J, Waterhouse D, Weidle P, Galang R, Gentry J, Peters P, Blosser S, Chapman E, Conrad C, Duwve J, Ganova‐Raeva L, Heneine W, Hillman D, Jia H, Liu L, Luo W, Lovchik J, Masciotra S, Owen S, Perez A, Peyrani P, Pontones P, Ramachandran S, Roseberry J, Sandoval M, Shankar A, Thai H, Xia G, Khudyakov Y, Switzer W, Mannheimer S, Hirsch‐Moverman Y, Loquere A, Franks J, Hughes J, Ou S, Amico K, Hendrix C, Dye B, Piwowar‐Manning E, Marzinke M, Elharrar V, Stirratt M, Grant R, Team H, Holtz T, Chitwarakorn A, Curlin M, Hughes J, Amico K, Hendrix C, Dye B, Anderson P, Ou S, Elharrar V, Eshleman S, Stirratt M, Grant R, Team B, Doherty M, Beusenberg M, Asamoah‐Odei E, Lule F, Pendse R, Ghidinelli M, Lo Y, Reidner G, Donoghoe M, Vitoria M, Hirnschall G, Levi J, Raymond A, Pozniak A, Vernazza P, Kohler P, Ford N, Hill A, Wolff M, Cortes C, Shepherd B, Giganti M, Mc Gowan C, Caribbean C, Rawat A, Uebel K, Moore D, Yassi A, Wilkinson L, Harley B, Jacobs S, Cragg C, Kriel E, Solomon S, Peton N, Jennings K, Youngleson M, Grimsrud A, Joy J, Liang R, McCloskey R, Nguyen T, Brumme C, Colley G, Hogg R, Montaner J, Harrigan P, Poon A, Klein K, Ratcliff A, Nickel G, Nankya I, Lobritz M, Gao Y, Shattock R, Arts E, Kinloch N, Macmillan D, Le A, Cotton L, McCloskey R, Bangsberg D, Buchbinder S, Carrington M, Fuchs J, Harrigan P, Koblin B, Markowitz M, Mayer K, Milloy M, Schechter M, Wagner T, Walker B, Carlson J, Poon A, Brumme Z, Mesplède T, Anstett K, Osman N, Hassounah S, Liang J, Han Y, Wainberg M, Demeulemeester J, Vets S, Schrijvers R, Madlala P, De Maeyer M, De Rijck J, Ndung'u T, Debyser Z, Gijsbers R, Prentice H, Tomaras G, Geraghty D, Apps R, Fong Y, Ehrenberg P, Rolland M, Kijak G, Nelson W, Decamp A, Shen X, Yates N, Zolla‐Pazner S, Nitayaphan S, Rerks‐Ngarm S, Pitisuttithum P, Ferrari G, Montefiori D, McElrath J, Bailer R, Koup R, O'Connell R, Robb M, Michael N, Kim J, Thomas R, Peterson C, Wang J, Polacino P, Holmes M, Hu S, Gregory P, Kiem H, Kaminski R, Hu W, Zhang Y, Karn J, Khalili K, Chew G, Fujita T, Clayton K, Ishii N, Abdel‐Mohsen M, Liegler T, Hecht F, Ostrowski M, Shikuma C, Maurer M, Korman A, Deeks S, Ndhlovu L, Karn J, Das B, Dobrowolski C, Scully E, Deeks S, Gandhi M, Johnston R, Bunupuradah T, Kiertiburanakul S, Avihingsanon A, Chetchotisakd P, Techapornroong M, Leerattanapetch N, Kantipong P, Bowonwatanuwong C, Banchongkit S, Klinbuayaem V, Mekviwattanawan S, Nimitvilai S, Jirajariyavej S, Prasithsirikul W, Munsakul W, Bhakeecheep S, Chaivooth S, Phanuphak P, Cooper D, Apornpong T, Kerr S, Emery S, Ruxrungtham K, Group L, Mills T, Andrade J, Diperri G, Van Lunzen J, Koenig E, Elion R, Cavassini M, Madruga J, Brunetta J, Shamblaw D, Dejesus E, Cohen C, Plummer A, Liu Y, McCallister S, Gupta S, Pozniak A, Arribas J, Post F, Bloch M, Gathe J, Benson P, Custodio J, Abram M, Wei X, Cheng A, McCallister S, Fordyce M, Gatell J, Raffi F, Plettenberg A, Smith D, Portilla J, Hoffmann C, Arasteh K, Thompson M, Hagins D, Morales‐Ramirez J, Xu X, Teppler H, Trahan M, Lamarre V, Metras M, Lapointe N, Kakkar F, Hwang C, Schürmann D, Sobotha C, Boffito M, Sevinsky H, Ray N, Ravindran P, Xiao H, Krystal M, Dicker I, Grasela D, Lataillade M, Team F, Brunet L, Moodie E, Young J, Walmsley S, Hull M, Cooper C, Klein M, Investigators C, Naggie S, Cooper C, Saag M, Yang J, Stamm L, Pang P, McHutchison J, Dieterich D, Sulkowski M, Wyles D, Eron J, Lalezari J, Wang C, Ruane P, Blick G, Bhatti L, Hu Y, Co M, Gibbons K, Trinh R, Sulkowski M, Casado J, Bañon S, Quereda C, Moreno A, Elías M, Moreno S, Saeed S, Rollet‐Kurhajec K, Strumpf E, Klein M, Cohort T, Rockstroh J, Nelson M, Katlama C, Lalezari J, Mallolas J, Bloch M, Matthews G, Saag M, Zamor P, Orkin C, Gress J, Shaughnessy M, Klopfer S, Platt H, Robertson M, Sulkowski M, Lacombe K, Fontaine H, Dhiver C, Rosenthal E, Metivier S, Antonini‐Michelle T, Valantin M, Miailhes P, Harent S, Batisse D, Pageaux G, Aumaitre H, Dominguez S, Chas J, Allegre T, Lafeuillade A, De Truchis P, De Ledinghen V, Leroy V, Billaud E, Sogni P, Dabis F, Wittkop L, Duvivier C, Filipovics A, Fedchuk L, Bennai Y, Salmon D, Karim Q, Leask K, Kharsany A, Humphries H, Ntombela F, Samsunder N, Baxter C, Frohlich J, van der Elst L, Karim S, Thirumurthy H, Masters S, Rao S, Murray K, Omanga E, Agot K, Marshall B, Elston B, Dobrer S, Montaner J, Kerr T, Wood E, Milloy M, Czaicki N, Njau P, Bautista‐Arredondo S, Simba O, Padian N, McCoy S, Haber N, Tanser F, Herbst K, Pillay D, Bärnighausen T, Studies W, Pettifor A, MacPhail C, Selin A, Gomez‐Olivé X, Hughes J, Wagner R, Mabuza W, Mokoena I, Eshleman S, Piwowar‐Manning E, Twine R, Julien A, Marcus C, Andrew P, Wang J, Xing Y, McKinstry L, Hamilton E, Agyei Y, Allison S, Sato P, Townley E, Tollman S, Kahn K, Team H, Solomon M, Schechter M, Liu A, McMahan V, Guanira J, Hance R, Chariyalertsak S, Mayer K, Grant R, Team I, Liu A, Cohen S, Vittinghoff E, Anderson P, Doblecki‐Lewis S, Bacon O, Chege W, Elion R, Buchbinder S, Kolber M, Group D, Henderson F, Taylor A, Chirwa L, Williams T, Borkowf C, Kasonde M, Mutanhaurwa R, Matlhaba O, Hageman K, Casillas P, Hosek S, Rudy B, Landovitz R, Kapogiannis B, Siberry G, Liu N, Rutledge B, Brothers J, Rooney J, Wilson C, Interventions A, Hoagland B, Veloso V, De Boni R, Madruga J, Kallas E, Fernandes N, Moreira R, Liu A, Grinsztejn B, Team P, Nair G, Justman J, Piper J, Marzinke M, Hendrix C, Dai J, Pan J, Galaska B, Levy L, Shwartz J, McGowan I, Dezutti C, Xu J, Tang W, Zou H, Mahapatra T, Hu Q, Fu G, Wang Z, Lu L, Zhuang M, Chen X, Fu J, Yu Y, Lu J, Jiang Y, Geng W, Han X, Shang H, Wimonsate W, Pattanasin S, Sriporn A, Luechai P, Satumay K, Tippanonth N, Promda N, Holtz T, Chitwarakorn A, Dunne E, Chan G, Bennett A, Buskin S, Dombrowski J, Golden M, Grosso A, Stahlman S, Mothopeng T, Taruberekera N, Ouedraogo G, Ky‐Zerbo O, Pitche V, Anato S, Sithole B, Mabuza X, Ceesay N, Diouf D, Trapence G, Umar E, Baral S, Khosropour C, Katz D, Dombrowski J, Golden M, Bavinton B, Jin F, Prestage G, Zablotska I, Grinsztejn B, Phanuphak N, Friedman R, Grulich A, Group O, Sathane I, Horth R, Boothe M, Baltazar C, Young P, Fisher H, Teodoro E, Gouveia M, Lane T, McFarland W, Booth R, Davis J, Dvoryak S, Brewster J, Strathdee S, Latkin C, Joseph B, Milloy M, Nguyen H, Bui D, Dinh T, Nguyen M, Tran H, Nguyen L, Van Nguyen T, Vu Q, Nhan T, Le A, Nguyen B, Suthar A, Lo Y, Pham H, Le M, Nguyen H, Kato M, Richardson L, Kerr T, Hogg B, Guillemi S, Montaner J, Wood E, Milloy M, Cousien A, Leclerc P, Morissette C, Bruneau J, Roy É, Yazdanpanah Y, Cox J, Bershteyn A, Klein D, Oishi K, Eckhoff P, Leisegang R, McMahon J, Hislop M, Stinson K, Boulle A, Elliott J, Maartens G, Kim A, Nganga L, Mukui I, Wamicwe J, Mwanyumba S, Bowen N, Wiesner L, De Cock K, Group K, Han L, Tang W, Best J, Zhang Y, Kim J, Liu F, Mollan K, Hudgens M, Bayus B, Terris‐Prestholt F, Galler S, Yang L, Peeling R, Volberding P, Ma B, Yang B, Huang S, Fenton K, Wei C, Tucker J, Dombrowski J, Hughes J, Buskin S, Simoni J, Katz D, Fleming M, Nunez A, Golden M, Schmitz K, Scheepers E, Okonji E, Kawooya V, Yotebieng M, Thirumurthy H, Moracco K, Kawende B, Chalachala J, Wenzi L, Ravelomanana N, Edmonds A, Thompson D, Okitolonda E, Behets F, Musarandega R, Mahomva A, Robinson J, Tumbare E, Sen P, Hakobyan A, Mushavi A, Domercant J, Puttkammer N, Lu L, Francois K, Duncan D, Grand'Pierre R, Lowrance D, Adler M, Tih P, Katayi E, Mboh E, Bonje E, Lem E, Awa J, Lim J, Duncan D, Petit L, Bianchi F, Welty T, Achu M, Tayong G, Tene G, Mosoko J, Bolu O, Kieffer M, Woelk G, Mpofu D, Cathcart R, Group A, Okala S, King D, Shattock R, Jacob R, Moyo T, Schomaker M, Abrahams F, Pujol B, Dorfman J, Valenzuela‐Ponce H, Ávila‐Ríos S, Garrido‐Rodríguez D, García‐Téllez T, Soto‐Nava M, Escamilla‐Gómez T, García‐Morales C, Cortés‐Álvarez J, Hernández‐Juan R, Murakami‐Ogasawara A, Mejía‐Villatoro C, Pascale J, Porras G, Quant C, Lorenzana I, Meza R, Palou E, Manzanero M, Reyes‐Terán G, Group M, Mailiiard R, Smith K, Piazza P, Mullins J, Rinaldo C, Planas D, Gosselin A, Monteiro P, Goulet J, Da Fonseca S, Cléret‐Buhot A, Jenabian M, Routy J, Ancuta P, Jensen K, dela Pena‐Ponce M, Piatak M, Jacobs W, Fennelly G, Mollan K, Hudgens M, Kozlowski P, Amedee A, Estes J, Lifson J, Van Rompay K, Larsen M, De Paris K, Malatinkova E, De Spiegelaere W, Bonczkowski P, Kiselinova M, Vervisch K, Trypsteen W, Johnson M, Verhofstede C, de Looze D, Murray C, Loes S, Vandekerckhove L, Fletcher J, Pinyakorn S, de Souza M, Akapirat S, Trichavaroj R, Pankam T, Kroon E, Colby D, Prueksakaew P, Suttichom D, Kim J, Phanuphak P, Phanuphak N, Ananworanich J, Group T, Vandendriessche A, Mourez T, Lemée V, Debab Y, Peytavin G, Ladner J, Caron F, Plantier J, Leporrier J, Colby D, Phanuphak N, Sirivichayakul S, Prueksakaew P, Saengtawan P, Trichavaroj R, Crowell T, Kim J, Ananworanich J, Phanuphak P, Group R, Argento E, Duff P, Bingham B, Nguyen P, Strathdee S, Shannon K, Namey E, Perry B, Headley J, Yao K, Ouattara M, Shighata C, Ferguson M, Lane T, Sibanyoni M, Manyuchi A, Osmand T, Marr A, Grasso M, Isdahl Z, Mutanha N, Makhubela P, Silima M, Zuma N, Struthers H, McIntyre J, Rees H, Venter F, Lancaster K, Lungu T, Hosseinipour M, Chadwick K, Dibb Z, Go V, Pence B, Powers K, Hoffman I, Miller W, Sedaghat A, Karamouzian M, Sharifi H, Mirzazadeh A, Shokoohi M, Haghdoost A, Schwartz S, Lambert A, Phaswana‐Mafuya N, Holland C, Kose Z, McIngana M, Sweitzer S, Baral S, Grimsrud A, Lesosky M, Kalombo C, Bekker L, Myer L, Caballero P, Da Silva C, Da Cruz M, Plazy M, ElFarouki K, Iwuji C, Okesola N, Orne‐Gliemann J, Larmarange J, Newell M, Pillay D, Dabis F, Dray‐Spira R, Group F, Rebeiro P, Cesar C, Shepherd B, De Boni R, Cortés C, Rodriguez F, Belaunzarán‐Zamudio P, Pape J, Padgett D, Hoces D, McGowan C, Cahn P, Pilcher C, Hatano H, Dasgupta A, Jones D, Torres S, Calderon F, Ospina‐Norvell C, Hartogensis W, Demicco E, Geng E, Gandhi M, Havlir D, Wagner A, Njuguna I, Mugo C, Inwani I, Maleche‐Obimbo E, Sherr K, Wamalwa D, John‐Stewart G, Slyker J, Bandason T, McHugh G, Ferrand R, Munyati S, Kranzer K, Chonzi P, Elyanu P, Magongo E, Asire B, Lukabwe I, Bitimwine H, Katureebe C, Achii P, Mulema V, Dziuban E, Sugandhi N, Musiime V, Namuwenge N, Musinguzi J, Manno E, Bamford A, Conejo P, Marquez L, Mellado M, Muñoz‐Fernández M, Spoulou V, Klein N, Ananworanich J, Della Negra M, Ziegler J, Meanson E, Lyall H, Shingadia D, Di Biagio A, Giacomet V, Vibeke R, de Sousa Marques H, Salo E, Volokha A, Scherpbier H, Niehues T, Levy J, Marczynska M, Mardarescu M, Reliquet V, Giaquinto C, Bernardi S, Palma P, Ronen K, McGrath C, Langat A, Kinuthia J, Omolo D, Singa B, Katana A, Nganga L, John‐Stewart G, Krebs E, Min J, Barrios R, Montaner J, Nosyk B, Group S, Kelly S, Shattock A, Kerr C, Stuart R, Papoyan A, Grigoryan T, Hovhannisyan R, Grigoryan S, Wilson D, Rajkotia Y, Zang O, Nguimkeu P, Djurovic I, Estill J, Ford N, Salazar‐Vizcaya L, Haas A, Blaser N, Egger M, Habiyambere V, Keiser O, Africa I, Chuma B, Koseki S, Musau S, Johns B, Gatome‐Munyua A, Honermann B, Millett G, Lindsey K, Wijayaratne S, Sherwood J, MacAllister J, Le A, Taylor J, Dong W, McCloskey R, Woods C, Hayashi K, Milloy M, Harrigan P, Poon A, Brumme Z, Garrido‐Rodriguez D, Avila‐Rios S, Valenzuela‐Ponce H, García‐Tellez T, Quiroz‐Morales V, García‐Morales C, Soto‐Nava M, Murakami‐Ogasawara A, Fernandez‐Lopez J, Terán G, Alcami J, Bermejo M, Descours B, Mateos E, Lederman M, Benkirane M, Coiras M, Purcell D, Jacobson J, Harty L, Jarman K, Lackovic K, Khoury G, Mota T, Lee M, Bernardi G, Saleh S, Sonza S, Lewin S, Capoferri A, Sievers M, Redd A, Cash A, Xu D, Porcella S, Quinn T, Siliciano R, Levis M, Ambinder R, Durand C, Lee S, Zhou S, Archin N, Margolis D, Swanstrom R, Alcaide M, Chisembele M, Malupande E, Arheart K, Jones D, Fischl M, Vicol L, Hornsberger A, Pick N, Van Schalkwyk J, Bloomenthal D, Christilaw J, Money D, Pyra M, Heffron R, Mugo N, Nanda K, Thomas K, Celum C, Kourtis A, Baeten J, Teams P, Ajibola G, Shapiro R, Zash R, Holmes L, Batlang O, Ramogothobeng K, Chilisa F, Bennett K, Makhema J, Lockman S, Powis K, Lippman S, Pettifor A, Neilands T, MacPhail C, Peacock D, Maman S, Twine R, Selin A, Kahn K, Derksen L, Muula A, van Oosterhout J, van Lettow M, Matengeni A, Sodhi S, Katz D, Golden M, Hughes J, Farquhar C, Stekler J, Lippman S, Moran M, Ventura A, Castillo L, Buchbinder S, Treves‐Kagan S, Sevelius J, Mavedzenge S, Sibanda E, Mavengere Y, Hatzold K, Mugurungi O, Ncube G, Cowan F, Muffih P, Mboh E, Fang E, Wainfen W, Fon H, Welty T, Shields R, Golden M, Bachireddy C, Izenberg J, Soule M, Dvoryak S, Altice F, Nosyk B, Min J, Evans E, Li L, Liu L, Lima V, Wood E, Montaner J, Beletsky L, Gonzalez‐Zuniga P, Rangel G, Werb D, Arredondo J, Strathdee S, Lambdin B, Nyandindi C, Bruce D, Sabuni N, Magimba A, Matiko E, Milloy M, Kerr T, Hogg R, Guillemi S, Montaner J, Wood E, Merlini E, Iannuzzi F, Bai F, Trunfio M, Bonora S, Calcagno A, Cannizzo E, Basilissi M, Bini T, Monforte A, Marchetti G, O'Brien M, Manches O, Wilen C, Wu V, Sunseri N, Bhardwaj N, Bego M, Côté É, Aschman N, Mercier J, Weissenhorn W, Cohen É, Turrini F, Kajaste‐Rudnitski A, Marelli S, Van Lint C, Das A, Berkout B, Vicenzi E, Simpson S, deSilva T, Yindom L, Leligdowicz A, Vincent T, Rowland‐Jones S, Webb G, Chew G, Fujita T, Burwitz B, Wu H, Reed J, Hammond K, Hansen S, Maurer M, Korman A, Ndhlovu L, Sacha J, Esser S, Geisel M, Arendt M, Schulze C, Holzendorf V, Warnke A, Brockmeyer N, Hower M, Schadendorf D, Neumann T, Eisele L, Erbel R, Moebus S, Jöckel K, Reinsch N, Group H, Hamzah L, Tiraboschi J, Toby M, Iveson H, Mant C, John C, Burling K, Kulasegaram R, Teague A, Post F, Fox J, Group M, Grant P, Kitch D, McComsey G, Collier A, Koletar S, Erlandson K, Yin M, Bartali B, Ha B, Melbourne K, Brown T, Sudjaritruk T, Bunupuradah T, Aurpibul L, Kosalaraksa, Kurniati N, Puthanakit T, Spinner C, Kern K, Noe S, von Werder A, Schwerdtfeger C, Schmid R, Zink A, Wolf E, Iakoubov R, Paraskevis D, Nikolopoulos G, Sypsa V, Psichogiou M, Malliori M, Friedman S, Hatzakis A, Thompson L, Wertheim J, Reza T, Wylie J, Emmanuel F, Brooks J, Blanchard J, Sandstrom P, Tee K, Kantor R, Sungkanuparph S, Takebe Y, Li P, Ditangco R, Phanuphak P, Sirisanthana T, Sim B, Ratanasuwan W, Kantipong P, Mustafa M, Merati T, Jiamsakul A, Singtoroj T, Kamarulzaman A, Monitoring T, Sulaberidze L, Mirzazadeh A, Chikovani I, Shengelia N, Tsereteli N, Gotsadze G, Mulawa M, Reyes H, Foshee V, Halpern C, Kajula L, Maman S, Treves‐Kagan S, Ayadi A, Pettifor A, MacPhail C, Twine R, Maman S, Kahn K, Lippman S, Camlin C, Ssemmondo E, Chamie G, Kwarisiima D, Sang N, Bukusi E, Cohen C, Kamya M, Havlir D, Schley A, Skowronska E, Okonji E, Scheepers E, Feldacker C, Myers S, Cesar F, Parades Z, Ferrao C, Citao S, Mudender F, Golden M, Mark J, Kinuthia J, Osoti A, Gone M, Asila V, Parikh S, Krakowiak D, Betz B, Richardson B, Roxby A, Farquhar C, Pina C, Dange A, Neytra S, Kambli H, Karambe S, Chhabra R, Patel V, Ndlovu B, Hermanus T, Tumba N, Moore P, Jaggernath M, Walker B, Morris L, Ndung'u T, Leitman E, Hurst J, Mori M, Matthews P, Frahm N, Kublin J, Gray G, Goulder P, Demarco T, Rountree W, Hora B, Chen Y, Keinonen S, Racz L, Daniell L, Louzao R, Sanchez A, Busch M, Denny T, Gao F, Johnson A, Jacob R, Haeryfar M, Dikeakos J, Mohammed T, Gaseitsiwe S, Matlhagela K, Matsheka M, Moyo S, Musonda R, Moukambi F, Rabezanahary H, Rodrigues V, Estaquier J, Ndjoyi‐Mbiguino A, Nzengui G, Kamdem H, Bélec L, Viana R, Xaba T, Stojiljkovic T, Gunther N, Wallis C, Grimsrud A, Cornell M, Schomaker M, Fox M, Orrell C, Prozesky H, Stinson K, Tanser F, Egger M, Myer L, Collaboration I, Nsumba M, Barbara C, Musomba R, Kaimal A, Ivan K, Isaac L, Laurence J, Rosalind P, Andrew K, Khan A, Hans L, Gonzales L, Carmona S, Hsiao N, Brophy J, Lee T, Sauve L, Bitnun A, Singer J, Kakkar F, Lapointe N, Alimenti A, Money D, Vaudry W, Samson L, Group F, Singer J, Bitnun A, Lee T, Samson L, Brophy J, Money D, Alimenti A, Vaudry W, Kakkar F, Lapointe N, Sauve L, Group C, du Lou A, Pannetier J, Ravalihasy A, Gosselin A, Supervie V, Bajos N, Lert F, Lydie N, Dray‐Spira R, Kerani R, Herbeck J, Buskin S, Dombrowski J, Bennett A, Barash E, Barbee L, Golden M, Chang L, Grabowski M, Ssekubugu R, Nalugoda F, Reynolds S, Lessler J, Moore S, Quinn T, Gray R, Serwadda D, Wawer M, Ramachandran A, Manabe Y, Rajasingham R, Shah M, Schwarz M, Flick R, Harawa M, Simon K, Kim M, Robison J, Ahmed S, Schramm B, Tayea A, Wolters L, Nicholas S, Masiku C, Zolowere D, Mhango E, Kandulu J, Etard J, Amaros I, Szumilin E, Gueguen M, Ndulue N, Etsetowaghan A, Gabriel C, Ibrahim J, Seclen‐Palacin J, Natumanya E, Nabitaka L, Bitarakwate E, Ismail S, Moshgabadi N, Galli R, Daly A, Ko S, Zhang M, Westgard T, Bulpitt A, Shackleton C. 8th IAS Conference on HIV Pathogenesis, Treatment & Prevention 19–22 July 2015, Vancouver, Canada. Journal Of The International AIDS Society 2015, 18: 20479. PMID: 26205488, PMCID: PMC4513179, DOI: 10.7448/ias.18.5.20479.Peer-Reviewed Original ResearchPeripheral blood mononuclear cellsUndetectable plasma viral loadPlasma viral loadSuppressive antiretroviral therapySimian immunodeficiency virusElite suppressorsViral loadAntiretroviral therapyT cellsHIV-1Viral outgrowthResidual virusMeasurable viral loadQuantitative viral outgrowthResidual HIV-1Viral amplificationUndetectable viral loadBlood mononuclear cellsSubset of miceDepleting antibodyHumanized miceImmunodeficiency virusViral reservoirMononuclear cellsSuccessful xenografts
2014
Serial Cervicovaginal Exposures With Replication-Deficient SIVsm Induce Higher Dendritic Cell (pDC) and CD4+ T-Cell Infiltrates Not Associated With Prevention but a More Severe SIVmac251 Infection of Rhesus Macaques
Abdulhaqq S, Martinez M, Kang G, Foulkes A, Rodriguez I, Nichols S, Hunter M, Sariol C, Ruiz L, Ross B, Yin X, Speicher D, Haase A, Marx P, Li Q, Kraiselburd E, Montaner L. Serial Cervicovaginal Exposures With Replication-Deficient SIVsm Induce Higher Dendritic Cell (pDC) and CD4+ T-Cell Infiltrates Not Associated With Prevention but a More Severe SIVmac251 Infection of Rhesus Macaques. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2014, 65: 405-413. PMID: 24226059, PMCID: PMC3943721, DOI: 10.1097/qai.0000000000000047.Peer-Reviewed Original ResearchConceptsPlasmacytoid dendritic cellsSimian immunodeficiency virusT cell infiltrationDendritic cellsCD4 T cell lossCD4+ T cell infiltrationPlasmacytoid dendritic cell recruitmentRate of CD4 declineInfection of rhesus macaquesCD4 T cell infiltrationRate of viral replicationT cell lossPlasma viral loadRhesus macaquesCD4 T cellsCD4 T lymphocytesImmune cell infiltrationIndian rhesus macaquesAssociated with preventionCD4 countVaginal exposureCD4 declineImmunodeficiency virusVaginal tissueT cells
2012
Prevention, Detection, and Treatment of Coinfections: A Priority in Human Immunodeficiency Virus–Infected Persons to Reduce Viral Load and Consequent Disease Progression and Transmission : Comment on “Effect of Early Syphilis Infection on Plasma Viral Load and CD4 Cell Count in Human Immunodeficiency Virus–Infected Men”
Vermund SH. Prevention, Detection, and Treatment of Coinfections: A Priority in Human Immunodeficiency Virus–Infected Persons to Reduce Viral Load and Consequent Disease Progression and Transmission : Comment on “Effect of Early Syphilis Infection on Plasma Viral Load and CD4 Cell Count in Human Immunodeficiency Virus–Infected Men”. JAMA Internal Medicine 2012, 172: 1243-1244. PMID: 22824925, DOI: 10.1001/archinternmed.2012.3770.Peer-Reviewed Original ResearchCerebrospinal fluid HIV escape associated with progressive neurologic dysfunction in patients on antiretroviral therapy with well controlled plasma viral load
Peluso MJ, Ferretti F, Peterson J, Lee E, Fuchs D, Boschini A, Gisslén M, Angoff N, Price RW, Cinque P, Spudich S. Cerebrospinal fluid HIV escape associated with progressive neurologic dysfunction in patients on antiretroviral therapy with well controlled plasma viral load. AIDS 2012, 26: 1765-1774. PMID: 22614889, PMCID: PMC3881435, DOI: 10.1097/qad.0b013e328355e6b2.Peer-Reviewed Original ResearchConceptsCSF HIV RNAAntiretroviral therapyHIV RNACopies/CSF escapeNeurologic abnormalitiesCerebrospinal fluidMedian CD4 T-cell countDetectable CSF HIV RNAMedian plasma HIV RNACD4 T-cell countCentral nervous system exposureNew neurologic abnormalitiesPlasma HIV levelsPlasma HIV RNAProgressive neurologic abnormalitiesStable ART regimenPlasma viral loadT-cell countsElevated CSF proteinRetrospective case seriesProgressive neurologic dysfunctionUrban medical centerCSF RNAHIV escape
2011
Prevalence of Low-Level HIV-1 Variants with Reverse Transcriptase Mutation K65R and the Effect of Antiretroviral Drug Exposure on Variant Levels
Kozal MJ, Chiarella J, St John EP, Moreno EA, Simen BB, Arnold TE, Lataillade M. Prevalence of Low-Level HIV-1 Variants with Reverse Transcriptase Mutation K65R and the Effect of Antiretroviral Drug Exposure on Variant Levels. Antiviral Therapy 2011, 16: 925-929. PMID: 21900725, DOI: 10.3851/imp1851.Peer-Reviewed Original ResearchConceptsTreatment-naive individualsDifferent HIV-1 subtypesARV-naive subjectsHIV-1 subtypesAntiretroviral exposureViral loadSubtype CUltra-deep sequencingReverse Transcriptase Mutation K65RRitonavir-boosted protease inhibitorHIV-1 subtype CResistant variantsAntiretroviral drug exposurePlasma viral loadTreatment-naive subjectsLow-level variantsPre-therapy levelsHIV-1 variantsDrug resistance mutationsMutation K65RVirological failureSubtype BDrug exposureMutational loadHigh mutation load
2010
Effect of treating co-infections on HIV-1 viral load: a systematic review
Modjarrad K, Vermund SH. Effect of treating co-infections on HIV-1 viral load: a systematic review. The Lancet Infectious Diseases 2010, 10: 455-463. PMID: 20610327, PMCID: PMC3071714, DOI: 10.1016/s1473-3099(10)70093-1.Peer-Reviewed Original ResearchConceptsViral load differencesViral loadPlasma HIV-1 RNA concentrationSystematic reviewMean plasma viral loadPlasma HIV RNA concentrationHIV-1 RNA concentrationsHIV-1 viral loadHIV RNA concentrationPlasma viral loadHIV transmission riskViral load reductionNon-pathogenic infectionsCo-infecting pathogensSyphilis treatmentHIV progressionTuberculosis treatmentEligible studiesPopulation-level benefitsTransmission riskLow-income countriesHIVTreatmentInfectionReview
2005
Immunization of Macaques with Single-Cycle Simian Immunodeficiency Virus (SIV) Stimulates Diverse Virus-Specific Immune Responses and Reduces Viral Loads after Challenge with SIVmac239
Evans D, Bricker J, Sanford H, Lang S, Carville A, Richardson B, Piatak M, Lifson J, Mansfield K, Desrosiers R. Immunization of Macaques with Single-Cycle Simian Immunodeficiency Virus (SIV) Stimulates Diverse Virus-Specific Immune Responses and Reduces Viral Loads after Challenge with SIVmac239. Journal Of Virology 2005, 79: 7707-7720. PMID: 15919923, PMCID: PMC1143664, DOI: 10.1128/jvi.79.12.7707-7720.2005.Peer-Reviewed Original ResearchConceptsSingle-Cycle Simian Immunodeficiency VirusesRNA copies/AIDS vaccine approachSingle-cycle SIVEnzyme-linked immunospotViral loadSimian immunodeficiency virusCopies/Immunodeficiency virusVaccine approachesGamma interferon enzyme-linked immunospotGag-specific T-cell responsesVirus-specific immune responsesMajor Histocompatibility Complex Class I DownregulationT cell proliferative responsesImmunization of macaquesPlasma viral loadT cell responsesMHC class IThird doseChronic phasePeripheral bloodWeek 8Immune responseControl animals
2004
Prevention of mother-to-child transmission of HIV in Africa.
Vermund SH. Prevention of mother-to-child transmission of HIV in Africa. Topics In Antiviral Medicine 2004, 12: 130-4. PMID: 15647608.Peer-Reviewed Original ResearchConceptsChild transmissionHIV infectionInternational AIDS Society-USA courseMaternal plasma viral loadExclusive formula feedingNevirapine resistance mutationsSingle-dose nevirapinePrevention of motherPlasma viral loadPerinatal transmission ratePerinatal transmissionAntiretroviral therapyExclusive breastfeedingFormula feedingViral loadMaternal mortalityRisk factorsMortality rateHIVAfrican childrenMixed feedingGreater riskResistance mutationsEarly weaningBreastfeeding
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