2025
Development of the natural history component of an early economic model for primary sclerosing cholangitis
Bowlus C, Levy C, Kowdley K, Kachru N, Jeyakumar S, Rodriguez-Guadarrama Y, Smith N, Briggs A, Sculpher M, Ollendorf D. Development of the natural history component of an early economic model for primary sclerosing cholangitis. Orphanet Journal Of Rare Diseases 2025, 20: 133. PMID: 40102907, PMCID: PMC11921552, DOI: 10.1186/s13023-025-03658-8.Peer-Reviewed Original ResearchConceptsQuality-adjusted life yearsTransplant-free survivalProportion of patientsRecurrent PSCLiver transplantationDisease progressionOverall survivalSclerosing cholangitisSecondary cancersCumulative incidenceCumulative incidence of secondary cancersIncidence of secondary cancersChronic cholestatic diseasePrimary sclerosing cholangitisProgression to cirrhosisLifetime quality-adjusted life yearsBackgroundPrimary sclerosing cholangitisMarkov cohort modelInflammatory bowel diseaseEconomic modelGallbladder cancerEstimates of disease progressionCholestatic diseasesFibrosis stageLiver failure
2024
Simple versus radical cholecystectomy and survival for pathologic stage T1B gallbladder cancer
Rhodin K, Goins S, Kramer R, Eckhoff A, Herbert G, Shah K, Allen P, Nussbaum D, Blazer D, Zani S, Lidsky M. Simple versus radical cholecystectomy and survival for pathologic stage T1B gallbladder cancer. Hepato Pancreato Biliary 2024, 26: 594-602. PMID: 38336604, DOI: 10.1016/j.hpb.2024.01.012.Peer-Reviewed Original ResearchConceptsT1b gallbladder cancerRadical cholecystectomyNational Cancer DatabaseGallbladder cancerOverall survivalExtended resectionMultivariate Cox proportional hazards methodCox proportional hazards methodProportional hazards methodStandard of careAssociated with greater hazardMedian OSR0 resectionResidual diseaseT1b diseaseNodal metastasisCancer DatabaseSurgical managementKaplan-MeierProspective validationCholecystectomyHazards methodResectionLow riskPatients
2023
Trends in Receipt of Adjuvant Chemotherapy and its Impact on Survival in Resected Biliary Tract Cancers
Rhodin K, Liu A, Bartholomew A, Kramer R, Parameswaran A, Uronis H, Strickler J, Hsu D, Morse M, Shah K, Herbert G, Zani S, Nussbaum D, Allen P, Lidsky M. Trends in Receipt of Adjuvant Chemotherapy and its Impact on Survival in Resected Biliary Tract Cancers. Annals Of Surgical Oncology 2023, 30: 4813-4821. PMID: 37188803, PMCID: PMC10330866, DOI: 10.1245/s10434-023-13567-4.Peer-Reviewed Original ResearchConceptsBiliary tract cancerResected biliary tract cancerNational Cancer DatabaseAdjuvant chemotherapyGallbladder cancerIntrahepatic CCAExtrahepatic CCAMethodsThe National Cancer DatabaseMultivariate Cox proportional hazards methodBiliary tract cancer subtypesOdds of ACCox proportional hazards methodReceipt of adjuvant chemotherapyCurative-intent treatmentReceipt of ACFactors associated with receiptYear of diagnosisHigher comorbidity scoreProportional hazards methodStage of diseaseFactors associated with ACMultivariate logistic regressionAssociated with reduced oddsIII diseasePositive margins
2021
Genomic profiling of biliary tract cancers to reveal clinically actionable genes and therapeutic biomarkers.
Shao Y, Ou Q, Fang Z, Liu R, Bao H, Wu X. Genomic profiling of biliary tract cancers to reveal clinically actionable genes and therapeutic biomarkers. Journal Of Clinical Oncology 2021, 39: e16187-e16187. DOI: 10.1200/jco.2021.39.15_suppl.e16187.Peer-Reviewed Original ResearchTumor mutation burdenMicrosatellite instability statusGallbladder cancerTelomeric allelic imbalanceBTC patientsDistal cholangiocarcinomaPerihilar cholangiocarcinomaTract cancerIntrahepatic cholangiocarcinomaCancer patientsBiliary tract cancer patientsHigh tumor mutation burdenDNA damage repair pathway genesImpaired mismatch repairBiliary tract cancerHomologous recombination repairPoly (ADP-ribose) polymerase (PARP) inhibitorsDDR gene alterationsTumor tissue samplesMismatch repairBase excision repair genesBTC subtypesHRR mutationsClinical outcomesPoor prognosisGallbladder Disorders: A Comprehensive Review
Lam R, Zakko A, Petrov JC, Kumar P, Duffy AJ, Muniraj T. Gallbladder Disorders: A Comprehensive Review. Disease-a-Month 2021, 67: 101130. PMID: 33478678, DOI: 10.1016/j.disamonth.2021.101130.Peer-Reviewed Original Research
2020
Pancreatobiliary Maljunction-associated Gallbladder Cancer Is as Common in the West, Shows Distinct Clinicopathologic Characteristics and Offers an Invaluable Model for Anatomy-induced Reflux-associated Physio-chemical Carcinogenesis
Muraki T, Pehlivanoglu B, Memis B, Reid M, Uehara T, Basturk O, Pernicka J, Klimstra D, Jarnagin W, Ito T, Hasebe O, Okaniwa S, Horigome N, Hisa T, Mittal P, Sarmiento J, Maithel S, Koshiol J, Tsai S, Evans D, Erkan M, Adsay V. Pancreatobiliary Maljunction-associated Gallbladder Cancer Is as Common in the West, Shows Distinct Clinicopathologic Characteristics and Offers an Invaluable Model for Anatomy-induced Reflux-associated Physio-chemical Carcinogenesis. Annals Of Surgery 2020, 276: e32-e39. PMID: 33201123, PMCID: PMC9305302, DOI: 10.1097/sla.0000000000004482.Peer-Reviewed Original ResearchConceptsPancreatobiliary maljunctionGallbladder cancerAdenoma-carcinoma sequenceRate of tumor-infiltrating lymphocytesReflux of pancreatic enzymesRisk of gallbladder cancerTumor-infiltrating lymphocytesAssociated with gallstonesBile duct carcinomaOrigin work-upGBC casesPancreatobiliary disordersDuct carcinomaCarcinoma typesCholedochal cystClinicopathological characteristicsClinicopathological featuresBile ductRadiological imagingWork-upPancreatic enzymesYounger ageCarcinomaCancerDisorders
2019
Liver resection for extra-pancreatic biliary cancer: what is the role of laparoscopic approach?
Elmoghazy W, Cowan J, Tabchouri N, Tinguely P, Bennamoun M, Tubbax C, Sarran A, Lefevre M, Lamer C, Gayet B, Fuks D. Liver resection for extra-pancreatic biliary cancer: what is the role of laparoscopic approach? Surgical Endoscopy 2019, 33: 3711-3717. PMID: 30693390, DOI: 10.1007/s00464-019-06664-7.Peer-Reviewed Original ResearchConceptsPeri-hilar cholangiocarcinomaIntra-hepatic cholangiocarcinomaBiliary tract cancerGallbladder cancerLiver resectionBiliary cancerConclusionsThe present seriesGallbladder cancer groupBackgroundLaparoscopic liver resectionEstimated blood lossMedian operative timeMedian hospital stayShort-term outcomesInstitut Mutualiste MontsourisR0 resectionCurative intentPostoperative morbidityLaparoscopic approachPerioperative outcomesBlood lossMedian agePostoperative mortalityHospital stayPatient characteristicsOperative time
2018
Regional differences in gallbladder cancer pathogenesis: Insights from a multi‐institutional comparison of tumor mutations
Narayan R, Creasy J, Goldman D, Gönen M, Kandoth C, Kundra R, Solit D, Askan G, Klimstra D, Basturk O, Allen P, Balachandran V, D’Angelica M, DeMatteo R, Drebin J, Kingham T, Simpson A, Abou‐Alfa G, Harding J, O’Reilly E, Butte J, Matsuyama R, Endo I, Jarnagin W. Regional differences in gallbladder cancer pathogenesis: Insights from a multi‐institutional comparison of tumor mutations. Cancer 2018, 125: 575-585. PMID: 30427539, PMCID: PMC6636637, DOI: 10.1002/cncr.31850.Peer-Reviewed Original ResearchConceptsGallbladder cancer pathogenesisErb-b2 receptor tyrosine kinase 3Gallbladder cancerJapanese patientsSMAD family member 4Overall survivalTumor mutationsAT-rich interactive domain 2Associated with worse survivalPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaAT-rich interactive domain 1AMedian mutational burdenCause of cancer deathKaplan-Meier methodKruskal-Wallis tests assessed differencesTime of surgeryTyrosine kinase 3Cancer-associated genesCatalytic subunit alphaMulti-institutional comparisonsTests assessed differencesPrimary tumorClinicopathological variablesWorse survivalMutational burden
2016
A literature review of radiological findings to guide the diagnosis of gallbladder adenomyomatosis
Hammad A, Miura J, Turaga K, Johnston F, Hohenwalter M, Gamblin T. A literature review of radiological findings to guide the diagnosis of gallbladder adenomyomatosis. Hepato Pancreato Biliary 2016, 18: 129-135. PMID: 26902131, PMCID: PMC4814619, DOI: 10.1016/j.hpb.2015.09.006.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingGallbladder adenomyomatosisComputed tomographyGallbladder massDifferentiate benign diseaseReview of radiological findingsReview imaging modalitiesSmall cystic spacesRokitansky-Aschoff sinusesContemporary seriesAsymptomatic patientsSymptomatic patientsBenign diseaseOncologic resectionGallbladder cancerRadiological findingsLaparoscopic cholecystectomyDiagnosing GAGa imagingNon-operativelyDifferential diagnosisCystic spacesImaging modalitiesResonance imagingGallbladder
2015
Intrahepatic cholangiocarcinoma and gallbladder cancer: distinguishing molecular profiles to guide potential therapy
Potkonjak M, Miura J, Turaga K, Johnston F, Tsai S, Christians K, Gamblin T. Intrahepatic cholangiocarcinoma and gallbladder cancer: distinguishing molecular profiles to guide potential therapy. Hepato Pancreato Biliary 2015, 17: 1119-1123. PMID: 26374242, PMCID: PMC4644364, DOI: 10.1111/hpb.12504.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAntineoplastic Combined Chemotherapy ProtocolsBile Duct NeoplasmsBiomarkers, TumorCholangiocarcinomaDiagnosis, DifferentialFemaleGallbladder NeoplasmsHumansImmunohistochemistryMaleMiddle AgedMolecular Diagnostic TechniquesMolecular Targeted TherapyPatient SelectionPredictive Value of TestsRetrospective StudiesConceptsGallbladder adenocarcinomaIntrahepatic cholangiocarcinomaMolecular profilingGC patientsCaris Life SciencesLow thymidylate synthaseBiomarker expression patternsThymidylate synthasePotential therapeutic implicationsFrequency of GCChemotherapy regimensICC tumorsPlatinum agentsGallbladder cancerTumor originPotential increased benefitsPathological specimensLevels of TSImmunohistochemical analysisSubgroup analysisTreatment strategiesPotential therapiesTherapeutic implicationsResponse rateTumor
2014
Cost Effectiveness of Routine Laparoscopic Ultrasound for Assessment of Resectability of Gallbladder Cancer
Nadeem H, Jayakrishnan T, Groeschl R, Zacharias A, Clark Gamblin T, Turaga K. Cost Effectiveness of Routine Laparoscopic Ultrasound for Assessment of Resectability of Gallbladder Cancer. Annals Of Surgical Oncology 2014, 21: 2413-2419. PMID: 24590431, DOI: 10.1245/s10434-014-3487-y.Peer-Reviewed Original ResearchConceptsGall bladder cancerQuality-adjusted life weeksDiagnostic laparoscopyLaparoscopic ultrasoundIncremental cost-effectiveness ratioResection of gallbladder cancerExclusion of metastasesAssessment of resectabilityCost of ultrasoundCost-effectiveness ratioLife weeksSurgical resectionHepatic metastasesPreoperative imagingAdvanced diseaseGallbladder cancerBladder cancerResectionPatientsCost-effective strategyMetastasisUltrasoundCancerBackgroundIn additionWeeksOverexpression of the HER2/neu Gene: A New Therapeutic Possibility for Patients With Advanced Gallbladder Cancer.
Roa I, de Toro G, Schalper K, de Aretxabala X, Churi C, Javle M. Overexpression of the HER2/neu Gene: A New Therapeutic Possibility for Patients With Advanced Gallbladder Cancer. Gastrointestinal Cancer Research : GCR 2014, 7: 42-8. PMID: 24799970, PMCID: PMC4007675.Peer-Reviewed Original ResearchHER2/neu overexpressionHER2/neu geneGallbladder cancerHER2/neuNeu overexpressionHER2/neu expressionNeu geneHer2/neu pathwaySubgroup of patientsWorse overall survivalAdvanced gallbladder cancerSingle large studyAnti-ErbB2 antibodyNew therapeutic possibilitiesGallbladder cancer casesASCO criteriaOverall survivalAdvanced cancerControl subjectsNeu expressionTargeted therapyEquivocal stainingBreast cancerCancer casesImmunohistochemical techniquesCost-effectiveness of routine laparoscopic ultrasound for the assessment of resectability of gallbladder cancer.
Jayakrishnan T, Nadeem H, Groeschl R, Zacharias A, Gamblin T, Turaga K. Cost-effectiveness of routine laparoscopic ultrasound for the assessment of resectability of gallbladder cancer. Journal Of Clinical Oncology 2014, 32: 272-272. DOI: 10.1200/jco.2014.32.3_suppl.272.Peer-Reviewed Original ResearchGall bladder cancerIncremental-cost-effectiveness-ratioLaparoscopic ultrasoundDiagnostic laparoscopyResection of gallbladder cancerSurgical resectionHepatic metastasesAdvanced diseaseGallbladder cancerBladder cancerCost-effective strategyPatientsCancerUltrasoundLaparoscopyResectionMetastasisBase case scenario
2013
Bile duct involvement portends poor prognosis in resected gallbladder carcinoma.
Eil R, Hansen P, Cassera M, Orloff S, Sheppard B, Diggs B, Billingsley K. Bile duct involvement portends poor prognosis in resected gallbladder carcinoma. Gastrointestinal Cancer Research : GCR 2013, 6: 101-5. PMID: 24147157, PMCID: PMC3782874.Peer-Reviewed Original ResearchDisease-specific survivalDisease-free survivalBile duct involvementGallbladder cancerDuct involvementMedian disease-free survivalResection of GBCResectable gallbladder cancerSubset of patientsLog-rank analysisAdjuvant therapyLN involvementPrognostic factorsCox regressionPoor prognosisRetrospective studyUnfavorable prognosisUnivariate analysisGallbladder carcinomaUnivariate associationsStudy populationHigh riskIntraoperative methodHigh mortalityMultivariate analysisKey Factors Influencing Prognosis in Relation to Gallbladder Cancer
Pilgrim C, Groeschl R, Turaga K, Gamblin T. Key Factors Influencing Prognosis in Relation to Gallbladder Cancer. Digestive Diseases And Sciences 2013, 58: 2455-2462. PMID: 23695876, DOI: 10.1007/s10620-013-2713-y.Peer-Reviewed Original ResearchConceptsGallbladder cancerPrognostic significanceFactors of prognostic significanceCystic duct marginBile duct resectionLymph node ratioFactor influencing prognosisLymph node diseaseEarly stage diseaseDuct resectionR0 resectionResidual diseaseAdequate lymphadenectomyPrognostic factorsR statusNode diseasePrognostic categoriesStage diseaseNode ratioN stageStratify patientsInfluence prognosisLymph nodesPathological featuresGallbladder
2012
Regional Differences in Gallbladder Cancer Pathogenesis: Insights from a Comparison of Cell Cycle-Regulatory, PI3K, and Pro-Angiogenic Protein Expression
Butte J, Torres J, Veras E, Matsuo K, Gönen M, D’Angelica M, Waugh E, Meneses M, Inayama Y, Fong Y, DeMatteo R, De La Fuente H, Endo I, Klimstra D, Jarnagin W. Regional Differences in Gallbladder Cancer Pathogenesis: Insights from a Comparison of Cell Cycle-Regulatory, PI3K, and Pro-Angiogenic Protein Expression. Annals Of Surgical Oncology 2012, 20: 1470-1481. PMID: 23212762, PMCID: PMC4048130, DOI: 10.1245/s10434-012-2761-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overChileCyclin-Dependent Kinase Inhibitor p21FemaleGallbladder NeoplasmsHumansJapanKaplan-Meier EstimateKi-67 AntigenMaleMiddle AgedMultivariate AnalysisNeoplasm StagingProliferating Cell Nuclear AntigenProto-Oncogene Proteins c-mdm2United StatesVascular Endothelial Growth Factor Receptor-2ConceptsMedian disease-specific survivalCell cycle-regulatoryGallbladder cancerEarly tumorsProtein expressionDisease-specific survival of patientsKi-67 labeling indexIncidence of gallbladder cancerDisease-specific survivalGallbladder cancer pathogenesisSurvival of patientsAbsence of p21MethodsImmunohistochemical expressionCurative intentClinicopathological variablesAngiogenesis-relatedKi-67Labeling indexP27 expressionProtein expression patternsTumorMSKCCMDM2 overexpressionCancer pathogenesisPathogenetic differences
2011
High-grade dysplasia of the cystic duct margin in the absence of malignancy after cholecystectomy
Bickenbach K, Shia J, Klimstra D, DeMatteo R, Fong Y, Kingham T, Allen P, Jarnagin W, D'Angelica M. High-grade dysplasia of the cystic duct margin in the absence of malignancy after cholecystectomy. Hepato Pancreato Biliary 2011, 13: 865-868. PMID: 22081921, PMCID: PMC3244625, DOI: 10.1111/j.1477-2574.2011.00388.x.Peer-Reviewed Original ResearchConceptsCystic duct marginHigh-grade dysplasiaInvasive gallbladder cancerCystic duct stumpGallbladder cancerNode-positive adenocarcinomaAbsence of malignancyEvidence of malignancyPortacaval lymph nodeIncidence of cholangiocarcinomaLymph nodesChart reviewCross-sectional imagingClinical dataCystic ductBile ductDysplasiaRadiological imagingPatientsMalignancyNo dataCholecystectomyCholangiocarcinomaCancerDuctEarly-Stage Gallbladder Cancer in the Surveillance, Epidemiology, and End Results Database: Effect of Extended Surgical Resection
Downing SR, Cadogan KA, Ortega G, Oyetunji TA, Siram SM, Chang DC, Ahuja N, Leffall LD, Frederick WA. Early-Stage Gallbladder Cancer in the Surveillance, Epidemiology, and End Results Database: Effect of Extended Surgical Resection. JAMA Surgery 2011, 146: 734-738. PMID: 21690451, DOI: 10.1001/archsurg.2011.128.Peer-Reviewed Original ResearchConceptsEarly-stage gallbladder cancerEnd Results (SEER) databaseMore lymph nodesLymph nodesGallbladder cancerSurgical resectionSurvival benefitT2 lesionsResults databaseMultivariate analysisDisease-positive lymph nodesPrimary gallbladder cancerExtended surgical resectionLN excisionOverall survivalSimple cholecystectomyAdvanced cancerFemale patientsCertain patientsRetrospective analysisSurgical proceduresSurvival advantagePatientsCancerResection
2010
Malignant tumours of gallbladder and extrahepatic bile ducts
Flood T, Jain D, Marginean E. Malignant tumours of gallbladder and extrahepatic bile ducts. Diagnostic Histopathology 2010, 16: 360-370. DOI: 10.1016/j.mpdhp.2010.06.003.Peer-Reviewed Original ResearchExtrahepatic bile duct cancerExtrahepatic bile ductBile ductGallbladder cancerBiliary tract neoplasmsBile duct cancerStage of diseaseUseful prognostic indicatorManagement of cancerDuct cancerOlder patientsAggressive courseFavorable prognosisClinical presentationHistologic typePancreaticobiliary typeChronic inflammationHistologic featuresPoor prognosisHistologic gradePrognostic indicatorGeographic predilectionHistologic variantsBiliary epitheliumMalignant tumors
2009
Genome wide analysis and clinical correlation of chromosomal and transcriptional mutations in cancers of the biliary tract
Miller G, Socci N, Dhall D, D'Angelica M, DeMatteo R, Allen P, Singh B, Fong Y, Blumgart L, Klimstra D, Jarnagin W. Genome wide analysis and clinical correlation of chromosomal and transcriptional mutations in cancers of the biliary tract. Journal Of Experimental & Clinical Cancer Research 2009, 28: 62. PMID: 19435499, PMCID: PMC2698861, DOI: 10.1186/1756-9966-28-62.Peer-Reviewed Original ResearchConceptsOver-Representation AnalysisCGH analysisBiliary cancerGene expressionCopy numberGenome wide analysisGlobal gene expression patternsFunctional gene groupsBiliary tract cancer specimensAnatomic site of originFunctional over-representation analysisDNA copy numberGene expression patternsUnsupervised hierarchical clustering analysisTranscript mutationsAmplified regionGene groupsIdentification of therapeutic targetsWide analysisClinical-pathological correlationChromosome 1pSite of originGallbladder cancerExpression patternsExtrahepatic cholangiocarcinoma
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