Pancreatobiliary Maljunction-associated Gallbladder Cancer Is as Common in the West, Shows Distinct Clinicopathologic Characteristics and Offers an Invaluable Model for Anatomy-induced Reflux-associated Physio-chemical Carcinogenesis
Muraki T, Pehlivanoglu B, Memis B, Reid M, Uehara T, Basturk O, Pernicka J, Klimstra D, Jarnagin W, Ito T, Hasebe O, Okaniwa S, Horigome N, Hisa T, Mittal P, Sarmiento J, Maithel S, Koshiol J, Tsai S, Evans D, Erkan M, Adsay V. Pancreatobiliary Maljunction-associated Gallbladder Cancer Is as Common in the West, Shows Distinct Clinicopathologic Characteristics and Offers an Invaluable Model for Anatomy-induced Reflux-associated Physio-chemical Carcinogenesis. Annals Of Surgery 2020, 276: e32-e39. PMID: 33201123, PMCID: PMC9305302, DOI: 10.1097/sla.0000000000004482.Peer-Reviewed Original ResearchConceptsPancreatobiliary maljunctionGallbladder cancerAdenoma-carcinoma sequenceRate of tumor-infiltrating lymphocytesReflux of pancreatic enzymesRisk of gallbladder cancerTumor-infiltrating lymphocytesAssociated with gallstonesBile duct carcinomaOrigin work-upGBC casesPancreatobiliary disordersDuct carcinomaCarcinoma typesCholedochal cystClinicopathological characteristicsClinicopathological featuresBile ductRadiological imagingWork-upPancreatic enzymesYounger ageCarcinomaCancerDisorders
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