2024
Simple versus radical cholecystectomy and survival for pathologic stage T1B gallbladder cancer
Rhodin K, Goins S, Kramer R, Eckhoff A, Herbert G, Shah K, Allen P, Nussbaum D, Blazer D, Zani S, Lidsky M. Simple versus radical cholecystectomy and survival for pathologic stage T1B gallbladder cancer. Hepato Pancreato Biliary 2024, 26: 594-602. PMID: 38336604, DOI: 10.1016/j.hpb.2024.01.012.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma in SituCholecystectomyGallbladder NeoplasmsHumansLymph Node ExcisionNeoplasm StagingRetrospective StudiesConceptsT1b gallbladder cancerRadical cholecystectomyNational Cancer DatabaseGallbladder cancerOverall survivalExtended resectionMultivariate Cox proportional hazards methodCox proportional hazards methodProportional hazards methodStandard of careAssociated with greater hazardMedian OSR0 resectionResidual diseaseT1b diseaseNodal metastasisCancer DatabaseSurgical managementKaplan-MeierProspective validationCholecystectomyHazards methodResectionLow riskPatients
2023
Trends in Receipt of Adjuvant Chemotherapy and its Impact on Survival in Resected Biliary Tract Cancers
Rhodin K, Liu A, Bartholomew A, Kramer R, Parameswaran A, Uronis H, Strickler J, Hsu D, Morse M, Shah K, Herbert G, Zani S, Nussbaum D, Allen P, Lidsky M. Trends in Receipt of Adjuvant Chemotherapy and its Impact on Survival in Resected Biliary Tract Cancers. Annals Of Surgical Oncology 2023, 30: 4813-4821. PMID: 37188803, PMCID: PMC10330866, DOI: 10.1245/s10434-023-13567-4.Peer-Reviewed Original ResearchMeSH KeywordsBile Duct NeoplasmsBile Ducts, IntrahepaticBiliary Tract NeoplasmsChemotherapy, AdjuvantCholangiocarcinomaFemaleGallbladder NeoplasmsHumansConceptsBiliary tract cancerResected biliary tract cancerNational Cancer DatabaseAdjuvant chemotherapyGallbladder cancerIntrahepatic CCAExtrahepatic CCAMethodsThe National Cancer DatabaseMultivariate Cox proportional hazards methodBiliary tract cancer subtypesOdds of ACCox proportional hazards methodReceipt of adjuvant chemotherapyCurative-intent treatmentReceipt of ACFactors associated with receiptYear of diagnosisHigher comorbidity scoreProportional hazards methodStage of diseaseFactors associated with ACMultivariate logistic regressionAssociated with reduced oddsIII diseasePositive margins
2021
Yale Cancer Center Precision Medicine Tumor Board: molecular findings alter a diagnosis and treatment plan
Gibson JA, Finberg KE, Nalbantoglu I, Cecchini M, Ganzak A, Walther Z, Sklar JL, Eder JP, Goldberg SB. Yale Cancer Center Precision Medicine Tumor Board: molecular findings alter a diagnosis and treatment plan. The Lancet Oncology 2021, 22: 306-307. PMID: 33662283, DOI: 10.1016/s1470-2045(20)30683-5.Peer-Reviewed Original ResearchGallbladder Disorders: A Comprehensive Review
Lam R, Zakko A, Petrov JC, Kumar P, Duffy AJ, Muniraj T. Gallbladder Disorders: A Comprehensive Review. Disease-a-Month 2021, 67: 101130. PMID: 33478678, DOI: 10.1016/j.disamonth.2021.101130.Peer-Reviewed Original Research
2020
Pancreatobiliary Maljunction-associated Gallbladder Cancer Is as Common in the West, Shows Distinct Clinicopathologic Characteristics and Offers an Invaluable Model for Anatomy-induced Reflux-associated Physio-chemical Carcinogenesis
Muraki T, Pehlivanoglu B, Memis B, Reid M, Uehara T, Basturk O, Pernicka J, Klimstra D, Jarnagin W, Ito T, Hasebe O, Okaniwa S, Horigome N, Hisa T, Mittal P, Sarmiento J, Maithel S, Koshiol J, Tsai S, Evans D, Erkan M, Adsay V. Pancreatobiliary Maljunction-associated Gallbladder Cancer Is as Common in the West, Shows Distinct Clinicopathologic Characteristics and Offers an Invaluable Model for Anatomy-induced Reflux-associated Physio-chemical Carcinogenesis. Annals Of Surgery 2020, 276: e32-e39. PMID: 33201123, PMCID: PMC9305302, DOI: 10.1097/sla.0000000000004482.Peer-Reviewed Original ResearchMeSH KeywordsBile DuctsCarcinogenesisCommon Bile DuctFemaleGallbladder NeoplasmsGastrointestinal NeoplasmsHumansMiddle AgedPancreatic DuctsConceptsPancreatobiliary maljunctionGallbladder cancerAdenoma-carcinoma sequenceRate of tumor-infiltrating lymphocytesReflux of pancreatic enzymesRisk of gallbladder cancerTumor-infiltrating lymphocytesAssociated with gallstonesBile duct carcinomaOrigin work-upGBC casesPancreatobiliary disordersDuct carcinomaCarcinoma typesCholedochal cystClinicopathological characteristicsClinicopathological featuresBile ductRadiological imagingWork-upPancreatic enzymesYounger ageCarcinomaCancerDisorders
2019
Interventional radiology's role in the diagnosis and management of patients with gallbladder carcinoma.
Fine GC, Smith TA, Stein SI, Madoff DC. Interventional radiology's role in the diagnosis and management of patients with gallbladder carcinoma. Chinese Clinical Oncology 2019, 8: 40. PMID: 31431037, DOI: 10.21037/cco.2019.07.09.Peer-Reviewed Original ResearchConceptsPreoperative portal vein embolizationManagement of patientsGallbladder carcinomaAggressive biliary tract malignancyInterventional radiology’s roleLate disease statesPortal vein embolizationPost-operative complicationsBiliary tract malignancyCommon gastrointestinal malignancyBile leakGastrointestinal malignanciesSurgical candidatesVein embolizationBiliary drainageBiliary obstructionChronic painPorcelain gallbladderPercutaneous imageRisk factorsInterventional radiologistsPatientsCarcinomaTissue samplingDisease statesLiver resection for extra-pancreatic biliary cancer: what is the role of laparoscopic approach?
Elmoghazy W, Cowan J, Tabchouri N, Tinguely P, Bennamoun M, Tubbax C, Sarran A, Lefevre M, Lamer C, Gayet B, Fuks D. Liver resection for extra-pancreatic biliary cancer: what is the role of laparoscopic approach? Surgical Endoscopy 2019, 33: 3711-3717. PMID: 30693390, DOI: 10.1007/s00464-019-06664-7.Peer-Reviewed Original ResearchConceptsPeri-hilar cholangiocarcinomaIntra-hepatic cholangiocarcinomaBiliary tract cancerGallbladder cancerLiver resectionBiliary cancerConclusionsThe present seriesGallbladder cancer groupBackgroundLaparoscopic liver resectionEstimated blood lossMedian operative timeMedian hospital stayShort-term outcomesInstitut Mutualiste MontsourisR0 resectionCurative intentPostoperative morbidityLaparoscopic approachPerioperative outcomesBlood lossMedian agePostoperative mortalityHospital stayPatient characteristicsOperative time
2018
Regional differences in gallbladder cancer pathogenesis: Insights from a multi‐institutional comparison of tumor mutations
Narayan R, Creasy J, Goldman D, Gönen M, Kandoth C, Kundra R, Solit D, Askan G, Klimstra D, Basturk O, Allen P, Balachandran V, D’Angelica M, DeMatteo R, Drebin J, Kingham T, Simpson A, Abou‐Alfa G, Harding J, O’Reilly E, Butte J, Matsuyama R, Endo I, Jarnagin W. Regional differences in gallbladder cancer pathogenesis: Insights from a multi‐institutional comparison of tumor mutations. Cancer 2018, 125: 575-585. PMID: 30427539, PMCID: PMC6636637, DOI: 10.1002/cncr.31850.Peer-Reviewed Original ResearchConceptsGallbladder cancer pathogenesisErb-b2 receptor tyrosine kinase 3Gallbladder cancerJapanese patientsSMAD family member 4Overall survivalTumor mutationsAT-rich interactive domain 2Associated with worse survivalPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaAT-rich interactive domain 1AMedian mutational burdenCause of cancer deathKaplan-Meier methodKruskal-Wallis tests assessed differencesTime of surgeryTyrosine kinase 3Cancer-associated genesCatalytic subunit alphaMulti-institutional comparisonsTests assessed differencesPrimary tumorClinicopathological variablesWorse survivalMutational burden
2016
A literature review of radiological findings to guide the diagnosis of gallbladder adenomyomatosis
Hammad A, Miura J, Turaga K, Johnston F, Hohenwalter M, Gamblin T. A literature review of radiological findings to guide the diagnosis of gallbladder adenomyomatosis. Hepato Pancreato Biliary 2016, 18: 129-135. PMID: 26902131, PMCID: PMC4814619, DOI: 10.1016/j.hpb.2015.09.006.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingGallbladder adenomyomatosisComputed tomographyGallbladder massDifferentiate benign diseaseReview of radiological findingsReview imaging modalitiesSmall cystic spacesRokitansky-Aschoff sinusesContemporary seriesAsymptomatic patientsSymptomatic patientsBenign diseaseOncologic resectionGallbladder cancerRadiological findingsLaparoscopic cholecystectomyDiagnosing GAGa imagingNon-operativelyDifferential diagnosisCystic spacesImaging modalitiesResonance imagingGallbladder
2015
Malignancies in Primary Sclerosing Cholangitis - A Continuing Threat
Bonato G, Cristoferi L, Strazzabosco M, Fabris L. Malignancies in Primary Sclerosing Cholangitis - A Continuing Threat. Digestive Diseases 2015, 33: 140-148. PMID: 26641079, PMCID: PMC4939833, DOI: 10.1159/000440826.Peer-Reviewed Original ResearchMeSH KeywordsBile Duct NeoplasmsCholangiocarcinomaCholangitis, SclerosingColorectal NeoplasmsGallbladder NeoplasmsHumansInflammatory Bowel DiseasesNeoplasmsConceptsInflammatory bowel diseaseUlcerative colitisEffective medical treatmentGallbladder carcinomaColorectal carcinomaUnknown etiologyEarly diagnosisMedical treatmentChronic inflammatory liver diseaseManagement of PSCInflammatory liver diseasePrimary sclerosing cholangitisGroup of patientsChronic inflammatory conditionsChronic inflammatory diseaseBile duct systemRisk of cancerDevelopment of malignancyEffective surveillance strategiesExtensive histologicLiver transplantationNeoadjuvant chemoradiotherapySclerosing cholangitisFeared complicationFrequent complicationIntrahepatic cholangiocarcinoma and gallbladder cancer: distinguishing molecular profiles to guide potential therapy
Potkonjak M, Miura J, Turaga K, Johnston F, Tsai S, Christians K, Gamblin T. Intrahepatic cholangiocarcinoma and gallbladder cancer: distinguishing molecular profiles to guide potential therapy. Hepato Pancreato Biliary 2015, 17: 1119-1123. PMID: 26374242, PMCID: PMC4644364, DOI: 10.1111/hpb.12504.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAntineoplastic Combined Chemotherapy ProtocolsBile Duct NeoplasmsBiomarkers, TumorCholangiocarcinomaDiagnosis, DifferentialFemaleGallbladder NeoplasmsHumansImmunohistochemistryMaleMiddle AgedMolecular Diagnostic TechniquesMolecular Targeted TherapyPatient SelectionPredictive Value of TestsRetrospective StudiesConceptsGallbladder adenocarcinomaIntrahepatic cholangiocarcinomaMolecular profilingGC patientsCaris Life SciencesLow thymidylate synthaseBiomarker expression patternsThymidylate synthasePotential therapeutic implicationsFrequency of GCChemotherapy regimensICC tumorsPlatinum agentsGallbladder cancerTumor originPotential increased benefitsPathological specimensLevels of TSImmunohistochemical analysisSubgroup analysisTreatment strategiesPotential therapiesTherapeutic implicationsResponse rateTumor
2014
The gallbladder: uncommon gallbladder conditions and unusual presentations of the common gallbladder pathological processes
Revzin MV, Scoutt L, Smitaman E, Israel GM. The gallbladder: uncommon gallbladder conditions and unusual presentations of the common gallbladder pathological processes. Abdominal Radiology 2014, 40: 385-399. PMID: 25063238, DOI: 10.1007/s00261-014-0203-0.Peer-Reviewed Original ResearchMeSH KeywordsGallbladderGallbladder DiseasesGallbladder NeoplasmsHumansMagnetic Resonance ImagingTomography, X-Ray ComputedUltrasonography, Doppler, ColorConceptsGallbladder conditionsCost Effectiveness of Routine Laparoscopic Ultrasound for Assessment of Resectability of Gallbladder Cancer
Nadeem H, Jayakrishnan T, Groeschl R, Zacharias A, Clark Gamblin T, Turaga K. Cost Effectiveness of Routine Laparoscopic Ultrasound for Assessment of Resectability of Gallbladder Cancer. Annals Of Surgical Oncology 2014, 21: 2413-2419. PMID: 24590431, DOI: 10.1245/s10434-014-3487-y.Peer-Reviewed Original ResearchConceptsGall bladder cancerQuality-adjusted life weeksDiagnostic laparoscopyLaparoscopic ultrasoundIncremental cost-effectiveness ratioResection of gallbladder cancerExclusion of metastasesAssessment of resectabilityCost of ultrasoundCost-effectiveness ratioLife weeksSurgical resectionHepatic metastasesPreoperative imagingAdvanced diseaseGallbladder cancerBladder cancerResectionPatientsCost-effective strategyMetastasisUltrasoundCancerBackgroundIn additionWeeks
2013
Es posible utilizar las muestras de colecistectomas con cncer en investigacin?: Calidad del ADN de muestras obtenidas del sistema pblico y privado de salud
Roa I, de Toro G, Snchez T, Slater J, Ziegler AM, Game A, Arellano L, Schalper K, de Aretxabala X. Es posible utilizar las muestras de colecistectomas con cncer en investigacin?: Calidad del ADN de muestras obtenidas del sistema pblico y privado de salud. Revista Medica De Chile 2013, 141: 1528-1533. PMID: 24728429, DOI: 10.4067/s0034-98872013001200005.Peer-Reviewed Original ResearchKey Factors Influencing Prognosis in Relation to Gallbladder Cancer
Pilgrim C, Groeschl R, Turaga K, Gamblin T. Key Factors Influencing Prognosis in Relation to Gallbladder Cancer. Digestive Diseases And Sciences 2013, 58: 2455-2462. PMID: 23695876, DOI: 10.1007/s10620-013-2713-y.Peer-Reviewed Original ResearchConceptsGallbladder cancerPrognostic significanceFactors of prognostic significanceCystic duct marginBile duct resectionLymph node ratioFactor influencing prognosisLymph node diseaseEarly stage diseaseDuct resectionR0 resectionResidual diseaseAdequate lymphadenectomyPrognostic factorsR statusNode diseasePrognostic categoriesStage diseaseNode ratioN stageStratify patientsInfluence prognosisLymph nodesPathological featuresGallbladder
2012
Regional Differences in Gallbladder Cancer Pathogenesis: Insights from a Comparison of Cell Cycle-Regulatory, PI3K, and Pro-Angiogenic Protein Expression
Butte J, Torres J, Veras E, Matsuo K, Gönen M, D’Angelica M, Waugh E, Meneses M, Inayama Y, Fong Y, DeMatteo R, De La Fuente H, Endo I, Klimstra D, Jarnagin W. Regional Differences in Gallbladder Cancer Pathogenesis: Insights from a Comparison of Cell Cycle-Regulatory, PI3K, and Pro-Angiogenic Protein Expression. Annals Of Surgical Oncology 2012, 20: 1470-1481. PMID: 23212762, PMCID: PMC4048130, DOI: 10.1245/s10434-012-2761-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overChileCyclin-Dependent Kinase Inhibitor p21FemaleGallbladder NeoplasmsHumansJapanKaplan-Meier EstimateKi-67 AntigenMaleMiddle AgedMultivariate AnalysisNeoplasm StagingProliferating Cell Nuclear AntigenProto-Oncogene Proteins c-mdm2United StatesVascular Endothelial Growth Factor Receptor-2ConceptsMedian disease-specific survivalCell cycle-regulatoryGallbladder cancerEarly tumorsProtein expressionDisease-specific survival of patientsKi-67 labeling indexIncidence of gallbladder cancerDisease-specific survivalGallbladder cancer pathogenesisSurvival of patientsAbsence of p21MethodsImmunohistochemical expressionCurative intentClinicopathological variablesAngiogenesis-relatedKi-67Labeling indexP27 expressionProtein expression patternsTumorMSKCCMDM2 overexpressionCancer pathogenesisPathogenetic differences
2011
Accurate Staging for Gallbladder Cancer
Ito H, Ito K, D'Angelica M, Gonen M, Klimstra D, Allen P, DeMatteo R, Fong Y, Blumgart L, Jarnagin W. Accurate Staging for Gallbladder Cancer. Annals Of Surgery 2011, 254: 320-325. PMID: 21617582, DOI: 10.1097/sla.0b013e31822238d8.Peer-Reviewed Original ResearchConceptsTotal lymph node countDisease-specific survivalLiver involvementT2 tumorsLymph nodesSurgical treatmentAssociated with decreased recurrence-freeMedian total lymph node countTNM stageAssociated with liver involvementMedian follow-up periodAdjacent organ resectionHistologic tumor involvementResidual liver diseaseT-stage tumorsDefinitive surgical treatmentLymph node countAdequate surgical treatmentSurvival of patientsInvolvement of liverRegional lymph nodesFollow-up periodAssociated with outcomeLN dissectionNodal involvementEarly-Stage Gallbladder Cancer in the Surveillance, Epidemiology, and End Results Database: Effect of Extended Surgical Resection
Downing SR, Cadogan KA, Ortega G, Oyetunji TA, Siram SM, Chang DC, Ahuja N, Leffall LD, Frederick WA. Early-Stage Gallbladder Cancer in the Surveillance, Epidemiology, and End Results Database: Effect of Extended Surgical Resection. JAMA Surgery 2011, 146: 734-738. PMID: 21690451, DOI: 10.1001/archsurg.2011.128.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCholecystectomyFemaleGallbladder NeoplasmsHumansLymph Node ExcisionMaleMiddle AgedProportional Hazards ModelsSEER ProgramSurvival RateConceptsEarly-stage gallbladder cancerEnd Results (SEER) databaseMore lymph nodesLymph nodesGallbladder cancerSurgical resectionSurvival benefitT2 lesionsResults databaseMultivariate analysisDisease-positive lymph nodesPrimary gallbladder cancerExtended surgical resectionLN excisionOverall survivalSimple cholecystectomyAdvanced cancerFemale patientsCertain patientsRetrospective analysisSurgical proceduresSurvival advantagePatientsCancerResectionEarly Gallbladder Carcinoma
Albores-Saavedra J, Chable-Montero F, Angeles-Albores D, Schwartz A, Klimstra D, Henson D. Early Gallbladder Carcinoma. American Journal Of Clinical Pathology 2011, 135: 637-642. PMID: 21411787, DOI: 10.1309/ajcpfrkcfedlv03y.Peer-Reviewed Original ResearchConceptsSmall cell carcinomaIntramucosal carcinomaCell carcinomaFollow-upLost to follow-upCases of intramucosal carcinomaSquamous cell carcinomaPancreatic ductal carcinomaUndifferentiated carcinomaCholecystectomy specimensDisseminated metastasesDuctal carcinomaWhipple procedureClinicopathological featuresDisease-freeCurative procedureCarcinomaIncidental findingPatientsGallbladderAdenocarcinomaCholecystectomyCholelithiasisMetastasis
2009
Incidental gallbladder cancer and single-incision laparoscopic cholecystectomy
Gibbs K, Kaleya R. Incidental gallbladder cancer and single-incision laparoscopic cholecystectomy. Surgical Endoscopy 2009, 23: 1680-1680. PMID: 19360366, DOI: 10.1007/s00464-009-0458-7.Peer-Reviewed Original Research
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