2024
Biliary atresia susceptibility gene EFEMP1 regulates extrahepatic bile duct elastic fiber formation and mechanics
Gupta K, Llewellyn J, Roberts E, Liu C, Naji A, Assoian R, Wells R. Biliary atresia susceptibility gene EFEMP1 regulates extrahepatic bile duct elastic fiber formation and mechanics. JHEP Reports 2024, 7: 101215. PMID: 39717503, PMCID: PMC11663959, DOI: 10.1016/j.jhepr.2024.101215.Peer-Reviewed Original ResearchExtrahepatic bile ductNeonatal extrahepatic bile ductsBiliary atresiaSusceptibility genesBile ductFibulin-3Genome wide association studiesExtracellular matrix protein 1Pressure myographyGene EFEMP1Elastic fibersExtracellular matrix proteinsAssociation studiesHuman extrahepatic bile ductsExtracellular matrix componentsElastic fiber organizationMatrix protein 1Decreased elastic fibersBile duct structuresMatrix proteinsFormation of elastic fibersFunctional relevanceGenesFiber formationNormal ductsModulation of canonical Wnt signaling regulates peribiliary mesenchymal identity during homeostasis and injury
Singh S, Budiman T, Redmond D, Gupta V. Modulation of canonical Wnt signaling regulates peribiliary mesenchymal identity during homeostasis and injury. Hepatology Communications 2024, 8: e0368. PMID: 38251878, PMCID: PMC10805418, DOI: 10.1097/hc9.0000000000000368.Peer-Reviewed Original ResearchConceptsT-box transcription factorTranscription factorsMesenchymal gene expressionSignaling effectorsGene expressionGli transcription factorsGene transcription programUpregulation of TBX2Gain of functionSingle-cell sequencingExtrahepatic bile ductCellular identityTranscriptome analysisTranscriptional programsReceptor-ligand analysisMyofibroblast transdifferentiationIn vivo approachesB-cateninT-boxSignaling pathwayBile ductTbx3 expressionTbx3Primary sclerosing cholangitisBile duct ligation
2021
Primary sclerosing cholangitis
Rabiee A, Silveira MG. Primary sclerosing cholangitis. Translational Gastroenterology And Hepatology 2021, 6: 29-29. PMID: 33824933, PMCID: PMC7829069, DOI: 10.21037/tgh-20-266.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsInflammatory bowel diseaseLiver transplantationDominant stricturesRare chronic cholestatic liver diseaseChronic cholestatic liver diseaseEnd-stage PSCEtiology of PSCManagement of PSCCommon presenting symptomAbnormal immune responseCumulative lifetime riskEffective medical therapyExtrahepatic bile ductCholestatic liver diseaseTreatment of symptomsScreening of patientsBacterial cholangitisEligible patientsLT indicationAbdominal painPresenting symptomColorectal malignancyInflammatory destructionProgressive diseaseBile stasisCongenital Cystic Lesions of the Biliary Tree
Lasagni A, Morana G, Strazzabosco M, Fabris L, Cadamuro M. Congenital Cystic Lesions of the Biliary Tree. 2021, 19-46. DOI: 10.1007/978-3-030-65908-0_2.Peer-Reviewed Original ResearchFibropolycystic liver diseasePolycystic liver diseaseFibrocystic liver diseaseHepatorenal fibrocystic diseaseIntrahepatic bile ductsCholedochal cystLiver diseaseBile ductBiliary treeLarge intrahepatic bile ductsSmall intrahepatic bile ductsBile duct dilationRenal function impairmentEarly surgical interventionOnly curative approachCongenital cystic lesionsExtrahepatic bile ductDuctal plate malformationRecessive polycystic kidney diseasePotential therapeutic targetSpectrum of disordersGrowth of cystsPolycystic kidney diseaseBiliary microhamartomasLiver transplantation
2020
Tumors of the Liver
Albores-Saavedra J, Henson D, Klimstra D. Tumors of the Liver. 2020, 871-917. DOI: 10.1007/978-3-319-96681-6_13.Peer-Reviewed Original Research
2019
Cholangiolithiasis postliver transplantation: Successful treatment utilizing percutaneous transhepatic cholangioscopy and laser lithotripsy
Nezami N, Benchetrit L, Latich I, Schlachter T. Cholangiolithiasis postliver transplantation: Successful treatment utilizing percutaneous transhepatic cholangioscopy and laser lithotripsy. Radiology Case Reports 2019, 14: 1459-1466. PMID: 31641393, PMCID: PMC6796643, DOI: 10.1016/j.radcr.2019.09.020.Peer-Reviewed Original ResearchPercutaneous transhepatic cholangioscopyLiver transplantLaser lithotripsyMajor procedure-related complicationsProcedure-related complicationsExtrahepatic bile ductAbdominal CT scanDuctal calculiHepaticojejunal anastomosisPostliver transplantationNew onsetSelect patientsLiver biopsyPersistent painBile ductDuct calculiRisk factorsSuccessful treatmentRemoval of intraSuitable alternative optionCT scanEndoscopic techniquesBasket retrievalLarge calculiCholangioscopyCholangiocyte pathobiology
Banales JM, Huebert RC, Karlsen T, Strazzabosco M, LaRusso NF, Gores GJ. Cholangiocyte pathobiology. Nature Reviews Gastroenterology & Hepatology 2019, 16: 269-281. PMID: 30850822, PMCID: PMC6563606, DOI: 10.1038/s41575-019-0125-y.Peer-Reviewed Original ResearchConceptsCholangiocyte pathobiologyNew disease-modifying therapiesLiver regenerationRole of cholangiocytesAdvanced liver failureDisease-modifying therapiesExtrahepatic bile ductChronic disease statesAdaptive immune responsesReactive ductular cellsLiver failureBiliary tractLiver diseaseBile ductBile productionImmune responseHepatocyte regenerationImmune systemDuctular cellsCholangiopathyDisease statesCholangiocytesEpithelial cellsAnatomic nicheRepair response
2018
Pancreatic-Type Mixed Acinar Neuroendocrine Carcinoma Arising in the Common Bile Duct: A Case Report
Shafique K, Lee L, Samad A, Wang L, Klimstra D. Pancreatic-Type Mixed Acinar Neuroendocrine Carcinoma Arising in the Common Bile Duct: A Case Report. Advances In Anatomic Pathology 2018, 23: 266-270. DOI: 10.1097/pcr.0000000000000278.Peer-Reviewed Original ResearchMixed acinar-neuroendocrine carcinomaAcinar-neuroendocrine carcinomaBile ductNeuroendocrine carcinomaPancreatic heterotopiaHigh-power fieldsExtrahepatic bile ductNeuroendocrine neoplasmsGranular chromatinProminent nucleoliAbdominal discomfortCase reportMalignant transformationSolid massExtrapancreatic locationImaging studiesMinimal to moderate amountsSolid sheetsPancreatic typeBileCarcinomaTumorImmunohistochemistryDuctHeterotopiaRamucirumab Plus Pembrolizumab in Patients with Previously Treated Advanced or Metastatic Biliary Tract Cancer: Nonrandomized, Open‐Label, Phase I Trial (JVDF)
Arkenau H, Martin‐Liberal J, Calvo E, Penel N, Krebs MG, Herbst RS, Walgren RA, Widau RC, Mi G, Jin J, Ferry D, Chau I. Ramucirumab Plus Pembrolizumab in Patients with Previously Treated Advanced or Metastatic Biliary Tract Cancer: Nonrandomized, Open‐Label, Phase I Trial (JVDF). The Oncologist 2018, 23: 1407-e136. PMID: 29853658, PMCID: PMC6292555, DOI: 10.1634/theoncologist.2018-0044.Peer-Reviewed Original ResearchConceptsMetastatic biliary tract cancerTreatment-related adverse eventsBiliary tract cancerObjective response rateProgression-free survivalOverall survivalTract cancerCommon grade 3 treatment-related adverse eventsGrade 3 treatment-related adverse eventsGrade 4 treatment-related adverse eventsDay 1Response rateAdvanced biliary tract cancerMedian progression-free survivalBiomarker-unselected patientsEfficacy of ramucirumabInfrequent grade 3Limited clinical activityPD-1 antagonistsTreatment-related deathsUnexpected safety findingsVEGFR-2 antagonistGrowth factor receptor 2Phase I trialExtrahepatic bile duct
2015
IgG4-related sclerosing cholangitis in the absence of autoimmune pancreatitis mimicking extrahepatic cholangiocarcinoma
Lin J, Cummings OW, Greenson JK, House MG, Liu X, Nalbantoglu I, Pai R, Davidson DD, Reuss SA. IgG4-related sclerosing cholangitis in the absence of autoimmune pancreatitis mimicking extrahepatic cholangiocarcinoma. Scandinavian Journal Of Gastroenterology 2015, 50: 447-453. PMID: 25635498, DOI: 10.3109/00365521.2014.962603.Peer-Reviewed Original ResearchConceptsIgG4-positive plasma cells/high-power fieldPlasma cells/high-power fieldHigh-power fieldCells/high power fieldAutoimmune pancreatitisExtrahepatic cholangiocarcinomaSclerosing cholangitisClinicopathological featuresBile duct injuryLymphoid follicle formationPrimary sclerosing cholangitisSecondary sclerosing cholangitisDense lymphoplasmacytic infiltrateEvidence of relapseExtrahepatic bile ductIgG4 serologyDuct injuryLymphoplasmacytic infiltrateRetroperitoneal fibrosisBenign courseBile ductPreoperative diagnosisCholangitisHigh percentageIgG4
2012
Advances in cholangiocyte immunobiology
Syal G, Fausther M, Dranoff JA. Advances in cholangiocyte immunobiology. AJP Gastrointestinal And Liver Physiology 2012, 303: g1077-g1086. PMID: 22961800, PMCID: PMC3517647, DOI: 10.1152/ajpgi.00227.2012.Peer-Reviewed Original ResearchConceptsImmune responseMajor histocompatibility complex antigensExtrahepatic bile ductAdaptive immune responsesHistocompatibility complex antigensHepatic stellate cellsBiliary infectionBiliary cirrhosisInflammatory mediatorsBiliary tractPortal fibroblastsBile ductProfessional APCsBiliary systemInflammatory modulatorsImmune cellsComplex antigensStellate cellsDuct epitheliumMyofibroblastic differentiationIntracellular signaling cascadesCholangiocytesFirst lineAdhesion moleculesCytokines
2010
Malignant tumours of gallbladder and extrahepatic bile ducts
Flood T, Jain D, Marginean E. Malignant tumours of gallbladder and extrahepatic bile ducts. Diagnostic Histopathology 2010, 16: 360-370. DOI: 10.1016/j.mpdhp.2010.06.003.Peer-Reviewed Original ResearchExtrahepatic bile duct cancerExtrahepatic bile ductBile ductGallbladder cancerBiliary tract neoplasmsBile duct cancerStage of diseaseUseful prognostic indicatorManagement of cancerDuct cancerOlder patientsAggressive courseFavorable prognosisClinical presentationHistologic typePancreaticobiliary typeChronic inflammationHistologic featuresPoor prognosisHistologic gradePrognostic indicatorGeographic predilectionHistologic variantsBiliary epitheliumMalignant tumorsBenign tumors and tumor-like lesions of the gallbladder and extrahepatic biliary tract
Van Patten K, Jain D. Benign tumors and tumor-like lesions of the gallbladder and extrahepatic biliary tract. Diagnostic Histopathology 2010, 16: 371-379. DOI: 10.1016/j.mpdhp.2010.06.001.Peer-Reviewed Original ResearchTumor-like lesionsBenign tumorsChronic cholecystitisTypes of metaplasiaExtrahepatic bile ductExtrahepatic biliary tractSoft tissue counterpartsSurgical pathology laboratoryBiliary typeBiliary tractBile ductNeurogenic lesionsMesenchymal tumorsEpithelial tumorsBenign lesionsLesionsGallbladderTumorsTissue counterpartsPathology laboratoryWrong diagnosisCholecystitisMalignancyCommon specimensVast majority
2009
Isospora cholangiopathy: case study with histologic characterization and molecular confirmation
Walther Z, Topazian MD. Isospora cholangiopathy: case study with histologic characterization and molecular confirmation. Human Pathology 2009, 40: 1342-1346. PMID: 19447468, DOI: 10.1016/j.humpath.2009.01.020.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAcquired Immunodeficiency SyndromeAdultAnimalsAnti-Infective AgentsAntiparasitic AgentsBile Ducts, ExtrahepaticBile Ducts, IntrahepaticBiopsyCholangiopancreatography, Endoscopic RetrogradeCholangitis, SclerosingHumansIsosporaIsosporiasisIvermectinMalePolymerase Chain ReactionTreatment OutcomeTrimethoprim, Sulfamethoxazole Drug CombinationConceptsAIDS patientsBile ductIsospora belliCommon bile duct biopsiesPolymerase chain reaction-based molecular analysisBile duct biopsyPrimary sclerosing cholangitisExtrahepatic bile ductRare opportunistic pathogenEndoscopic retrograde cholangiopancreatographyIntracellular protozoan parasiteDuct biopsySclerosing cholangitisUncommon causeAcute illnessHIV statusRadiologic findingsRetrograde cholangiopancreatographyTravelers' diarrheaWest African menHepatobiliary diseaseHistologic characterizationSmall intestineDiarrheaIsosporiasis
2008
Functional Anatomy of Normal Bile Ducts
Strazzabosco M, Fabris L. Functional Anatomy of Normal Bile Ducts. The Anatomical Record 2008, 291: 653-660. PMID: 18484611, PMCID: PMC3743051, DOI: 10.1002/ar.20664.Peer-Reviewed Original ResearchConceptsBile ductBiliary treeExtrahepatic bile ductSmall bile ductsNormal bile ductsLiver progenitor cellsBile productionBiliary epitheliumMajor ductsSecretory functionVascular structuresProgenitor cellsCholangiocyte functionFunctional anatomyBileDuctCholangiocytesIntestineFunctional interactionMorphological heterogeneityNerveGallbladderVariety of functionsEpithelium
2000
Carcinoid Tumors of the Extrahepatic Bile Ducts
Maitra A, Krueger J, Tascilar M, Offerhaus G, Angeles–Angeles A, Klimstra D, Hruban R, Albores–Saavedra J. Carcinoid Tumors of the Extrahepatic Bile Ducts. The American Journal Of Surgical Pathology 2000, 24: 1501-1510. PMID: 11075851, DOI: 10.1097/00000478-200011000-00005.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBile Duct NeoplasmsBile Ducts, ExtrahepaticCarcinoid TumorChromograninsCytoplasmic GranulesDNA-Binding ProteinsDNA, NeoplasmFemaleFollow-Up StudiesGastrinsHumansImmunoenzyme TechniquesLoss of HeterozygosityLymph NodesLymphatic MetastasisMicrosatellite RepeatsMiddle AgedNeurosecretory SystemsPancreatic PolypeptidePancreaticoduodenectomySerotoninSmad4 ProteinSomatostatinSynaptophysinTrans-ActivatorsTreatment OutcomeConceptsExtrahepatic bile ductCarcinoid tumorsBile ductPresence of lymph node metastasisLoss of heterozygosity analysisCodon 12 of K-rasDisease free 2Low malignant potentialLymph node metastasisPancreatic polypeptideRound neurosecretory granulesPeptic ulcer diseaseIndolent coursePainless jaundiceExpressed synaptophysinP53 mutationsPresenting symptomsMalignant potentialDpc4 proteinNode metastasisObstructive jaundiceGranular chromatinSegmental resectionEndocrine manifestationsP53 loss
1998
Clear cell papillary carcinoma of the liver: An unusual variant of peripheral cholangiocarcinoma
Tihan T, Blumgart L, Klimstra D. Clear cell papillary carcinoma of the liver: An unusual variant of peripheral cholangiocarcinoma. Human Pathology 1998, 29: 196-200. PMID: 9490284, DOI: 10.1016/s0046-8177(98)90235-0.Peer-Reviewed Original ResearchConceptsCell papillary carcinomaPeripheral cholangiocarcinomaPapillary carcinomaCell changesEvidence of diseaseExtrahepatic bile ductComplete resectionPrimary carcinomaCell carcinomaExtrahepatic cholangiocarcinomaCholangio-carcinomaUnusual variantUrinary bladderHepatocellular carcinomaCarcinomaPeripheral typeBile ductPrimary siteCholangiocarcinomaNeoplasmsPatientsCellsLiverResectionProstate
1996
Carcinoid tumor of the common bile duct producing gastrin and serotonin.
Hao L, Friedman A, Navarro V, West B, Robert M. Carcinoid tumor of the common bile duct producing gastrin and serotonin. Journal Of Clinical Gastroenterology 1996, 23: 63-5. PMID: 8835905, DOI: 10.1097/00004836-199607000-00018.Peer-Reviewed Original Research
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