2024
6645 Paraganglioma or Benign Ectopic Thyroid Tissue?
Dower J, MacLeod R, Cardoso B, Matouk C, Mehra S, Riccio G, Williams L, Majumdar S. 6645 Paraganglioma or Benign Ectopic Thyroid Tissue? Journal Of The Endocrine Society 2024, 8: bvae163.2032. PMCID: PMC11454000, DOI: 10.1210/jendso/bvae163.2032.Peer-Reviewed Original ResearchEctopic thyroid tissueBenign thyroid tissueThyroid tissueHealthy 32-year-old womanLateral ectopic thyroid tissueLow likelihood of malignancyRight carotid spaceRight thyroid lobeInternal carotid artery branchesLikelihood of malignancyCarotid artery branchesPermanent tissue sectionsDOTATATE PET/CTCervical adenopathyJaw painNeck dissectionBiochemical workupTumor embolizationMimics malignancyNeck CTNeck MRIPlasma metanephrinesT2 lesionsChest CTThyroid FNAClinical Implications of C2 Lesion in IgA Nephropathy: A Cohort Study
Wang Z, Zhou X, Shi S, Liu L, Lv J, Zhang H. Clinical Implications of C2 Lesion in IgA Nephropathy: A Cohort Study. American Journal Of Nephrology 2024, 55: 529-538. PMID: 39074466, DOI: 10.1159/000540268.Peer-Reviewed Original ResearchConceptsEnd-stage kidney diseaseC2 lesionsCohort studyCox regressionMonths prior to biopsyPeking University First HospitalProportion of crescentsMultivariate Cox regressionProspective cohort studyEffective treatment strategiesKidney prognosisImmunosuppressive treatmentRenal prognosisT2 lesionsMean proteinuriaCombined steroidCrescentic lesionsOxford classificationGlomerular crescentsClinical prognosisUnivariate analysisPathological findingsClinical significanceIgA nephropathyKidney function
2023
Phase 3 REMODEL I/II Trials: Efficacy, Safety, and Tolerability of Remibrutinib in Patients with Relapsing Multiple Sclerosis
Wiendl H, Airas L, Chitnis T, Williams M, Nakahara J, Bermel R, Loop B, Hayek G, Bhatt A, Hunter B, Zhang Y, Karan R, Willi R, Kieseier B, Montalban X. Phase 3 REMODEL I/II Trials: Efficacy, Safety, and Tolerability of Remibrutinib in Patients with Relapsing Multiple Sclerosis. Multiple Sclerosis And Related Disorders 2023, 80: 105315. DOI: 10.1016/j.msard.2023.105315.Peer-Reviewed Original ResearchBruton's tyrosine kinaseDisease activitySerum neurofilament light chain concentrationNeurofilament light chain concentrationOpen-label extensionKey secondary endpointDisability Status ScaleNew oral treatmentRecent disease activityLight chain concentrationsPercentage of participantsCovalent BTK inhibitorImmune regulatory networkRelated neuroinflammationDisability progressionPrimary endpointSecondary endpointsT1 lesionsTyrosine kinaseOral treatmentRelapse rateT2 lesionsMulticenter studyMultiple sclerosisSafety profileIndirect detection of deuterated glucose brain metabolism at 3 Tesla: preliminary findings in volunteers and patients with gliomas
Autry A, LaFontaine M, Villanueva-Meyer J, Chang S, de Feyter H, Li Y. Indirect detection of deuterated glucose brain metabolism at 3 Tesla: preliminary findings in volunteers and patients with gliomas. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/2502.Peer-Reviewed Original ResearchIndirect detectionMagnetic resonance spectroscopic imagingAnterior cingulate cortexSingle-voxel spectroscopyGlucose metabolismLevels of glutamateSpectroscopic imagingReduced levels of glutamateGlucose brain metabolismT2 lesionsHealthy subjectsCingulate cortexBrain tumorsTeslaPatientsBrain metabolismGray matterPreliminary dataReduced levelsMetabolismThe radiologically isolated syndrome: revised diagnostic criteria
Lebrun-Frénay C, Okuda D, Siva A, Landes-Chateau C, Azevedo C, Mondot L, Carra-Dallière C, Zephir H, Louapre C, Durand-Dubief F, Le Page E, Bensa C, Ruet A, Ciron J, Laplaud D, Casez O, Mathey G, de Seze J, Zeydan B, Makhani N, Tutuncu M, Levraut M, Cohen M, Thouvenot E, Pelletier D, Kantarci O. The radiologically isolated syndrome: revised diagnostic criteria. Brain 2023, 146: 3431-3443. PMID: 36864688, PMCID: PMC11004931, DOI: 10.1093/brain/awad073.Peer-Reviewed Original ResearchConceptsRadiologically isolated syndromeClinical eventsGroup 1Risk factorsDIS criteriaPresence of spinal cord lesionsClinical follow-up timeCSF-restricted oligoclonal bandsMultivariate Cox regression modelDiagnostic criteriaFocal T2 hyperintensitiesGadolinium-enhancing lesionsMultiple sclerosisNegative predictive valueFollow-up scansFollow-up timeArea under the curveClass I evidenceSpinal cord lesionsCox regression modelsRisk of developmentWhite matter lesionsProspective databaseSymptomatic MST2 lesions
2021
Supraspinal Sensorimotor and Pain-Related Reorganization after a Hemicontusion Rat Cervical Spinal Cord Injury
Sanganahalli BG, Chitturi J, Herman P, Elkabes S, Heary R, Hyder F, Kannurpatti SS. Supraspinal Sensorimotor and Pain-Related Reorganization after a Hemicontusion Rat Cervical Spinal Cord Injury. Journal Of Neurotrauma 2021, 38: 3393-3405. PMID: 34714150, PMCID: PMC8713267, DOI: 10.1089/neu.2021.0190.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCervical spinal cord injuryAnterior cingulate cortexFunctional magnetic resonance imagingPre-frontal cortexNociceptive regionsCord injuryPresence of painSecondary somatosensory cortexFunctional connectivity densityElectrical forepaw stimulationFemale adult ratsTranslational animal modelsMost cortical regionsMagnetic resonance imagingDiscernable lesionsIpsilesional forelimbKdyn forceRSFC decreasesRsFC increasesSupraspinal changesMotor recoveryThermal hyperalgesiaT2 lesionsPain behavior
2014
Examining the management of muscle-invasive bladder cancer by medical oncologists in the United States11Funding source: The US Office of Management and Budget (0925-0046).
Apolo AB, Kim JW, Bochner BH, Steinberg SM, Bajorin DF, Kelly K, Agarwal PK, Koppie TM, Kaag MG, Quinn DI, Vogelzang NJ, Sridhar SS. Examining the management of muscle-invasive bladder cancer by medical oncologists in the United States11Funding source: The US Office of Management and Budget (0925-0046). Urologic Oncology Seminars And Original Investigations 2014, 32: 637-644. PMID: 24840869, PMCID: PMC6771274, DOI: 10.1016/j.urolonc.2013.12.012.Peer-Reviewed Original ResearchConceptsMuscle-invasive bladder cancerTreatment of MIBCUpper tract urothelial carcinomaNeoadjuvant chemotherapyMedical oncologistsUrothelial carcinomaBladder cancerEastern Cooperative Oncology Group performance statusHigh grade upper tract urothelial carcinomaBladder Cancer Advocacy NetworkUse of NACDose-dense methotrexateGemcitabine/carboplatinGemcitabine/cisplatinGlomerular filtration rateAdjuvant chemotherapyPerioperative chemotherapyChemotherapy regimensLymphovascular invasionPerformance statusT2 lesionsStandardization of practiceMost referralsFiltration rateChemotherapy management
2012
Effect of increased time from chemoradiation to surgery on the pathologic complete response rate in patients with esophageal cancer.
Shaikh T, Ruth K, Scott W, Burtness B, Cohen S, Konski A, Cooper H, Astsaturov I, Meyer J. Effect of increased time from chemoradiation to surgery on the pathologic complete response rate in patients with esophageal cancer. Journal Of Clinical Oncology 2012, 30: 84-84. DOI: 10.1200/jco.2012.30.4_suppl.84.Peer-Reviewed Original ResearchPathologic complete responseEsophageal cancerPathologic complete response rateT3/T4 lesionsT1/T2 lesionsCarboplatin-based therapyTri-modality treatmentComplete response rateMedian radiation doseType of chemotherapyResectable esophageal cancerMultivariable logistic regressionSquamous cell carcinomaRadiation doseEnd of chemoradiationTrimodality therapyDistant recurrenceSubsequent surgeryT4 lesionsComplete responseMedian ageRectal cancerT2 lesionsMedian timeMultivariable analysis
2011
Early-Stage Gallbladder Cancer in the Surveillance, Epidemiology, and End Results Database: Effect of Extended Surgical Resection
Downing SR, Cadogan KA, Ortega G, Oyetunji TA, Siram SM, Chang DC, Ahuja N, Leffall LD, Frederick WA. Early-Stage Gallbladder Cancer in the Surveillance, Epidemiology, and End Results Database: Effect of Extended Surgical Resection. JAMA Surgery 2011, 146: 734-738. PMID: 21690451, DOI: 10.1001/archsurg.2011.128.Peer-Reviewed Original ResearchConceptsEarly-stage gallbladder cancerEnd Results (SEER) databaseMore lymph nodesLymph nodesGallbladder cancerSurgical resectionSurvival benefitT2 lesionsResults databaseMultivariate analysisDisease-positive lymph nodesPrimary gallbladder cancerExtended surgical resectionLN excisionOverall survivalSimple cholecystectomyAdvanced cancerFemale patientsCertain patientsRetrospective analysisSurgical proceduresSurvival advantagePatientsCancerResectionInterferon regulatory factor 5 gene variants and pharmacological and clinical outcome of Interferonβ therapy in multiple sclerosis
Vosslamber S, van der Voort LF, van den Elskamp IJ, Heijmans R, Aubin C, Uitdehaag BM, Crusius JB, van der PouwKraan T, Comabella M, Montalban X, Hafler DA, De Jager PL, Killestein J, Polman CH, Verweij CL. Interferon regulatory factor 5 gene variants and pharmacological and clinical outcome of Interferonβ therapy in multiple sclerosis. Genes & Immunity 2011, 12: 466-472. PMID: 21471993, DOI: 10.1038/gene.2011.18.Peer-Reviewed Original ResearchConceptsRelapsing-remitting multiple sclerosisNon-responder statusInterferon regulatory factor 5IFNβ treatmentMultiple sclerosisT2 lesionsClinical outcomesMore magnetic resonance imagingMore T2 lesionsStart of therapyGene variantsInterferon-β TherapyIFN response genesRegulatory factor 5Poor pharmacological responseMagnetic resonance imagingIFNβ therapyClinical responseFirst relapseIndependent cohortPharmacological responseClinical relevanceG allelePatientsResonance imaging
2008
Relationship of pre-surgery metabolic and physiological MR imaging parameters to survival for patients with untreated GBM
Crawford FW, Khayal IS, McGue C, Saraswathy S, Pirzkall A, Cha S, Lamborn KR, Chang SM, Berger MS, Nelson SJ. Relationship of pre-surgery metabolic and physiological MR imaging parameters to survival for patients with untreated GBM. Journal Of Neuro-Oncology 2008, 91: 337. PMID: 19009235, PMCID: PMC3022444, DOI: 10.1007/s11060-008-9719-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAspartic AcidBrain MappingBrain NeoplasmsCholineCreatineDiagnosis, DifferentialDiffusion Magnetic Resonance ImagingFemaleGlioblastomaHumansImage EnhancementImage Processing, Computer-AssistedKaplan-Meier EstimateLactic AcidLipidsMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMiddle AgedProtonsRadionuclide ImagingRetrospective StudiesConceptsGlioblastoma multiformeApparent diffusion coefficientPoor survivalConventional anatomical MR imagingAnatomical MR imagingUntreated glioblastoma multiformeT2 hyperintense lesionsMedian survival timeLow-risk groupBlood-brain barrierStratification of patientsContrast-enhancing lesionsPerfusion-weighted imagingDiffusion-weighted imagingPhysiological MRProton MR spectroscopicFavorable survivalSurgical resectionT2 lesionsHyperintense lesionsPrognostic valueBrain barrierElevated cholineClinical trialsLesion volume
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