Development of the natural history component of an early economic model for primary sclerosing cholangitis
Bowlus C, Levy C, Kowdley K, Kachru N, Jeyakumar S, Rodriguez-Guadarrama Y, Smith N, Briggs A, Sculpher M, Ollendorf D. Development of the natural history component of an early economic model for primary sclerosing cholangitis. Orphanet Journal Of Rare Diseases 2025, 20: 133. PMID: 40102907, PMCID: PMC11921552, DOI: 10.1186/s13023-025-03658-8.Peer-Reviewed Original ResearchConceptsQuality-adjusted life yearsTransplant-free survivalProportion of patientsRecurrent PSCLiver transplantationDisease progressionOverall survivalSclerosing cholangitisSecondary cancersCumulative incidenceCumulative incidence of secondary cancersIncidence of secondary cancersChronic cholestatic diseasePrimary sclerosing cholangitisProgression to cirrhosisLifetime quality-adjusted life yearsBackgroundPrimary sclerosing cholangitisMarkov cohort modelInflammatory bowel diseaseEconomic modelGallbladder cancerEstimates of disease progressionCholestatic diseasesFibrosis stageLiver failure
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