2019
The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function
Rai R, Gu P, Broton C, Kumar-Sinha C, Chen Y, Chang S. The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function. Cell Reports 2019, 29: 3708-3725.e5. PMID: 31825846, PMCID: PMC7001145, DOI: 10.1016/j.celrep.2019.11.012.Peer-Reviewed Original ResearchMeSH KeywordsAcid Anhydride HydrolasesAdaptor Proteins, Signal TransducingAminopeptidasesAnimalsCell Cycle ProteinsCell Line, TumorCells, CulturedCheckpoint Kinase 1Dipeptidyl-Peptidases and Tripeptidyl-PeptidasesDNA End-Joining RepairDNA Repair EnzymesDNA-Binding ProteinsDNA-Directed DNA PolymeraseExodeoxyribonucleasesHEK293 CellsHumansMiceMRE11 Homologue ProteinMultienzyme ComplexesProliferating Cell Nuclear AntigenSerine ProteasesShelterin ComplexTelomereTelomere-Binding ProteinsTelomeric Repeat Binding Protein 2ConceptsReplication protein AReplisome complexPOT1-TPP1Dysfunctional telomeresDNA damage sensor MRE11-RAD50DNA damage checkpoint responseAlternative non-homologous endNon-homologous endMRN functionChromosome endsMre11-Rad50Checkpoint responseDNA-PKTelomeric overhangMre11 nucleaseTelomere repairEnd resectionRAD-51Repair pathwaysAtaxia telangiectasiaTelomeresC-strandDNA damageReplisomeClaspinMedial artery calcification increases neointimal hyperplasia after balloon injury
Marshall AP, Luo W, Wang XL, Lin T, Cai Y, Guzman RJ. Medial artery calcification increases neointimal hyperplasia after balloon injury. Scientific Reports 2019, 9: 8193. PMID: 31160618, PMCID: PMC6547750, DOI: 10.1038/s41598-019-44668-4.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, BalloonAnimalsBone Morphogenetic Protein 2CalcinosisCalcium ChlorideCarotid ArteriesCarotid Artery InjuriesCell ProliferationCoronary RestenosisDisease Models, AnimalHyperplasiaMaleMuscle, Smooth, VascularMyocytes, Smooth MuscleNeointimaProliferating Cell Nuclear AntigenRatsRats, Sprague-DawleyTunica IntimaConceptsSmooth muscle cellsNeointimal hyperplasiaBalloon injuryArterial calcificationCalcified arteriesMedial smooth muscle cellsCell nuclear antigen stainingBalloon catheter injuryMedial artery calcificationTime of injuryVascular smooth muscle cellsNeointimal cell proliferationCell proliferationCatheter injuryArtery calcificationMedial calcificationSubcutaneous injectionAntigen stainingVitamin D3Rat carotidEffect of calcificationArteryHyperplasiaAdventitial applicationInjuryAdipocyte alterations in endometriosis: reduced numbers of stem cells and microRNA induced alterations in adipocyte metabolic gene expression
Zolbin MM, Mamillapalli R, Nematian SE, Goetz T, Taylor HS. Adipocyte alterations in endometriosis: reduced numbers of stem cells and microRNA induced alterations in adipocyte metabolic gene expression. Reproductive Biology And Endocrinology 2019, 17: 36. PMID: 30982470, PMCID: PMC6463663, DOI: 10.1186/s12958-019-0480-0.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAnimalsCell DifferentiationCell ProliferationEndometriosisFemaleGene ExpressionHumansInsulin ResistanceLipid MetabolismMice, Inbred C57BLMicroRNAsProliferating Cell Nuclear AntigenConceptsBody mass indexFat metabolismFat tissueMouse modelAdipose tissueMetabolic gene expressionLower body mass indexOld female C57BL/6 miceAdipocytes of womenMicroRNA let‑7bSerum of womenReproductive-aged womenEffect of endometriosisFemale C57BL/6 miceStem cellsAdipose-derived mesenchymal stem cellsBrown adipocyte differentiationInhibitors of microRNAsStem cell contentMass indexMetabolic abnormalitiesC57BL/6 miceInflammatory disordersIL-6Insulin sensitivity
2017
MMP-2: A modulator of neuronal precursor activity and cognitive and motor behaviors
Li Q, Michaud M, Shankar R, Canosa S, Schwartz M, Madri JA. MMP-2: A modulator of neuronal precursor activity and cognitive and motor behaviors. Behavioural Brain Research 2017, 333: 74-82. PMID: 28666838, DOI: 10.1016/j.bbr.2017.06.041.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornCell MovementCell ProliferationCells, CulturedCognitionExploratory BehaviorGene Expression RegulationMatrix Metalloproteinase 2MiceMice, Inbred C57BLMice, KnockoutMotor ActivityNerve Tissue ProteinsNeural Stem CellsNeurogenesisOncogene Protein v-aktProliferating Cell Nuclear AntigenReceptors, CXCR4Spatial LearningConceptsNeural precursor cellsBroad substrate specificityNeurosphere formationAdherent neurospheresSecondary neurosphere formationNPC activitySubstrate specificityNPC numberCell surface moleculesZinc-containing enzymesAkt activationAbsence of MMP2Cell typesExtracellular matrixActivity assaysPrecursor cellsImportant roleNPC migrationMatrix metalloproteinase2Surface moleculesExpressionKO miceBioactive moleculesNestin expressionMMP2Effect of simvastatin on baboon endometriosis†
Taylor HS, Alderman M, D'Hooghe TM, Fazleabas AT, Duleba AJ. Effect of simvastatin on baboon endometriosis†. Biology Of Reproduction 2017, 97: 32-38. PMID: 28637327, PMCID: PMC6248548, DOI: 10.1093/biolre/iox058.Peer-Reviewed Original ResearchConceptsEffect of simvastatinEndometriotic lesionsRed lesionsMarkers of inflammationEndometrial stromal cellsDevelopment of endometriosisEstrogen receptor betaImmune system activationEstrogen receptor alphaMarkers of proliferationSteroid hormone responsesCell nuclear antigenEndometrial lesionsEndometrial tissueEutopic endometriumReproductive agePrimate modelWhite lesionsCommon disorderEstrogen receptorBaboon modelMurine modelTreatment groupsSystem activationReceptor alpha
2015
Long-acting progestin-only contraceptives impair endometrial vasculature by inhibiting uterine vascular smooth muscle cell survival
Kayisli UA, Basar M, Guzeloglu-Kayisli O, Semerci N, Atkinson HC, Shapiro J, Summerfield T, Huang SJ, Prelle K, Schatz F, Lockwood CJ. Long-acting progestin-only contraceptives impair endometrial vasculature by inhibiting uterine vascular smooth muscle cell survival. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 5153-5158. PMID: 25847994, PMCID: PMC4413279, DOI: 10.1073/pnas.1424814112.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CountCell DifferentiationCell MovementCell ProliferationCell SurvivalCells, CulturedChemokine CCL2Contraceptive Agents, FemaleDesogestrelEndometriumFemaleGene Expression ProfilingGene Expression RegulationGuinea PigsHumansMedroxyprogesterone AcetateModels, BiologicalMuscle, Smooth, VascularMyocytes, Smooth MuscleOvariectomyProgestinsProliferating Cell Nuclear AntigenSignal TransductionSTAT1 Transcription FactorConceptsVascular smooth muscle cellsChemokine ligand 2Medroxyprogesterone acetateEndometrial vasculatureVSMC proliferationCultured vascular smooth muscle cellsSmooth muscle cellsSmooth muscle cell survivalVascular smooth muscle cell survivalCell nuclear antigenFragile microvesselsΑSMA immunoreactivityEndometrial vesselsΑSMA stainingPericyte proliferationSTAT1 inhibitorGuinea pigsMuscle cellsMuscle cell survivalCCL2 effectsEtonogestrelMigration assaysNuclear antigenVSMC differentiationWomen
2012
Regional Differences in Gallbladder Cancer Pathogenesis: Insights from a Comparison of Cell Cycle-Regulatory, PI3K, and Pro-Angiogenic Protein Expression
Butte J, Torres J, Veras E, Matsuo K, Gönen M, D’Angelica M, Waugh E, Meneses M, Inayama Y, Fong Y, DeMatteo R, De La Fuente H, Endo I, Klimstra D, Jarnagin W. Regional Differences in Gallbladder Cancer Pathogenesis: Insights from a Comparison of Cell Cycle-Regulatory, PI3K, and Pro-Angiogenic Protein Expression. Annals Of Surgical Oncology 2012, 20: 1470-1481. PMID: 23212762, PMCID: PMC4048130, DOI: 10.1245/s10434-012-2761-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overChileCyclin-Dependent Kinase Inhibitor p21FemaleGallbladder NeoplasmsHumansJapanKaplan-Meier EstimateKi-67 AntigenMaleMiddle AgedMultivariate AnalysisNeoplasm StagingProliferating Cell Nuclear AntigenProto-Oncogene Proteins c-mdm2United StatesVascular Endothelial Growth Factor Receptor-2ConceptsMedian disease-specific survivalCell cycle-regulatoryGallbladder cancerEarly tumorsProtein expressionDisease-specific survival of patientsKi-67 labeling indexIncidence of gallbladder cancerDisease-specific survivalGallbladder cancer pathogenesisSurvival of patientsAbsence of p21MethodsImmunohistochemical expressionCurative intentClinicopathological variablesAngiogenesis-relatedKi-67Labeling indexP27 expressionProtein expression patternsTumorMSKCCMDM2 overexpressionCancer pathogenesisPathogenetic differencesCytosolic sulfotransferase 2B1b promotes hepatocyte proliferation gene expression in vivo and in vitro
Zhang X, Bai Q, Xu L, Kakiyama G, Pandak WM, Zhang Z, Ren S. Cytosolic sulfotransferase 2B1b promotes hepatocyte proliferation gene expression in vivo and in vitro. AJP Gastrointestinal And Liver Physiology 2012, 303: g344-g355. PMID: 22679001, PMCID: PMC3423104, DOI: 10.1152/ajpgi.00403.2011.Peer-Reviewed Original ResearchMeSH KeywordsAdenoviridaeAnimalsCell ProliferationCytosolGene ExpressionHepatocytesLiver X ReceptorsMiceOrphan Nuclear ReceptorsProliferating Cell Nuclear AntigenRatsRNA, MessengerSignal TransductionSulfotransferasesConceptsLiver X receptorMouse liver tissueLiver tissueSulfotransferase 2B1bLiver proliferationPCNA-positive cellsPrimary rat hepatocytesCell nuclear antigenOxysterol sulfotransferaseWestern blot analysisCell cycle regulatory gene expressionProliferation gene expressionTime-dependent mannerGene expressionC57BL/6 miceQuantitative real-time PCRReal-time PCRLXR activationDouble immunofluorescenceLabeling indexSelective cholesterolAntiproliferative factorPCNA expressionLipid metabolismIncreased expressionComparison of hepatocellular carcinoma in American and Asian patients by tissue array analysis
Song T, Fong Y, Cho S, Gönen M, Hezel M, Tuorto S, Choi S, Kim Y, Suh S, Koo B, Chae Y, Jarnagin W, Klimstra D. Comparison of hepatocellular carcinoma in American and Asian patients by tissue array analysis. Journal Of Surgical Oncology 2012, 106: 84-88. PMID: 22234941, PMCID: PMC3346847, DOI: 10.1002/jso.23036.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAsian PeopleBiomarkers, TumorCarcinoma, HepatocellularCyclin D1Cyclin-Dependent Kinase Inhibitor p21FemaleGene Expression Regulation, NeoplasticHepatitis BHepatitis CHumansImmunohistochemistryKi-67 AntigenLiver NeoplasmsLymphatic MetastasisMaleMiddle AgedNeoplasm InvasivenessParaffinPrognosisProliferating Cell Nuclear AntigenProto-Oncogene Proteins c-bcl-2Proto-Oncogene Proteins c-mdm2Republic of KoreaRisk FactorsTissue Array AnalysisTumor Suppressor Protein p53United StatesConceptsHepatocellular carcinomaKorea University Medical CenterMolecular pathogenesis of hepatocellular carcinomaMolecular targeted therapyViral hepatitis infectionWestern hepatocellular carcinomaMarkers of proliferationTissue array analysisPathogenesis of hepatocellular carcinomaComparisons of hepatocellular carcinomaExpression of Ki67Expression of p53University Medical CenterMDM2 stainingMicroarray sectionsNo significant differenceAsian patientsTissue microarrayVascular invasionHepatitis infectionImmunohistochemical stainingPositive stainingRegulation of cell cycleHCC specimensPathologic correlation
2011
Treatment with Bazedoxifene, a Selective Estrogen Receptor Modulator, Causes Regression of Endometriosis in a Mouse Model
Kulak J, Fischer C, Komm B, Taylor HS. Treatment with Bazedoxifene, a Selective Estrogen Receptor Modulator, Causes Regression of Endometriosis in a Mouse Model. Endocrinology 2011, 152: 3226-3232. PMID: 21586552, PMCID: PMC3138238, DOI: 10.1210/en.2010-1010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCaspase 3Disease Models, AnimalEndometriosisFemaleIndolesMiceProliferating Cell Nuclear AntigenReceptors, EstrogenSelective Estrogen Receptor ModulatorsConceptsSelective estrogen receptor modulatorsRegression of endometriosisTreatment of endometriosisEstrogen receptor modulatorsReceptor modulatorsEstrogen-dependent disorderTissue-selective actionSignificant side effectsCD-1 miceEndometrial gene expressionCentral nervous systemEffective novel agentsExpression of PREndometrial stimulationGnRH agonistOvarian enlargementER expressionLIF mRNAExperimental endometriosisEstrogen antagonismER antagonistNovel agentsSERM bazedoxifeneEndometriosisMouse modelMaternal Ghrelin Deficiency Compromises Reproduction in Female Progeny through Altered Uterine Developmental Programming
Martin JR, Lieber SB, McGrath J, Shanabrough M, Horvath TL, Taylor HS. Maternal Ghrelin Deficiency Compromises Reproduction in Female Progeny through Altered Uterine Developmental Programming. Endocrinology 2011, 152: 2060-2066. PMID: 21325042, PMCID: PMC3075930, DOI: 10.1210/en.2010-1485.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEmbryo ImplantationFemaleFertilityGene Expression Regulation, DevelopmentalGhrelinHeterozygoteHomeobox A10 ProteinsHomeodomain ProteinsImmunohistochemistryLitter SizeMaleMiceMice, KnockoutProliferating Cell Nuclear AntigenReproductionReverse Transcriptase Polymerase Chain ReactionTranscription FactorsUterusWnt ProteinsConceptsGhrelin deficiencyDevelopmental programmingAbnormal endometrial functionFemale wild-type miceUterus of miceLevels of ghrelinRegulation of appetiteWild-type miceReproductive tract developmentWild-type offspringSubsequent subfertilityEndometrial proliferationUnexposed miceEndometrial functionUtero exposureUterine expressionEmbryo implantationOvarian folliclesCorpora luteaGhrelinReproductive tractTract developmentMiceSignificant alterationsSubfertility
2010
The Four-Herb Chinese Medicine PHY906 Reduces Chemotherapy-Induced Gastrointestinal Toxicity
Lam W, Bussom S, Guan F, Jiang Z, Zhang W, Gullen EA, Liu SH, Cheng YC. The Four-Herb Chinese Medicine PHY906 Reduces Chemotherapy-Induced Gastrointestinal Toxicity. Science Translational Medicine 2010, 2: 45ra59. PMID: 20720216, DOI: 10.1126/scitranslmed.3001270.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic Agents, PhytogenicApoptosisbeta CateninBiomarkers, TumorBromodeoxyuridineCamptothecinCell ProliferationDNA DamageDrugs, Chinese HerbalGastrointestinal TractGlucuronidaseHumansInflammationIrinotecanMedicine, Chinese TraditionalMiceProliferating Cell Nuclear AntigenRecovery of FunctionSignal TransductionStem CellsTransplantation, HomologousWeight LossWnt ProteinsWnt3 ProteinWnt3A ProteinConceptsCPT-11Gastrointestinal toxicityFour-herb Chinese medicine formulaPhase I/II clinical studyTumor necrosis factor-alpha expressionChemotherapy-induced gastrointestinal toxicityNecrosis factor-alpha expressionInducible nitric oxide synthaseProinflammatory cytokine concentrationsInfiltration of neutrophilsAnti-inflammatory effectsII clinical studyAnimal weight lossCPT-11 treatmentNitric oxide synthaseChinese medicine formulaNuclear factor-kappaBHuman embryonic kidney 293 cellsEmbryonic kidney 293 cellsAllograft modelCytokine concentrationsIntestinal toxicityOxide synthaseCyclooxygenase-2Clinical studies
2009
ERK1/2-Dependent Vascular Endothelial Growth Factor Signaling Sustains Cyst Growth in Polycystin-2 Defective Mice
Spirli C, Okolicsanyi S, Fiorotto R, Fabris L, Cadamuro M, Lecchi S, Tian X, Somlo S, Strazzabosco M. ERK1/2-Dependent Vascular Endothelial Growth Factor Signaling Sustains Cyst Growth in Polycystin-2 Defective Mice. Gastroenterology 2009, 138: 360-371.e7. PMID: 19766642, PMCID: PMC3000794, DOI: 10.1053/j.gastro.2009.09.005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedCyclic AMP-Dependent Protein KinasesCystsHypoxia-Inducible Factor 1, alpha SubunitIndolesLiver DiseasesMAP Kinase Signaling SystemMiceMice, KnockoutMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3PhenotypePhosphorylationProliferating Cell Nuclear AntigenProtein Kinase InhibitorsPyrrolesRepressor ProteinsTRPP Cation ChannelsTumor Suppressor ProteinsVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2ConceptsVascular endothelial growth factorPolycystic liver diseaseVEGF secretionLiver cystsLiver diseaseVEGFR-2Cyst growthLiver/body weight ratioAdult dominant polycystic kidney diseaseParacrine vascular endothelial growth factorSecretion of VEGFHIF-1alphaBody weight ratioEffects of VEGFAutocrine vascular endothelial growth factorDominant polycystic kidney diseaseExpression of pERKVascular endothelial growth factor signalingPhosphorylated VEGFR-2Liver cyst growthEndothelial growth factorPolycystic kidney diseaseCyst epithelial cellsExtracellular signal-regulated kinase 1/2Hypoxia-inducible factor
2008
Correlates and Determinants of Nuclear Epidermal Growth Factor Receptor Content in an Oropharyngeal Cancer Tissue Microarray
Psyrri A, Egleston B, Pectasides E, Weinberger P, Yu Z, Kowalski D, Sasaki C, Haffty B, Rimm D, Burtness B. Correlates and Determinants of Nuclear Epidermal Growth Factor Receptor Content in an Oropharyngeal Cancer Tissue Microarray. Cancer Epidemiology Biomarkers & Prevention 2008, 17: 1486-1492. PMID: 18559565, DOI: 10.1158/1055-9965.epi-07-2684.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceBiomarkers, TumorCell NucleusErbB ReceptorsHumansImage Processing, Computer-AssistedImmunoenzyme TechniquesLinear ModelsOropharyngeal NeoplasmsProliferating Cell Nuclear AntigenStatistics, Nonparametric
2006
Optimization of endometrial preparation results in a normal endometrial function test® (EFT®) and good reproductive outcome in donor ovum recipients
Kliman HJ, Honig S, Walls D, Luna M, McSweet JC, Copperman AB. Optimization of endometrial preparation results in a normal endometrial function test® (EFT®) and good reproductive outcome in donor ovum recipients. Journal Of Assisted Reproduction And Genetics 2006, 23: 299-303. PMID: 16983518, DOI: 10.1007/s10815-006-9061-1.Peer-Reviewed Original ResearchConceptsFunction testsCourse of estrogensOvum donation cyclesUnexplained infertility patientsBetter reproductive outcomesCyclin EOvum recipientsClinical pregnancyEndometrial biopsyInfertility patientsProgesterone supplementationSuch patientsEndometrial receptivityDonation cyclesSuccessful pregnancyPregnancy failureDonor oocytesLeuprolide acetateSole patientUterine preparationsImmunohistochemical stainingReproductive outcomesStimulation protocolTransfer cyclesSuccessful implantationDifferential Cell Cycle–Regulatory Protein Expression in Biliary Tract Adenocarcinoma: Correlation With Anatomic Site, Pathologic Variables, and Clinical Outcome
Jarnagin W, Klimstra D, Hezel M, Gonen M, Fong Y, Roggin K, Cymes K, DeMatteo R, D'Angelica M, Blumgart L, Singh B. Differential Cell Cycle–Regulatory Protein Expression in Biliary Tract Adenocarcinoma: Correlation With Anatomic Site, Pathologic Variables, and Clinical Outcome. Journal Of Clinical Oncology 2006, 24: 1152-1160. PMID: 16505435, DOI: 10.1200/jco.2005.04.6631.Peer-Reviewed Original ResearchMeSH KeywordsAgedBile Duct NeoplasmsBile Ducts, IntrahepaticBiomarkers, TumorCell Cycle ProteinsCholangiocarcinomaCyclin D1Cyclin-Dependent Kinase Inhibitor p21FemaleGallbladder NeoplasmsGene Expression Regulation, NeoplasticHumansImmunohistochemistryKi-67 AntigenMaleMiddle AgedNeoplasm Recurrence, LocalProliferating Cell Nuclear AntigenProto-Oncogene Proteins c-bcl-2Proto-Oncogene Proteins c-mdm2Survival AnalysisTumor Suppressor Protein p53Up-RegulationConceptsBiliary tract adenocarcinomaPathological variablesProtein expressionAnatomical sitesP27 expressionParaffin-embedded surgical specimensTumor site of originImmunohistochemical expression of p53Cyclin D1Aberrant p53 stainingDistal bile ductExpression of p53Cyclin D1 overexpressionOverexpression of MDM2Cell cycle-regulatory proteinsSite of originHilar tumorsR0 resectionP53 stainingPapillary tumorsPrognostic roleSurgical specimensTumor locationSclerosing tumorsHilar cholangiocarcinoma
2005
Resveratrol inhibits vascular smooth muscle cell proliferation and induces apoptosis
Poussier B, Cordova AC, Becquemin JP, Sumpio BE. Resveratrol inhibits vascular smooth muscle cell proliferation and induces apoptosis. Journal Of Vascular Surgery 2005, 42: 1190-1190.e14. PMID: 16376213, DOI: 10.1016/j.jvs.2005.08.014.Peer-Reviewed Original ResearchMeSH KeywordsAngiogenesis InhibitorsAnimalsAnimals, NewbornAntioxidantsAorta, ThoracicApoptosisBlotting, WesternCattleCell ProliferationCells, CulturedDNADose-Response Relationship, DrugFlow CytometryIn Situ Nick-End LabelingIn Vitro TechniquesMuscle, Smooth, VascularProliferating Cell Nuclear AntigenResveratrolStilbenesConceptsSmooth muscle cell proliferationMuscle cell proliferationVascular smooth muscle cell proliferationDose-dependent mannerSMC proliferationCell proliferationG1-S phaseBeneficial effectsFrench paradoxDose-dependent apoptotic effectTerminal deoxynucleotidyl transferase-mediated dUTP-biotin nickTransferase-mediated dUTP-biotin nickCardiovascular death ratesRed wine intakeRed wine consumptionEffects of resveratrolAortic SMC proliferationEnd labeling stainingVascular SMC proliferationDUTP-biotin nickMajor polyphenol componentHealthy life styleCell cycle analysisCardiovascular mortalityFlow-activated cell sortingDifferential responsiveness of early- and late-passage endothelial cells to shear stress
Kudo FA, Warycha B, Juran PJ, Asada H, Teso D, Aziz F, Frattini J, Sumpio BE, Nishibe T, Cha C, Dardik A. Differential responsiveness of early- and late-passage endothelial cells to shear stress. The American Journal Of Surgery 2005, 190: 763-769. PMID: 16226955, DOI: 10.1016/j.amjsurg.2005.07.017.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAortaApoptosisBlotting, WesternCattleCell CountCell DivisionCell ProliferationCells, CulturedEndothelium, VascularIn Vitro TechniquesMuscle, Smooth, VascularPhosphorylationProliferating Cell Nuclear AntigenProtein Serine-Threonine KinasesProtein-Tyrosine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-aktShear StrengthStress, MechanicalTumor Suppressor Protein p53ConceptsLate passage endothelial cellsOrbital shear stressEarly passage cellsSmooth muscle cell migrationMuscle cell migrationEndothelial cellsSenescence modelAkt phosphorylationCell migrationProtein kinase B activationPassage cellsKinase B activationCell proliferationVascular disease increasesLate passage cellsBovine aortic endothelial cellsNuclear antigen reactivityAortic endothelial cellsEndothelial cell proliferationNeointimal hyperplasiaAntigen reactivityTotal AktBoyden chamberB activationWestern blotting
2004
Caspase-3 in Postnatal Retinal Development and Degeneration
Zeiss CJ, Neal J, Johnson EA. Caspase-3 in Postnatal Retinal Development and Degeneration. Investigative Ophthalmology & Visual Science 2004, 45: 964-970. PMID: 14985318, DOI: 10.1167/iovs.03-0439.Peer-Reviewed Original ResearchConceptsTerminal dUTP transferase nick end labelingPostnatal retinal developmentCaspase-3Photoreceptor degenerationRod deathMutant miceRetinal developmentInner nuclear layerDouble mutant miceNick end labelingLight microscopic levelRod photoreceptor developmentCell nuclear antigenNeonatal deathRetinal morphometryDysplastic lesionsRetinal dysplasiaNuclear layerPhotoreceptor protectionImmunohistochemical stainingRodent modelsFactor VIICaspase-3 activationNuclear antigenEnd labelingProliferation of Microglia, but not Photoreceptors, in the Outer Nuclear Layer of the rd-1 Mouse
Zeiss CJ, Johnson EA. Proliferation of Microglia, but not Photoreceptors, in the Outer Nuclear Layer of the rd-1 Mouse. Investigative Ophthalmology & Visual Science 2004, 45: 971-976. PMID: 14985319, DOI: 10.1167/iovs.03-0301.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBiomarkersCDC2-CDC28 KinasesCell Cycle ProteinsCell DivisionCyclin-Dependent Kinase 2Cyclin-Dependent Kinase 4Cyclin-Dependent KinasesDNA ReplicationImmunohistochemistryIn Situ Nick-End LabelingKi-67 AntigenMiceMice, Inbred C57BLMice, Mutant StrainsMicrogliaPhotoreceptor Cells, VertebrateProliferating Cell Nuclear AntigenProto-Oncogene ProteinsRetinal DegenerationConceptsOuter nuclear layerTerminal dUTP transferase nick end labelingNuclear layerCell cycle progressionMicroglial cellsPhotoreceptor deathCycle progressionProliferation of microgliaNick end labelingCell nuclear antigenControl miceNeurotrophic factorPeripheral gradientInner retinaNeuronal deathCell cycle proteinsPhotoreceptor lossRD-1Ki-67Postnatal dayPreexisting conditionsNeurodegenerative conditionsDouble immunolabelingBromodeoxyuridine uptakePhotoreceptor apoptosis
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