2012
Regional Differences in Gallbladder Cancer Pathogenesis: Insights from a Comparison of Cell Cycle-Regulatory, PI3K, and Pro-Angiogenic Protein Expression
Butte J, Torres J, Veras E, Matsuo K, Gönen M, D’Angelica M, Waugh E, Meneses M, Inayama Y, Fong Y, DeMatteo R, De La Fuente H, Endo I, Klimstra D, Jarnagin W. Regional Differences in Gallbladder Cancer Pathogenesis: Insights from a Comparison of Cell Cycle-Regulatory, PI3K, and Pro-Angiogenic Protein Expression. Annals Of Surgical Oncology 2012, 20: 1470-1481. PMID: 23212762, PMCID: PMC4048130, DOI: 10.1245/s10434-012-2761-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overChileCyclin-Dependent Kinase Inhibitor p21FemaleGallbladder NeoplasmsHumansJapanKaplan-Meier EstimateKi-67 AntigenMaleMiddle AgedMultivariate AnalysisNeoplasm StagingProliferating Cell Nuclear AntigenProto-Oncogene Proteins c-mdm2United StatesVascular Endothelial Growth Factor Receptor-2ConceptsMedian disease-specific survivalCell cycle-regulatoryGallbladder cancerEarly tumorsProtein expressionDisease-specific survival of patientsKi-67 labeling indexIncidence of gallbladder cancerDisease-specific survivalGallbladder cancer pathogenesisSurvival of patientsAbsence of p21MethodsImmunohistochemical expressionCurative intentClinicopathological variablesAngiogenesis-relatedKi-67Labeling indexP27 expressionProtein expression patternsTumorMSKCCMDM2 overexpressionCancer pathogenesisPathogenetic differences
2002
Tissue microarray molecular profiling of early, node-negative adenocarcinoma of the rectum: a comprehensive analysis.
Hoos A, Nissan A, Stojadinovic A, Shia J, Hedvat C, Leung D, Paty P, Klimstra D, Cordon-Cardo C, Wong W. Tissue microarray molecular profiling of early, node-negative adenocarcinoma of the rectum: a comprehensive analysis. Clinical Cancer Research 2002, 8: 3841-9. PMID: 12473598.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overBiomarkers, TumorCell Cycle ProteinsCyclin D1Cyclin-Dependent Kinase Inhibitor p21Cyclin-Dependent Kinase Inhibitor p27CyclinsDisease-Free SurvivalFemaleHumansImmunoenzyme TechniquesKi-67 AntigenMaleMiddle AgedNeoplasm ProteinsNuclear ProteinsProtein Array AnalysisProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2Proto-Oncogene Proteins c-mdm2Rectal NeoplasmsTumor Suppressor Protein p53Tumor Suppressor ProteinsConceptsDisease-specific survivalNode-negative adenocarcinomaTreated by surgeryCell cycle-regulatoryDown-regulation of p27Reduced DFSTumor suppressor genes associated with developmentMolecular profilingFavorable overall prognosisHomogeneous group of patientsDied of diseaseAssociated with recurrenceStages of colorectal cancerTumor-related mortalityDevelopment of metastasesAggressive biological behaviorGroup of patientsEarly-stage adenocarcinomaExpression of p53Cyclin-dependent kinase inhibitorDown-regulationProliferation-related markersCurative intentMetastatic diseasePrimary tumor
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