2021
Intraoperative Consultation
Buza N, Euscher E. Intraoperative Consultation. Practical Anatomic Pathology 2021, 317-343. DOI: 10.1007/978-3-030-68608-6_13.Peer-Reviewed Original ResearchFuture fertilityCommon differential diagnostic considerationsIntraoperative frozen section evaluationIntraoperative consultationExtent of surgeryFrozen section evaluationClinical differential diagnosisPatient's future fertilityPreoperative diagnostic workupDifferential diagnostic considerationsFrozen section laboratoryEndometrial cancerOvarian neoplasmsPelvic massCervical carcinomaDiagnostic workupGynecologic pathologyMalignant entitiesDiagnostic challengeSurgical specimensDiagnostic considerationsDifferential diagnosisPathology evaluationSurgical teamDisease type
2019
Extent of surgery for low-risk thyroid cancer in the elderly: Equipoise in survival but not in short-term outcomes
Zambeli-Ljepović A, Wang F, Dinan MA, Hyslop T, Stang MT, Roman SA, Sosa JA, Scheri RP. Extent of surgery for low-risk thyroid cancer in the elderly: Equipoise in survival but not in short-term outcomes. Surgery 2019, 166: 895-900. PMID: 31288935, PMCID: PMC6802283, DOI: 10.1016/j.surg.2019.05.035.Peer-Reviewed Original ResearchConceptsPapillary thyroid cancerLow-risk papillary thyroid cancerEmergency department visitsShort-term outcomesTotal thyroidectomyThyroid cancerFemale patientsBlack patientsEnd Results-Medicare databaseMore emergency department visitsLow-risk thyroid cancerExtent of thyroidectomyExtent of surgeryMultivariable logistic regressionUnderwent lobectomyUnplanned readmissionOlder patientsAvoidable complicationsMean ageMorbidity increasesThyroidectomyPatientsReadmissionComplicationsLobectomyLow-Risk Thyroid Cancer in Elderly: Total Thyroidectomy/RAI Predominates but Lacks Survival Advantage
Zambeli-Ljepović A, Wang F, Dinan MA, Hyslop T, Roman SA, Sosa J, Scheri RP. Low-Risk Thyroid Cancer in Elderly: Total Thyroidectomy/RAI Predominates but Lacks Survival Advantage. Journal Of Surgical Research 2019, 243: 189-197. PMID: 31185435, PMCID: PMC6773493, DOI: 10.1016/j.jss.2019.05.029.Peer-Reviewed Original ResearchConceptsDisease-specific survivalPapillary thyroid cancerExtent of surgeryTotal thyroidectomyTumor sizeThyroid cancerLow-risk papillary thyroid cancerEnd Results-Medicare databaseLow-risk thyroid cancerOlder adultsNational treatment patternsRadioactive iodine administrationUnderwent total thyroidectomyLarger tumor sizeMultivariable logistic regressionQuality of lifeMost older adultsPostoperative RAIRAI administrationCompletion thyroidectomyExcellent prognosisOlder patientsExtensive surgeryFavorable prognosisMedian ageFrozen Section Diagnosis of Ovarian Epithelial Tumors: Diagnostic Pearls and Pitfalls
Buza N. Frozen Section Diagnosis of Ovarian Epithelial Tumors: Diagnostic Pearls and Pitfalls. Archives Of Pathology & Laboratory Medicine 2019, 143: 47-64. PMID: 30785337, DOI: 10.5858/arpa.2018-0289-ra.Peer-Reviewed Original ResearchConceptsFrozen section evaluationOvarian epithelial tumorsIntraoperative frozen section evaluationFrozen section diagnosisEpithelial tumorsOvarian tumorsSection evaluationSection diagnosisClear cell ovarian tumorsExtensive staging proceduresExtent of surgeryCareful gross examinationPreoperative diagnostic workupCommon clinical scenariosAccurate frozen section diagnosisSignificant diagnostic challengePotential diagnostic pitfallFrozen section laboratorySurgical stagingStaging procedureYounger patientsBorderline tumorsSerum markersOvarian massesDiagnostic challenge
2015
American Association of Clinical Endocrinologists and American College of Endocrinology Disease State Clinical Review: The Increasing Incidence of Thyroid Cancer
Davies L, Morris LG, Haymart M, Chen AY, Goldenberg D, Morris J, Ogilvie JB, Terris DJ, Netterville J, Wong RJ, Randolph G. American Association of Clinical Endocrinologists and American College of Endocrinology Disease State Clinical Review: The Increasing Incidence of Thyroid Cancer. Endocrine Practice 2015, 21: 686-696. PMID: 26135963, PMCID: PMC4923940, DOI: 10.4158/ep14466.dscr.Peer-Reviewed Original ResearchConceptsThyroid cancerEndocrinology Disease State Clinical ReviewAsymptomatic thyroid cancersEnd Results systemExtent of surgeryLarge size tumorsAutoimmune thyroid diseaseThyroid cancer incidenceHealth care system accessEnglish-language articlesClinical EndocrinologistsClinical reviewCurrent epidemiologyFrequent biopsiesIncidental detectionIodine excessThyroid diseaseCancer incidenceDietary nitrateIncreasing incidenceSmall tumorsNonlethal diseaseAmerican CollegeClinical actionsAdditional cases
2014
Extent of Surgery for Papillary Thyroid Cancer Is Not Associated With Survival
Adam MA, Pura J, Gu L, Dinan MA, Tyler DS, Reed SD, Scheri R, Roman SA, Sosa JA. Extent of Surgery for Papillary Thyroid Cancer Is Not Associated With Survival. Annals Of Surgery 2014, 260: 601-607. PMID: 25203876, PMCID: PMC4532384, DOI: 10.1097/sla.0000000000000925.Peer-Reviewed Original ResearchConceptsPapillary thyroid cancerExtent of surgeryTotal thyroidectomyOverall survivalTumor sizeDistant metastasisThyroid cancerSurvival advantagePTC tumorsRadioactive iodine treatmentLarge contemporary cohortOverall survival advantageUnderwent total thyroidectomyProportional hazards modelPresence of nodalMultivariable adjustmentAdult patientsClinical factorsContemporary cohortMultifocal diseaseAbsolute indicationMale sexTumors 1.0Black racePTC patientsImpact of Extent of Surgery on Survival in Patients with Small Nonfunctional Pancreatic Neuroendocrine Tumors in the United States
Gratian L, Pura J, Dinan M, Roman S, Reed S, Sosa JA. Impact of Extent of Surgery on Survival in Patients with Small Nonfunctional Pancreatic Neuroendocrine Tumors in the United States. Annals Of Surgical Oncology 2014, 21: 3515-3521. PMID: 24841347, PMCID: PMC4510956, DOI: 10.1245/s10434-014-3769-4.Peer-Reviewed Original ResearchConceptsNonfunctional pancreatic neuroendocrine tumorsPancreatic neuroendocrine tumorsExtent of surgerySmall Nonfunctional Pancreatic Neuroendocrine TumorsFive-year OSOverall survivalMalignant potentialNeuroendocrine tumorsNational Cancer Data BaseLymph node dissectionLymph node resectionKaplan-Meier analysisType of surgeryLog-rank testUncertain malignant potentialImpact of extentNode dissectionNode resectionTotal pancreatectomyPatient characteristicsRegional lymphRegional lymphadenectomySurgical resectionImproved survivalDistant metastasis
2013
Size discrepancy between sonographic and pathological evaluation of solitary papillary thyroid carcinoma
Bachar G, Buda I, Cohen M, Hadar T, Hilly O, Schwartz N, Shpitzer T, Segal K. Size discrepancy between sonographic and pathological evaluation of solitary papillary thyroid carcinoma. European Journal Of Radiology 2013, 82: 1899-1903. PMID: 23948454, DOI: 10.1016/j.ejrad.2013.07.002.Peer-Reviewed Original ResearchConceptsPapillary thyroid carcinomaThyroid carcinomaThyroid nodulesSonographic sizesLarge thyroid tumorsSolitary papillary thyroid carcinomaExtent of surgeryRabin Medical CenterTreatment of patientsSuspicious thyroid lesionsActual tumor sizePotential clinical implicationsHistological diameterPathological diameterPreoperative SonographicFinal pathologyPathological evaluationThyroid surgeryTumor sizeUltrasound findingsNeedle biopsyHistological examinationMedical CenterPapillary carcinomaStudy populationThyroid Surgery in the Elderly
Schwartz N, Shpitzer T, Feinmesser R, Robenshtok E, Bachar G. Thyroid Surgery in the Elderly. Gerontology 2013, 59: 401-407. PMID: 23988591, DOI: 10.1159/000351197.Peer-Reviewed Original ResearchConceptsOlder patientsThyroid diseaseIndividual risk-benefit analysisOlder groupPrevalence of comorbiditiesRetrospective cohort studyExtent of surgeryTertiary medical centerAdvanced disease stageBetween-group differencesRisk-benefit analysisBasis of ageMore comorbiditiesAdvanced diseasePostoperative complicationsTotal thyroidectomyCohort studyElderly patientsYounger patientsMedical chartsDistant metastasisHistologic subtypeSurgical managementOperative managementRecurrence rate
2012
The Surgical Treatment of Breast Cancer in the Elderly: A Single Institution Comparative Review of 5235 Patients with 1028 Patients ≥70 years
Kaur P, Santillan A, McGuire K, Turaga K, Shamehdi C, Meade T, Ramos D, Mathias M, Parbhoo J, Davis M, Khakpour N, King J, Balducci L, Cox C. The Surgical Treatment of Breast Cancer in the Elderly: A Single Institution Comparative Review of 5235 Patients with 1028 Patients ≥70 years. The Breast Journal 2012, 18: 428-435. PMID: 22957995, DOI: 10.1111/j.1524-4741.2012.01272.x.Peer-Reviewed Original ResearchConceptsBreast-conserving surgeryDuctal carcinoma in situSurgical management of breast cancerManagement of breast cancerYears of ageBreast cancerInvasive carcinomaSurgical managementElderly womenSurgical treatment of breast cancerBreast-conserving surgery rateTreatment of breast cancerExtent of surgeryCarcinoma in situStandard surgical procedureMoffitt Cancer CenterBreast cancer treatmentDemographics of patientsConservative surgeryMastectomy ratesOperative mortalityRetrospective reviewSurgical mortalitySurgical treatmentStandard treatment
2006
The Interactions of Polarographic Measurements of Oxygen Tension and Histological Grade in Human Glioma
Lally BE, Rockwell S, Fischer DB, Collingridge DR, Piepmeier JM, Knisely JP. The Interactions of Polarographic Measurements of Oxygen Tension and Histological Grade in Human Glioma. The Cancer Journal 2006, 12: 461-466. PMID: 17207315, DOI: 10.1097/00130404-200611000-00005.Peer-Reviewed Original ResearchConceptsHistological gradeHigh-grade gliomasLow-grade gliomasTumor oxygen tensionUnivariate analysisOxygen tensionGrade gliomasSignificant independent prognostic indicatorExtent of surgeryType of anesthesiaIndependent prognostic indicatorEppendorf pO2 histographTissue oxygen tensionNormal brain tissueImplications of hypoxiaOverall survivalProspective trialPatient ageEntire cohortPrognostic indicatorPatient genderPoor survivalMedian pO2PatientsPO2 histographImpact of Preoperative Versus Postoperative Chemotherapy on the Extent and Number of Surgical Procedures in Patients Treated in Randomized Clinical Trials for Breast Cancer
Boughey JC, Peintinger F, Meric-Bernstam F, Perry AC, Hunt KK, Babiera GV, Singletary SE, Bedrosian I, Lucci A, Buzdar AU, Pusztai L, Kuerer HM. Impact of Preoperative Versus Postoperative Chemotherapy on the Extent and Number of Surgical Procedures in Patients Treated in Randomized Clinical Trials for Breast Cancer. Annals Of Surgery 2006, 124: 130-136. PMID: 16926572, PMCID: PMC1856540, DOI: 10.1097/01.sla.0000234897.38950.5c.Peer-Reviewed Original ResearchConceptsBreast-Conserving TherapyRe-excision ratesExtent of surgeryPreoperative chemotherapyInitial tumor sizeRandomized clinical trialsBreast operationsBreast cancerSurgical proceduresBCT patientsPostoperative chemotherapyBreast tissueTumor sizeClinical trialsRates of BCTProspective randomized clinical trialsFinal surgical procedureLarge breast tumorsConsecutive patientsExtensive resectionChemotherapyPatientsVolume of tissueBreast tumorsT1-T3
1996
Variations in the natural history and survival of patients with supratentorial low-grade astrocytomas.
Piepmeier J, Susan Christopher R, Spencer D, Byrne T, Kim J, Knisel J, Lacy J, Tsukerman L, Makuch R. Variations in the natural history and survival of patients with supratentorial low-grade astrocytomas. Neurosurgery 1996, 38: 872-8; discussion 878-9. PMID: 8727811, DOI: 10.1097/00006123-199605000-00002.Peer-Reviewed Original ResearchConceptsLow-grade astrocytomasGross total resectionChronic epilepsySupratentorial low-grade astrocytomasNatural historyGross total tumor resectionImmediate postoperative radiotherapyExtent of surgerySurvival of patientsTen-year survivalPopulation of patientsUse of radiotherapyRisk of recurrenceHigh-grade lesionsLength of survivalMore malignant tumorsTypes of symptomsAggressive surgeryPostoperative radiotherapyPreoperative symptomsConsecutive patientsBetter prognosisTumor recurrenceTumor resectionMalignant tumors
1993
Malignant peripheral nerve sheath tumors. A clinicopathologic study of 28 cases
Wanebo J, Malik J, Vandenberg S, Wanebo H, Driesen N, Persing J. Malignant peripheral nerve sheath tumors. A clinicopathologic study of 28 cases. Cancer 1993, 71: 1247-1253. PMID: 8435801, DOI: 10.1002/1097-0142(19930215)71:4<1247::aid-cncr2820710413>3.0.co;2-s.Peer-Reviewed Original ResearchConceptsMalignant peripheral nerve sheath tumorDisease-free survivalSurgical marginsTumor sizeTumor locationSurvival timeMedian disease-free survival timeBetter disease-free survivalMedian overall survival timePeripheral nerve sheath tumorsDisease-free survival timeVirginia Health Sciences CenterAdjuvant radiation therapyExtent of surgeryWide surgical marginsNerve sheath tumorsOverall survival timeQuality of marginsNeurofibromatosis type 1Type of treatmentHealth Sciences CenterAggressive surgeryClinicopathologic studyOverall survivalPatient age
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