2017
Breast conservation after neoadjuvant chemotherapy for triple-negative breast cancer: Surgical results from an international randomized trial (BrighTNess).
Golshan M, Loibl S, Huober J, O'Shaughnessy J, Rugo H, Wolmark N, McKee M, Maag D, Sullivan D, Giranda V, Liu X, Von Minckwitz G, Geyer C, Sikov W, Untch M. Breast conservation after neoadjuvant chemotherapy for triple-negative breast cancer: Surgical results from an international randomized trial (BrighTNess). Journal Of Clinical Oncology 2017, 35: 514-514. DOI: 10.1200/jco.2017.35.15_suppl.514.Peer-Reviewed Original ResearchTriple-negative breast cancerNeoadjuvant systemic therapyBreast-Conserving TherapyBCT ratesBreast cancerSurgical assessmentOperable triple-negative breast cancerGermline BRCA mutation statusHigher mastectomy ratesInternational randomized trialsLarge prospective analysisBRCA mutation statusBCT eligibilityMastectomy ratesNeoadjuvant chemotherapySystemic therapyBreast conservationRandomized trialsSurgical managementSurgical resultsSurgical choicePatient's discretionProspective analysisMutation statusStage II
2015
Growing Use of Mastectomy for Ductal Carcinoma-In Situ of the Breast Among Young Women in the United States
Rutter CE, Park HS, Killelea BK, Evans SB. Growing Use of Mastectomy for Ductal Carcinoma-In Situ of the Breast Among Young Women in the United States. Annals Of Surgical Oncology 2015, 22: 2378-2386. PMID: 25564175, DOI: 10.1245/s10434-014-4334-x.Peer-Reviewed Original ResearchConceptsContralateral prophylactic mastectomyUse of mastectomyYounger patientsHigh-risk histopathologic featuresNational Cancer Data BaseGreater medical comorbidityRate of mastectomyYounger patient ageBreast conservation therapyMultivariable logistic regressionHigh tumor gradeProportion of womenBackgroundDuctal carcinomaPreinvasive formExtensive diseaseMastectomy ratesMedical comorbiditiesPatient ageConservation therapyDuctal carcinomaHistopathologic featuresExcellent outcomesProphylactic mastectomySurgical choiceTumor grade
2012
The Surgical Treatment of Breast Cancer in the Elderly: A Single Institution Comparative Review of 5235 Patients with 1028 Patients ≥70 years
Kaur P, Santillan A, McGuire K, Turaga K, Shamehdi C, Meade T, Ramos D, Mathias M, Parbhoo J, Davis M, Khakpour N, King J, Balducci L, Cox C. The Surgical Treatment of Breast Cancer in the Elderly: A Single Institution Comparative Review of 5235 Patients with 1028 Patients ≥70 years. The Breast Journal 2012, 18: 428-435. PMID: 22957995, DOI: 10.1111/j.1524-4741.2012.01272.x.Peer-Reviewed Original ResearchConceptsBreast-conserving surgeryDuctal carcinoma in situSurgical management of breast cancerManagement of breast cancerYears of ageBreast cancerInvasive carcinomaSurgical managementElderly womenSurgical treatment of breast cancerBreast-conserving surgery rateTreatment of breast cancerExtent of surgeryCarcinoma in situStandard surgical procedureMoffitt Cancer CenterBreast cancer treatmentDemographics of patientsConservative surgeryMastectomy ratesOperative mortalityRetrospective reviewSurgical mortalitySurgical treatmentStandard treatmentSurvival Implications Associated with Variation in Mastectomy Rates for Early‐Staged Breast Cancer
Brooks JM, Chrischilles EA, Landrum MB, Wright KB, Fang G, Winer EP, Keating NL. Survival Implications Associated with Variation in Mastectomy Rates for Early‐Staged Breast Cancer. International Journal Of Surgical Oncology 2012, 2012: 127854. PMID: 22928097, PMCID: PMC3423912, DOI: 10.1155/2012/127854.Peer-Reviewed Original ResearchEarly-stage breast cancerMastectomy ratesESBC patientsRCT populationBreast cancerSurvival implicationsHealth Consensus Development ConferenceHigher mastectomy ratesConsensus Development ConferenceSurgery choicePatientsMastectomyDevelopment ConferenceNIH guidelinesNational InstituteRecent evidenceRCTsCancerBreastSurvivalPatient alignmentGuidelinesSurgeryPopulation
2011
P2-15-01: Surgical Patterns of Care after Magnetic Resonance Imaging in the Academic Setting in Patients with Operable Breast Cancer Treated with Neoadjuvant Systemic Therapy: A Secondary Analysis of TBCRC 017.
De L, Cantor A, Mcguire K, Golshan M, Meric-Bernstam F, Horton J, Nanda R, Amos K, Forero A, Hudis C, Meszoely I, Hwang S. P2-15-01: Surgical Patterns of Care after Magnetic Resonance Imaging in the Academic Setting in Patients with Operable Breast Cancer Treated with Neoadjuvant Systemic Therapy: A Secondary Analysis of TBCRC 017. Cancer Research 2011, 71: p2-15-01-p2-15-01. DOI: 10.1158/0008-5472.sabcs11-p2-15-01.Peer-Reviewed Original ResearchNeoadjuvant systemic therapyT stageMastectomy ratesBreast conservationMRI responseJonckheere-Terpstra testChemotherapy regimenSystemic therapyCancer CenterSurgical patternsSecondary analysisBreast MRIHigher mastectomy ratesPotential response biomarkersT1-T2 patientsUse of mastectomyOperable breast cancerLarger tumor sizeHigher T stageComprehensive cancer centerLogistic regression analysisMagnetic resonance imagingNeoadjuvant chemotherapyNeoadjuvant therapyPreoperative chemotherapy
2008
Trends in Racial and Age Disparities in Definitive Local Therapy of Early-Stage Breast Cancer
Freedman RA, He Y, Winer EP, Keating NL. Trends in Racial and Age Disparities in Definitive Local Therapy of Early-Stage Breast Cancer. Journal Of Clinical Oncology 2008, 27: 713-719. PMID: 19103731, DOI: 10.1200/jco.2008.17.9234.Peer-Reviewed Original ResearchConceptsDefinitive local therapyBreast-conserving surgeryEarly-stage breast cancerLocal therapyBreast cancerHispanic womenStage I/II breast cancerEnd Results registry dataAsian womenReceipt of radiationMultivariate logistic regressionBreast cancer therapyRace/ethnicityMastectomy ratesTherapy ratesBreast conservationAdjusted analysisRegistry dataWomen 61Stage ITherapyAdult womenLogistic regressionCancerStudy period
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