2025
Patients with status epilepticus and new‐onset refractory status epilepticus display drastically altered fecal microbiomes compared to chronic epilepsy patients
Steriade C, Thomas S, Xu F, Ahituv A, Hanin A, Pleshkevich M, Hwang S, Ramirez A, Foreman B, Yoo J, Eka O, Kellogg M, Oliger A, Wainwright M, Morales M, Gaspard N, Hirsch L, Devinsky O, Saxena D. Patients with status epilepticus and new‐onset refractory status epilepticus display drastically altered fecal microbiomes compared to chronic epilepsy patients. Epilepsia 2025 PMID: 40387216, DOI: 10.1111/epi.18450.Peer-Reviewed Original ResearchChronic epilepsy patientsSE patientsStatus epilepticusEpilepsy patientsChronic epilepsyPre-existing epilepsyFuture treatment strategiesDisease time pointsInflammatory cytokine levelsFecal microbiomeMicrobiome structureLongitudinal cohort studyMicrobiome featuresCytokine levelsEffective therapyCohort studyTreatment strategiesInflammatory cytokinesSE resolutionInflammatory responseCritical illnessPatientsGut dysbiosisMortality rateClinical treatmentDisease modification upon 2 weeks of tofacitinib treatment in a mouse model of chronic epilepsy
Hoffman O, Koehler J, Espina J, Patterson A, Gohar E, Coleman E, Schoenike B, Espinosa-Garcia C, Paredes F, Varvel N, Dingledine R, Maguire J, Roopra A. Disease modification upon 2 weeks of tofacitinib treatment in a mouse model of chronic epilepsy. Science Translational Medicine 2025, 17: eadt0527. PMID: 40106581, DOI: 10.1126/scitranslmed.adt0527.Peer-Reviewed Original ResearchConceptsTranscriptome dataJanus kinase/signal transducer and activatorKinase/signal transducer and activatorReverse cognitive deficitsJAK/STAT activationJAK/STAT3 signalingChronic epilepsyModel of temporal lobe epilepsySpontaneous seizuresMouse models of chronic epilepsyMouse modelCognitive deficitsSpatial memoryTransient inductionTemporal lobe epilepsyMouse model of temporal lobe epilepsyModel of chronic epilepsyLobectomy samplesDisease modificationTreat symptomsLobe epilepsyWhole tissueDrug treatmentEpileptogenic insultTofacitinib treatment
2024
A selective small-molecule agonist of G protein-gated inwardly-rectifying potassium channels reduces epileptiform activity in mouse models of tumor-associated and provoked seizures
Rifkin R, Wu X, Pereira B, Gill B, Merricks E, Michalak A, Goldberg A, Humala N, Dovas A, Rai G, McKhann G, Slesinger P, Canoll P, Schevon C. A selective small-molecule agonist of G protein-gated inwardly-rectifying potassium channels reduces epileptiform activity in mouse models of tumor-associated and provoked seizures. Neuropharmacology 2024, 265: 110259. PMID: 39662702, PMCID: PMC11726401, DOI: 10.1016/j.neuropharm.2024.110259.Peer-Reviewed Original ResearchConceptsMouse modelInwardly-rectifying potassium channelRegulation of neuronal excitabilityMouse models of tumorsSeizure-like activityGIRK channelsNeuronal excitabilityModels of tumorsPeritumoral regionEpileptiform activityTumor-associatedTumor progressionAntiseizure medicationsPotassium channelsChronic epilepsyFocal seizuresAnimal modelsTumorBrain tumorsGIRKInadequate treatmentGlioma cellsMiceSeizuresChemoconvulsant modelsCongenital, Non-lesional Lennox-Gastaut Syndrome
Herlopian A. Congenital, Non-lesional Lennox-Gastaut Syndrome. 2024, 889-906. DOI: 10.1007/978-3-031-23828-4_35.Peer-Reviewed Original ResearchLennox-Gastaut syndromeVagus nerve stimulationNerve stimulationTreatment of Lennox-Gastaut syndromeTolerability of vagus nerve stimulationCerebellar volume lossPalliative therapyElectroclinical characteristicsSurgical interventionTonic seizuresChronic epilepsyDeep brain stimulationCentromedian nucleusStimulationBrain stimulationVolume loss
2013
Anti-epileptogenesis: Electrophysiology, diffusion tensor imaging and behavior in a genetic absence model
van Luijtelaar G, Mishra AM, Edelbroek P, Coman D, Frankenmolen N, Schaapsmeerders P, Covolato G, Danielson N, Niermann H, Janeczko K, Kiemeneij A, Burinov J, Bashyal C, Coquillette M, Lüttjohann A, Hyder F, Blumenfeld H, van Rijn CM. Anti-epileptogenesis: Electrophysiology, diffusion tensor imaging and behavior in a genetic absence model. Neurobiology Of Disease 2013, 60: 126-138. PMID: 23978468, PMCID: PMC3952020, DOI: 10.1016/j.nbd.2013.08.013.Peer-Reviewed Original ResearchConceptsDays post treatmentWAG/Rij ratsCritical treatment periodDuration of ADDepressive-like behaviorDepressive-like symptomsEarly pharmacological treatmentPost treatmentTreatment of patientsWhite matter changesGenetic absence modelCortical network activityDiffusion tensor imagingChronic epilepsySymptom onsetInternal capsulaCortical excitabilityPharmacological treatmentDecreased immobilitySwim testControl ratsTreatment periodCorpus callosumMatter changesPotential amplitude
2012
In vivo MRS and histochemistry of status epilepticus‐induced hippocampal pathology in a juvenile model of temporal lobe epilepsy
van der Hel W, van Eijsden P, Bos IW, de Graaf R, Behar KL, van Nieuwenhuizen O, de Graan P, Braun KP. In vivo MRS and histochemistry of status epilepticus‐induced hippocampal pathology in a juvenile model of temporal lobe epilepsy. NMR In Biomedicine 2012, 26: 132-140. PMID: 22806932, DOI: 10.1002/nbm.2828.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyStatus epilepticusSynthase immunoreactivityNeuronal lossHippocampal pathologyLobe epilepsyDevelopment of TLECholine-containing compound concentrationsChildhood status epilepticusPre-epileptic stateSpontaneous recurrent seizuresVivo MRSJuvenile rat modelHippocampal injuryChronic epilepsyRecurrent seizuresSpontaneous seizuresNeurotransmitter imbalanceParvalbumin immunoreactivityVivo immunohistochemistryInhibitory neurotransmissionΓ-aminobutyric acidEpileptogenic processMRS findingsNeuronal death
1998
Surgical outcome in occipital lobe epilepsy: Implications for pathophysiology
Aykut‐Bingol C, Bronen R, Kim J, Spencer D, Spencer S. Surgical outcome in occipital lobe epilepsy: Implications for pathophysiology. Annals Of Neurology 1998, 44: 60-69. PMID: 9667593, DOI: 10.1002/ana.410440112.Peer-Reviewed Original ResearchConceptsOccipital lobe epilepsyClinical seizure characteristicsFocal cortical dysplasiaLobe epilepsyLobe locationPathological substrateSeizure characteristicsSurgical outcomesCortical dysplasiaSurgical approachSurgical proceduresRefractory occipital lobe epilepsyDevelopmental abnormalitiesOccipital lobe seizuresChronic inflammatory changesSturge-Weber syndromeMain pathological substrateOccipital lobe tumorElectroclinical variablesElectroclinical featuresMost patientsSeizure controlChronic epilepsyInflammatory changesLobe tumors
1997
Low-grade gliomas of chronic epilepsy: A distinct clinical and pathological entity
Bartolomei J, Christopher S, Vives K, Spencer D, Piepmeier J. Low-grade gliomas of chronic epilepsy: A distinct clinical and pathological entity. Journal Of Neuro-Oncology 1997, 34: 79-84. PMID: 9210054, DOI: 10.1023/a:1005711321343.Peer-Reviewed Original ResearchConceptsLow-grade gliomasChronic epilepsyDysembryoplastic neuroepithelial tumorPathological entityLong-term patient outcomesSpecific pathological entityManagement of patientsResults of patientsDistinct pathological entityLack of mortalityPreoperative seizuresNeuroepithelial tumorsTumor recurrencePatient outcomesAnaplastic transformationEpilepsySame tumorGliomasCortical locationTumorsPatientsRecurrenceSeizuresPopulationMortality
1996
Variations in the natural history and survival of patients with supratentorial low-grade astrocytomas.
Piepmeier J, Susan Christopher R, Spencer D, Byrne T, Kim J, Knisel J, Lacy J, Tsukerman L, Makuch R. Variations in the natural history and survival of patients with supratentorial low-grade astrocytomas. Neurosurgery 1996, 38: 872-8; discussion 878-9. PMID: 8727811, DOI: 10.1097/00006123-199605000-00002.Peer-Reviewed Original ResearchConceptsLow-grade astrocytomasGross total resectionChronic epilepsySupratentorial low-grade astrocytomasNatural historyGross total tumor resectionImmediate postoperative radiotherapyExtent of surgerySurvival of patientsTen-year survivalPopulation of patientsUse of radiotherapyRisk of recurrenceHigh-grade lesionsLength of survivalMore malignant tumorsTypes of symptomsAggressive surgeryPostoperative radiotherapyPreoperative symptomsConsecutive patientsBetter prognosisTumor recurrenceTumor resectionMalignant tumors
1981
Paroxysmal, rhythmic lingual movements and chronic epilepsy.
Jabbari B, Coker S. Paroxysmal, rhythmic lingual movements and chronic epilepsy. Neurology 1981, 31: 1364-7. PMID: 7202144, DOI: 10.1212/wnl.31.10.1364.Peer-Reviewed Original Research
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