2024
Folate metabolism and risk of childhood acute lymphoblastic leukemia: a genetic pathway analysis from the Childhood Cancer and Leukemia International Consortium
Metayer C, Spector L, Scheurer M, Jeon S, Scott R, Takagi M, Clavel J, Manabe A, Ma X, Hailu E, Lupo P, Urayama K, Bonaventure A, Kato M, Meirhaeghe A, Chiang C, Morimoto L, Wiemels J. Folate metabolism and risk of childhood acute lymphoblastic leukemia: a genetic pathway analysis from the Childhood Cancer and Leukemia International Consortium. Cancer Epidemiology Biomarkers & Prevention 2024, 33: 1248-1252. PMID: 38904462, PMCID: PMC11369612, DOI: 10.1158/1055-9965.epi-24-0189.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsGenome-wide dataAncestry groupsFolate metabolic pathwayGenetic variantsChildhood cancerMetabolic pathwaysGenetic pathway analysisRisk of childhood ALLRisk of childhood acute lymphoblastic leukemiaGene-folate interactionsChildhood ALL riskCase-control studyDNA methylationMETAL softwareGenetic studiesNucleotide polymorphismsPathway analysisMeta-analysis of original dataALL riskGenetic effectsAncestryFolate pathwayMaternal genetic effectsFolate intakeThe protective effect of dietary folate intake on gastric cancer is modified by alcohol consumption: A pooled analysis of the StoP Consortium
Gonzalez‐Palacios S, Compañ‐Gabucio L, Torres‐Collado L, Oncina‐Canovas A, García‐de‐la‐Hera M, Collatuzzo G, Negri E, Pelucchi C, Rota M, López‐Carrillo L, Lunet N, Morais S, Ward M, Martin V, Lozano‐Lorca M, Malekzadeh R, Pakseresht M, Hernández‐Ramírez R, Bonzi R, Patel L, López‐Cervantes M, Rabkin C, Tsugane S, Hidaka A, Trichopoulou A, Karakatsani A, Camargo M, Curado M, Zhang Z, La Vecchia C, Boffetta P, Vioque J. The protective effect of dietary folate intake on gastric cancer is modified by alcohol consumption: A pooled analysis of the StoP Consortium. International Journal Of Cancer 2024, 155: 1367-1375. PMID: 38757245, PMCID: PMC11326987, DOI: 10.1002/ijc.35004.Peer-Reviewed Original ResearchDietary folate intakeHigh folate intakeFolate intakeRisk of GCOdds ratioGastric cancerAlcoholic drinks/dayAlcohol consumptionEffect of dietary folate intakeEffect of folate intakeQuartile of folate intakeFood frequency questionnaireCalculate adjusted odds ratiosCase-control studyConfidence intervalsAdjusted odds ratiosFrequency questionnaireGC casesGC riskPooled analysisQuartile incrementLowest quartileLow riskLinear mixed modelsModifiable factors
2023
Folate Intake and Ovarian Cancer Risk among Women with Endometriosis: A Case–Control Study from the Ovarian Cancer Association Consortium
Gersekowski K, Ibiebele T, Group F, Doherty J, Harris H, Goodman M, Terry K, Wu A, Bandera E, Qin B, Ong J, Tyrer J, Dixon-Suen S, Modugno F, Risch H, Webb P. Folate Intake and Ovarian Cancer Risk among Women with Endometriosis: A Case–Control Study from the Ovarian Cancer Association Consortium. Cancer Epidemiology Biomarkers & Prevention 2023, 32: of1-of10. PMID: 37220873, PMCID: PMC10390886, DOI: 10.1158/1055-9965.epi-23-0121.Peer-Reviewed Original ResearchConceptsOvarian cancer riskHigh dietary folate intakeDietary folate intakeCase-control studyFolate intakeOvarian cancerOvarian Cancer Association ConsortiumCancer riskOdds ratioMendelian randomizationSelf-reported endometriosisSupplemental folate intakeHigh folate intakeHigh folate dietCancer-promoting effectsPooled analysisFolate dietPrecancerous lesionsFolate statusEndometriosisIncrease riskCancerCancer typesLogistic regressionIntake
2018
The effect of risk factor misclassification on the partial population attributable risk
Wong BHW, Peskoe SB, Spiegelman D. The effect of risk factor misclassification on the partial population attributable risk. Statistics In Medicine 2018, 37: 1259-1275. PMID: 29333614, PMCID: PMC6003717, DOI: 10.1002/sim.7559.Peer-Reviewed Original ResearchConceptsPartial population attributable riskPopulation attributable riskRisk factorsAttributable riskRelative riskMultivariate-adjusted relative riskRed meatHealth Professionals FollowModifiable risk factorsLow folate intakeExposure of interestBackground risk factorsProfessionals FollowAlcohol intakeColorectal cancerFolate intakePublic health researchMultifactorial diseasePreventive interventionsPopulation-level impactJoint prevalenceHealth researchRiskIntakeExposure
2015
Folic acid supplementation in early pregnancy and the risk of preeclampsia, small for gestational age offspring and preterm delivery
Martinussen MP, Bracken MB, Triche EW, Jacobsen GW, Risnes KR. Folic acid supplementation in early pregnancy and the risk of preeclampsia, small for gestational age offspring and preterm delivery. European Journal Of Obstetrics & Gynecology And Reproductive Biology 2015, 195: 94-99. PMID: 26500184, PMCID: PMC4684439, DOI: 10.1016/j.ejogrb.2015.09.022.Peer-Reviewed Original ResearchMeSH KeywordsAdultCohort StudiesFemaleFolic AcidHumansInfant, Low Birth WeightInfant, NewbornInfant, Small for Gestational AgeObesityOdds RatioPre-EclampsiaPregnancyPregnancy ComplicationsPregnancy Trimester, FirstPremature BirthProspective StudiesProtective FactorsRisk FactorsVitamin B ComplexYoung AdultConceptsFolic acid supplementationLow birth weightFolic acid intakePreterm birthAcid supplementationFirst trimesterLean mothersBirth weightAcid intakeEarly pregnancyOdds ratioGestational age offspringProspective cohort studyFolic acid supplementsFolic acid usePregnancy outcome dataRisk of preeclampsiaPossible protective effectMonths of pregnancyObese mothersPreterm deliveryCohort studyObstetric recordsAge offspringFolate intake
2013
Polymorphisms in genes related to one-carbon metabolism are not related to pancreatic cancer in PanScan and PanC4
Leenders M, Bhattacharjee S, Vineis P, Stevens V, Bueno-de-Mesquita HB, Shu XO, Amundadottir L, Gross M, Tobias GS, Wactawski-Wende J, Arslan AA, Duell EJ, Fuchs CS, Gallinger S, Hartge P, Hoover RN, Holly EA, Jacobs EJ, Klein AP, Kooperberg C, LaCroix A, Li D, Mandelson MT, Olson SH, Petersen G, Risch HA, Yu K, Wolpin BM, Zheng W, Agalliu I, Albanes D, Boutron-Ruault MC, Bracci PM, Buring JE, Canzian F, Chang K, Chanock SJ, Cotterchio M, Gaziano JM, Giovanucci EL, Goggins M, Hallmans G, Hankinson SE, Hoffman-Bolton JA, Hunter DJ, Hutchinson A, Jacobs KB, Jenab M, Khaw KT, Kraft P, Krogh V, Kurtz RC, McWilliams RR, Mendelsohn JB, Patel AV, Rabe KG, Riboli E, Tjønneland A, Trichopoulos D, Virtamo J, Visvanathan K, Elena JW, Yu H, Zeleniuch-Jacquotte A, Stolzenberg-Solomon RZ. Polymorphisms in genes related to one-carbon metabolism are not related to pancreatic cancer in PanScan and PanC4. Cancer Causes & Control 2013, 24: 595-602. PMID: 23334854, PMCID: PMC4127987, DOI: 10.1007/s10552-012-0138-0.Peer-Reviewed Original ResearchConceptsCase-control studyOne-carbon metabolismSingle nucleotide polymorphismsPancreatic cancerOne-carbon biomarkersEuropean Prospective InvestigationCorrelation of SNPsProspective InvestigationFolate intakePancreatic carcinogenesisLarge genetic studiesGene polymorphismsSignificant associationPANCACancerMetabolite levelsGermline variationP-valueMultiple comparisonsAssociationSuggestive associationPolymorphismSuggestive evidenceMetabolismOCM pathway
2011
Validity and reproducibility of a food frequency questionnaire to estimate folate intake in a Mexican population.
Galván-Portillo M, Torres-Sánchez L, Hernández-Ramírez RU, Anaya-Loyola MA. Validity and reproducibility of a food frequency questionnaire to estimate folate intake in a Mexican population. Salud Pública De México 2011, 53: 237-46. PMID: 21829889, DOI: 10.1590/s0036-36342011000300008.Peer-Reviewed Original Research
2009
Relationship of dietary micronutrient intake with fasting plasma glucose and HbA1c: DIALBEST Trial Preliminary Results
Chhabra J, Vega‐López S, D'Agostino D, Fernandez M, Segura‐Pérez S, Damio G, Pérez‐Escamilla R. Relationship of dietary micronutrient intake with fasting plasma glucose and HbA1c: DIALBEST Trial Preliminary Results. The FASEB Journal 2009, 23: 550.3-550.3. DOI: 10.1096/fasebj.23.1_supplement.550.3.Peer-Reviewed Original ResearchPlausible reportersImplausible reportersPlasma glucoseEnergy intakeTotal sampleDietary micronutrient intakeType 2 diabetesVit KDietary recallsLatino patientsVit DFolate intakeMicronutrient intakeDietary micronutrientsHealth disparitiesVit B6FPGDemographic informationIntakePatientsDlHartford CountyMcgRetinolGlucose
2006
Alcohol intake and ovarian cancer risk: a pooled analysis of 10 cohort studies
Genkinger JM, Hunter DJ, Spiegelman D, Anderson KE, Buring JE, Freudenheim JL, Goldbohm RA, Harnack L, Hankinson SE, Larsson SC, Leitzmann M, McCullough ML, Marshall J, Miller AB, Rodriguez C, Rohan TE, Schatzkin A, Schouten LJ, Wolk A, Zhang SM, Smith-Warner SA. Alcohol intake and ovarian cancer risk: a pooled analysis of 10 cohort studies. British Journal Of Cancer 2006, 94: 757-762. PMID: 16495916, PMCID: PMC2361197, DOI: 10.1038/sj.bjc.6603020.Peer-Reviewed Original ResearchConceptsOvarian cancer riskCohort studyCancer riskPooled analysisAlcohol intakeRelative riskStudy-specific relative risksCox proportional hazards modelDepletion of folateModerate alcohol intakeOral contraceptive useProspective cohort studyHormone replacement therapyBody mass indexConfidence intervalsLevels of estrogenSerous ovarian cancerProportional hazards modelRandom-effects modelOvarian casesMenopausal statusMass indexReplacement therapyFolate intakeOvarian cancer
2005
Molecular biomarkers for the study of childhood leukemia
Smith MT, McHale CM, Wiemels JL, Zhang L, Wiencke JK, Zheng S, Gunn L, Skibola CF, Ma X, Buffler PA. Molecular biomarkers for the study of childhood leukemia. Toxicology And Applied Pharmacology 2005, 206: 237-245. PMID: 15967214, DOI: 10.1016/j.taap.2004.11.026.Peer-Reviewed Original ResearchConceptsAcute myeloid leukemiaAcute lymphocytic leukemiaChildhood leukemiaLeukemia riskChildhood acute lymphocytic leukemiaC609T polymorphismLow folate intakeNeonatal blood spotsYears of lifeMethylenetetrahydrofolate reductase (MTHFR) geneDifferent cytogenetic subgroupsPerinatal exposureFolate intakeMyeloid leukemiaLymphocytic leukemiaT polymorphismUseful biomarkerInfectious agentsAberrant gene methylationLeukemiaCytogenetic subgroupsBlood spotsMolecular biomarkersIndoor pesticidesGene methylation
2003
Joint Association of Alcohol and Folate Intake with Risk of Major Chronic Disease in Women
Jiang R, Hu FB, Giovannucci EL, Rimm EB, Stampfer MJ, Spiegelman D, Rosner BA, Willett WC. Joint Association of Alcohol and Folate Intake with Risk of Major Chronic Disease in Women. American Journal Of Epidemiology 2003, 158: 760-771. PMID: 14561666, DOI: 10.1093/aje/kwg221.Peer-Reviewed Original ResearchConceptsMajor chronic diseasesFolate intakeChronic diseasesCardiovascular diseaseLower total folate intakeJoint associationsMultivariate relative riskNonfatal cardiovascular diseaseTotal folate intakeHigh folate intakeAdequate folate intakeAge 60 yearsLow folate intakePrimary preventionNontraumatic deathsRelative riskHigh riskPrevious historyDietary dataHeavy drinkersNew casesYoung womenDiseaseHeavy drinkingIntakeThe Use of B Vitamin Supplements and Peripheral Arterial Disease Risk in Men Are Inversely Related
Merchant AT, Hu FB, Spiegelman D, Willett WC, Rimm EB, Ascherio A. The Use of B Vitamin Supplements and Peripheral Arterial Disease Risk in Men Are Inversely Related. Journal Of Nutrition 2003, 133: 2863-2867. PMID: 12949378, DOI: 10.1093/jn/133.9.2863.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseasePAD riskFolate intakePrevention of PADPeripheral arterial disease riskVitamin BArterial disease riskIncident PAD casesU.S. health professionalsB vitamin intakeVitamin supplement useB-vitamin supplementsCoronary heart diseaseWeak inverse associationMultivariate adjustmentArterial diseaseVitamin intakeSupplement useHeart diseaseInverse associationCardiovascular diseaseD incrementStudy populationVitamin supplementsDietary folate
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