2022
SOCIAL SUPPORT AND STRAIN AS PREDICTORS OF MULTIMORBIDITY FOLLOWING A MARITAL TRANSITION
Denning E, Newsom J, Botoseneanu A, Allore H, Nagel C, Dorr D, Quiñones A. SOCIAL SUPPORT AND STRAIN AS PREDICTORS OF MULTIMORBIDITY FOLLOWING A MARITAL TRANSITION. Innovation In Aging 2022, 6: 567-567. PMCID: PMC9770881, DOI: 10.1093/geroni/igac059.2136.Peer-Reviewed Original ResearchMore chronic conditionsChronic conditionsPredictors of multimorbiditySocial supportAdults age 50Race/ethnicityAge 50Multimorbidity trajectoriesOlder adultsMarital transitionsHealth declineSocial strainStressful eventsRetirement StudyChildrenSpousal supportGrowth curve modelingPiecewise growth curve modelingHealthLtParticipantsMultimorbidityEmergency Department Presentations of Acute Primary Angle Closure in the United States from 2008 to 2017
Mehta SK, Mir T, Freedman IG, Sheth AH, Sarrafpour S, Liu J, Teng CC. Emergency Department Presentations of Acute Primary Angle Closure in the United States from 2008 to 2017. Clinical Ophthalmology 2022, 16: 2341-2351. PMID: 35924186, PMCID: PMC9342660, DOI: 10.2147/opth.s368453.Peer-Reviewed Original ResearchAcute primary angle closureNationwide Emergency Department SamplePrimary angle closureED visitsHighest average incidenceED presentationsAngle closureUnited States emergency departmentsRetrospective cross-sectional studyAverage incidenceStates emergency departmentsICD-9/10 codesEmergency department presentationsEmergency Department SampleHigh-risk groupCross-sectional studyLow socioeconomic statusLowest income quartileClinical characteristicsVisual morbidityMedian ageOphthalmologic emergencyEmergency departmentSeventh decadeAge 50Growth rate of ascending thoracic aortic aneurysms in a non-referral-based population
Weininger G, Mori M, Yousef S, Hur DJ, Assi R, Geirsson A, Vallabhajosyula P. Growth rate of ascending thoracic aortic aneurysms in a non-referral-based population. Journal Of Cardiothoracic Surgery 2022, 17: 14. PMID: 35109884, PMCID: PMC8812194, DOI: 10.1186/s13019-022-01761-6.Peer-Reviewed Original ResearchConceptsAneurysm growth rateAortic dilatationAortic aneurysmStudy populationCT scanInitial aneurysm sizeTrue natural historyPatients age 50High-risk patientsMedian time intervalLarge institutional databaseThoracic aortic aneurysmComputed tomography scanAortic aneurysm diseaseRisk patientsAortic sizeInstitutional databaseTomography scanAneurysm diseaseRadiologic diagnosisAneurysm sizeBackgroundPrior studiesAge 50PatientsNatural history
2021
Age‐Related Trajectories of Cardiovascular Risk and Use of Aspirin and Statin Among U.S. Adults Aged 50 or Older, 2011–2018
Rhee TG, Kumar M, Ross JS, Coll PP. Age‐Related Trajectories of Cardiovascular Risk and Use of Aspirin and Statin Among U.S. Adults Aged 50 or Older, 2011–2018. Journal Of The American Geriatrics Society 2021, 69: 1272-1282. PMID: 33598936, PMCID: PMC9869399, DOI: 10.1111/jgs.17038.Peer-Reviewed Original ResearchConceptsUse of aspirinStatin useAspirin useCardiovascular riskSecondary preventionMedication usePrimary preventionAge-related trajectoriesAge 50Prevention treatmentAngina/angina pectorisLow-dose aspirin dailyLong-term statin useOlder adultsDaily aspirin usePrimary prevention treatmentSecondary prevention treatmentSubsequent CVD eventsFirst cardiovascular eventCoronary heart diseaseAdults Aged 50Nutrition Examination SurveyCross-sectional studyHealth Interview SurveyNon-institutionalized adults
2020
Diet and Risk of Myeloproliferative Neoplasms in Older Individuals from the NIH-AARP Cohort
Podoltsev NA, Wang X, Wang R, Hofmann JN, Liao LM, Zeidan AM, Mesa RA, Ma X. Diet and Risk of Myeloproliferative Neoplasms in Older Individuals from the NIH-AARP Cohort. Cancer Epidemiology Biomarkers & Prevention 2020, 29: 2343-2350. PMID: 32868318, PMCID: PMC8895351, DOI: 10.1158/1055-9965.epi-20-0592.Peer-Reviewed Original ResearchConceptsRisk of MPNPolycythemia veraEssential thrombocythemiaMyeloproliferative neoplasmsHazard ratioSugar intakeDietary factorsMultivariable Cox proportional hazards modelsRisk of PVCox proportional hazards modelHigh sugar intakeNIH-AARP DietIntake of fatConfidence intervalsNIH-AARP cohortRole of dietProportional hazards modelPotential confounding variablesParticipants ages 50Warrants further investigationProspective cohortHigh intakePV riskAge 50Health StudyRisk Factors for Intensive Care Unit Admission and In-hospital Mortality Among Hospitalized Adults Identified through the US Coronavirus Disease 2019 (COVID-19)-Associated Hospitalization Surveillance Network (COVID-NET)
Kim L, Garg S, O’Halloran A, Whitaker M, Pham H, Anderson EJ, Armistead I, Bennett NM, Billing L, Como-Sabetti K, Hill M, Kim S, Monroe ML, Muse A, Reingold AL, Schaffner W, Sutton M, Talbot HK, Torres SM, Yousey-Hindes K, Holstein R, Cummings C, Brammer L, Hall AJ, Fry AM, Langley GE. Risk Factors for Intensive Care Unit Admission and In-hospital Mortality Among Hospitalized Adults Identified through the US Coronavirus Disease 2019 (COVID-19)-Associated Hospitalization Surveillance Network (COVID-NET). Clinical Infectious Diseases 2020, 72: e206-e214. PMID: 32674114, PMCID: PMC7454425, DOI: 10.1093/cid/ciaa1012.Peer-Reviewed Original ResearchConceptsIntensive care unit admissionCare unit admissionHospital mortalityICU admissionUnit admissionMale sexRisk factorsAge 50Independent factorsCOVID-19-related complicationsLaboratory-confirmed COVID-19Surveillance networkCoronavirus disease 2019 (COVID-19) casesInvasive mechanical ventilationIn-Hospital MortalityChronic lung diseaseAcute care hospitalsCoronavirus disease 2019COVID-19Rigorous hand hygieneRenal diseaseMechanical ventilationMultivariable analysisLung diseaseSevere outcomes
2019
Scoring colorectal cancer risk with an artificial neural network based on self-reportable personal health data
Nartowt BJ, Hart GR, Roffman DA, Llor X, Ali I, Muhammad W, Liang Y, Deng J. Scoring colorectal cancer risk with an artificial neural network based on self-reportable personal health data. PLOS ONE 2019, 14: e0221421. PMID: 31437221, PMCID: PMC6705772, DOI: 10.1371/journal.pone.0221421.Peer-Reviewed Original ResearchConceptsNational Health Interview SurveyUnited States Preventative Services Task ForceColorectal cancerPredictive valueDiagnosis of CRCColorectal cancer riskHealth Interview SurveyHigh-risk categoryNegative predictive valuePositive predictive valueMultivariable prediction modelHealth dataUSPSTF guidelinesRisk score methodCRC riskFamily historyCancer riskHigh riskAge 50Individual prognosisLower riskPersonal health dataClinical applicabilityInterview SurveyCancer
2017
Aspirin for Primary Prevention
Richman IB, Owens DK. Aspirin for Primary Prevention. 2017, 101: 713-724. PMID: 28577622, DOI: 10.1016/j.mcna.2017.03.004.BooksMeSH KeywordsAge FactorsAspirinCardiovascular DiseasesColorectal NeoplasmsDiabetes MellitusGastrointestinal HemorrhageHumansHypertensionLipidsMyocardial InfarctionPlatelet Aggregation InhibitorsPractice Guidelines as TopicPrimary PreventionRacial GroupsRisk AssessmentRisk FactorsSex FactorsSmokingStrokeConceptsColorectal cancerPrimary preventionCardiovascular diseaseUS Preventive Services Task ForceNonfatal myocardial infarctionCardiovascular disease riskAdults age 50Intracranial bleedingOlder patientsMyocardial infarctionSelect populationAge 50AspirinAdults 60Disease riskAvailable evidenceRiskCancerDiseasePreventionTask ForceBleedingInfarctionPatientsStrokePREDICTORS OF CRASHES AND MOVING VIOLATIONS IN A DIVERSE SAMPLE OF OLDER WOMEN: THE WHIMS STUDIES
Marottoli R, Dugan E, Gaussoin S, Naughton M, Rapp S, Snively B, Vaughan L. PREDICTORS OF CRASHES AND MOVING VIOLATIONS IN A DIVERSE SAMPLE OF OLDER WOMEN: THE WHIMS STUDIES. Innovation In Aging 2017, 1: 650-650. PMCID: PMC6247174, DOI: 10.1093/geroni/igx004.2305.Peer-Reviewed Original ResearchSelf-reported crashesPredictors of crashesAdverse driving outcomesCognitive health outcomesLower cognitive scoresWHI Memory StudyAdverse driving eventsWHI hormone therapy trialsDriving outcomesOlder DriversAge differencesCognitive scoresHormone therapy trialsMemory studiesOlder US womenSocial supportDiverse sampleDriving eventsParticipantsTelephone questionnaireOlder womenUS womenAge 50Therapy trialsHealth outcomes
2016
Gastric and small intestine gastrointestinal stromal tumors: Do outcomes differ?
Giuliano K, Nagarajan N, Canner J, Najafian A, Wolfgang C, Schneider E, Meyer C, Lennon AM, Johnston FM, Ahuja N. Gastric and small intestine gastrointestinal stromal tumors: Do outcomes differ? Journal Of Surgical Oncology 2016, 115: 351-357. PMID: 27885685, DOI: 10.1002/jso.24514.Peer-Reviewed Original ResearchConceptsSmall intestine gastrointestinal stromal tumorGastrointestinal stromal tumorsCause-specific mortalityGIST patientsDiagnosis of GISTCases of GISTLarge nation-wide studyGastric gastrointestinal stromal tumorsGastric GIST patientsCommon mesenchymal tumorsFive-year survivalApproval of imatinibNation-wide studySEER databaseStromal tumorsMesenchymal tumorsGastrointestinal tractAge 50PatientsSurvival analysisSimilar outcomesTumorsPrevious reportsFrequent useOutcomes
2015
Family history of skin cancer is associated with early-onset basal cell carcinoma independent of MC1R genotype
Berlin NL, Cartmel B, Leffell DJ, Bale AE, Mayne ST, Ferrucci LM. Family history of skin cancer is associated with early-onset basal cell carcinoma independent of MC1R genotype. Cancer Epidemiology 2015, 39: 1078-1083. PMID: 26381319, PMCID: PMC4679454, DOI: 10.1016/j.canep.2015.09.005.Peer-Reviewed Original ResearchConceptsEarly-onset basal cell carcinomaBasal cell carcinomaFamily historySkin cancerAge of onsetLifestyle factorsBenign skin conditionsStrong risk factorFirst-degree relativesMC1R genotypeCell carcinomaRisk factorsAge 40High riskLifestyle characteristicsAge 50Particular malignancySkin conditionsBCC casesCancerGenetic susceptibilitySaliva samplesMultivariate modelIndividual riskAffected relatives
2014
Excess of Proximal Microsatellite-Stable Colorectal Cancer in African Americans from a Multiethnic Study
Xicola RM, Gagnon M, Clark JR, Carroll T, Gao W, Fernandez C, Mijic D, Rawson JB, Janoski A, Pusatcioglu CK, Rajaram P, Gluskin AB, Regan M, Chaudhry V, Abcarian H, Blumetti J, Cintron J, Melson J, Xie H, Guzman G, Emmadi R, Alagiozian-Angelova V, Kupfer SS, Braunschweig C, Ellis NA, Llor X. Excess of Proximal Microsatellite-Stable Colorectal Cancer in African Americans from a Multiethnic Study. Clinical Cancer Research 2014, 20: 4962-4970. PMID: 25013126, PMCID: PMC4167473, DOI: 10.1158/1078-0432.ccr-14-0353.Peer-Reviewed Original ResearchConceptsProximal colorectal cancerColorectal cancerMicrosatellite instabilityLymphocytic infiltrateKRAS mutationsAfrican AmericansMicrosatellite stable colorectal cancerDistal colorectal cancerFisher's exact testMicrosatellite stable tumorsMann-Whitney U testYoung African AmericansMedian ageAA patientsHigher BMICancer disparitiesChicago HospitalsStable tumorsAge 50High incidenceMultiethnic StudyExact testYounger ageCancerOlder ageOutcomes among older adult liver transplantation recipients in the model of end stage liver disease (MELD) era.
Malinis MF, Chen S, Allore HG, Quagliarello VJ. Outcomes among older adult liver transplantation recipients in the model of end stage liver disease (MELD) era. Annals Of Transplantation 2014, 19: 478-87. PMID: 25256592, PMCID: PMC4201657, DOI: 10.12659/aot.890934.Peer-Reviewed Original ResearchConceptsFunctional statusHepatitis CDonor ageHepatocellular carcinomaLT recipientsMELD eraAge 50End‐stage liver disease eraFive-year graft survival ratesEnd-stage liver disease (MELD) scoreSurvival rateAdult liver transplantation recipientsStage liver disease scoreLong-term graft survivalCox proportional hazard modelingHazard modelingPre-MELD eraGraft survival ratesLiver Disease scoreRetrospective cohort studyLiver transplantation recipientsLong-term graftModifiable risk factorsAdult LT recipientsShort-term outcomes
2011
Calcium intake in the United States from dietary and supplemental sources across adult age groups: new estimates from NHANES 2003–2006
Mangano K, Walsh S, Insogna K, Kenny A, Kerstetter J. Calcium intake in the United States from dietary and supplemental sources across adult age groups: new estimates from NHANES 2003–2006. The FASEB Journal 2011, 25: 993.1-993.1. DOI: 10.1096/fasebj.25.1_supplement.993.1.Peer-Reviewed Original ResearchDietary calcium intakeCalcium intakeAdult age groupsAge groupsEnergy intakeCalcium densityNutrition Examination Survey dataAdequate intake standardsCalcium supplement useMedian energy intakeY age groupRecent National HealthOlder age groupsMedical Research FoundationCross-sectional analysisNHANES respondentsBone healthCalcium supplementationSupplement useSupplement usersNational HealthNHANES 2003Age 50Intake standardsIntake
2010
Patterns of drug use and abuse among aging adults with and without HIV: A latent class analysis of a US Veteran cohort
Green TC, Kershaw T, Lin H, Heimer R, Goulet JL, Kraemer KL, Gordon AJ, Maisto SA, Day NL, Bryant K, Fiellin DA, Justice AC. Patterns of drug use and abuse among aging adults with and without HIV: A latent class analysis of a US Veteran cohort. Drug And Alcohol Dependence 2010, 110: 208-220. PMID: 20395074, PMCID: PMC3087206, DOI: 10.1016/j.drugalcdep.2010.02.020.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudyHIV statusMultidrug usersDrug useLatent class analysisUS Veteran cohortAging Cohort StudyActive drug useSelf-reported drug useMental health disordersProblem of obesityElectronic medical recordsUninfected veteransCohort studyClinical variablesDrug use consequencesSocio-demographic covariatesMedical recordsHigh prevalenceUninfected adultsAge 50HIVHealth disordersDrug usersVeteran cohort
2009
A multimedia patient education program on colorectal cancer screening increases knowledge and willingness to consider screening among Hispanic/Latino patients
Makoul G, Cameron K, Baker D, Francis L, Scholtens D, Wolf M. A multimedia patient education program on colorectal cancer screening increases knowledge and willingness to consider screening among Hispanic/Latino patients. Patient Education And Counseling 2009, 76: 220-226. PMID: 19250791, DOI: 10.1016/j.pec.2009.01.006.Peer-Reviewed Original ResearchConceptsMultimedia patient education programPatient education programScreening behaviorLatino adultsHispanic/Latino adultsHispanic/Latino patientsPast screening behaviourColorectal cancer screeningImportant health messagesActual screening behaviorHispanic/Latino communityStand-alone interventionCRC screeningLatino patientsCancer screeningAge 50Screening optionsHealth messagesPatientsEducation programsSignificant differencesPretest-posttest designStructured interviewsCRCAdditional researchThe joint contribution of sex, age and type of myocardial infarction on hospital mortality following acute myocardial infarction
Champney K, Frederick P, Bueno H, Parashar S, Foody J, Merz C, Canto J, Lichtman J, Vaccarino V, Investigators F. The joint contribution of sex, age and type of myocardial infarction on hospital mortality following acute myocardial infarction. Heart 2009, 95: 895. PMID: 19147625, PMCID: PMC3065924, DOI: 10.1136/hrt.2008.155804.Peer-Reviewed Original ResearchConceptsNon-ST elevation MIST-elevation MIElevation myocardial infarctionMyocardial infarctionNSTEMI patientsNon-ST elevation myocardial infarctionST-elevation myocardial infarctionRetrospective cohort studyExcess mortality riskShort-term mortalityAcute myocardial infarctionSex-related differencesHospital mortalityUnadjusted RRHospital deathCohort studyPatient ageExcess riskNational registryHospital participantsMAIN OUTCOMEMortality riskOlder womenAge 50Better survival
2007
Investigating Hispanic/Latino perceptions about colorectal cancer screening: A community-based approach to effective message design
Cameron K, Francis L, Wolf M, Baker D, Makoul G. Investigating Hispanic/Latino perceptions about colorectal cancer screening: A community-based approach to effective message design. Patient Education And Counseling 2007, 68: 145-152. PMID: 17517486, DOI: 10.1016/j.pec.2007.04.004.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overChicagoColorectal NeoplasmsCommunity Health CentersEducational StatusFearFemaleFocus GroupsHealth EducationHealth Knowledge, Attitudes, PracticeHealth PromotionHealth Services AccessibilityHealth Services Needs and DemandHispanic or LatinoHumansMaleMass ScreeningMiddle AgedNursing Methodology ResearchRisk FactorsSurveys and QuestionnairesConceptsHispanic/Latino communityLower colorectal cancer screening ratesScreening testColorectal cancer screening ratesHispanic/Latino patientsCancer screening ratesLate-stage presentationColorectal cancer screeningStandard screening testAdults age 50Hispanic/Latino populationStool cardsUnscreened patientsAsymptomatic presentationScreening ratesLatino patientsCancer screeningRisk factorsAge 50Eighth-grade educationHealth messagesRelevant anatomyLatino communityDevelopment of messagesSenior centers
2004
Occupational asbestos exposure and the incidence of non-hodgkin lymphoma of the gastrointestinal tract: an ecologic study
Treggiari MM, Weiss NS. Occupational asbestos exposure and the incidence of non-hodgkin lymphoma of the gastrointestinal tract: an ecologic study. Annals Of Epidemiology 2004, 14: 168-171. PMID: 15036219, DOI: 10.1016/s1047-2797(03)00241-2.Peer-Reviewed Original ResearchConceptsOccupational asbestos exposureNon-Hodgkin lymphomaRates of mesotheliomaAsbestos exposureGastrointestinal tractNational Cancer Institute's SurveillanceEcologic studyPrevious case-control studyIncidence of malignancyEnd Results ProgramCase-control studyMen age 50Results ProgramOccupational exposureSubsequent incidenceAge 50IncidenceMesotheliomaStrong associationLymphomaTractExposureSurveillanceUS regionsSan Francisco
2001
The relation of type 2 diabetes and cancer.
Strickler H, Wylie-Rosett J, Rohan T, Hoover D, Smoller S, Burk R, Yu H. The relation of type 2 diabetes and cancer. Diabetes Technology & Therapeutics 2001, 3: 263-74. PMID: 11478333, DOI: 10.1089/152091501300209633.Peer-Reviewed Original ResearchConceptsType 2 diabetesHigh waist circumferenceBody mass indexAdditional risk factorsInsulin-like growthCommon human malignanciesWaist circumferenceHip ratioMass indexOccult tumorsVisceral fatProspective InvestigationRisk factorsEtiologic associationSedentary lifestyleConsistent positive resultsElevated riskAge 50Cancer associationCurrent evidenceDiabetesEnergy intakeMethodologic issuesHuman malignanciesCancer
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