2024
A Principled Framework to Assess the Information-Theoretic Fitness of Brain Functional Sub-Circuits
Duong-Tran D, Nguyen N, Mu S, Chen J, Bao J, Xu F, Garai S, Cadena-Pico J, Kaplan A, Chen T, Zhao Y, Shen L, Goñi J. A Principled Framework to Assess the Information-Theoretic Fitness of Brain Functional Sub-Circuits. Mathematics 2024, 12: 2967. PMID: 38979488, PMCID: PMC11230349, DOI: 10.3390/math12192967.Peer-Reviewed Original ResearchStochastic block modelMultiple levels of granularityLevels of granularityFunctional networksInformation-theoreticThreshold methodThreshold strategyFunctional connectomeSub-circuitsGranularityHuman brain connectomeNetworkHuman Connectome ProjectBlock modelBrain connectome analysisFunctional sub-circuitsTopological featuresFrameworkPrinciples frameworkConnectome ProjectBrain connectomeNetwork neuroscienceThreshold valueMultiple levelsPartitioningIntegrating and fragmenting memories under stress and alcohol
Loetscher K, Goldfarb E. Integrating and fragmenting memories under stress and alcohol. Neurobiology Of Stress 2024, 30: 100615. PMID: 38375503, PMCID: PMC10874731, DOI: 10.1016/j.ynstr.2024.100615.Peer-Reviewed Original ResearchMemory representationsMemory integrationMemory-guided behaviorPre-existing schemaEffects of alcoholMemory bindingAversive learningNegative affectCognitive mechanismsPreclinical findingsMemoryDesign appropriate interventionsIndividual experienceAppropriate interventionsFragmented memoryAlcoholCausal structureAffectBehaviorMultiple levelsFindingsRepresentationStressSchemaIntervention
2023
Multilevel Stigma and Depression Among a National Sample of Black and Latinx LGBTQ+ Adolescents in the United States
Jackson S, Harvey T, Watson R, Pereira K, Clark K. Multilevel Stigma and Depression Among a National Sample of Black and Latinx LGBTQ+ Adolescents in the United States. Journal Of Psychopathology And Clinical Science 2023, 132: 577-589. PMID: 37347909, DOI: 10.1037/abn0000841.Peer-Reviewed Original ResearchConceptsStructural stigmaEthnic bullyingGender minority adolescentsNational sampleStigma indicatorsIntersectional interventionsLatinxMinority adolescentsStigmaUnited StatesBullyingMultiple formsComposite indexBlacksLimited researchMultiple levelsRacismHeterosexismLesbiansOppressionTransgenderQueerDepressive symptomsMental healthState
2022
Mechanisms of Action in Exposure Therapy
Knowles K, Tolin D. Mechanisms of Action in Exposure Therapy. Current Psychiatry Reports 2022, 24: 861-869. PMID: 36399234, DOI: 10.1007/s11920-022-01391-8.Peer-Reviewed Original ResearchConceptsExposure-based interventionsExposure therapyReturn of fearAnxiety-related disordersExtinction learningFear extinctionNeural levelPrefrontal regionsNeurobiological mechanismsSafety behaviorSuch translational researchTherapy workPromising future directionsBehavioral mechanismsPharmacological augmentationMixed resultsBehavioral changesIncreased activationFull symptom reliefMultiple levelsFuture directionsRecent FindingsRecent studiesSymptom improvementMechanism of actionSymptom reliefMultimodal imaging of synaptic vesicles with a single probe
An SJ, Stagi M, Gould TJ, Wu Y, Mlodzianoski M, Rivera-Molina F, Toomre D, Strittmatter SM, De Camilli P, Bewersdorf J, Zenisek D. Multimodal imaging of synaptic vesicles with a single probe. Cell Reports Methods 2022, 2: 100199. PMID: 35497490, PMCID: PMC9046237, DOI: 10.1016/j.crmeth.2022.100199.Peer-Reviewed Original ResearchConceptsC2 domainSynaptic vesiclesSynaptic vesicle recyclingMembrane-binding C2 domainMultiple microscopy methodsEndocytic markersMembrane recyclingVesicle functionVesicle populationsCytosolic phospholipase ACell typesPhospholipase ADetectable tagMicroscopy modalitiesModular probesMultiple microscopy techniquesVesiclesComplete understandingDomainMicroscopy methodsMultiple levelsProbeAvailable probesMicroscopy techniquesPathway
2021
Computational Mechanism for the Effect of Psychosis Community Treatment: A Conceptual Review From Neurobiology to Social Interaction
Benrimoh D, Sheldon A, Sibarium E, Powers AR. Computational Mechanism for the Effect of Psychosis Community Treatment: A Conceptual Review From Neurobiology to Social Interaction. Frontiers In Psychiatry 2021, 12: 685390. PMID: 34385938, PMCID: PMC8353084, DOI: 10.3389/fpsyt.2021.685390.Peer-Reviewed Original ResearchComputational modelAssertive community treatmentProcessing-based accountExperience of psychosisEvidence-based clinical interventionsCommunity treatmentPrevious computational modelsCognitive resourcesPositive psychotic symptomsComputational underpinningsComputational mechanismsSocial interactionStrong social elementSensory informationPositive symptomsConceptual reviewClinical interventionsEarly psychosisSocial elementsCandidate mechanismPsychotic symptomsNeurobiologyPsychosisConceptual paperMultiple levelsLearning hierarchical sequence representations across human cortex and hippocampus
Henin S, Turk-Browne NB, Friedman D, Liu A, Dugan P, Flinker A, Doyle W, Devinsky O, Melloni L. Learning hierarchical sequence representations across human cortex and hippocampus. Science Advances 2021, 7: eabc4530. PMID: 33608265, PMCID: PMC7895424, DOI: 10.1126/sciadv.abc4530.Peer-Reviewed Original ResearchConceptsOrdinal positionTransitional probabilitiesBrain areasEarliest brain areasGradient of complexityVisual sequencesCortico-hippocampal circuitsNeural representationNeural trackingEarly processingBrain's abilityTemporal regularityStatistical learningAssociative regionsSensory inputLow-level featuresHuman cortexSequence representationParallel computational systemsMultiple levelsComputational systemsIntracranial electrodesCortexHippocampusProcessing
2020
Prefrontal–amygdala circuits in social decision-making
Gangopadhyay P, Chawla M, Dal Monte O, Chang SWC. Prefrontal–amygdala circuits in social decision-making. Nature Neuroscience 2020, 24: 5-18. PMID: 33169032, PMCID: PMC7899743, DOI: 10.1038/s41593-020-00738-9.Peer-Reviewed Original ResearchConceptsSocial behaviorSystems neuroscience perspectivePrefrontal-amygdala pathwaysPrefrontal-amygdala circuitsPrefrontal cortical regionsSocial cognitionNeuroscience perspectiveNeural basisNeuropeptide oxytocinBrains of primatesNeural mechanismsCortical regionsNon-human primatesSpecific instantiationSocial constructMultiple levelsCognitionNeuronal activityMultiple animal speciesNeurobiologyAmygdalaBehaviorUnderpinningsPrimatesConstructsCyclic and multilevel causation in evolutionary processes
Warrell J, Gerstein M. Cyclic and multilevel causation in evolutionary processes. Biology & Philosophy 2020, 35: 50. DOI: 10.1007/s10539-020-09753-3.Peer-Reviewed Original ResearchEvolutionary processesComplex trait analysisModel of evolutionMultilevel selectionIndirect selectionTrait analysisEvolutionary variablesObserved traitsMultiple levelsMutation processCancer geneticsFitness modelFitnessMultilevel causal modelEnvironmental sourcesPrice equationObserved variationPotential relevanceGeneticsBiologyTraitsSelectionEvolution
2019
Coarse Graining of Data via Inhomogeneous Diffusion Condensation
Brugnone N, Gonopolskiy A, Moyle MW, Kuchroo M, van Dijk D, Moon KR, Colon-Ramos D, Wolf G, Hirn MJ, Krishnaswamy S. Coarse Graining of Data via Inhomogeneous Diffusion Condensation. 2024 IEEE International Conference On Big Data (BigData) 2019, 00: 2624-2633. PMID: 32747879, PMCID: PMC7398322, DOI: 10.1109/bigdata47090.2019.9006013.Peer-Reviewed Original ResearchLevels of resilience and delivery of HIV care in response to urban violence and crime
Cooper D, Green G, Tembo D, Christie S. Levels of resilience and delivery of HIV care in response to urban violence and crime. Journal Of Advanced Nursing 2019, 75: 1723-1731. PMID: 30972850, DOI: 10.1111/jan.14022.Peer-Reviewed Original ResearchConceptsUrban violenceEffects of crimeHIV care deliveryEndemic violenceDelivery of HIVInductive thematic analysisDepth interviewsViolenceCrimeLevel of resilienceThematic analysisCape TownSouth AfricaQualitative designCare deliveryKey conceptsResilienceLess researchOrganizational levelEco-systemHIV careContextMultiple levelsNursing staffGangsterismDNA Methylation and Susceptibility to Autism Spectrum Disorder
Tremblay MW, Jiang YH. DNA Methylation and Susceptibility to Autism Spectrum Disorder. Annual Review Of Medicine 2019, 70: 151-166. PMID: 30691368, PMCID: PMC6597259, DOI: 10.1146/annurev-med-120417-091431.Peer-Reviewed Original ResearchConceptsDNA methylationAbnormal DNA methylationDNA methylation reprogrammingGenome-wide changesMethylation-dependent regulationMethylation reprogrammingEpigenetic machineryNext-generation sequencingEmbryonic developmentMolecular basisDNA modificationsMethylationASD etiologyGenetic mutationsAttractive hypothesisRecent advancesReprogrammingEpimutationsTranscriptionASD casesMultiple levelsMachinerySequencingTechnical advancesMutations
2018
Change, Challenge, and Prospects for a Diversity Paradigm in Social Psychology
Jones J, Dovidio J. Change, Challenge, and Prospects for a Diversity Paradigm in Social Psychology. Social Issues And Policy Review 2018, 12: 7-56. DOI: 10.1111/sipr.12039.Peer-Reviewed Original ResearchSocial psychologyStudy of prejudiceDiversity paradigmSocial identityGroup membershipIndividual levelPsychologyJoint influenceDiversity challengesParadigmPrejudiceMultiple levelsTraditional emphasisDiversity objectivesStereotypingPractical benefitsFinal sectionPossible answersDiversity principleChallenges of diversityPotential benefitsQuestionsMembershipCurrent workMultiple groups
2017
The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission
Ugur B, Bao H, Stawarski M, Duraine LR, Zuo Z, Lin YQ, Neely GG, Macleod GT, Chapman ER, Bellen HJ. The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission. Cell Reports 2017, 21: 3794-3806. PMID: 29281828, PMCID: PMC5747319, DOI: 10.1016/j.celrep.2017.12.005.Peer-Reviewed Original ResearchConceptsSynaptic vesiclesKrebs cycle enzymeRole of metabolitesC2 domainPlasma membraneMitochondrial metabolismSynaptic transmissionMetabolic regulationCycle enzymesSynaptic roleAlpha-ketoglutarateSyt1ΑKGNeurodegenerative disordersDependent processesRegulationMetabolitesIDH3ASynaptotagmin1Multiple levelsFliesRoleFusionVesiclesATPMolecular and cellular reorganization of neural circuits in the human lineage
Sousa AMM, Zhu Y, Raghanti MA, Kitchen RR, Onorati M, Tebbenkamp ATN, Stutz B, Meyer KA, Li M, Kawasawa YI, Liu F, Perez RG, Mele M, Carvalho T, Skarica M, Gulden FO, Pletikos M, Shibata A, Stephenson AR, Edler MK, Ely JJ, Elsworth JD, Horvath TL, Hof PR, Hyde TM, Kleinman JE, Weinberger DR, Reimers M, Lifton RP, Mane SM, Noonan JP, State MW, Lein ES, Knowles JA, Marques-Bonet T, Sherwood CC, Gerstein MB, Sestan N. Molecular and cellular reorganization of neural circuits in the human lineage. Science 2017, 358: 1027-1032. PMID: 29170230, PMCID: PMC5776074, DOI: 10.1126/science.aan3456.Peer-Reviewed Original ResearchConceptsSingle-cell transcriptomic dataDistinct functional categoriesDistinct cell typesBiosynthesis genesTranscriptome sequencingHuman lineageTranscriptomic dataFunctional categoriesCellular reorganizationExpression differencesPhylogenetic reorganizationFunctional analysisCell typesGenesCellular featuresCellular differencesHuman specificityNeural circuitsLineagesMultiple levelsReorganizationSequencingHumansChimpanzeesAdult humansAn assessment of the social cognitive predictors of exclusive breastfeeding behavior using the Health Action Process Approach
Martinez-Brockman JL, Shebl FM, Harari N, Pérez-Escamilla R. An assessment of the social cognitive predictors of exclusive breastfeeding behavior using the Health Action Process Approach. Social Science & Medicine 2017, 182: 106-116. PMID: 28437693, DOI: 10.1016/j.socscimed.2017.04.014.Peer-Reviewed Original ResearchConceptsHealth Action Process ApproachSocial cognitive predictorsExclusive breastfeeding behaviorCognitive predictorsHAPA modelEffect of intentionOutcome expectanciesSocial ecological modelProcess approachStructural equationSound textCounseling programCounseling processAddress factorsIntentionPeer counseling programWeighted least squares estimationMultiple levelsLactation AdviceTheoretical modelBreastfeeding behaviorExclusive breastfeeding durationInterventionPredictorsBehaviorA qualitative analysis of multi-level barriers to HIV testing among women in Lebanon
Clark KA, Keene DE, Pachankis JE, Fattal O, Rizk N, Khoshnood K. A qualitative analysis of multi-level barriers to HIV testing among women in Lebanon. Culture Health & Sexuality 2017, 19: 996-1010. PMID: 28276925, DOI: 10.1080/13691058.2017.1282045.Peer-Reviewed Original ResearchConceptsNon-governmental organizationsCulture of sexNorth Africa (MENA) regionSocial ecological modelSemi-structured interviewsSexual health educationMulti-level barriersKey informantsMiddle EastSexual healthcare providersSexual health interventionsAfrica regionLebanonQualitative analysisFinancial barriersProvider attitudesHigh-risk populationInsurance policiesTheory frameworkMultiple levelsWomenPrimary findingsHIV testingHIV casesPolicy
2016
Training primary care physicians in cognitive behavioral therapy: A review of the literature
Dorflinger LM, Fortin AH, Foran-Tuller KA. Training primary care physicians in cognitive behavioral therapy: A review of the literature. Patient Education And Counseling 2016, 99: 1285-1292. PMID: 26979474, DOI: 10.1016/j.pec.2016.02.014.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyBehavioral therapyCBT training programCommon mental health concernsPrimary care physiciansTraining contentMental health concernsMental health treatmentSkills-based approachCBT trainingHealth treatmentCare physiciansTraining programLearning outcomesMedical settingsMultiple levelsAssessment of outcomesFull-text articlesPrimary careRoutine practiceSubstantial variabilityHealth concernStudy designAdditional studiesFuture studiesSocial Determinants of Population Health: A Systems Sciences Approach
Fink D, Keyes K, Cerdá M. Social Determinants of Population Health: A Systems Sciences Approach. Current Epidemiology Reports 2016, 3: 98-105. PMID: 27642548, PMCID: PMC5025257, DOI: 10.1007/s40471-016-0066-8.Peer-Reviewed Original ResearchSocial determinantsSystems science approachSocial determinants of healthUnequal distribution of healthStudy of population healthDeterminants of healthSocial epidemiological perspectiveHealth-related factorsDistribution of healthReduce such inequalitiesPopulation healthEpidemiological perspectiveHealthHealth emergencySocietal levelScience approachPopulationUnequal distributionIndividualsConceptual frameworkMultiple levelsSocial networksComplex interplayPopulation distributionEmergency
2015
Transgender stigma and health: A critical review of stigma determinants, mechanisms, and interventions
Hughto J, Reisner SL, Pachankis JE. Transgender stigma and health: A critical review of stigma determinants, mechanisms, and interventions. Social Science & Medicine 2015, 147: 222-231. PMID: 26599625, PMCID: PMC4689648, DOI: 10.1016/j.socscimed.2015.11.010.Peer-Reviewed Original ResearchConceptsAdverse health-related effectsForms of stigmaTransgender peopleSocial ecological modelStigma preventionMental healthTransgender stigmaStigma determinantsWidespread prejudiceMulti-level interventionsStigmaAdverse healthEcological modelMultiple levelsCritical domainsLimit opportunitiesAdditional researchCritical reviewInterventionPeopleHealth-related effectsTransgender populationCausal relationshipModeratorPrejudice
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