2019
Downregulation of p66Shc can reduce oxidative stress and apoptosis in oxidative stress model of marginal cells of stria vascularis in Sprague Dawley rats
Hao C, Wu X, Zhou R, Zhang H, Zhou Y, Wang X, Feng Y, Mei L, He C, Cai X, Wu L. Downregulation of p66Shc can reduce oxidative stress and apoptosis in oxidative stress model of marginal cells of stria vascularis in Sprague Dawley rats. Drug Design Development And Therapy 2019, 13: 3199-3206. PMID: 31686782, PMCID: PMC6751335, DOI: 10.2147/dddt.s214918.Peer-Reviewed Original ResearchConceptsReactive oxygen speciesMarginal cellsStria vascularisOxidative stressAnnexin V/7-AAD stainingInner ear agingResistance to oxidative stressAnnexin-V/7-AADAdenovirus expressing siRNAKnockdown of p66shcEnhanced resistance to oxidative stressSprague Dawley ratsOxidative stress modelMarginal cells of stria vascularisIn vitro oxidative stress modelP66Shc inhibitionReactive oxygen species levelsNeonatal ratsDCFH-DA probeGlucose oxidaseOxidative stress signalingReducing oxidative stressStress signalsDawley ratsP66Shc levels
2018
Metabolic imaging with the use of fluorescence lifetime imaging microscopy (FLIM) accurately detects mitochondrial dysfunction in mouse oocytes
Sanchez T, Wang T, Pedro MV, Zhang M, Esencan E, Sakkas D, Needleman D, Seli E. Metabolic imaging with the use of fluorescence lifetime imaging microscopy (FLIM) accurately detects mitochondrial dysfunction in mouse oocytes. Fertility And Sterility 2018, 110: 1387-1397. PMID: 30446247, PMCID: PMC6289735, DOI: 10.1016/j.fertnstert.2018.07.022.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedComputer SystemsEmbryo Culture TechniquesEmbryo, MammalianEmbryonic DevelopmentEndopeptidase ClpFemaleFlavin-Adenine DinucleotideFluorescenceMaleMaternal AgeMiceMice, Inbred C57BLMice, KnockoutMicroscopy, FluorescenceMitochondriaMolecular ImagingNADOocytesReactive Oxygen SpeciesConceptsBlastocyst development rateOocyte dysfunctionReactive oxygen species levelsFlavin adenine dinucleotide (FAD) autofluorescenceMetabolic dysfunctionOxygen species levelsYoung miceMetabolic parametersOld miceMAIN OUTCOMEGlobal knockoutDysfunctionNoninvasive toolNormal oocytesMetabolic imagingMitochondrial dysfunctionMiceOld oocytesFLIM parametersROS levelsMetabolic differencesMitochondrial functionNicotinamide adenine dinucleotide dehydrogenaseIndividual oocytesWild-type oocytes
2017
Direct exposure to mild heat promotes proliferation and neuronal differentiation of neural stem/progenitor cells in vitro
Hossain E, Matsuzaki K, Katakura M, Sugimoto N, Al Mamun AA, Islam R, Hashimoto M, Shido O. Direct exposure to mild heat promotes proliferation and neuronal differentiation of neural stem/progenitor cells in vitro. PLOS ONE 2017, 12: e0190356. PMID: 29287093, PMCID: PMC5747471, DOI: 10.1371/journal.pone.0190356.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain-Derived Neurotrophic FactorCell DifferentiationCell ProliferationCells, CulturedChromonesCREB-Binding ProteinHeat-Shock ProteinsHot TemperatureMorpholinesNeural Stem CellsNeuronsPhosphorylationProto-Oncogene Proteins c-aktRatsReactive Oxygen SpeciesReal-Time Polymerase Chain ReactionConceptsNSC/NPC proliferationBrain-derived neurotrophic factorNSCs/NPCsNeural stem/progenitor cellsStem/progenitor cellsNeurosphere diameterMild heat exposureNPC proliferationMRNA expressionHeat exposureHeat shock proteinsNeuronal differentiationBDNF mRNA expressionProgenitor cellsEffective therapeutic strategyHeat-acclimated ratsCAMP response element-binding proteinResponse element-binding proteinReactive oxygen species levelsHeat acclimationAkt phosphorylation levelsForebrain cortexProportion of cellsEnhanced neurogenesisNeurotrophic factorOxalate-curcumin–based probe for micro- and macroimaging of reactive oxygen species in Alzheimer’s disease
Yang J, Zhang X, Yuan P, Yang J, Xu Y, Grutzendler J, Shao Y, Moore A, Ran C. Oxalate-curcumin–based probe for micro- and macroimaging of reactive oxygen species in Alzheimer’s disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 12384-12389. PMID: 29109280, PMCID: PMC5703278, DOI: 10.1073/pnas.1706248114.Peer-Reviewed Original ResearchConceptsCerebral amyloid angiopathyAD brainAlzheimer's diseaseTwo-photon imagingNIRF imagingAmyloid-beta plaquesROS levelsIrreversible neurodegenerative disorderAD pathological conditionsAge-related increaseReactive oxygen species levelsAmyloid angiopathyBeta plaquesOxygen species levelsDrug treatmentHealthy brainNeurodegenerative disordersDiseaseOxidative stressHigh ROS levelsPathological conditionsReactive oxygen speciesBrainFluorescence imaging probeOxygen species
2015
Autophagy Alleviates Melamine-Induced Cell Death in PC12 Cells Via Decreasing ROS Level
Wang H, Gao N, Li Z, Yang Z, Zhang T. Autophagy Alleviates Melamine-Induced Cell Death in PC12 Cells Via Decreasing ROS Level. Molecular Neurobiology 2015, 53: 1718-1729. PMID: 25724280, DOI: 10.1007/s12035-014-9073-2.Peer-Reviewed Original ResearchConceptsPC12 cellsLC3-II/LC3Western blot assaysCell deathReactive oxygen species levelsSuperoxide dismutase activityMDA levelsOxygen species levelsGeneration of ROSATG-7Autophagy markersBlot assaysIncrease of autophagosomesBeclin-1Oxidative stressDismutase activityROS levelsRapamycinExcessive generationExpression levelsCell viabilityOxidative damageAutophagyMalondialdehydeDeath
2013
Neuroprotective Effect of Leukemia Inhibitory Factor on Antimycin A-Induced Oxidative Injury in Differentiated PC12 Cells
Han Y, Xu J, Li Z, Yang Z. Neuroprotective Effect of Leukemia Inhibitory Factor on Antimycin A-Induced Oxidative Injury in Differentiated PC12 Cells. Journal Of Molecular Neuroscience 2013, 50: 577-585. PMID: 23636893, DOI: 10.1007/s12031-013-0004-x.Peer-Reviewed Original ResearchConceptsLeukemia inhibitory factorOxidative injuryNeuroprotective effectsPC12 cellsInhibitory factorOxidative stressExerts neuroprotective effectsSuperoxide dismutase levelsElevated reactive oxygen species (ROS) levelsPC12 cell viabilityReactive oxygen species levelsHoechst 33342 stainingNeuron injuryDifferentiated PC12 cellsDiphenyltetrazolium bromide assayNeuroendocrine effectsNeurotrophic cytokinesPresence of LIFOxygen species levelsDismutase levelsInjuryAntioxidative effectsBromide assayDimethylthiazol-2Cell viabilityUpregulation of Cytoprotective Defense Mechanisms and Hypoxia-Responsive Proteins Imparts Tolerance to Acute Hypobaric Hypoxia
Jain K, Suryakumar G, Prasad R, Ganju L. Upregulation of Cytoprotective Defense Mechanisms and Hypoxia-Responsive Proteins Imparts Tolerance to Acute Hypobaric Hypoxia. High Altitude Medicine & Biology 2013, 14: 65-77. PMID: 23537263, DOI: 10.1089/ham.2012.1064.Peer-Reviewed Original ResearchMeSH KeywordsAltitudeAnimalsAtmospheric PressureCatalaseCreatine Kinase, MB FormDyspneaEndothelin-1ErythropoietinHeme Oxygenase-1HSP70 Heat-Shock ProteinsHSP90 Heat-Shock ProteinsHypoxiaHypoxia-Inducible Factor 1, alpha SubunitMaleMalondialdehydeMyocarditisMyocardiumNitric OxideOxidative StressProtein CarbonylationRatsRats, Sprague-DawleyReactive Oxygen SpeciesSuperoxide DismutaseTime FactorsUp-RegulationVascular Endothelial Growth Factor AConceptsEnvironmental stressHypoxia-responsive proteinsSubsequent oxidative damageReactive oxygen species levelsCellular machineryHypoxia-responsive moleculesResponsive genesOxygen species levelsSpecies levelDifferential expressionTolerant animalsDefense mechanismsOxidative damageCytoprotective chaperoneAntioxidant enzymesHypobaric hypoxiaHigh expressionHIF-1αProteinAdult Sprague-Dawley ratsExpressionMyocardial antioxidant enzymesAcute hypobaric hypoxiaSprague-Dawley ratsCK-MB activity
2011
Aldehyde dehydrogenases are regulators of hematopoietic stem cell numbers and B-cell development
Gasparetto M, Sekulovic S, Brocker C, Tang P, Zakaryan A, Xiang P, Kuchenbauer F, Wen M, Kasaian K, Witty MF, Rosten P, Chen Y, Imren S, Duester G, Thompson DC, Humphries RK, Vasiliou V, Smith C. Aldehyde dehydrogenases are regulators of hematopoietic stem cell numbers and B-cell development. Experimental Hematology 2011, 40: 318-329.e2. PMID: 22198153, DOI: 10.1016/j.exphem.2011.12.006.Peer-Reviewed Original ResearchMeSH KeywordsAldehyde DehydrogenaseAldehyde Dehydrogenase 1 FamilyAldehydesAnimalsAnimals, CongenicB-LymphocytesBone Marrow TransplantationCell CountCell CycleCell LineageCells, CulturedColony-Forming Units AssayDNA DamageEnzyme InductionGene Expression RegulationHematopoiesisHematopoietic Stem CellsLymphopeniaMiceMice, Inbred C57BLMice, Knockoutp38 Mitogen-Activated Protein KinasesRadiation ChimeraReactive Oxygen SpeciesRetinal DehydrogenaseSignal TransductionConceptsB cell developmentHematopoietic stem cellsReactive oxygen speciesMitogen-activated protein kinase activityP38 mitogen-activated protein kinase activityProtein kinase activityExcess reactive oxygen speciesOxygen speciesReactive aldehydesStem cell numbersHematopoietic stem cell numbersReactive oxygen species levelsEarly B cellsNumber of HSCsHSC biologyCell cycle distributionKinase activityOxygen species levelsAldh1a1 deficiencyGene expressionSpecies levelIntracellular signalingAldehyde dehydrogenasesDNA damageCell cycling
2003
The proapoptotic benzodiazepine Bz-423 affects the growth and survival of malignant B cells.
Boitano A, Ellman JA, Glick GD, Opipari AW. The proapoptotic benzodiazepine Bz-423 affects the growth and survival of malignant B cells. Cancer Research 2003, 63: 6870-6. PMID: 14583485.Peer-Reviewed Original ResearchConceptsB cell linesSystemic lupus erythematosusMalignant B-cell linesMalignant B cellsPeripheral benzodiazepine receptorReactive oxygen species levelsEBV statusLupus erythematosusLymphoproliferative diseaseAntineoplastic therapyOxygen species levelsBurkitt's lymphomaAnimal modelsBenzodiazepine receptorsClinical developmentB cellsPotent antiproliferative agentBz-423Phase arrestBcl-2Expression levelsLymphomaAntiproliferative agentsCell deathDisease
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