Downregulation of p66Shc can reduce oxidative stress and apoptosis in oxidative stress model of marginal cells of stria vascularis in Sprague Dawley rats
Hao C, Wu X, Zhou R, Zhang H, Zhou Y, Wang X, Feng Y, Mei L, He C, Cai X, Wu L. Downregulation of p66Shc can reduce oxidative stress and apoptosis in oxidative stress model of marginal cells of stria vascularis in Sprague Dawley rats. Drug Design Development And Therapy 2019, 13: 3199-3206. PMID: 31686782, PMCID: PMC6751335, DOI: 10.2147/dddt.s214918.Peer-Reviewed Original ResearchConceptsReactive oxygen speciesMarginal cellsStria vascularisOxidative stressAnnexin V/7-AAD stainingInner ear agingResistance to oxidative stressAnnexin-V/7-AADAdenovirus expressing siRNAKnockdown of p66shcEnhanced resistance to oxidative stressSprague Dawley ratsOxidative stress modelMarginal cells of stria vascularisIn vitro oxidative stress modelP66Shc inhibitionReactive oxygen species levelsNeonatal ratsDCFH-DA probeGlucose oxidaseOxidative stress signalingReducing oxidative stressStress signalsDawley ratsP66Shc levels
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